Publikationen
2026
Immune-metabolic trajectories delineate subgroups in paediatric long COVID
Vilser, Daniel; Han, Irina; Vogel, Katrin; Jakobs, Pauline; Lorenz, Michael; Huppke, Peter; Newman, Lars; Paszkier, Michelle; Kuhle, Jens; Mohr, Juliane; Aign, Clara; Reinhold, Annegret; Reinhold, Dirk; Weinzierl, Stefan; Ullmann, Elisabeth; Proquitté, Hans Michael; Brunner-Weinzierl, Monika
In: Nature Communications - [London] : Springer Nature, Bd. 17 (2026), Artikel 4023, insges. 14 S.
2025
SLAMF7 (CD319) on activated CD8+ T cells transduces environmental cues to initiate cytotoxic effector cell responses
Lingel, Holger; Fischer, Laura; Remstedt, Sven; Kuropka, Benno; Philipsen, Lars; Han, Irina; Sander, Jan-Erik; Freund, Christian; Arra, Aditya; Brunner-Weinzierl, Monika
In: Cell death and differentiation - [London] : Springer Nature, Bd. 32 (2025), Heft 3, S. 561-572
Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection
Lokau, Juliane; Garbers, Yvonne; Vicente, Manuel M.; Dittrich, Anna; Meltendorf, Stefan; Lingel, Holger; Münster-Kühnel, Anja K.; Brunner-Weinzierl, Monika; Garbers, Christoph
In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 15 (2025), Artikel 1488745, insges. 13 S.
PD1+ innate lymphoid cells 3 predict JAK-dependent inflammation in rheumatoid arthritis
Arra, Aditya; Vogel, Katrin; Han, Irina Han; Behrendt, Christine; Dunay, Ildikò Rita; Häupl, Thomas; Feist, Eugen; Brunner-Weinzierl, Monika
In: Journal of autoimmunity - [Amsterdam] : Elsevier, Bd. 154 (2025), Artikel 103424, insges. 11 S.
The immunosuppressive effect of glucocorticoids in human primary T cells is mainly mediated via a rapid inhibition of the IL-2/IL-2R signaling axis
Melo, L. Tatiana Albarracin; Abdulkhakov, Nekruz; Han, Irina; El-Bizri, Ali; Brunner-Weinzierl, Monika; Schraven, Burkhart; Simeoni, Luca
In: Cell communication and signaling - London : Biomed Central, Bd. 23 (2025), Artikel 268, insges. 17 S.
SLAMF7 (CD319) enhances cytotoxic T-cell differentiation and sensitizes CD8+ T cells to immune checkpoint blockade
Sander, Jan-Erik; Han, Irina; Fickenscher, Lisette; Schmidt, Jörg-Peter; Kroll, Hartmut; Vosiková, Tereza; Durisin, Martin; Lingel, Holger; Brunner-Weinzierl, Monika
In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 16 (2025), Artikel 1654374, insges. 14 S.
Cut or bind? - Antigen-specific processing mechanisms define CD4+ T cell immunodominant epitopes for SARS-CoV-2 S and N proteins
Álvaro-Benito, Miguel; Abualrous, Esam T.; Lingel, Holger; Meltendorf, Stefan; Holzapfel, Jakob; Diego Valera, de Paula; Sticht, Jana; Kuropka, Benno; Clementi, Cecilia; Kuppler, Frank; Brunner-Weinzierl, Monika; Freund, Christian
In: Genome medicine - London : BioMed Central, Bd. 17 (2025), Artikel 147, insges. 17 S.
Decoding of T cell immunodominance patterns by an integrated mechanistic approach
Álvaro-Benito, Miguel; Abualrous, Esam T.; Lingel, Holger; Meltendorf, Stefan; Holzapfel, Jakob; Diego Valera, de Paula; Sticht, Jana; Kuropka, Benno; Clementi, Cecilia; Kuppler, Frank; Brunner-Weinzierl, Monika; Freund, Christian
In: bioRxiv beta - Cold Spring Harbor : Cold Spring Harbor Laboratory, NY . - 2025, insges. 40 S.
2024
Effective assessment of CD4+ T cell immunodominance patterns - impact of antigen processing and HLA restriction
Álvaro-Benito, Miguel; Abualrous, Esam T.; Lingel, Holger; Meltendorf, Stefan; Holzapfel, Jakob; Sticht, Jana; Kuropka, Benno; Clementi, Cecilia; Kuppler, Frank; Brunner-Weinzierl, Monika; Freund, Christian
In: bioRxiv beta - Cold Spring Harbor : Cold Spring Harbor Laboratory, NY . - 2024, insges. 25 S.
Bifidobacterium shapes antimicrobial T-cell responses during infancy and adulthood
Vogel, Katrin; Arra, Aditya; Lingel, Holger; Bretschneider, Dirk; Prätsch, Florian; Schanze, Denny; Zenker, Martin; Bruder, Dunja; Geffers, Robert; Hachenberg, Thomas; Arens, Christoph; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 54 (2024), Heft Suppl. 1, S. 81, Artikel 531-WS10.4
Signaling lymphocyte activation molecule 7 (SLAMF7) in the differentiation of human, pathogen-specific T cells
Fickenscher, Lisette; Vogel, Katrin; Han, Irina; Arra, Aditya; Lingel, Holger; Sander, Jan-Erik; Bretschneider, Dirk; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 54 (2024), Heft Suppl. 1, S. 1122, Artikel 545-P2.09.06
Targeting of SLAMF7 on human CD8+ T cells to enhance responsiveness against tumor-associated antigens
Sander, Jan-Erik; Lingel, Holger; Vogel, Katrin; Arra, Aditya; Han, Irina; Fickenscher, Lisette; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 54 (2024), Heft Suppl. 1, S. 1123, Artikel 551-P2.09.07
2023
Age-related differences in immune reactions to SARS-CoV-2 spike and nucleocapsid antigens
Morhart, Patrick Daniel; Kehl, Sven; Schuh, Wolfgang; Hermes, Katharina; Meltendorf, Stefan; Neubert, Antje; Schneider, Michael; Brunner-Weinzierl, Monika; Schneider, Holm; Lingel, Holger
In: In vivo - Kapandriti, Attiki : IIAR, Bd. 37 (2023), Heft 1, S. 70-78
PD-1/PD-L1 control of antigen-specifically activated CD4 T-cells of neonates
Majer, Christiane; Lingel, Holger; Arra, Aditya; Heuft, Hans-Gert; Bretschneider, Dirk; Balk, Silke; Vogel, Katrin; Brunner-Weinzierl, Monika
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 6, Artikel 5662, insges. 13 S.
PD-1 limits differentiation and plasticity of Tc17 cells
Arra, Aditya; Lingel, Holger; Pierau, Mandy; Brunner-Weinzierl, Monika
In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 14 (2023), Artikel 1104730, insges. 13 S.
Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood
Vogel, Katrin; Arra, Aditya; Lingel, Holger; Bretschneider, Dirk; Prätsch, Florian; Schanze, Denny; Zenker, Martin; Balk, Silke; Bruder, Dunja; Geffers, Robert; Hachenberg, Thomas; Arens, Christoph; Brunner-Weinzierl, Monika
In: Nature Communications - [London] : Nature Publishing Group UK, Bd. 14 (2023), Artikel 5943, insges. 13 S.
An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells
Salerno, Fiamma; Howden, Andrew J. M.; Matheson, Louise, S.; Gizlenci, Özge; Screen, Michael; Lingel, Holger; Brunner-Weinzierl, Monika; Turner, Martin
In: Nature Communications - [London] : Nature Publishing Group UK, Bd. 14 (2023), Artikel 5116, insges. 18 S.
Das Bifidobakterium infantis als Wächter des Immunsystems
Vogel, Katrin; Brunner-Weinzierl, Monika
In: Ärzteblatt Sachsen-Anhalt - Magdeburg : Ärztekammer Sachsen-Anhalt, Bd. 34 (2023), Heft 12, S. 28-29
Proteomic profiling and cytokine analysis reveals molecular signatures and inflammatory factors associated with thrombosis in JAK2-V617F positive myeloproliferative neoplasm (MPN) cohorts
Bhuria, Vikas; Ham, van Marco Adrianus; Vogel, Katrin; Waldleben, Ana; Zeremski, Vanja; Böttcher, Martin; Brunner-Weinzierl, Monika; Mougiakakos, Dimitrios; Schraven, Burkhart; Jänsch, Lothar; Fischer, Thomas
In: Blood - Washington, DC : American Society of Hematology, Bd. 142 (2023), Heft Supplement 1, Artikel 6340, insges. 2 S.
SLAMF7 (CD319) lowers the threshold for differentiation commitment of cytotoxic T lymphocytes
Lingel, Holger; Arra, Aditya; Kuropka, Benno; Remstedt, Sven; Philipsen, Lars; Freund, Christian; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 53 (2023), Heft Suppl. 2, S. 148, Artikel O 32
SLAMF7-signals induce resistance against apoptosis in activated CD8+ T-cells
Orlov, Anastasia; Lingel, Holger; Arra, Aditya; Han, Irina; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 53 (2023), Heft Suppl. 2, S. 150, Artikel O 34
2022
IL-13 determines specific IgE responses and SARS-CoV-2 immunity after mild COVID-19 and novel mRNA vaccination
Meltendorf, Stefan; Vogel, Katrin; Thurm, Christoph; Prätsch, Florian; Reinhold, Annegret; Färber, Jacqueline; Heuft, Hans-Gert; Kaasch, Achim; Hachenberg, Thomas; Weinzierl, Stefan; Schraven, Burkhart; Reinhold, Dirk; Brunner-Weinzierl, Monika; Lingel, Holger
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft 12, S. 1972-1979
Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation
Zenke, Simon; Sica, Mauricio P.; Steinberg, Florian; Braun, Julia; Zink, Alicia; Gavrilov, Alina; Hilger, Alexander; Arra, Aditya; Brunner-Weinzierl, Monika; Elling, Roland; Beyersdorf, Niklas; Lämmermann, Tim; Smulski, Cristian R.; Rohr, Jan
In: Nature Communications - [London] : Springer Nature, Bd. 13 (2022), Artikel 6459, insges. 18 S.
Assessment of immune status using inexpensive cytokines - a literature review and learning approaches
Jamaludeen, Noor; Lehmann, Juliane; Beyer, Christian; Vogel, Katrin; Pierau, Mandy; Brunner-Weinzierl, Monika; Spiliopoulou, Myra
In: Sensors - Basel : MDPI, Bd. 22 (2022), Heft 24, Artikel 9785, insges. 26 S.
Analysis of exhausted T cells, systemically enhanced cytokine levels ex vivo and machine learning facilitated search for ageing-related biomarkers
Beyer, Christian; Jamaludeen, Noor; Vogel, Katrin; Pierau, Mandy; Lingel, Holger; Meltendorf, Stefan; Spiliopoulou, Myra; Brunner-Weinzierl, Monika
In: Das Gesundheitswesen - Stuttgart [u.a.] : Thieme, Bd. 84 (2022), Heft 8/9, S. 846
Developmental bias of newly synthesized proteins in Candida albicans-activated human CD4+ T-cells
Balk, Silke; Pierau, Mandy; Vogel, Katrin; Reinking, Janne; Vosiková, Tereza; Cakir, Eda; Bretschneider, Dirk; Jänsch, Lothar; Vorwerk, Ulrich; Heuft, Hans-Gert; Hütt, Marc-Thorsten; Arra, Aditya; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft Suppl. 1, S. 273-274, Artikel P 138
T cell responses after immune checkpoint blockade differ between children, teenagers and adults
Aign, Clara; Arra, Aditya; Vosiková, Tereza; Vorwerk, Ulrich; Heuft, Hans-Gert; Vogel, Katrin; Lingel, Holger; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft Suppl. 1, S. 275, Artikel P 140
Age dependence of T cell immune responses against bacteria and fungi in cystic fibrosis patients
Paszkier, Michelle; Vogel, Katrin; Pierau, Mandy; Meltendorf, Stefan; Vosiková, Tereza; Heuft, Hans-Gert; Gleißner, Michael; Bruder, Dunja; Arra, Aditya; Vorwerk, Ulrich; Schreiber, Jens; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft Suppl. 1, S. 277, Artikel P 142
SLAMF7 (CD319) is a co-stimulatory molecule on CD4+ T-cells and regulated by CTLA-4 and TGFβ
Han, Irina; Arra, Aditya; Lingel, Holger; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft Suppl. 1, S. 331-332, Artikel P 205
PD-1 suppresses differentiation and plasticity of IL-17 producing CD8+ T-cells (Tc17 cells)
Arra, Aditya; Pierau, Mandy; Lingel, Holger; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft Suppl. 1, S. 330-331, Artikel P 203
Staphylococcus aureus and Bifidobacterium longum are well recognized by T-cells with opposite results
Vogel, Katrin; Arra, Aditya; Lingel, Holger; Bretschneider, Dirk; Prätsch, Florian; Schanze, Denny; Zenker, Martin; Bruder, Dunja; Hachenberg, Thomas; Arens, Christoph; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft Suppl. 1, S. 265, Artikel P 129
Unique lasting effects on immune composition and autoantibody prevalence after mild SARS-CoV-2 infections
Lingel, Holger; Meltendorf, Stefan; Billing, Ulrike; Thurm, Christoph; Vogel, Katrin; Majer, Christiane; Prätsch, Florian; Roggenbuck, Dirk; Heuft, Hans-Gert; Hachenberg, Thomas; Feist, Eugen; Reinhold, Dirk; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft Suppl. 1, S. 173-174, Artikel P 028
2021
Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in mice
Korthals, Mark; Tech, Laura; Langnaese, Kristina; Gottfried, Anna; Hradsky, Johannes; Thomas, Ulrich; Zenclussen, Ana Claudia; Brunner-Weinzierl, Monika; Tedford, Kerry; Fischer, Klaus-Dieter
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 51 (2021), Heft 3, S. 594-602
Unique autoantibody prevalence in long-term recovered SARS-CoV-2-infected individuals
Lingel, Holger; Meltendorf, Stefan; Billing, Ulrike; Thurm, Christoph; Vogel, Katrin; Majer, Christiane; Prätsch, Florian; Roggenbuck, Dirk; Heuft, Hans-Gert; Hachenberg, Thomas; Feist, Eugen; Reinhold, Dirk; Brunner-Weinzierl, Monika
In: Journal of autoimmunity - London : Academic Press, Bd. 122 (2021), Artikel 102682, insges. 8 S.
Potential of point-of-care and at-home assessment of immune status via rapid cytokine detection and questionnaire-based anamnesis
Jamaludeen, Noor; Beyer, Christian; Billing, Ulrike; Vogel, Katrin; Brunner-Weinzierl, Monika; Spiliopoulou, Myra
In: Sensors - Basel : MDPI, Bd. 21 (2021), Heft 15, Artikel 4960, insges. 33 S.
Immune-checkpoint blockade of CTLA-4 (CD152) in antigen-specific human T-cell responses differs profoundly between neonates, children, and adults
Arra, Aditya; Pech, Maximilian; Fu, Hang; Lingel, Holger; Braun, Franziska; Beyer, Christian; Spiliopoulou, Myra; Bröker, Barbara; Lampe, Karen; Arens, Christoph; Vogel, Katrin; Pierau, Mandy; Brunner-Weinzierl, Monika
In: OncoImmunology - Abingdon : Taylor & Franics, Bd. 10 (2021), Heft 1, Artikel e1938475, insges. 12 S.
Preventing atopic diseases during childhood - early exposure matters
Pierau, Mandy; Arra, Aditya; Brunner-Weinzierl, Monika
In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 12 (2021), Artikel 617731, insges. 14 S.
The regulation of the expression of PMCA isoforms by neuroplastin has an impact on the calcium clearance in cultured hippocampal neurons
Junge, Lennart; Brunner-Weinzierl, Monika; Roßner, Steffen
In: Magdeburg: Otto-von-Guericke-Universität Magdeburg, Dissertation Universität Magdeburg 2021, vi, 55 Blätter
Opposing effects of Bifidobacterium longum and Staphylococcus aureus after recognition by paediatric T cells
Vogel, Katrin; Arra, Aditya; Lingel, Holger; Bretschneider, Dirk; Prätsch, Florian; Zenker, Martin; Freund, Christian; Bruder, Dunja; Hachenberg, Thomas; Arens, Christoph; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 51 (2021), Heft Suppl. 1, S. 350, Artikel P-0880
2020
CTLA-4-competent conventional T-cells back up regulatory T-cells to restrain memory T-helper type 2 cell responses. Letter to the editor
Pierau, Mandy; Lingel, Holger; Vogel, Katrin; Arra, Aditya; Brunner-Weinzierl, Monika
In: Allergy - Oxford : Wiley, Bd. 75 (2020), Heft 3, S. 684-687
Children from the age of three show a developmental switch in T-cell differentiation
Knolle, Julienne; Pierau, Mandy; Hebel, Katrin; Lampe, Karen; Jorch, Gerhard; Kropf, Siegfried; Arens, Christoph; Brunner-Weinzierl, Monika
In: Frontiers in immunology - Lausanne : Frontiers Media - Vol. 11.2020, Art.-Nr. 1640, insgesamt 12 Seiten
Cell survival failure in effector T cells from patients with systemic lupus erythematosus following insufficient upregulation of coldshock Ybox binding protein 1
Meltendorf, Stefan; Fu, Hang; Pierau, Mandy; Lindquist, Jonathan A.; Finzel, Stephanie; Mertens, Peter Rene; Gieseler-Halbach, Steffi; Ambach, Andreas; Thomas, Ulrich; Lingel, Holger; Voll, Reinhard; Brunner-Weinzierl, Monika
In: Arthritis & rheumatology - Hoboken, NJ : Wiley, Bd. 72 (2020), Heft 10, S. 1721-1733
YB-1 interferes with TNFα-TNFR binding and modulates progranulin-mediated inhibition of TNFα signaling
Hessman, Christopher L.; Hildebrandt, Josephine; Shah, Aneri; Brandt, Sabine; Bock, Antonia; Frye, Björn Christian; Raffetseder, Ute; Geffers, Robert; Brunner-Weinzierl, Monika; Isermann, Berend; Mertens, Peter Rene; Lindquist, Jonathan A.
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International - Vol. 21.2020, 19, Art.-Nr. 7076, insgesamt 17 Seiten
2019
IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration
Yshii, Lidia; Pignolet, Béatrice; Mauré, Emilie; Pierau, Mandy; Brunner-Weinzierl, Monika; Hartley, Oliver; Bauer, Jan; Liblau, Roland
In: JCI insight - Ann Arbor, Michigan : JCI Insight - Bd. 4.2019, 7, Art.-Nr. e127001, insges. 12 S.
CTLA-4 (CD152) - a versatile receptor for immune-based therapy
Lingel, Holger; Brunner-Weinzierl, Monika
In: Seminars in immunology - London : Academic Press - Bd.42.2019, Art.-Nr. 101298
Aktuelle Entwicklungen in der Allergieprävention
Brunner-Weinzierl, Monika; Kopp, Matthias
In: Consilium - Wien : Ärztekammer für Niederösterreich, Körperschaft Öffentlichen Rechts, Bd. 74 (2019), Heft 11, S. 26-31
2018
Paradigmenwechsel in der Allergieprävention
Brunner-Weinzierl, Monika; Kopp, Matthias
In: Monatsschrift Kinderheilkunde - Berlin : Springer, Bd. 166 (2018), Heft 8, S. 708-713
Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus
Vogel, Katrin; Pierau, Mandy; Arra, Aditya; Lampe, Karen; Schlüter, Dirk; Arens, Christoph; Brunner-Weinzierl, Monika
In: Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature - Bd. 8.2018, Art.-Nr. 16904, insges. 14 S.
CTLA-4 and PD-1 control of T-cell motility and migration - implications for tumor immunotherapy
Brunner-Weinzierl, Monika; Rudd, Christopher E.
In: Frontiers in immunology - Lausanne : Frontiers Media - Bd. 9.2018, Art.-Nr. 2737, insges. 8 S.
2017
RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts
Gieseler-Halbach, Steffi; Meltendorf, Stefan; Pierau, Mandy; Weinert, Sönke; Heidel, Florian; Fischer, Thomas; Handschuh, Juliane; Braun-Dullaeus, Ruediger C.; Schrappe, Martin; Lindquist, Jonathan A.; Mertens, Peter Rene; Thomas, Ulrich; Brunner-Weinzierl, Monika
In: Cell death and differentiation - Houndmills, Basingstoke : Nature Publishing Group, Bd. 24 (2017), Heft 2, S. 371-383
The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs
Arra, Aditya; Lingel, Holger; Kuropka, Benno; Pick, Jonas; Schnöder, Tina; Fischer, Thomas; Freund, Christian; Pierau, Mandy; Brunner-Weinzierl, Monika
In: OncoImmunology - Abingdon : Taylor & Franics - Bd. 6.2017, 2, Art.-Nr. e1273300, insges. 5 S.
Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1
Bernhardt, Anja; Fehr, Alexander; Brandt, Sabine; Jerchel, Saskia; Ballhause, Tobias M.; Philipsen, Lars; Stolze, Saskia; Geffers, Robert; Weng, Honglei; Fischer, Klaus-Dieter; Isermann, Berend; Brunner-Weinzierl, Monika; Batra, Arvind; Siegmund, Britta; Zhu, Cheng; Lindquist, Jonathan A.; Mertens, Peter Rene
In: Kidney international - New York, NY : Elsevier, Bd. 92 (2017), Heft 5, S. 1157-1177
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Ranjan, Satish; Goihl, Alexander; Kohli, Shrey; Gadi, Ihsan; Pierau, Mandy; Shahzad Hussain, Khurrum; Gupta, Dheerendra; Bock, Fabian; Wang, Hongjie; Shaikh, Haroon; Kähne, Thilo; Reinhold, Dirk; Bank, Ute; Zenclussen, Ana Claudia; Niemz, Jana; Schnöder, Tina; Brunner-Weinzierl, Monika; Fischer, Thomas; Kalinski, Thomas; Schraven, Burkhart; Luft, Thomas; Hühn, Jochen; Naumann, Michael; Heidel, Florian; Isermann, Berend
In: Nature Communications - [London] : Nature Publishing Group UK - 8(2017) Artikel-Nummer 311, 16 Seiten
CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation
Lingel, Holger; Wissing, Josef; Arra, Aditya; Schanze, Denny; Lienenklaus, Stefan; Klawonn, Frank; Pierau, Mandy; Zenker, Martin; Jänsch, Lothar; Brunner-Weinzierl, Monika
In: Cell death and differentiation - Houndmills, Basingstoke : Nature Publishing Group, Bd. 24 (2017), Heft 10, S. 1739-1749
CTLA-4 induced signal transduction in regulating differentiation and plasticity of Tc17 cells
Arra, Aditya; Brunner-Weinzierl, Monika
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Naturwissenschaften 2017, x, 84 Blätter [Literaturverzeichnis: Blatt 63-79][Literaturverzeichnis: Blatt 63-79]
Adaptives Immunsystem
Brunner-Weinzierl, Monika
In: Fetoneonatale Infektiologie , 1. Auflage - Stuttgart : Georg Thieme Verlag . - 2017, S. 27-34
Eingeschränkte Immunabwehr gegen bekapselte Bakterien
Brunner-Weinzierl, Monika
In: Fetoneonatale Infektiologie , 1. Auflage - Stuttgart : Georg Thieme Verlag . - 2017, S. 36
Angeborenes Immunsystem von Fötus, Neonaten und Kleinkind
Brunner-Weinzierl, Monika
In: Fetoneonatale Infektiologie , 1. Auflage - Stuttgart : Georg Thieme Verlag . - 2017, S. 23-27
Hygienehypothese
Brunner-Weinzierl, Monika
In: Fetoneonatale Infektiologie , 1. Auflage - Stuttgart : Georg Thieme Verlag . - 2017, S. 34-35
CTLA-4 mediated effects on STATs regulate differentiation and plasticity of Tc17 cells
Arra, Aditya; Lingel, Holger; Kuropka, Benno; Fischer, Thomas; Freund, Christian; Pierau, Mandy; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley VCH - Bd. 47.2017, Suppl. 2, P395, S. 277
Bacteria-specific CD4+T-cell responses of neonates, infants and adults show age-dependent characteristics
Vogel, Katrin; Braun, Franziska; Pierau, Mandy; Lampe, Karen; Jorch, Gerhard; Schlüter, Dirk; Arens, Christoph; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley - Bd. 47.2017, Suppl. 2, P357, S. 264
2016
Early changes in the metabolic profile of activated CD8+ T cells
Cammann, Clemens; Rath, Alexander; Reichl, Udo; Lingel, Holger; Brunner-Weinzierl, Monika; Simeoni, Luca; Schraven, Burkhart; Lindquist, Jonathan A.
In: BMC cell biology - London : BioMed Central - Bd. 17.2016, Art.-Nr. 28, insges. 11 S.
CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model
Yshii, Lidia M.; Gebauer, Christina M.; Pignolet, Béatrice; Mauré, Emilie; Quériault, Clémence; Pierau, Mandy; Saito, Hiromitsu; Suzuki, Noboru; Brunner-Weinzierl, Monika; Bauer, Jan; Liblau, Roland
In: Brain - Oxford : Oxford Univ. Press, Bd. 139 (2016), Heft 11, S. 2923-2934
T cells of infants are mature, but hyporeactive due to limited Ca2+ influx
Schmiedeberg, Kristin; Krause, Hardy; Röhl, Friedrich-Wilhelm; Hartig, Roland; Jorch, Gerhard; Brunner-Weinzierl, Monika
In: PLOS ONE - San Francisco, California, US : PLOS - Bd. 11.2016, 11, Art.-Nr. e0166633, insges. 27 S.
Charakterisierung infektionsspezifischer T-Zell-Antworten bei Neugeborenen und Kleinkindern
Vogel, Katrin; Pierau, Mandy; Lampe, Karen; Jorch, Gerhard; Schlüter, Dirk; Arens, Christoph; Brunner-Weinzierl, Monika
In: Allergologie - München-Deisenhofen [i.e.] Deisenhofen : Dustri-Verl. Feistle, Bd. 39 (2016), Heft 5, S. 227-228
Implikationen für allergische Erkrankungen - CTLA-4-Signale beeinflussen nachhaltig TH2-Immunantworten
Pierau, Mandy; Brunner-Weinzierl, Monika
In: Allergologie - München-Deisenhofen [i.e.] Deisenhofen : Dustri-Verl. Feistle, Bd. 39 (2016), Heft 5, S. 225
CTLA-4-targeted proteins in differentiating CD8+ T lymphocytes
Brunner-Weinzierl, Monika; Wissing, Josef; Arra, Aditya; Pierau, Mandy; Klawonn, Frank; Jänsch, Lothar; Lingel, Holger
In: The journal of immunology - Rockville, Md. : American Association of Immunologists - Bd. 196.2016, 1 Suppl., Abs. 72.19, insges. 1 S.
Intrinsic- and extrinsic- mediated CTLA-4-signals shape the TH2 response - implications for allergic disorders
Pierau, Mandy; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley VCH - Bd. 46.2016, Suppl. 1, Abs. 3557, Seite 1053
CD4+ T cells from human neonates and infants respond variously against antigens of Staphylococcus aureus, but not against Bifidobacter longum ssp. infantis
Brunner-Weinzierl, Monika; Pierau, Mandy; Schlüter, Dirk; Lampe, Karen; Arens, Christoph; Jorch, Gerhard; Vogel, Katrin
In: The journal of immunology - Rockville, Md. : American Association of Immunologists - Bd. 196.2016, 1 Suppl., Abs. 66.24, insges. 1 S.
Plasticity along with differentiation of Tc17 cells is controlled by CTLA-4 (CD152)
Brunner-Weinzierl, Monika; Lingel, Holger; Pick, Jonas; Huber, Magdalena; Pierau, Mandy; Arra, Aditya
In: The journal of immunology - Rockville, Md. : American Association of Immunologists - Bd. 196.2016, 1 Suppl., Abs. 133.15, insges. 1 S.
2014
CTLA-4 is expressed by activated mouse NK cells and inhibits NK cell IFN-[gamma] production in response to mature dendritic cells
Stojanovic, Ana; Fiegler, Nathalie; Brunner-Weinzierl, Monika; Cerwenka, Adelheid
In: The journal of immunology - Bethesda, Md. : Soc., Bd. 192 (2014), Heft 9, S. 4184-4191
CTLA-4 (CD152) enhances the Tc17 differentiation program
Pick, Jonas; Arra, Aditya; Lingel, Holger; Hegel, J. Kolja; Huber, Magdalena; Nishanth, Gopala; Jorch, Gerhard; Fischer, Klaus-Dieter; Schlüter, Dirk; Tedford, Kerry; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 44 (2014), Heft 7, S. 2139-2152
Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function
Wolleschak, Denise; Mack, Thomas S.; Perner, Florian; Frey, Stephanie; Schnöder, Tina; Wagner, Marie-Christine; Höding, Christine; Pils, Marina C.; Parkner, Andreas; Kliche, Stefanie; Schraven, Burkhart; Hebel, Katrin; Brunner-Weinzierl, Monika; Ranjan, Satish; Isermann, Berend; Lipka, Daniel; Fischer, Thomas; Heidel, Florian
In: Haematologica - Pavia : Ferrata Storti Foundation - Bd. 99.2014, 6, S. e90-e93
CD4+ T cells from human neonates and infants are poised spontaneously to run a nonclassical IL-4 program
Hebel, Katrin; Weinert, Soenke; Kuropka, Benno; Knolle, Julienne; Kosak, Bernhard; Jorch, Gerhard; Arens, Christoph; Krause, Eberhard; Braun-Dullaeus, Ruediger C.; Brunner-Weinzierl, Monika
In: The journal of immunology - Bethesda, Md : Soc, Bd. 192 (2014), Heft 11, S. 5160-5170
Autoimmune pancreatitis in MRL/Mp mice is a T cell-mediated disease responsive to cyclosporine A and rapamycin treatment
Schwaiger, Theresa; Brandt, Cindy; Fitzner, Brit; Zaatreh, Sarah; Kraatz, Franziska; Dummer, Annegret; Nizze, Horst; Evert, Matthias; Bröker, Barbara; Brunner-Weinzierl, Monika; Wartmann, Thomas; Salem, Tareq; Lerch, Markus M.; Jaster, Robert; Mayerle, Julia
In: Gut - London : BMJ Publishing Group, Bd. 63 (2014), Heft 3, S. 494-505
2013
Das neonatale Immunsystem - Modulation durch regulatorische T-Zellen und CTLA-4 (CD152) : modulation by regulatory T-cells and CTLA-4 - The neonatal immune system
Hebel, Katrin; Pierau, Mandy; Lingel, Holger; Steiner, Michael; Krause, Hardy; Jorch, Gerhard; Brunner-Weinzierl, Monika
In: Laboratoriumsmedizin - Berlin [u.a.] : de Gruyter, Bd. 37 (2013), Heft 3, S. 123-129
Impact of the CTLA-4/CD28 axis on the processes of joint inflammation in rheumatoid arthritis
Körmendy, Dezsö; Hoff, Holger; Hoff, Paula; Bröker, Barbara; Burmester, Gerd-Rüdiger; Brunner-Weinzierl, Monika
In: Arthritis & rheumatism - Hoboken, NJ : Wiley-Blackwell, Bd. 65 (2013), Heft 1, S. 81-87
Acute psychological stress increases peripheral blood CD3+CD56+ natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders
Atanackovic, Djordje; Nowottne, Ulrike; Freier, Eva; Weber, Cora Stefanie; Meyer, Sabrina; Bartels, Katrin; Hildebrandt, York; Cao, Yanran; Kröger, Nicolaus; Brunner-Weinzierl, Monika; Bokemeyer, Carsten; Deter, Hans-Christian
In: Stress - London : Informa Healthcare, Bd. 16 (2013), Heft 4, S. 421-428
Immune privilege as an intrinsic CNS property - astrocytes protect the CNS against T-cell-mediated neuroinflammation
Gimsa, Ulrike; Mitchison, Avrion; Brunner-Weinzierl, Monika
In: Mediators of inflammation - Sylvania, Ohio : Hindawi Publishing Corp. - 2013, Article ID 320519, insges. 11 S.
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells
Smida, Michal; Cammann, Clemens; Gurbiel, Slavyana; Kerstin, Nadja; Lingel, Holger; Lindquist, Sabine; Simeoni, Luca; Brunner-Weinzierl, Monika; Suchanek, Miloslav; Schraven, Burkhart; Lindquist, Jonathan A.
In: Cell communication and signaling - London : Biomed Central - Bd. 11.2013, Art.-Nr. 28, insges. 13 S.
Untersuchung des Einflusses der Histon-H3K9-Acetylierung auf die Prognose beim Neuroblastom
Dietl, Johanna; Brunner-Weinzierl, Monika
In: Magdeburg, Univ., Med. Fak., Diss., 2013, XVIII, 53 Bl
2012
Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell
Thaventhiran, James E. D.; Hoffmann, Anja; Magiera, Lukasz; Roche, Maike de la; Lingel, Holger; Brunner-Weinzierl, Monika; Fearon, Douglas T.
In: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : National Acad. of Sciences - Bd. 109.2012, 33, S. E2223-E2229
Pro-inflammatory effector Th cells transmigrate through anti-inflammatory environments into the murine fetus
Wienecke, Janine; Hebel, Katrin; Hegel, Kolja J.; Pierau, Mandy; Brune, Thomas; Reinhold, Dirk; Pethe, Annette; Brunner-Weinzierl, Monika
In: Placenta - Amsterdam [u.a.] : Elsevier, Bd. 33 (2012), Heft 1, S. 39-46
Migration of Th1 lymphocytes is regulated by CD152 (CTLA-4)-mediated signaling via PI3 kinase-dependent Akt activation
Knieke, Karin; Lingel, Holger; Chamaon, Kathrin; Brunner-Weinzierl, Monika
In: PLOS ONE - San Francisco, California, US : PLOS - Bd. 7.2012, 3, Artikel-Nr. e31391, insges. 9 S.
2011
Glycogen synthase kinase-3[beta] is a crucial mediator of signal-induced RelB degradation
Neumann, Manfred; Klar, S.; Wilisch-Neumann, Annette; Hollenbach, Eike; Kavuri, Shyam; Leverkus, Martin; Kandolf, Reinhard; Brunner-Weinzierl, Monika; Klingel, Karin
In: Oncogene - New York, NY : Springer Nature, Bd. 30 (2011), Heft 21, S. 2485-2492
Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T Cells in vivo
Rudolph, Marion; Hebel, Katrin; Miyamura, Yoshinori; Maverakis, Emanual; Brunner-Weinzierl, Monika
In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 186 (2011), Heft 10, S. 5580-5589
IL-1[beta] and TGF-[beta] act antagonistically in induction and differentially in propagation of human proinflammatory precursor CD4+ T cells
Hebel, Katrin; Rudolph, Marion; Kosak, Bernhard; Chang, Hyun-Dong; Butzmann, Jana; Brunner-Weinzierl, Monika
In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 187 (2011), Heft 11, S. 5627-5635
CTLA-4 (CD152) blockade does not cause a pro-inflammatory cytokine profile in regulatory T cells
Kolar, Paula; Hoff, Holger; Maschmeyer, Patrick; Burmester, Gerd-Rüdiger; Brunner-Weinzierl, Monika
In: Clinical and experimental rheumatology - Pisa : Pacini, Bd. 29 (2011), Heft 2, S. 254-260
Einfluss von CD152-Signalen auf das Migrationsverhalten von T H 1-Lymphozyten
Knieke, Karin; Brunner-Weinzierl, Monika C.
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2011, 114 Bl.
2010
CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch
Hoff, Holger; Kolar, Paula; Ambach, Andreas; Radbruch, Andreas; Brunner-Weinzierl, Monika
In: Molecular immunology - Amsterdam [u.a.] : Elsevier, Bd. 47 (2010), Heft 10, S. 1875-1881
Female-biased incidence of experimental autoimmune encephalomyelitis reflects sexually dimorphic expression of surface CTLA-4 (CD152) on T lymphocytes
Luna, Rosa María Licón; Körmendy, Dezsö; Brunner-Weinzierl, Monika
In: Gender medicine - Hillsborough, NJ : Excerpta Medica, Bd. 7 (2010), Heft 4, S. 296-308
Decrease of CD4+FOXP3+ T regulatory cells in the peripheral blood of human subjects undergoing a mental stressor
Freier, Eva; Weber, Cora Stefanie; Nowottne, Ulrike; Horn, Christiane; Bartels, Katrin; Meyer, Sabrina; Hildebrandt, York; Luetkens, Tim; Cao, Yanran; Pabst, Caroline; Muzzulini, Julia; Schnee, Benjamin; Brunner-Weinzierl, Monika; Marangolo, Maurizio; Bokemeyer, Carsten; Deter, Hans-Christian; Atanackovic, Djordje
In: Psychoneuroendocrinology - Oxford [u.a.] : Elsevier, Bd. 35 (2010), Heft 5, S. 663-673, insges. 11 S. [Im Titel sind die Pluszeichen jeweils hochgestellt]
2009
CD152 (CTLA-4) determines CD4 T cell migration in vitro and in vivo
Knieke, Karin; Hoff, Holger; Maszyna, Frank; Kolar, Paula; Schrage, Arnhild; Hamann, Alf; Debes, Gudrun F.; Brunner-Weinzierl, Monika
In: PLOS ONE - San Francisco, California, US : PLOS - Bd. 4.2009, 5, Art. e5702, insges. 11 S.
Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28null T cells
Hoff, Holger; Knieke, Karin; Cabail, Zulema; Hirseland, Heike; Vratsanos, George; Burmester, Gerd-Rüdiger; Jorch, Gerhard; Nadler, Steven G.; Bröker, Barbara; Hebel, Katrin; Brunner-Weinzierl, Monika
In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 182 (2009), Heft 9, S. 5342-5351
CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice
Kolar, Paula; Knieke, Karin; Hegel, J. Kolja E.; Quandt, Dagmar; Burmester, Gerd-Rüdiger; Hoff, Holger; Brunner-Weinzierl, Monika
In: Arthritis & rheumatism - Hoboken, NJ : Wiley-Blackwell, Bd. 60 (2009), Heft 1, S. 123-132
CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin
Hegel, Johannes K.; Knieke, Karin; Kolar, Paula; Reiner, Steven L.; Brunner-Weinzierl, Monika
In: European journal of immunology - Weinheim : Wiley, Bd. 39 (2009), Heft 3, S. 883-893
2008
CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice
Kolar, Paula; Knieke, Karin; Hegel, J. Kolja E.; Quandt, Dagmar; Burmester, Gerd-R.; Hoff, Holger; Brunner-Weinzierl, Monika
In: Arthritis & rheumatism - Hoboken, NJ : Wiley-Blackwell, Bd. 60 (2008), Heft 1, S. 123-32
2007
A new role of CTLA-4 on B cells in thymus-dependent immune responses in vivo
Quandt, Dagmar; Hoff, Holger; Rudolph, Marion; Fillatreau, Simon; Brunner-Weinzierl, Monika
In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 179 (2007), Heft 11, S. 7316-7324
High IFN- Production of Individual CD8 T Lymphocytes Is Controlled by CD152 (CTLA-4)
Pandiyan, Pushpa; Hegel, Kolja E.; Krueger, Manuela; Quandt, Dagmar; Brunner-Weinzierl, Monika C.
In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 178 (2007), Heft 4, S. 2132-2140
A new role of CTLA-4 on B cells in thymus-dependent immune responses in vivo
Quandt, Dagmar; Hoff, Holger; Rudolph, Marion; Fillatreau, Simon; Brunner-Weinzierl, Monika
In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 179 (2007), Heft 11, S. 7316-7324
2006
CD25 regulatory T cells determine secondary but not primary remission in EAE: impact on long-term disease progression
Gärtner, Dagmar; Hoff, Holger; Gimsa, Ulrike; Burmester, Gerd-R.; Brunner-Weinzierl, Monika C.
In: Journal of neuroimmunology . - Amsterdam : Elsevier, Bd. 172.2006, 1, S. 73-84