Publikationen
2023
Begutachteter Zeitschriftenartikel
CD248 induces a maladaptive unfolded protein response in diabetic kidney disease
In: Kidney international - New York, NY: Elsevier, 1972, Bd. 103 (2023), insges. 16 S., 2022
MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD
In: Redox Biology - Amsterdam [u.a.]: Elsevier, 2013, Bd. 59 (2023), insges. 13 S.
The COP9 signalosome - a versatile regulatory hub of Cullin-RING ligases
In: Trends in biochemical sciences - Amsterdam [u.a.]: Elsevier Science, Bd. 48 (2023), 1, S. 82-95
ZOMES - cell physiology determined by PCI complexes and protein turnover
In: Biochimica et biophysica acta / Molecular cell research - Amsterdam [u.a.]: Elsevier, Bd. 1870 (2023), 2
2022
Begutachteter Zeitschriftenartikel
A20 undermines alternative NF-[kappa]B activity and expression of anti-apoptotic genes in Helicobacter pylori infection
In: Cellular and molecular life sciences - Cham (ZG): Springer International Publishing AG, 1997, Bd. 79 (2022), 2, insges. 12 S.
Ca2+ signaling in postsynaptic neurons - neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors
In: Cell calcium - Edinburgh [u.a.]: Churchill Livingstone, 1980, Bd. 106 (2022), insges. 14 S.
Helicobacter pylori-induced NF-[kappa]B - trailblazer for gastric pathophysiology
In: Trends in molecular medicine - Amsterdam [u.a.]: Elsevier Science, Bd. 28 (2022), 3, S. 210-222
Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death
In: Cellular and molecular life sciences - Cham (ZG): Springer International Publishing AG, 1997, Bd. 79 (2022), 2, insges. 16 S.
Human gastric fibroblasts ameliorate A20-dependent cell survival in co-cultured gastric epithelial cells infected by Helicobacter pylori
In: Biochimica et biophysica acta / Molecular cell research - Amsterdam [u.a.]: Elsevier, Bd. 1869 (2022), 12
Matrix metalloproteinases in Helicobacter pylori-associated gastritis and gastric cancer
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 3, insges. 17 S.
Ovarian tumor domain proteases in pathogen infection
In: Trends in microbiology - Amsterdam [u.a.]: Elsevier Science, Bd. 30 (2022), 1, S. 22-33
Substrate-assisted activation and selectivity of the bacterial RavD effector deubiquitinylase
In: Proteins - New York, NY: Wiley-Liss, 1986, Bd. 90 (2022), 4, S. 947-958
USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection
In: Cellular and molecular life sciences - Cham (ZG): Springer International Publishing AG, 1997, Bd. 79 (2022), insges. 13 S.
Ubiquitin-modifying enzymes as regulators of colitis
In: Trends in molecular medicine - Amsterdam [u.a.]: Elsevier Science, Bd. 28 (2022), 4, S. 304-318
Dissertation
Function of A20 in the regulation of Helicobacter pylori-induced alternative NK-B and caspase-8-dependent apoptotic cell death
In: Magdeburg: Universitätsbibliothek, 2022, 1 Online-Ressource (XI, 90 Seiten, 3,51 MB), Illustrationen
Function of STAMBPL1 in Helicobacter pylori-associated cell death
In: Magdeburg: Universitätsbibliothek, 2022, 1 Online-Ressource (ii, 82 Blätter, 3,89 MB), Illustrationen
Molecular recognition and selectivity - computational investigations on the dynamics of non-bonded interactions
In: Magdeburg: Universitätsbibliothek, 2022, 1 Online-Ressource (192, XV, 13,18 MB), Illustrationen
2021
Begutachteter Zeitschriftenartikel
Discovery of Zika virus host dependency factors in trophoblasts using CRISPR/Cas9 screening
In: Journal of virological methods - Amsterdam [u.a.]: Elsevier Science, Bd. 290 (2021)
From 3D back to 2D monolayer stomach organoids-on-a-chip
In: Trends in biotechnology - Amsterdam [u.a.]: Elsevier Science, Bd. 39 (2021), 8, S. 745-748
Importance of cortactin for efficient epithelial NF-[kappa]B activation by Helicobacter pylori, Salmonella enterica and Pseudomonas aeruginosa, but not Campylobacter spp.
In: European journal of microbiology and immunology - Budapest: Akad. Kiadó, 2011, Bd. 11 (2021), 4, S. 95-103
Interactome mapping of eIF3A in a colon cancer and an immortalized embryonic cell line using proximity-dependent biotin identification
In: Cancers - Basel: MDPI, 2009, Bd. 13 (2021), 6, insges. 21 S.
Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer
In: Cellular and molecular life sciences - Cham (ZG): Springer International Publishing AG, 1997 - (CMLS), Bd. 78 (2021), 10, S. 4765-4783
NF-[kappa]B in gastric cancer development and therapy
In: Biomedicines - Basel: MDPI, 2013, Bd. 9 (2021), 8, insges. 21 S.
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation
In: Cell death and differentiation - Houndmills, Basingstoke: Nature Publishing Group, 1997, Bd. 28 (2021), 7, S. 2257-2275
On-a-chip-based sensitive detection of drug-induced apoptosis in polarized gastric epithelial cells
In: ACS biomaterials science & engineering/ American Chemical Society - Washington, DC: ACS Publ., Bd. 7 (2021), 12, S. 5474-5483
Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test development
In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 51 (2021), 7, S. 1839-1849
Signal peptidase complex subunit 1 is an essential Zika virus host factor in placental trophoblasts
In: Virus research - Amsterdam [u.a.]: Elsevier Science, Vol. 296.2021, 198338
TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-[kappa]B pathways
In: EMBO reports/ European Molecular Biology Organization - Heidelberg: EMBO Press, 2000, Bd. 22 (2021), 9, insges. 12 S.
The activation and selectivity of the Legionella RavD deubiquitinase
In: Frontiers in molecular biosciences - Lausanne: Frontiers, 2014, Bd. 8 (2021), insges. 4 S.
The deubiquitinase OTUB1 augments NF-[kappa]B-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13
In: Cellular & molecular immunology - London [u.a.]: Nature Publ. Group, 2004, Bd. 18 (2021), 6, S. 1512-1527
2020
Abstract
Expression der eukaryotischen Initiationsfaktoren (eIFs) in plattenepithelialen Kopf- und Halskarzinomen (HNSCC) - potenzielle therapeutische Implikationen
In: Laryngo-Rhino-Otologie - Stuttgart [u.a.]: Thieme, 1980, Bd. 99.2020, S 02, S. S90-S91
Begutachteter Zeitschriftenartikel
Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases
In: The journal of biological chemistry - Bethesda, Md.: Soc., 1905, Bd. 295.2020, 20, S. 6972-6982
CEACAMs interaction with Helicobacter pylori HopQ supports the type 4 secretion system-dependent activation of non-canonical NF-[kappa]B
In: International journal of medical microbiology: IJMM - München: Elsevier, 2000, Bd. 310.2020, 6, Art.-Nr. 151444, insges. 6 Seiten
The COP9 signalosome - a multi-DUB complex
In: Biomolecules: open access journal - Basel: MDPI, 2011, Bd. 10.2020, 7, Art.-Nr. 1082, insgesamt 11 Seiten
The interaction of TRAF6 with neuroplastin promotes spinogenesis during early neuronal development
In: Frontiers in cell and developmental biology - Lausanne: Frontiers Media, 2013, Vol. 8.2020, 579513, insgesamt 18 Seiten
2019
Abstract
Expression levels of eukaryotic initiation factors (eIFs) are significantly altered in head and neck squamous cell carcinomas (HNSCC)
In: Der Pathologe - Berlin: Springer, 1994, Bd. 40.2019, Suppl. 2, AG11.05, Seite S139
Neuroplastin-plasma membrane Ca2+ ATPases complexes - a new team regulating Ca2+ clearance, signaling, and synaptic plasticity
In: Journal of neurochemistry - Oxford: Wiley-Blackwell, 1956, Vol. 150.2019, Suppl. 1, MTU02-05, S. 77
Role of Otubain-1 (OTUB1) during inflammatory liver diseases
In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 1, O1, Seite 13
Begutachteter Zeitschriftenartikel
Catalytic domain of deubiquitinylase USP48 directs interaction with Rel homology domain of nuclear factor kappaB transcription factor RelA
In: Molecular biology reports - Dordrecht [u.a.]: Springer Science + Business Media B.V, Bd. 46.2019, 1, S. 1369-1375
Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis
In: Current topics in microbiology and immunology - Berlin: Springer, Bd. 421.2019, S. 107-137
NF-kappaB-inducing kinase in cancer
In: Biochimica et biophysica acta / Reviews on cancer: BBA - Amsterdam: Elsevier, Bd. 1871 (2019), 1, S. 40-49
Targeting RIPK1 in AML cells carrying FLT3-ITD
In: International journal of cancer - Bognor Regis: Wiley-Liss, Bd. 145 (2019), 6, S. 1558-1569
2018
Begutachteter Zeitschriftenartikel
Computational studies on the inhibitor selectivity of human JAMM deubiquitinylases Rpn11 and CSN5
In: Frontiers in Chemistry - Lausanne: Frontiers Media, Bd. 6.2018, Art.-Nr. 480, insges. 12 S.
Constitutive activation of nuclear factor kappa B-inducing kinase counteracts apoptosis in cells with rearranged mixed lineage leukemia gene
In: Leukemia: normal and malignant hemopoiesis ; a peer-reviewed journal - London: Springer Nature, Bd. 32 (2018), 11, S. 2498-2501
Cullin 3-based ubiquitin ligases as master regulators of mammalian cell differentiation
In: Trends in biochemical sciences: TIBS - Amsterdam [u.a.]: Elsevier Science, Bd. 43 (2018), 2, S. 95-107
Deubiquitinylase USP47 promotes RelA phosphorylation and survival in gastric cancer cells
In: Biomedicines: open access journal - Basel: MDPI, Bd. 6.2018, 2, Art.-Nr. 62, insges. 9 S.
Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells
In: Journal of cancer research and clinical oncology: official organ of the Deutsche Krebsgesellschaft - Berlin: Springer, Bd. 144.2018, 10, S. 1933-1944
Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling
In: Biochimica et biophysica acta / Molecular cell research: BBA - Amsterdam [u.a.]: Elsevier, Bd. 1865 (2018), 4, S. 545-550
HopQ impacts the integrin [alpha]5[beta]1-independent NF-[kappa]B activation by Helicobacter pylori in CEACAM expressing cells
In: International journal of medical microbiology: IJMM - München: Elsevier, Bd. 308 (2018), 5, S. 527-533
Influence of eukaryotic translation initiation factor 6 on nonsmall cell lung cancer development and progression
In: European journal of cancer - Amsterdam [u.a.]: Elsevier, 1965, Bd. 101.2018, S. 165-180
Interactome analysis of transforming growth factor-[beta]-activated kinase 1 in Helicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37
In: OncoTarget: open access impact journal - [S.l.]: Impact Journals LLC, Bd. 9.2018, 18, S. 14366-14381
NF-[kappa]B-regulated ubiquitin-editing enzyme A20 paves the way for infection persistency
In: Cell cycle - Abingdon: Taylor & Francis Group, 2002, Bd. 17.2018, 1, S. 3-4
The cell fate determinant Scribble is required for maintenance of hematopoietic stem cell function
In: Leukemia: normal and malignant hemopoiesis ; a peer-reviewed journal - London: Springer Nature, Bd. 32.2018, 5, S. 1211-1221
2017
Abstract
A new way to create synapses - neuroplastin-TRAF6-dependent signaling induces excitatory synapse formation
In: Journal of neurochemistry - Oxford: Wiley-Blackwell, 1956, Bd. 142.2017, Suppl. 1, MTU08-08, S. 130
CYLD-deficiency protects from experimental cerebral malaria
In: European journal of immunology - Weinheim: Wiley, 1971, Bd. 47.2017, Suppl. 2, O74, S. 42
Begutachteter Zeitschriftenartikel
A complex of neuroplastin and plasma membrane Ca2+ ATPase controls T cell activation
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 7.2017, Art.-Nr. 8358, insges. 13 S.
A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development
In: Cancer cell - Cambridge, Mass.: Cell Press, 2002, Bd. 32 (2017), 3, S. 342-359
ALPK1- and TIFA-dependent innate immune response triggered by the helicobacter pylori type IV secretion system
In: Cell reports - Maryland Heights, MO: Cell Press, 2012, Bd. 20 (2017), 10, S. 2384-2395
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, 8(2017) Artikel-Nummer 311, 16 Seiten
Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis
In: Biochimica et biophysica acta / Molecular cell research: BBA - Amsterdam [u.a.]: Elsevier, Bd. 1864 (2017), 8, S. 1405-1412
Double phosphorylation-induced structural changes in the signal-receiving domain of I[kappa]B[alpha] in complex with NF-[kappa]B
In: Proteins: structure, function, and bioinformatics - New York, NY: Wiley-Liss, 1986, Bd. 85.2017, 1, S. 17-29
Double phosphorylation-induced structural changes in the signal-receiving domain of IκBα in complex with NF-κB
In: Proteins: Structure, Function, and Bioinformatics, 2017, S. 17-29, ISSN 08873585, 10.1002/prot.25181
Helicobacter pylori - a paradigm pathogen for subverting host cell signal transmission
In: Trends in microbiology - Amsterdam [u.a.]: Elsevier Science, Bd. 25 (2017), 4, S. 316-328
Helicobacter pylori employs a unique basolateral type IV secretion mechanism for CagA delivery
In: Cell host and microbe - Amsterdam [u.a.]: Elsevier, Bd. 22.2017, 4, S. 552-560
NEMO links nuclear factor-[kappa]B to human diseases
In: Trends in molecular medicine - Amsterdam [u.a.]: Elsevier Science, 2001, Bd. 23.2017, 12, S. 1138-1155
NF[kappa]B signaling in gastric cancer
In: Toxins - Basel: MDPI, 2009, Bd. 9.2017, 4, Art.-Nr. 119, insges. 21 S.
Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-B and caspase-8-dependent apoptotic cell death
In: Cell death and differentiation - Houndmills, Basingstoke: Nature Publishing Group, 1997, Bd. 24 (2017), 9, S. 1621-1631
The Helicobacter pylori type IV secretion system encoded by the cag pathogenicity island - architecture, function, and signaling
In: Current topics in microbiology and immunology - Berlin: Springer, Bd. 413.2017, S. 187-220
The deubiquitinating enzyme cylindromatosis dampens CD8+ T cell responses and is a critical factor for experimental cerebral malaria and bloodbrain barrier damage
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 8.2017, Art.-Nr. 27, insges. 17 S.
2016
Abstract
NF-KappaB dependent expression of a20 controls cell death in H. pylori-infected cells
In: Helicobacter - Oxford [u.a.]: Wiley-Blackwell, 1996, Bd. 21.2016, Suppl. 1, Abs. P09.03, S. 162
Begutachteter Zeitschriftenartikel
A20 curtails primary but augments secondary CD8+ T cell responses in intracellular bacterial infection
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 6.2016, Art.-Nr. 39796, insges. 15 S.
High resolution quantitative synaptic proteome profiling of mouse brain regions after auditory discrimination learning. Video article
In: JoVE - [S.l.], 2006, 2016, 118, Art.-Nr. e54992, insges. 12 S.
Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner
In: Experimental & molecular medicine: EMM - [London]: Macmillan Publishers Limited, part of Springer Nature, 1996, Bd. 48.2016, Art.-Nr. e270, insges. 10 S.
Molecular architecture of the DED chains at the DISC - regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain
In: Cell death and differentiation - Houndmills, Basingstoke: Nature Publishing Group, Bd. 23 (2016), 4, S. 681-694
New insights into the mechanism of COP9 signalosomecullin-RING ubiquitin-ligase pathway deregulation in urological cancers
In: International review of cell and molecular biology - Amsterdam [u.a.]: Elsevier, Bd. 323 (2016), S. 181-229
Pathogenesis of Helicobacter pylori infection
In: Helicobacter - Oxford [u.a.]: Wiley-Blackwell, 1996, Bd. 21 (2016), Suppl.1, Seite 19-25
Proteome rearrangements after auditory learning - high-resolution profiling of synapse-enriched protein fractions from mouse brain
In: Journal of neurochemistry - Oxford: Wiley-Blackwell, 1956, Bd. 138.2016, 1, S. 124-138
Receptor-interacting protein kinase-2 inhibition by CYLD impairs antibacterial immune responses in macrophages
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 6.2016, Art.-Nr. 650, insges. 13 S.
Receptor-interacting protein kinase-2 inhibition by CYLD impairs antibacterial immune responses in macrophages
In: Frontiers in immunology. - Lausanne : Frontiers Media; Bd. 6.2016, Art.-Nr. 650, insges. 13 S.
p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IBα and the preceding liberation of RelA from ubiquitinated IBα
In: Journal of cellular and molecular medicine: an international journal ; JCMM - Hoboken, NJ: Wiley-Blackwell, 2000, Bd. 20 (2016), 1, S. 58-70
2015
Abstract
The role of Helicobacter pylori-induced canonical- and non-canonical NF-KB signaling in cell survival
In: Helicobacter - Oxford [u.a.]: Wiley-Blackwell, Bd. 20.2015, Suppl. 1, Abs. P04.18, S. 108-109
Begutachteter Zeitschriftenartikel
A20 expression in dendritic cells protects mice from LPS-induced mortality
In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 45 (2015), 3, S. 818-828
CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis
In: International journal of biochemistry & cell biology - Amsterdam: Elsevier, Bd. 66 (2015), S. 95-100
CSN-associated USP48 confers stability to nuclear NF-[kappa]B/RelA by trimming K48-linked Ub-chains
In: Biochimica et biophysica acta / Molecular cell research: BBA - Amsterdam [u.a.]: Elsevier, Bd. 1853 (2015), 2, S. 453-469
DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1
In: Cardiovascular research - Oxford: Oxford University Press, Bd. 106 (2015), 3, S. 488-497
Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain
In: Proteome science - London: BioMed Central, 2003, Bd. 13.2015, Art.-Nr.13, insges. 17 S.
Diversity of COP9 signalosome structures and functional consequences
In: FEBS letters: for the rapid publication of short reports in biochemistry, biophysics, and molecular biology/ Vereinigung der Europäischen Biochemischen Gesellschaften - Chichester: Wiley, Bd. 589.2015, 19 Pt.A, S. 2507-2513
Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD
In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 45 (2015), 5, S. 1366-1376
Quantification of CD95-induced apoptosis and NF-[Kappa]B activation at the single cell level
In: Journal of immunological methods: JIM - Amsterdam [u.a.]: Elsevier Science, Bd. 423 (2015), S. 12-17
Role of calprotectin as a modulator of the IL27-mediated proinflammatory effect on endothelial cells
In: Mediators of inflammation - Sylvania, Ohio: Hindawi Publishing Corp., 2015, Art.-ID 737310, insges. 16 S.
Structural modeling of the N-terminal signal-receiving domain of I[kappa]B[alpha]
In: Frontiers in molecular biosciences - Lausanne: Frontiers, Bd. 2.2015, Art.-Nr. 32, insges. 16 S.
2014
Abstract
JAK2V617F mutation is sufficient for autocrine induction of IP-10 in hematopoietic cells
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, V618, S. 199
Begutachteter Zeitschriftenartikel
Experimental design, validation and computational modeling uncover DNA damage sensing by DNA-PK and ATM
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, 2005, Bd. 10.2014, 7, S. 1978-1986
Helicobacter pylori promotes eukaryotic protein translation by activating phosphatidylinositol 3 kinase/mTOR
In: International journal of biochemistry & cell biology - Amsterdam: Elsevier, Bd. 55 (2014), S. 157-163
MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection
In: Biochimica et biophysica acta / Molecular cell research: BBA - Amsterdam [u.a.]: Elsevier, Bd. 1843 (2014), 4, S. 715-724
Dissertation
Molekulare Charakterisierung der Interaktion des COP9-Signalosoms mit NF-[Kappa]B/RelA und I[Kappa]Bα
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014, 102 Bl., graph. Darst.
2013
Begutachteter Zeitschriftenartikel
Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-[kappa]B- and STAT1-dependent chemokine production in astrocytes
In: Acta neuropathologica - Berlin: Springer, 1961, Bd. 126.2013, 5, S. 711-724
CAND1-dependent control of cullin 1-RING Ub ligases is essential for adipogenesis
In: Biochimica et biophysica acta: BBA ; international journal of biochemistry, biophysics and molecular biology - Amsterdam [u.a.]: Elsevier, Bd. 1833 (2013), 5, S. 1078-1084
Ca2+/calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation in Helicobacter pylori infection
In: International journal of cancer. - Malden, Mass : Wiley-Blackwell, Bd. 133.2013, 6, S. 1507-1512
Crystal structure and versatile functional roles of the COP9 signalosome subunit 1
In: Proceedings of the National Academy of Sciences of the United States of America: PNAS/ National Academy of Sciences - Washington, DC: NAS, 1877, Bd. 110.2013, 29, S. 11845-11850
Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus
In: Cell - Cambridge, Mass.: Cell Press, Bd. 152 (2013), 5, S. 1119-1133
Helicobacter pylori induces type 4 secretion system-dependent, but CagA-independent activation of I[kappa]Bs and NF-[kappa]B/RelA at early time points
In: International journal of medical microbiology - München: Elsevier, Bd. 303 (2013), 8, S. 548-552
Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection
In: Gut. - London : BMJ Publishing Group, Bd. 62.2013, 3, S. 358-367
Rapid interaction of Helicobacter pylori with microvilli of the polar human gastric epithelial cell line NCI-N87
In: The anatomical record: AR ; advances in integrative anatomy and evolutionary biology ; an official publication of the American Association of Anatomists - Hoboken, NJ: Wiley-Liss, 2007, Bd. 296.2013, 12, S. 1800-1805
Rapid interaction of Helicobacter pylori with microvilli of the polar human gastric epithelial cell line NCI-N87
In: The anatomical record: AR ; advances in integrative anatomy and evolutionary biology ; an official publication of the American Association of Anatomists - Hoboken, NJ: Wiley-Liss, 2007, Bd. 296.2013, 12, S. C1
Originalartikel in begutachteter internationaler Zeitschrift
CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production
In: PLoS pathogens/ Public Library of Science - Lawrence, Kan.: PLoS, Bd. 9.2013, 6, Art. e1003455, insges. 17 S.
2012
Originalartikel in begutachteter internationaler Zeitschrift
Cyclin-dependent kinase 6 phosphorylates NF-[kappa]B p65 at serine 536 and contributes to the regulation of inflammatory gene expression
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 7.2012, 12, Art. e51847, insges. 13 S.
Synaptic proteome changes in mouse brain regions upon auditory discrimination learning
In: Proteomics: proteomics and systems biology - Weinheim: Wiley-VCH, Bd. 12 (2012), 15/16, S. 2433-2444
2011
Nicht begutachteter Zeitschriftenartikel
Therapierelevante Forschung in der Inneren Medizin
In: Ärzteblatt Sachsen-Anhalt. - Magdeburg : Ärztekammer Sachsen-Anhalt, Bd. 22.2011, 4, S. 25-26
Originalartikel in begutachteter internationaler Zeitschrift
Helicobacter pylori-induced tyrosine phosphorylation of IKK[beta] contributes to NF-[kappa]B activation
In: Biological chemistry. - Berlin [u.a.] : de Gruyter, Bd. 392.2011, 4, S. 387-393
Microbial-induced immunomodulation by targeting the NF-[Kappa]B system
In: Trends in microbiology. - Cambridge : Elsevier, Bd. 19.2011, 12, S. 596-605
2010
Originalartikel in begutachteter internationaler Zeitschrift
Control of NF-[kappa]B activation by the COP9 signalosome
In: Biochemical Society : Biochemical Society transactions . - London : Portland Pr., Bd. 38.2010, 1, S. 156-161
Disposable micro-fluidic biosensor array for online parallelized cell adhesion kinetics analysis on quartz crystal resonators
In: Measurement science and technology . - Bristol : IOP Publ. Ltd., Bd. 21.2010, 8, insges. 12 S.
Dynamics of bionanoparticle targeting in mixtures of human tumour cells by validated population balance modelling
In: Soft matter / publ. by the Royal Society of Chemistry - Cambridge: RSC Publ., 2005, Bd. 6.2010, 6, S. 1203-1216
Helicobacter pylori induces NF-[kappa]B independent of CagA. Correspondence
In: European Molecular Biology Organization : EMBO reports . - London : Nature Publ. Group, Bd. 11.2010, 1, S. 10-11
Helicobacter pylori-induced activation of [beta]-catenin involves low density lipoprotein receptor-related protein 6 and dishevelled
In: Molecular cancer . - London : Biomed Central, Bd. 9.2010, 31, insges. 9 S.
Interleukin 1 beta (IL1B) gene polymorphisms are not associated with gastric carcinogenesis in Germany
In: Anticancer research . - Kapandriti : International Inst. of Anticancer Research, Bd. 30.2010, 2, S. 505-511
Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells
In: Cellular signalling - Amsterdam: Elsevier, Bd. 22 (2010), 3, S. 395-403
Novel plant metalloproteinase from Dieffenbachia seguine causes fingertip necrosis. Correspondence
In: The British journal of dermatology . - Oxford : Wiley-Blackwell, Bd. 162.2010, 5, S. 1150-1152
Protective toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta
In: Infection and immunity: IAI ; a publication of the American Society for Microbiology - Washington, DC: Soc., Bd. 78 (2010), 8, S. 3454-3464
Studies on neuronal differentiation and signalling processes with a novel impedimetric biosensor
In: Biosensors & bioelectronics: an international journal - Barking, Essex: Elsevier, Bd. 26 (2010), 4, S. 1407-1413
What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori
In: Trends in microbiology: virulence, infection and pathogenesis - Cambridge, Mass.: Cell Press, Bd. 18 (2010), 11, S. 479-486
2009
Originalartikel in begutachteter internationaler Zeitschrift
Bis(1H-indol-2-yl)methanones are effective inhibitors of FLT3-ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro
In: British journal of haematology . - Oxford [u.a.] : Wiley-Blackwell, Bd. 144.2009, 6, S. 865-874
COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation
In: EMBO reports / publ. for EMBO/ European Molecular Biology Organization - Weinheim: Wiley, Bd. 10 (2009), 6, S. 642-648
Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection
In: Experimental cell research: ECR ; emphasizing molecular approaches to cell biology - San Diego, Calif.: Elsevier, 1950, Bd. 315.2009, 20, S. 3500-3508
Electrical impedance analysis of N2a neuroblastoma cells in gel matrices after ACh-receptor triggering with an impedimetric biosensor
In: Procedia chemistry . - Amsterdam [u.a.] : Elsevier, Bd. 1.2009, 1, S. 734-737
Electrical impedance spectroscopy of gel embedded neuronal cells based on a novel impedimetric biosensor
In: Procedia chemistry . - Amsterdam [u.a.] : Elsevier, Bd. 1.2009, 1, S. 261-264
Identification of novel Cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo
In: Molecular cancer . - London : Biomed Central, Bd. 8.2009, 22, insges. 13 S.
Impact of flow-through regime on the cultivation of epithelial cells on quartz crystal resonators in micro fluidic channels
In: Procedia chemistry . - Amsterdam [u.a.] : Elsevier, Bd. 1.2009, 1, S. 365-368
Influence of statistical variations in cell distribution on the proliferation kinetics of Madin-Darby canine kidney cells on quartz crystal resonator
In: Procedia chemistry. - Amsterdam [u.a.] : Elsevier, Bd. 1.2009, 1, S. 373-376
Logical network of genotoxic stress-induced NF-[kappa]B signal transduction predicts putative target structures for therapeutic intervention strategies
In: Advances and applications in bioinformatics and chemistry - Albany, Auckland: Dove Medical Press, Bd. 2 (2009), S. 125-138
Originalartikel in begutachteter zeitschriftenartiger Reihe
Impedimetric biosensor system for the on-line analysis of stimulated neuronal cells embedded in gel matrices
In: IEEE Sensors 2009 . - IEEE, ISBN 978-1-424-45335-1, S. 1864-1867 ; Kongress: IEEE Conference on Sensors; 8 (Christchurch) : 2009.10.25-28 ; [Auch auf CD-ROM erschienen]
2008
Originalartikel in begutachteter internationaler Zeitschrift
Helicobacter pylori regulates p21WAF1 by histone H4 acetylation
In: Biochemical and biophysical research communications: BBRC - San Diego, Calif.: Elsevier, 1959, Bd. 369.2008, 2, S. 526-531
Helicobacter pylori suppresses glycogen synthase kinase 3[beta] to promote [beta]-catenin activity
In: The journal of biological chemistry: JBC - Bethesda, Md.: ASBMB, 1905, Bd. 283.2008, 43, S. 29367-29374
Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction
In: BMC systems biology . - London : BioMed Central, Bd. 2.2008, 4, insges. 17 S.
Protein kinase C-[theta] critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 180.2008, 8, S. 5601-5612
Originalartikel in begutachteter zeitschriftenartiger Reihe
Disposable micro fluidic biosensor array for parallelized online cell stimulation analysis
In: Proceedings: Dresden, Germany, 7 - 10 September 2008 - Düsseldorf: VDI/VDE-Ges. Mess- und Automatisierungstechnik, 2008 . - 2008, S. 1189-1192 ; Kongress: Eurosensors 22 (Dresden : 2008.09.07-10) ; [Beitrag auf CD-ROM]
Micro fluidic biosensor array for parallelized cell adhesion analysis during pathogenic infection
In: IEEE sensors 2008: the 7th IEEE Conference on Sensors ; Lecce, Italy, October 26-29, 2008/ Conference on Sensors, 2008 . - 2008, S. 1460-1463 ; Kongress: IEEE Conference on Sensors 7 (Lecce, Italy : 2008.10.26-29) ; [Beitrag auf CD-ROM]
Online adhesion analysis of hepatocyte growth factor stimulated cells with resonant biosensor
In: Proceedings: Dresden, Germany, 7 - 10 September 2008 - Düsseldorf: VDI/VDE-Ges. Mess- und Automatisierungstechnik, 2008 . - 2008, S. 1185-1188 ; Kongress: Eurosensors 22 (Dresden : 2008.09.07-10) ; [Beitrag auf CD-ROM]
Real-time analysis of hepatocyte growth factor induced cell motility with quartz crystal resonators
In: IEEE sensors 2008: the 7th IEEE Conference on Sensors ; Lecce, Italy, October 26-29, 2008/ Conference on Sensors, 2008 . - 2008, S. 246-249 ; Kongress: IEEE Conference on Sensors 7 (Lecce, Italy : 2008.10.26-29) ; [Beitrag auf CD-ROM]
2007
Buchbeitrag
Expression of ADAM19 in Helicobacter pylori-mediated diseases and gastric cancer
In: Gastric cancer research trends - New York: Nova Science . - 2007, S. 171-188
Originalartikel in begutachteter internationaler Zeitschrift
Beyond I[kappa]Bs: alternative regulation of NF-[kappa]B activity
In: The FASEB journal: the official journal of the Federation of American Societies for Experimental Biology/ Federation of American Societies for Experimental Biology - Bethesda, Md.: FASEB, Bd. 21 (2007), 11, S. 2642-2654
CSN controls NF-[kappa]B by deubiquitinylation of I[kappa]B[alpha]
In: The EMBO journal/ European Molecular Biology Organization - Heidelberg, Germany: Wiley, Bd. 26 (2007), 6, S. 1532-1541
Cholera toxin promotes the generation of semi-mature porcine monocyte-derived dendritic cells that are unable to stimulate T cells
In: Veterinary research / Institut National de la Recherche Agronomique - Paris: Ed.Scientifiques Elsevier, Bd. 38 (2007), 4, S. 597-612
Control of the NF-[kappa]B inhibitor I[kappa]B[alpha] in pathogen infection
In: Biochemical Society transactions/ Biochemical Society - London: Portland Press, Bd. 35 (2007), 2, S. 267-269
Soluble galectin-3 is a strong, colonic epithelial-cell-derived, lamina propria fibroblast-stimulating factor
In: Gut: the journal of the British Society of Gastroenterology ; an international journal of gastroenterology and hepatology / ed. Sheila Sherlock: the journal of the British Society of Gastroenterology ; an international journal of gastroenterology and hepatology - London: BMJ Publishing Group, Bd. 56 (2007), 1, S. 43-51
Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells
In: The EMBO journal/ European Molecular Biology Organization - Heidelberg, Germany: Wiley, Bd. 26 (2007), 4, S. 1140-1149
The Fusarium toxin deoxynivalenol disrupts phenotype and function of monocyte-derived dendritic cells in vivo and in vitro
In: Immunobiology: founded in 1909 - Amsterdam: Elsevier, Bd. 212 (2007), 8, S. 655-666
Originalartikel in begutachteter zeitschriftenartiger Reihe
Micro fluidic biosensor system based on quartz crystal resonators for fast online adherent cell proliferation and stimulation analysis
In: IEEE sensors 2007 conference, 2007 . - 2007, S. 720-723
2006
Originalartikel in begutachteter internationaler Zeitschrift
Epithelial cell signaling in Helicobacter pylori infection
In: Current signal transduction therapy . - San Francisco, Calif. [u.a.] : Bentham Science Publ., Bd. 1.2006, 1, S. 53-65
Helicobacter pylori encoding the pathogenicity island activates matrix-metalloproteinase 1 in gastric epithelial cells via JNK and ERK
In: The journal of biological chemistry - Bethesda, Md.: ASBMB, Bd. 281 (2006), 5, S. 2868-2875
The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NF-[kappa]B activation
In: Biological chemistry - Berlin [u.a.]: de Gruyter, Bd. 387 (2006), 1, S. 79-86
2005
Buchbeitrag
Helicobacter pylori mechanisms for inducing epithelial cell proliferation.
In: Lax, A. (Ed.): Bacterial protein toxins : role in the interference with cell growth regulation. Cambridge ; New York : Cambridge Univ. Press, 2005, S. 169 - 198 (Advances in molecular and cellular microbiology ; 7)
Originalartikel in begutachteter internationaler Zeitschrift
Consequences of COP9 signalosome and 26S proteasome interaction.
In: FEBS J. 272(2005), Nr. 15, S. 3909 - 3917
Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-alpha on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
In: J. Immunol. 174(2005), Nr. 10, S. 6524 - 6531
Helicobacter pylori eradication has the potential to prevent gastric cancer : a state-of-the- art critique.
In: Am. J. Gastroenterol. 100(2005), Nr. 9, S. 2100 - 2115
Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease.
In: J. Biol. Chem. 280(2005), Nr. 15, S. 14981 - 14988
Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells.
In: Int. J. Med. Microbiol. 295(2005), Nr. 5, S. 335 - 341
The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection.
In: Biol. Chem. 386(2005), Nr. 5, S. 481 - 490
Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
In: J. Pathol. 207(2005), Nr. 1, S. 32 - 42
2004
Originalartikel in begutachteter internationaler Zeitschrift
Analysis of the type IV secretion system-dependent cell motility of Helicobacter pylori- infected epithelial cells.
In: Biochem. Biophys. Res. Commun. 322(2004), Nr. 3, S. 860 - 866
Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells.
In: Biochem. Biophys. Res. Commun. 316(2004), Nr. 4, S. 1065 - 1072
Helicobacter pylori-induced epithelial cell signalling in gastric carcinogenesis.
In: Trends Microbiol. 12(2004), Nr. 1, S. 29 - 36
Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease.
In: Faseb J. 18(2004), S. 1550 - 1552
Prevention of gastric cancer by Helicobacter pylori eradication.
In: Dig. Dis. 22(2004), Nr. 4, S. 313 - 319
2003
Originalartikel in begutachteter internationaler Zeitschrift
Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.
In: Mol. Cell 11(2003), S. 927 - 938
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
In: J. Cell Biol. 161(2003), Nr. 2, S. 249 - 255
Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription : critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors.
In: Cell. Microbiol. 5(2003), Nr. 11, S. 821 - 834
Helicobacter pylori stimulates host vascular endothelial growth factor-A (vegf-A) gene expression via MEK/ERK-dependent activation of Sp1 and Sp3. . - Gedr. ersch. in: FASEB J. 18(2004)1, S. 218 - 220.
In: Faseb J.(2003)
The mitogen-activated protein kinase p38 : a new molecular target for anti-inflammatory therapy in Crohn's disease?.
In: Gastroenterol. Polska 10(2003), Nr. 4, S. 335 - 340
2002
Originalartikel in begutachteter internationaler Zeitschrift
Pathogenesis of Helicobacter pylori infection.
In: Helicobacter 7(2002), Suppl. 1, S. 17 - 23