Prof. Naumann

Prof. Dr. rer. nat. Michael Naumann
Institut für Experimentelle Innere Medizin (IEIM)
Aktuelle Projekte
- Maladaptive processes across physiological barriers in chronic diseases
Laufzeit: 01.10.2018 - 31.03.2023 - Helicobacter pylori type IV secretion system-directed membrane-proximal NF-kB signaling
Laufzeit: 01.01.2018 - 31.12.2021 - Plasticity and cell-type specific functions of OTUB1 in infection
Laufzeit: 01.01.2018 - 31.12.2021
Abgeschlossene Projekte
- ZIKAlliance Project 53
Laufzeit: 01.10.2016 - 30.09.2020 - Immunregulatory function of the deubiquitinylating enzymes A20 and OTUB1 in infectious and autoimmune diseases
Laufzeit: 01.01.2014 - 31.12.2017 - E3 Ubiquitin Ligase-abhängige NF-kB Regulation in der Helicobacter pylori Infektion
Laufzeit: 01.01.2014 - 31.12.2017 - Identifizierung neuer Zielmoleküle für die klinische Therapie der akuten myeloischen Leukämie
Laufzeit: 01.06.2014 - 31.05.2017 - Proteomanalytik und Massenspektrometrie
Laufzeit: 01.12.2012 - 31.12.2015 - NF-kB Regulation in der Helicobacter Infektion
Laufzeit: 01.01.2010 - 31.12.2013 - Immunregulatorische Funktion von Deubiquitinylasen bei der Toxoplasmose
Laufzeit: 01.01.2010 - 31.12.2013 - MODEXA
Laufzeit: 01.09.2009 - 31.08.2012 - Nedd8/COP9 Signalosom-abhängige Kontrolle von IkBs und RelA
Laufzeit: 01.10.2008 - 31.08.2012 - Proteomanalytik und Massenspektrometrie
Laufzeit: 01.01.2008 - 31.12.2011 - Stimulus-dependent molecular processes in cells
Laufzeit: 01.04.2007 - 31.12.2011 - Modellierung der NF-kB Signaltransduktion
Laufzeit: 01.01.2007 - 31.12.2011 - Dynamics of Helicobacter pylori-induced responses in epithelial cells
Laufzeit: 01.01.2007 - 31.12.2011 - Bilaterale Kooperation
Laufzeit: 01.09.2010 - 30.06.2011 - Regulation der IkB/NF-kB Signaltransduktion in der H. pylori-induzierten angeborenen Immunantwort
Laufzeit: 01.01.2007 - 31.12.2010 - Zell-Zell-Kommunikation in Nerven- und Immunsystem: Topologische Organisation von Signalwegen
Laufzeit: 01.10.2005 - 31.03.2010 - Modulation des Wnt-Signalweges und Bedeutung für die Invasion von Epithelzellen
Laufzeit: 01.10.2005 - 31.03.2010 - Regulation of the lipid-raft localised signal transduction in Helicobacter pylori infection
Laufzeit: 01.10.2005 - 31.03.2010 - Funktionelle Analyse signalübertragender Proteinkomplexe
Laufzeit: 01.07.2008 - 31.12.2009 - Funktionelle Analyse signalübertragender Proteinkomplexe in Lipid-raft-Strukturen Helicobacter-pylori-infizierter Epithelzellen
Laufzeit: 01.07.2005 - 30.06.2008 - Chromatin-assoziierte Veränderungen von Wnt-Zielgenen nach Helicobacter pylori Infektion im Magenepithel
Laufzeit: 01.09.2005 - 31.08.2007 - Zelldissoziation und Dysregulation von adherens junction Proteinen im Helicobacter pylori-infizierten Magenepithel
Laufzeit: 01.09.2004 - 31.08.2007 - Induktion der angeborenen Immunantwort durch Membran-Interaktion/Translokation von Helicobacter pylori Effektoren und Aktivierung der intrazellulären Signaltransduktion in Epithelzellen
Laufzeit: 01.01.2004 - 31.12.2006 - Mathematische Modellierung der Signaltransduktion bei der Stimulation des Tyrosinkinase Rezeptors c-Met durch HGF und Helicobacter pylori
Laufzeit: 01.10.2004 - 30.09.2006 - Regulation von NF-kappaB und MAP-Kinase Signalwegen bei chronisch entzündlichen Darmerkrankungen
Laufzeit: 01.01.2004 - 31.12.2005 - Signalwege zur NF-kappaB Regulation: Charakterisierung der NF-kappaB Kinasen
Laufzeit: 01.02.2000 - 30.01.2005 - Helicobacter pylori- induzierte Histidindecarboxylase-Genaktivität in gastralen Epithelzellen: Charakterisierung der molekularen Mechanismen und Virulenzfaktoren
Laufzeit: 01.02.2001 - 30.01.2004
2020
Abstract
Expression der eukaryotischen Initiationsfaktoren (eIFs) in plattenepithelialen Kopf- und Halskarzinomen (HNSCC) - potenzielle therapeutische Implikationen
In: Laryngo-Rhino-Otologie - Stuttgart [u.a.]: Thieme, 1980, Bd. 99.2020, S 02, S. S90-S91
Begutachteter Zeitschriftenartikel
Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases
In: The journal of biological chemistry - Bethesda, Md.: Soc., 1905, Bd. 295.2020, 20, S. 6972-6982
CEACAMs interaction with Helicobacter pylori HopQ supports the type 4 secretion system-dependent activation of non-canonical NF-[kappa]B
In: International journal of medical microbiology: IJMM - München: Elsevier, 2000, Bd. 310.2020, 6, Art.-Nr. 151444, insges. 6 Seiten
The COP9 signalosome - a multi-DUB complex
In: Biomolecules: open access journal - Basel: MDPI, 2011, Bd. 10.2020, 7, Art.-Nr. 1082, insgesamt 11 Seiten
The interaction of TRAF6 with neuroplastin promotes spinogenesis during early neuronal development
In: Frontiers in cell and developmental biology - Lausanne: Frontiers Media, 2013, Vol. 8.2020, 579513, insgesamt 18 Seiten
2019
Abstract
Expression levels of eukaryotic initiation factors (eIFs) are significantly altered in head and neck squamous cell carcinomas (HNSCC)
In: Der Pathologe - Berlin: Springer, 1994, Bd. 40.2019, Suppl. 2, AG11.05, Seite S139
Neuroplastin-plasma membrane Ca2+ ATPases complexes - a new team regulating Ca2+ clearance, signaling, and synaptic plasticity
In: Journal of neurochemistry: official journal of the International Society for Neurochemistry ; JNC - Oxford: Wiley-Blackwell, 1956, Vol. 150.2019, Suppl. 1, MTU02-05, S. 77
Role of Otubain-1 (OTUB1) during inflammatory liver diseases
In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 49.2019, Suppl. 1, O1, Seite 13
Begutachteter Zeitschriftenartikel
Catalytic domain of deubiquitinylase USP48 directs interaction with Rel homology domain of nuclear factor kappaB transcription factor RelA
In: Molecular biology reports - Dordrecht [u.a.]: Springer Science + Business Media B.V, Bd. 46.2019, 1, S. 1369-1375
Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis
In: Current topics in microbiology and immunology - Berlin: Springer, Bd. 421.2019, S. 107-137
NF-kappaB-inducing kinase in cancer
In: Biochimica et biophysica acta / Reviews on cancer: BBA - Amsterdam: Elsevier, 1974, Bd. 1871.2019, 1, S. 40-49
Targeting RIPK1 in AML cells carrying FLT3-ITD
In: International journal of cancer - Bognor Regis: Wiley-Liss, Bd. 145.2019, 6, S. 1558-1569
2018
Begutachteter Zeitschriftenartikel
Computational studies on the inhibitor selectivity of human JAMM deubiquitinylases Rpn11 and CSN5
In: Frontiers in Chemistry - Lausanne: Frontiers Media, Bd. 6.2018, Art.-Nr. 480, insges. 12 S.
Constitutive activation of nuclear factor kappa B-inducing kinase counteracts apoptosis in cells with rearranged mixed lineage leukemia gene
In: Leukemia: normal and malignant hemopoiesis ; a peer-reviewed journal - London: Springer Nature, 1997, Bd. 32.2018, 11, S. 2498-2501
Cullin 3-based ubiquitin ligases as master regulators of mammalian cell differentiation
In: Trends in biochemical sciences: TIBS - Amsterdam [u.a.]: Elsevier Science, Bd. 43.2018, 2, S. 95-107
Deubiquitinylase USP47 promotes RelA phosphorylation and survival in gastric cancer cells
In: Biomedicines: open access journal - Basel: MDPI, Bd. 6.2018, 2, Art.-Nr. 62, insges. 9 S.
Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells
In: Journal of cancer research and clinical oncology: official organ of the Deutsche Krebsgesellschaft - Berlin: Springer, Bd. 144.2018, 10, S. 1933-1944
Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling
In: Biochimica et biophysica acta / Molecular cell research - Amsterdam [u.a.]: Elsevier, 1982, Bd. 1865.2018, 4, S. 545-550
HopQ impacts the integrin [alpha]5[beta]1-independent NF-[kappa]B activation by Helicobacter pylori in CEACAM expressing cells
In: International journal of medical microbiology: IJMM - München: Elsevier, 2000, Bd. 308.2018, 5, S. 527-533
Influence of eukaryotic translation initiation factor 6 on nonsmall cell lung cancer development and progression
In: European journal of cancer - Amsterdam [u.a.]: Elsevier, 1965, Bd. 101.2018, S. 165-180
Interactome analysis of transforming growth factor-[beta]-activated kinase 1 in Helicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37
In: OncoTarget: open access impact journal - [S.l.]: Impact Journals LLC, Bd. 9.2018, 18, S. 14366-14381
NF-[kappa]B-regulated ubiquitin-editing enzyme A20 paves the way for infection persistency
In: Cell cycle - Abingdon: Taylor & Francis Group, 2002, Bd. 17.2018, 1, S. 3-4
The cell fate determinant Scribble is required for maintenance of hematopoietic stem cell function
In: Leukemia: normal and malignant hemopoiesis ; a peer-reviewed journal - London: Springer Nature, Bd. 32.2018, 5, S. 1211-1221
2017
Abstract
A new way to create synapses - neuroplastin-TRAF6-dependent signaling induces excitatory synapse formation
In: Journal of neurochemistry - Oxford: Wiley-Blackwell, 1956, Bd. 142.2017, Suppl. 1, MTU08-08, S. 130
CYLD-deficiency protects from experimental cerebral malaria
In: European journal of immunology - Weinheim: Wiley VCH, 1971, Bd. 47.2017, Suppl. 2, O74, S. 42
Begutachteter Zeitschriftenartikel
A complex of neuroplastin and plasma membrane Ca2+ ATPase controls T cell activation
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 7.2017, Art.-Nr. 8358, insges. 13 S.
A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development
In: Cancer cell - Cambridge, Mass: Cell Press, 2002, Bd. 32.2017, 3, S. 342-359
ALPK1- and TIFA-dependent innate immune response triggered by the helicobacter pylori type IV secretion system
In: Cell reports - Maryland Heights, MO: Cell Press, 2012, Bd. 20.2017, 10, S. 2384-2395
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, 8(2017) Artikel-Nummer 311, 16 Seiten
Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis
In: Biochimica et biophysica acta / Molecular cell research - Amsterdam [u.a.]: Elsevier, 1982, Bd. 1864.2017, 8, S. 1405-1412
Double phosphorylation-induced structural changes in the signal-receiving domain of I[kappa]B[alpha] in complex with NF-[kappa]B
In: Proteins: structure, function, and bioinformatics - New York, NY: Wiley-Liss, 1986, Bd. 85.2017, 1, S. 17-29
Double phosphorylation-induced structural changes in the signal-receiving domain of IκBα in complex with NF-κB
In: Proteins: Structure, Function, and Bioinformatics, 2017, S. 17-29, ISSN 08873585, 10.1002/prot.25181
Helicobacter pylori - a paradigm pathogen for subverting host cell signal transmission
In: Trends in microbiology - Amsterdam [u.a.]: Elsevier Science, 1993, Bd. 25.2017, 4, S. 316-328
Helicobacter pylori employs a unique basolateral type IV secretion mechanism for CagA delivery
In: Cell host and microbe - Amsterdam [u.a.]: Elsevier, Bd. 22.2017, 4, S. 552-560
NEMO links nuclear factor-[kappa]B to human diseases
In: Trends in molecular medicine - Amsterdam [u.a.]: Elsevier Science, 2001, Bd. 23.2017, 12, S. 1138-1155
NF[kappa]B signaling in gastric cancer
In: Toxins - Basel: MDPI, 2009, Bd. 9.2017, 4, Art.-Nr. 119, insges. 21 S.
Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-B and caspase-8-dependent apoptotic cell death
In: Cell death and differentiation - Houndmills, Basingstoke: Nature Publishing Group, 1997, Bd. 24.2017, 9, S. 1621-1631
The Helicobacter pylori type IV secretion system encoded by the cag pathogenicity island - architecture, function, and signaling
In: Current topics in microbiology and immunology - Berlin: Springer, Bd. 413.2017, S. 187-220
The deubiquitinating enzyme cylindromatosis dampens CD8+ T cell responses and is a critical factor for experimental cerebral malaria and bloodbrain barrier damage
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 8.2017, Art.-Nr. 27, insges. 17 S.
2016
Abstract
NF-KappaB dependent expression of a20 controls cell death in H. pylori-infected cells
In: Helicobacter - Oxford [u.a.]: Wiley-Blackwell, 1996, Bd. 21.2016, Suppl. 1, Abs. P09.03, S. 162
Begutachteter Zeitschriftenartikel
A20 curtails primary but augments secondary CD8+ T cell responses in intracellular bacterial infection
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 6.2016, Art.-Nr. 39796, insges. 15 S.
High resolution quantitative synaptic proteome profiling of mouse brain regions after auditory discrimination learning. Video article
In: JoVE - [S.l.], 2006, 2016, 118, Art.-Nr. e54992, insges. 12 S.
Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner
In: Experimental & molecular medicine: EMM - [London]: Macmillan Publishers Limited, part of Springer Nature, 1996, Bd. 48.2016, Art.-Nr. e270, insges. 10 S.
Molecular architecture of the DED chains at the DISC - regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain
In: Cell death and differentiation - Houndmills, Basingstoke: Nature Publishing Group, 1997, Bd. 23.2016, 4, S. 681-694
New insights into the mechanism of COP9 signalosomecullin-RING ubiquitin-ligase pathway deregulation in urological cancers
In: International review of cell and molecular biology - Amsterdam [u.a.]: Elsevier, 2008, Bd. 323.2016, S. 181-229
Pathogenesis of Helicobacter pylori infection
In: Helicobacter - Oxford [u.a.]: Wiley-Blackwell, 1996, Bd. 21 (2016), Suppl.1, Seite 19-25
Proteome rearrangements after auditory learning - high-resolution profiling of synapse-enriched protein fractions from mouse brain
In: Journal of neurochemistry - Oxford: Wiley-Blackwell, 1956, Bd. 138.2016, 1, S. 124-138
Receptor-interacting protein kinase-2 inhibition by CYLD impairs antibacterial immune responses in macrophages
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 6.2016, Art.-Nr. 650, insges. 13 S.
Receptor-interacting protein kinase-2 inhibition by CYLD impairs antibacterial immune responses in macrophages
In: Frontiers in immunology. - Lausanne : Frontiers Media; Bd. 6.2016, Art.-Nr. 650, insges. 13 S.
p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IBα and the preceding liberation of RelA from ubiquitinated IBα
In: Journal of cellular and molecular medicine: an international journal : JCMM - Hoboken, NJ: Wiley-Blackwell, 2000, Bd. 20.2016, 1, S. 58-70
2015
Abstract
The role of Helicobacter pylori-induced canonical- and non-canonical NF-KB signaling in cell survival
In: Helicobacter - Oxford [u.a.]: Wiley-Blackwell, Bd. 20.2015, Suppl. 1, Abs. P04.18, S. 108-109
Begutachteter Zeitschriftenartikel
A20 expression in dendritic cells protects mice from LPS-induced mortality
In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 45.2015, 3, S. 818-828
CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis
In: International journal of biochemistry & cell biology - Amsterdam: Elsevier, 1995, Bd. 66.2015, S. 95-100
CSN-associated USP48 confers stability to nuclear NF-[kappa]B/RelA by trimming K48-linked Ub-chains
In: Biochimica et biophysica acta / Molecular cell research - Amsterdam [u.a.]: Elsevier, Bd. 1853.2015, 2, S. 453-469
DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1
In: Cardiovascular research - Oxford: Oxford University Press, 1967, Bd. 106.2015, 3, S. 488-497
Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain
In: Proteome science - London: BioMed Central, 2003, Bd. 13.2015, Art.-Nr.13, insges. 17 S.
Diversity of COP9 signalosome structures and functional consequences
In: FEBS letters: for the rapid publication of short reports in biochemistry, biophysics, and molecular biology - Chichester: Wiley, Bd. 589.2015, 19 Pt.A, S. 2507-2513
Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD
In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 45.2015, 5, S. 1366-1376
Quantification of CD95-induced apoptosis and NF-[Kappa]B activation at the single cell level
In: Journal of immunological methods - Amsterdam [u.a.]: Elsevier Science, 1971, Bd. 423.2015, S. 12-17
Role of calprotectin as a modulator of the IL27-mediated proinflammatory effect on endothelial cells
In: Mediators of inflammation. - Sylvania, Ohio : Hindawi Publishing Corp; 2015, Art.-ID 737310, insges. 16 S.
Structural modeling of the N-terminal signal-receiving domain of I[kappa]B[alpha]
In: Frontiers in molecular biosciences - Lausanne: Frontiers, Bd. 2.2015, Art.-Nr. 32, insges. 16 S.
2014
Abstract
JAK2V617F mutation is sufficient for autocrine induction of IP-10 in hematopoietic cells
In: Oncology research and treatment - Basel: Karger, Bd. 37.2014, Suppl. 5, V618, S. 199
Begutachteter Zeitschriftenartikel
Experimental design, validation and computational modeling uncover DNA damage sensing by DNA-PK and ATM
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, 2005, Bd. 10.2014, 7, S. 1978-1986
Helicobacter pylori promotes eukaryotic protein translation by activating phosphatidylinositol 3 kinase/mTOR
In: International journal of biochemistry & cell biology - Amsterdam: Elsevier, 1995, Bd. 55.2014, S. 157-163
MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection
In: Biochimica et biophysica acta / Molecular cell research - Amsterdam [u.a.]: Elsevier, 1982, Bd. 1843.2014, 4, S. 715-724
Dissertation
Molekulare Charakterisierung der Interaktion des COP9-Signalosoms mit NF-[Kappa]B/RelA und I[Kappa]Bα
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014, 102 Bl., graph. Darst.
2013
Begutachteter Zeitschriftenartikel
Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-[kappa]B- and STAT1-dependent chemokine production in astrocytes
In: Acta neuropathologica - Berlin: Springer, 1961, Bd. 126.2013, 5, S. 711-724
CAND1-dependent control of cullin 1-RING Ub ligases is essential for adipogenesis
In: Biochimica et biophysica acta: BBA ; international journal of biochemistry, biophysics and molecular biology - Amsterdam [u.a.]: Elsevier, 1947, Bd. 1833.2013, 5, S. 1078-1084
Ca2+/calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation in Helicobacter pylori infection
In: International journal of cancer. - Malden, Mass : Wiley-Blackwell, Bd. 133.2013, 6, S. 1507-1512
Crystal structure and versatile functional roles of the COP9 signalosome subunit 1
In: Proceedings of the National Academy of Sciences of the United States of America: PNAS/ National Academy of Sciences - Washington, DC: NAS, 1877, Bd. 110.2013, 29, S. 11845-11850
Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus
In: Cell - Cambridge, Mass.: Cell Press, 1974, Bd. 152.2013, 5, S. 1119-1133
Helicobacter pylori induces type 4 secretion system-dependent, but CagA-independent activation of I[kappa]Bs and NF-[kappa]B/RelA at early time points
In: International journal of medical microbiology - München: Elsevier, 2000, Bd. 303.2013, 8, S. 548-552
Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection
In: Gut. - London : BMJ Publishing Group, Bd. 62.2013, 3, S. 358-367
Rapid interaction of Helicobacter pylori with microvilli of the polar human gastric epithelial cell line NCI-N87
In: The anatomical record: AR ; advances in integrative anatomy and evolutionary biology ; an official publication of the American Association of Anatomists - Hoboken, NJ: Wiley-Liss, 2007, Bd. 296.2013, 12, S. C1
Rapid interaction of Helicobacter pylori with microvilli of the polar human gastric epithelial cell line NCI-N87
In: The anatomical record: AR ; advances in integrative anatomy and evolutionary biology ; an official publication of the American Association of Anatomists - Hoboken, NJ: Wiley-Liss, 2007, Bd. 296.2013, 12, S. 1800-1805
Originalartikel in begutachteter internationaler Zeitschrift
CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production
In: PLoS pathogens - Lawrence, Kan: PLoS, 2005, Bd. 9.2013, 6, Art. e1003455, insges. 17 S.
2012
Originalartikel in begutachteter internationaler Zeitschrift
Cyclin-dependent kinase 6 phosphorylates NF-[kappa]B p65 at serine 536 and contributes to the regulation of inflammatory gene expression
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 7.2012, 12, Art. e51847, insges. 13 S.
Synaptic proteome changes in mouse brain regions upon auditory discrimination learning
In: Proteomics: proteomics and systems biology - Weinheim: Wiley-VCH, 2001, Bd. 12.2012, 15/16, S. 2433-2444
2011
Nicht begutachteter Zeitschriftenartikel
Therapierelevante Forschung in der Inneren Medizin
In: Ärzteblatt Sachsen-Anhalt. - Magdeburg : Ärztekammer Sachsen-Anhalt, Bd. 22.2011, 4, S. 25-26
Originalartikel in begutachteter internationaler Zeitschrift
Helicobacter pylori-induced tyrosine phosphorylation of IKK[beta] contributes to NF-[kappa]B activation
In: Biological chemistry. - Berlin [u.a.] : de Gruyter, Bd. 392.2011, 4, S. 387-393
Microbial-induced immunomodulation by targeting the NF-[Kappa]B system
In: Trends in microbiology. - Cambridge : Elsevier, Bd. 19.2011, 12, S. 596-605
2010
Originalartikel in begutachteter internationaler Zeitschrift
Control of NF-[kappa]B activation by the COP9 signalosome
In: Biochemical Society : Biochemical Society transactions . - London : Portland Pr., Bd. 38.2010, 1, S. 156-161
Disposable micro-fluidic biosensor array for online parallelized cell adhesion kinetics analysis on quartz crystal resonators
In: Measurement science and technology . - Bristol : IOP Publ. Ltd., Bd. 21.2010, 8, insges. 12 S.
Dynamics of bionanoparticle targeting in mixtures of human tumour cells by validated population balance modelling
In: Soft matter / publ. by the Royal Society of Chemistry - Cambridge: RSC Publ., 2005, Bd. 6.2010, 6, S. 1203-1216
Helicobacter pylori induces NF-[kappa]B independent of CagA. Correspondence
In: European Molecular Biology Organization : EMBO reports . - London : Nature Publ. Group, Bd. 11.2010, 1, S. 10-11
Helicobacter pylori-induced activation of [beta]-catenin involves low density lipoprotein receptor-related protein 6 and dishevelled
In: Molecular cancer . - London : Biomed Central, Bd. 9.2010, 31, insges. 9 S.
Interleukin 1 beta (IL1B) gene polymorphisms are not associated with gastric carcinogenesis in Germany
In: Anticancer research . - Kapandriti : International Inst. of Anticancer Research, Bd. 30.2010, 2, S. 505-511
Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells
In: Cellular signalling - Amsterdam: Elsevier, 1988, Bd. 22.2010, 3, S. 395-403
Novel plant metalloproteinase from Dieffenbachia seguine causes fingertip necrosis. Correspondence
In: The British journal of dermatology . - Oxford : Wiley-Blackwell, Bd. 162.2010, 5, S. 1150-1152
Protective toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta
In: Infection and immunity: IAI ; a publication of the American Society for Microbiology - Washington, DC: Soc., 1970, Bd. 78.2010, 8, S. 3454-3464
Studies on neuronal differentiation and signalling processes with a novel impedimetric biosensor
In: Biosensors & bioelectronics . - Barking, Essex : Elsevier, Bd. 26.2010, 4, S. 1407-1413
What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori
In: Trends in microbiology . - Cambridge : Elsevier, Bd. 18.2010, 11, S. 479-486
2009
Originalartikel in begutachteter internationaler Zeitschrift
Bis(1H-indol-2-yl)methanones are effective inhibitors of FLT3-ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro
In: British journal of haematology . - Oxford [u.a.] : Wiley-Blackwell, Bd. 144.2009, 6, S. 865-874
COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation
In: European Molecular Biology Organization : EMBO reports . - London : Nature Publ. Group, Bd. 10.2009, 6, S. 642-648
Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection
In: Experimental cell research: ECR ; emphasizing molecular approaches to cell biology - San Diego, Calif.: Elsevier, 1950, Bd. 315.2009, 20, S. 3500-3508
Electrical impedance analysis of N2a neuroblastoma cells in gel matrices after ACh-receptor triggering with an impedimetric biosensor
In: Procedia chemistry . - Amsterdam [u.a.] : Elsevier, Bd. 1.2009, 1, S. 734-737
Electrical impedance spectroscopy of gel embedded neuronal cells based on a novel impedimetric biosensor
In: Procedia chemistry . - Amsterdam [u.a.] : Elsevier, Bd. 1.2009, 1, S. 261-264
Identification of novel Cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo
In: Molecular cancer . - London : Biomed Central, Bd. 8.2009, 22, insges. 13 S.
Impact of flow-through regime on the cultivation of epithelial cells on quartz crystal resonators in micro fluidic channels
In: Procedia chemistry . - Amsterdam [u.a.] : Elsevier, Bd. 1.2009, 1, S. 365-368
Influence of statistical variations in cell distribution on the proliferation kinetics of Madin-Darby canine kidney cells on quartz crystal resonator
In: Procedia chemistry. - Amsterdam [u.a.] : Elsevier, Bd. 1.2009, 1, S. 373-376
Logical network of genotoxic stress-induced NF-[kappa]B signal transduction predicts putative target structures for therapeutic intervention strategies
In: Advances and applications in bioinformatics and chemistry . - Albany, Auckland : Dove Medical Press, Bd. 2.2009, S. 125-138
Originalartikel in begutachteter zeitschriftenartiger Reihe
Impedimetric biosensor system for the on-line analysis of stimulated neuronal cells embedded in gel matrices
In: IEEE Sensors 2009 . - IEEE, ISBN 978-1-424-45335-1, S. 1864-1867 ; Kongress: IEEE Conference on Sensors; 8 (Christchurch) : 2009.10.25-28 ; [Auch auf CD-ROM erschienen]
2008
Originalartikel in begutachteter internationaler Zeitschrift
Helicobacter pylori regulates p21WAF1 by histone H4 acetylation
In: Biochemical and biophysical research communications: BBRC - San Diego, Calif.: Elsevier, 1959, Bd. 369.2008, 2, S. 526-531
Helicobacter pylori suppresses glycogen synthase kinase 3[beta] to promote [beta]-catenin activity
In: The journal of biological chemistry: JBC - Bethesda, Md.: ASBMB, 1905, Bd. 283.2008, 43, S. 29367-29374
Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction
In: BMC systems biology . - London : BioMed Central, Bd. 2.2008, 4, insges. 17 S.
Protein kinase C-[theta] critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 180.2008, 8, S. 5601-5612
Originalartikel in begutachteter zeitschriftenartiger Reihe
Disposable micro fluidic biosensor array for parallelized online cell stimulation analysis
In: Proceedings: Dresden, Germany, 7 - 10 September 2008 - Düsseldorf: VDI/VDE-Ges. Mess- und Automatisierungstechnik, 2008 . - 2008, S. 1189-1192 ; Kongress: Eurosensors 22 (Dresden : 2008.09.07-10) ; [Beitrag auf CD-ROM]
Micro fluidic biosensor array for parallelized cell adhesion analysis during pathogenic infection
In: IEEE sensors 2008: the 7th IEEE Conference on Sensors ; Lecce, Italy, October 26-29, 2008/ Conference on Sensors, 2008 . - 2008, S. 1460-1463 ; Kongress: IEEE Conference on Sensors 7 (Lecce, Italy : 2008.10.26-29) ; [Beitrag auf CD-ROM]
Online adhesion analysis of hepatocyte growth factor stimulated cells with resonant biosensor
In: Proceedings: Dresden, Germany, 7 - 10 September 2008 - Düsseldorf: VDI/VDE-Ges. Mess- und Automatisierungstechnik, 2008 . - 2008, S. 1185-1188 ; Kongress: Eurosensors 22 (Dresden : 2008.09.07-10) ; [Beitrag auf CD-ROM]
Real-time analysis of hepatocyte growth factor induced cell motility with quartz crystal resonators
In: IEEE sensors 2008: the 7th IEEE Conference on Sensors ; Lecce, Italy, October 26-29, 2008/ Conference on Sensors, 2008 . - 2008, S. 246-249 ; Kongress: IEEE Conference on Sensors 7 (Lecce, Italy : 2008.10.26-29) ; [Beitrag auf CD-ROM]
2007
Buchbeitrag
Expression of ADAM19 in Helicobacter pylori-mediated diseases and gastric cancer
In: Gastric cancer research trends - New York: Nova Science, 2007 . - 2007, S. 171-188
Originalartikel in begutachteter internationaler Zeitschrift
Beyond I[kappa]Bs: alternative regulation of NF-[kappa]B activity
In: Federation of American Societies for Experimental Biology : The FASEB journal . - Bethesda, Md. : FASEB, Bd. 21.2007, 11, S. 2642-2654
CSN controls NF-[kappa]B by deubiquitinylation of I[kappa]B[alpha]
In: European Molecular Biology Organization : The EMBO journal . - London : Nature Publ. Group, Bd. 26.2007, 6, S. 1532-1541
Cholera toxin promotes the generation of semi-mature porcine monocyte-derived dendritic cells that are unable to stimulate T cells
In: Veterinary research . - Paris : Ed.Scientifiques Elsevier, Bd. 38.2007, 4, S. 597-612
Control of the NF-[kappa]B inhibitor I[kappa]B[alpha] in pathogen infection
In: Biochemical Society : Biochemical Society transactions . - London : Portland Pr., Bd. 35.2007, 2, S. 267-269
Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-[beta]1 and ameliorates acute colitis in mice
In: International journal of molecular medicine: an international journal devoted to molecular mechanisms of human disease - Athens: Spandidos Publications, 1998, Bd. 20.2007, 4, S. 483-492
Soluble galectin-3 is a strong, colonic epithelial-cell-derived, lamina propria fibroblast-stimulating factor
In: Gut . - London : BMJ Publishing Group, Bd. 56.2007, 1, S. 43-51
Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells
In: European Molecular Biology Organization : The EMBO journal . - London : Nature Publ. Group, Bd. 26.2007, 4, S. 1140-1149
The Fusarium toxin deoxynivalenol disrupts phenotype and function of monocyte-derived dendritic cells in vivo and in vitro
In: Immunobiology . - Amsterdam : Elsevier, Bd. 212.2007, 8, S. 655-666
Originalartikel in begutachteter zeitschriftenartiger Reihe
Micro fluidic biosensor system based on quartz crystal resonators for fast online adherent cell proliferation and stimulation analysis
In: IEEE sensors 2007 conference: the 6th IEEE Conference on Sensors ; Atlanta, USA, 28 - 31 October 2007, 2007 . - 2007, S. 720-723
2006
Originalartikel in begutachteter internationaler Zeitschrift
Epithelial cell signaling in Helicobacter pylori infection
In: Current signal transduction therapy . - San Francisco, Calif. [u.a.] : Bentham Science Publ., Bd. 1.2006, 1, S. 53-65
Helicobacter pylori encoding the pathogenicity island activates matrix-metalloproteinase 1 in gastric epithelial cells via JNK and ERK
In: The journal of biological chemistry: JBC - Bethesda, Md.: ASBMB, 1905, Bd. 281.2006, 5, S. 2868-2875
The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NF-[kappa]B activation
In: Biological chemistry - Berlin [u.a.]: de Gruyter, 1996, Bd. 387.2006, 1, S. 79-86
2005
Buchbeitrag
Helicobacter pylori mechanisms for inducing epithelial cell proliferation.
In: Lax, A. (Ed.): Bacterial protein toxins : role in the interference with cell growth regulation. Cambridge ; New York : Cambridge Univ. Press, 2005, S. 169 - 198 (Advances in molecular and cellular microbiology ; 7)
Originalartikel in begutachteter internationaler Zeitschrift
Consequences of COP9 signalosome and 26S proteasome interaction.
In: FEBS J. 272(2005), Nr. 15, S. 3909 - 3917
Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-alpha on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
In: J. Immunol. 174(2005), Nr. 10, S. 6524 - 6531
Helicobacter pylori eradication has the potential to prevent gastric cancer : a state-of-the- art critique.
In: Am. J. Gastroenterol. 100(2005), Nr. 9, S. 2100 - 2115
Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease.
In: J. Biol. Chem. 280(2005), Nr. 15, S. 14981 - 14988
Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells.
In: Int. J. Med. Microbiol. 295(2005), Nr. 5, S. 335 - 341
The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection.
In: Biol. Chem. 386(2005), Nr. 5, S. 481 - 490
Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
In: J. Pathol. 207(2005), Nr. 1, S. 32 - 42
2004
Originalartikel in begutachteter internationaler Zeitschrift
Analysis of the type IV secretion system-dependent cell motility of Helicobacter pylori- infected epithelial cells.
In: Biochem. Biophys. Res. Commun. 322(2004), Nr. 3, S. 860 - 866
Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells.
In: Biochem. Biophys. Res. Commun. 316(2004), Nr. 4, S. 1065 - 1072
Helicobacter pylori-induced epithelial cell signalling in gastric carcinogenesis.
In: Trends Microbiol. 12(2004), Nr. 1, S. 29 - 36
Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease.
In: Faseb J. 18(2004), S. 1550 - 1552
Prevention of gastric cancer by Helicobacter pylori eradication.
In: Dig. Dis. 22(2004), Nr. 4, S. 313 - 319
2003
Originalartikel in begutachteter internationaler Zeitschrift
Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.
In: Mol. Cell 11(2003), S. 927 - 938
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
In: J. Cell Biol. 161(2003), Nr. 2, S. 249 - 255
Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription : critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors.
In: Cell. Microbiol. 5(2003), Nr. 11, S. 821 - 834
Helicobacter pylori stimulates host vascular endothelial growth factor-A (vegf-A) gene expression via MEK/ERK-dependent activation of Sp1 and Sp3. . - Gedr. ersch. in: FASEB J. 18(2004)1, S. 218 - 220.
In: Faseb J.(2003)
The mitogen-activated protein kinase p38 : a new molecular target for anti-inflammatory therapy in Crohn's disease?.
In: Gastroenterol. Polska 10(2003), Nr. 4, S. 335 - 340
2002
Originalartikel in begutachteter internationaler Zeitschrift
Pathogenesis of Helicobacter pylori infection.
In: Helicobacter 7(2002), Suppl. 1, S. 17 - 23
- Zelluläre Infektionsbiologie Helicobacter pylori
- Magenkrebs Präventionsforschung
- Multiproteinkomplex (COP9)
- Zelluläre Infektionsbiologie Helicobacter pylori
- Magenkrebs Präventionsforschung
- Multiproteinkomplex (COP9)