Chemoenzymatic Synthesis of Enantiopure Amino Alcohols from Simple Methyl Ketones

Neuburger, Jan Eric; Gazizova, Alina; Tiedemann, Sven; von Langermann, Jan

In: European Journal of Organic Chemistry, Wiley, Bd. 26, Heft 34

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Crystallization-based downstream processing of ω-transaminase- and amine dehydrogenase-catalyzed reactions

Belov, Feodor; Mildner, Andrea; Knaus, Tanja; Mutti, Francesco G.; von Langermann, Jan

In: Reaction Chemistry & Engineering, Royal Society of Chemistry (RSC), Bd. 8, Heft 6, S. 1427-1439

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Chemoenzymatic Synthesis of Chiral Building Blocks Based on the Kinetic Resolution of Glycerol‐Derived Cyclic Carbonates

Terazzi, Constanza; Spannenberg, Anke; von Langermann, Jan; Werner, Thomas

In: ChemCatChem, Wiley, Bd. 15, Heft 19

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Rare Earth Element‐Based Recovery Concept for Cofactors Containing Phosphate Groups from Aqueous Solutions

Neuburger, Jan Eric; Tiedemann, Sven; Michalik, Dirk; von Langermann, Jan

In: Chemical Engineering & Technology, Wiley, Bd. 46, Heft 4, S. 766-775

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(R)-Baclofen [(R)-4-amino-3-(4-chlorophenyl)butanoic acid]

Belov, Feodor; Villinger, Alexander; von Langermann, Jan

In: Acta Crystallographica Section E Crystallographic Communications, International Union of Crystallography (IUCr), Bd. 78, Heft 1, S. 33-35, unter URL: https://dx.doi.org/10.1107/s2056989021012809, unter URL: 10.1107/s2056989021012809

Hydroxylation and dimerization of para-dihydroxylated aromatic compounds mediated by cold atmospheric-pressure plasma in comparison with chemically catalyzed reactions

Hahn, Veronika; Mikolasch, Annett; Schmidt, Michael; Neuburger, Jan Eric; von Langermann, Jan; Lalk, Michael; Weltmann, Klaus-Dieter; von Woedtke, Thomas; Kolb, Jürgen

In: Green Chemistry, Royal Society of Chemistry (RSC), Bd. 24, Heft 20, S. 7951-7967, unter URL: https://dx.doi.org/10.1039/d2gc01624a, unter URL: 10.1039/d2gc01624a

Synthesis of cyclic carbonates catalyzed by CaI2Et3N and studies on their biocatalytic kinetic resolution

Terazzi, Constanza; Laatz, Karoline; Langermann und Erlencamp, Jan; Werner, Thomas

In: ACS sustainable chemistry & engineering / American Chemical Society - Washington, DC : ACS Publ., Bd. 10 (2022), Heft 40, S. 13335-13342

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Chemoenzymatic Asymmetric Synthesis of PyridineBased Fluorinated Secondary Alcohols

Broese, Timo; Ehlers, Peter; Langer, Peter; von Langermann, Jan

In: ChemBioChem, Wiley, 2021, Bd. 22, Heft 23, S. 3314-3318

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Implementation and scale-up of a semi-continuous transaminase-catalyzed reactive crystallization for the preparation of (S)-(3-methoxyphenyl)ethylamine

Neuburger, Jan; Helmholz, Falko; Tiedemann, Sven; Lehmann, Paul; Süss, Philipp; Menyes, Ulf; von Langermann, Jan

In: Chemical Engineering and Processing - Process Intensification, Elsevier BV, Bd. 168, S. 108578, unter URL: https://dx.doi.org/10.1016/j.cep.2021.108578, unter URL: 10.1016/j.cep.2021.108578

Kompartimentierung bei den Enzymkaskaden: statisch oder Durchfluss

Kara, Selin; von Langermann, Jan

In: BIOspektrum, Springer Science and Business Media LLC, Bd. 26, Heft 2, S. 215-217, unter URL: https://dx.doi.org/10.1007/s12268-020-1348-8, unter URL: 10.1007/s12268-020-1348-8

Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (S)-1-(3-Methoxyphenyl)ethylamine

Hülsewede, Dennis; Temmel, Erik; Kumm, Peter; von Langermann, Jan

In: Crystals, MDPI AG, Bd. 10, Heft 5, S. 345, unter URL: https://dx.doi.org/10.3390/cryst10050345, unter URL: 10.3390/cryst10050345

Integration of ion exchange resin materials for a downstreamprocessing approach of an imine reductasecatalyzed reaction

Meyer, LarsErik; Brundiek, Henrike; von Langermann, Jan

In: Biotechnology Progress, Wiley, 2020, Bd. 36, Heft 5

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Application of in situ-product crystallization in the amine transaminase from Silocibacter pomeroyi-catalyzed synthesis of (S)-1-(3-methoxyphenyl) ethylamine

Hülsewede, D.; Neuburger, J.E.; von Langermann, Jan

In: in: J. Whittal & Peter W. Sutton (Editors) Applied Biocatalysis: The Chemist's Enzyme Toolbox (2020), John Wiley & Sons, Hoboken, New Jersey, USA

Application of In Situ Product Crystallization and Related Techniques in Biocatalytic Processes

Hülsewede, Dennis; Meyer, LarsErik; von Langermann, Jan

In: unter URL: https://dx.doi.org/10.1002/chem.201804970, unter URL: 10.1002/chem.201804970

Donor Amine SaltBased Continuous in situ Product Crystallization in Amine TransaminaseCatalyzed Reactions

Hülsewede, Dennis; Dohm, JanNiklas; von Langermann, Jan

In: unter URL: https://dx.doi.org/10.1002/adsc.201900217, unter URL: 10.1002/adsc.201900217

Characterization and application of chemical-resistant polyurethane-based enzyme and whole cell compartments

Uhrich, Diana; Jang, Hyun-Young; Park, Jin-Byung; von Langermann, Jan

In: Journal of Biotechnology, Elsevier BV, Bd. 289, S. 31-38, unter URL: https://dx.doi.org/10.1016/j.jbiotec.2018.11.007, unter URL: 10.1016/j.jbiotec.2018.11.007

Development of Ionic LiquidWaterBased Thermomorphic Solvent (TMS)Systems for Biocatalytic Reactions

Meyer, LarsErik; Gummesson, Anja; Kragl, Udo; von Langermann, Jan

In: Biotechnology Journal, Wiley, 2019, Bd. 14, Heft 10, S. 1900215

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Adsorbent-Based Downstream-Processing of the Decarboxylase-Based Synthesis of 2,6-Dihydroxy-4-methylbenzoic Acid

Meyer, Lars-Erik; Plasch, Katharina; Kragl, Udo; von Langermann, Jan

In: Organic Process Research & Development, American Chemical Society (ACS), Bd. 22, Heft 8, S. 963-970, unter URL: https://dx.doi.org/10.1021/acs.oprd.8b00104, unter URL: 10.1021/acs.oprd.8b00104

Development of an in situ-Product Crystallization (ISPC)-Concept to Shift the Reaction Equilibria of Selected Amine Transaminase-Catalyzed Reactions - Development of an in situ-Product Crystallization (ISPC)-Concept to Shift the Reaction Equilibria of Selected Amine Transaminase-Catalyzed Reactions

Hülsewede, Dennis; Tänzler, Marco; Süss, Philipp; Mildner, Andrea; Menyes, Ulf; von Langermann, Jan

In: European Journal of Organic Chemistry, Wiley, Bd. 2018, Heft 18, S. 2130-2133, unter URL: https://dx.doi.org/10.1002/ejoc.201800323, unter URL: 10.1002/ejoc.201800323

Scoping the Enantioselective Desymmetrization of a Poorly Water-Soluble Diester by Recombinant Pig Liver Esterase

Meissner, Murray P.; Süss, Philipp; Brundiek, Henrike; Woodley, John M.; von Langermann, Jan

In: Organic Process Research & Development, American Chemical Society (ACS), Bd. 22, Heft 11, S. 1518-1523, unter URL: https://dx.doi.org/10.1021/acs.oprd.8b00277, unter URL: 10.1021/acs.oprd.8b00277

Recent developments in biocatalysis in multiphasic ionic liquid reaction systems

Meyer, Lars-Erik; von Langermann, Jan; Kragl, Udo

In: Biophysical Reviews, Springer Science and Business Media LLC, Bd. 10, Heft 3, S. 901-910, unter URL: https://dx.doi.org/10.1007/s12551-018-0423-6, unter URL: 10.1007/s12551-018-0423-6

Prinzipien der angewandten Biokatalyse

Kara, S.; von Langermann, Jan

In: in: Liese, A.; Jaeger, K.-E.; Syldatk, C. (Eds.) Einführung in die Enzymtechnologie (2018), chapter 13, Springer-Verlag GmbH, Berlin

Preparation and Characterization of Enzyme Compartments in UV-Cured Polyurethane-Based Materials and Their Application in Enzymatic Reactions

Uhrich, Diana; von Langermann, Jan

In: Frontiers in Microbiology, Frontiers Media SA, Bd. 8, unter URL: https://dx.doi.org/10.3389/fmicb.2017.02111, unter URL: 10.3389/fmicb.2017.02111

Recombinant Pig Liver Esterase-Catalyzed Synthesis of (1S,4R)-4-Hydroxy-2-cyclopentenyl Acetate Combined with Subsequent Enantioselective Crystallization

Hinze, Janine; Süss, Philipp; Strohmaier, Silja; Bornscheuer, Uwe T.; Wardenga, Rainer; von Langermann, Jan

In: Organic Process Research & Development, American Chemical Society (ACS), Bd. 20, Heft 7, S. 1258-1264, unter URL: https://dx.doi.org/10.1021/acs.oprd.6b00093, unter URL: 10.1021/acs.oprd.6b00093

Enantioselective synthesis of cyanohydrins catalysed by hydroxynitrile lyases a review

Bracco, Paula; Busch, Hanna; von Langermann, Jan; Hanefeld, Ulf

In: Organic & Biomolecular Chemistry, Royal Society of Chemistry (RSC), Bd. 14, Heft 27, S. 6375-6389, unter URL: https://dx.doi.org/10.1039/c6ob00934d, unter URL: 10.1039/c6ob00934d

Chemoenzymatic Sequential Multistep One-Pot Reaction for the Synthesis of (1S,2R)-1-(Methoxycarbonyl)cyclohex-4-ene-2-carboxylic Acid with Recombinant Pig Liver Esterase

Süss, Philipp; Borchert, Sonja; Hinze, Janine; Illner, Sabine; von Langermann, Jan; Kragl, Udo; Bornscheuer, Uwe T.; Wardenga, Rainer

In: Organic Process Research & Development, American Chemical Society (ACS), Bd. 19, Heft 12, S. 2034-2038, unter URL: https://dx.doi.org/10.1021/acs.oprd.5b00294, unter URL: 10.1021/acs.oprd.5b00294

Solid phase behavior in the chiral systems of various 2-hydroxy-2-phenylacetic acid (mandelic acid) derivatives

Langermann und Erlencamp, Jan; Temmel, Erik; Seidel-Morgenstern, Andreas; Lorenz, Heike

In: Journal of chemical & engineering data - Columbus, Ohio : American Chemical Society, Bd. 60 (2015), Heft 3, S. 721-728

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Occurrence and consequences of differences in the cation/anion ratios during classical resolution - D-/L-serine benzyl ester 2,3-toluyl-D-tartrate

Sistla, Venkata Subbarayudu; Langermann und Erlencamp, Jan; Lorenz, Heike; Seidel-Morgenstern, Andreas

In: Crystal research and technology - Weinheim : Wiley-VCH, Bd. 49 (2014), Heft 7, S. 514-520

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Hydroxynitrile Lyase-Catalyzed Synthesis of Enantiopure Cyanohydrins in Biocatalytic Active Static Emulsions (BASE) with Suppression of the Non-Enzymatic Side Reaction

von Langermann, Jan; Wapenhensch, Stefanie

In: unter URL: https://dx.doi.org/10.1002/adsc.201301149, unter URL: 10.1002/adsc.201301149

Microwaveassisted covalent immobilization of enzymes on inorganic surfaces

Plagemann, Regina; von Langermann, Jan; Kragl, Udo

In: Engineering in Life Sciences, Wiley, 2014, Bd. 14, Heft 5, S. 493-499

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Increasing the Reaction Rate of Hydroxynitrile Lyase fromHevea brasiliensistoward Mandelonitrile by Copying Active Site Residues from an Esterase that Accepts Aromatic Esters

von Langermann, Jan; Nedrud, David M.; Kazlauskas, Romas J.

In: ChemBioChem, Wiley, Bd. 15, Heft 13, S. 1931-1938, unter URL: https://dx.doi.org/10.1002/cbic.201402081, unter URL: 10.1002/cbic.201402081

Das schwer fassbare Cyanformiat: ein ungewöhnlicher Cyanidtransporter

Hering, Christian; von Langermann, Jan; Schulz, Axel

In: Angewandte Chemie, Wiley, 2014, Bd. 126, Heft 32, S. 8422-8424

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Scale-Up of a Recombinant Pig Liver Esterase-Catalyzed Desymmetrization of Dimethyl Cyclohex-4-ene-cis-1,2-dicarboxylate

Süss, Philipp; Illner, Sabine; von Langermann, Jan; Borchert, Sonja; Bornscheuer, Uwe T.; Wardenga, Rainer; Kragl, Udo

In: Organic Process Research & Development, American Chemical Society (ACS), Bd. 18, Heft 7, S. 897-903, unter URL: https://dx.doi.org/10.1021/op500129e, unter URL: 10.1021/op500129e

Synthesis of Aliphatic and -Halogenated Ketone Cyanohydrins with the Hydroxynitrile Lyase from Manihot esculenta

Diebler, Johannes; von Langermann, Jan; Mell, Annett; Hein, Martin; Langer, Peter; Kragl, Udo

In: ChemCatChem, Wiley, 2014, Bd. 6, Heft 4, S. 987-991

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Design of an integrated process of chromatography, crystallization and racemization for the resolution of 2',6'-pipecoloxylidide (PPX)

Langermann und Erlencamp, Jan; Kaspereit, Malte; Shakeri, Mozaffar; Lorenz, Heike; Hedberg, Martin; Jones, Matthew Jonathan; Larson, Kerstin; Herschend, Björn; Arnell, Robert; Temmel, Erik; Bäckvall, Jan-E.; Kienle, Achim; Seidel-Morgenstern, Andreas

In: Organic process research & development - Washington, DC : American Chemical Society, Bd. 16 (2012), Heft 2, S. 343-352

Chiral task-specific solvents for mandelic acid and their impact on solution thermodynamics and crystallization kinetics

Tulashie, Samuel K.; Langermann und Erlencamp, Jan; Lorenz, Heike; Seidel-Morgenstern, Andreas

In: Crystal growth & design - Washington, DC : American Chemical Society, Bd. 11 (2011), Heft 1, S. 240-246

The phase behavior and crystallization of 2-chloromandelic acid - the crystal structure of the pure enantiomer and the behavior of its metastable conglomerate

Lorenz, Heike; Langermann und Erlencamp, Jan; Sadiq, Ghazala; Seaton, Colin C.; Davey, Roger J.; Seidel-Morgenstern, Andreas

In: Crystal growth & design - Washington, DC : American Chemical Society, Bd. 11 (2011), Heft 5, S. 1549-1556

Analysis and comparison of commonly used acidic resolving agents in diastereomeric salt resolution - examples for dl-serine

Sistla, Venkata Subbarayudu; Langermann und Erlencamp, Jan; Lorenz, Heike; Seidel-Morgenstern, Andreas

In: Crystal growth & design - Washington, DC : American Chemical Society, Bd. 11 (2011), Heft 9, S. 3761-3768

Carbon dioxide and formic acidthe couple for environmental-friendly hydrogen storage?

Enthaler, Stephan; von Langermann, Jan; Schmidt, Thomas

In: Energy & Environmental Science, Royal Society of Chemistry (RSC), Bd. 3, Heft 9, S. 1207, unter URL: https://dx.doi.org/10.1039/b907569k, unter URL: 10.1039/b907569k

Kombination von Biokatalyse und Kristallisation zur Darstellung enantiomerenreiner Mandelsäurederivate

Seidel-Morgenstern, A.; von Langermann, J.; Tam, L.M.; Lorenz, H.

In: Chemie Ingenieur Technik, Wiley, Bd. 82, Heft 1-2, S. 93-100, unter URL: https://dx.doi.org/10.1002/cite.200900157, unter URL: 10.1002/cite.200900157

Kombination von Biokatalyse und Kristallisation zur Darstellung enantiomerenreiner Mandelsäurederivate

Langermann und Erlencamp, Jan; Tam, Le Minh; Lorenz, Heike; Seidel-Morgenstern, Andreas

In: Chemie - Ingenieur - Technik - Weinheim : Wiley-VCH Verl., Bd. 82 (2010), Heft 1/2, S. 93-100

Application of classical resolution for separation of DL-serine

Sistla, Venkata Subbarayudu; Langermann und Erlencamp, Jan; Lorenz, Heike; Seidel-Morgenstern, Andreas

In: Chemical engineering & technology - Weinheim : Wiley-VCH, Bd. 33 (2010), Heft 5, S. 780-786

Enantiomeric 3-chloromandelic acid system - binary melting point phase diagram, ternary solubility phase diagrams and polymorphism

Minh, Tam Le; von Langermann, Jan; Lorenz, Heike; Seidel-Morgenstern, Andreas

In: Journal of pharmaceutical sciences - New York, NY : Wiley, Bd. 99 (2010), Heft 9, S. 4084-4095

(3R *,5'S *)-6,7-Dimethoxy-3-(4'-methoxy-6'- methyl-5',6',7',8'-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5'-yl)isobenzofuran-1(3H)-one (racemic α-noscapine)

Langermann, Jan; Lorenz, Heike; Boehm, Oliver; Flemming, Anke; Bernsdorf, Arne; Köckerling, Martin; Schinzer, Dieter; Seidel-Morgenstern, Andreas

In: Acta crystallographica / E - Chester : International Union of Crystallography - Bd. 66.2010, 3, S. o570, insges. 11 S.

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Using isothermal and polythermal methods to investigate ternary diagrams of 3-Chloromandelic acid system in water and toluene

Le Minh, T.; von Langermann, Jan; Lorenz, Heike; Seidel-Morgenstern, Andreas

In: Journal of Science and Technology, 47, 56-62 (2009)

Uneven twins: Comparison of two enantiocomplementary hydroxynitrile lyases with /-hydrolase fold

Guterl, Jan-Karl; Andexer, Jennifer N.; Sehl, Torsten; von Langermann, Jan; Frindi-Wosch, Ilona; Rosenkranz, Tobias; Fitter, Jörg; Gruber, Karl; Kragl, Udo; Eggert, Thorsten; Pohl, Martina

In: Journal of Biotechnology, Elsevier BV, Bd. 141, Heft 3-4, S. 166-173, unter URL: https://dx.doi.org/10.1016/j.jbiotec.2009.03.010, unter URL: 10.1016/j.jbiotec.2009.03.010

How to overcome limitations in biotechnological processes - examples from hydroxynitrile lyase applications

Andexer, J.N.; von Langermann, Jan; Kragl, U.; Pohl, M.

In: Trends in Biotechnology, Elsevier BV, 2009, Bd. 27, Heft 10, S. 599-607

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Hydroxynitrile lyase catlysed synthesis of enantiopure (S)-acetophenone cyanohydrins

von Langermann, Jan; Mell, A.; Paetzold, E.; Kragl, U.

In: in: J. Whittal & Peter W. Sutton (Editors) Practical Methods in Biocatalysis and Biotransformations (2009), John Wiley & Sons Ltd, Chichester, 262-265

Hydroxynitrile lyase catalyzed cyanohydrin synthesis at high pH-values

von Langermann, Jan; Guterl, Jan-Karl; Pohl, Martina; Wajant, Harald; Kragl, Udo

In: Bioprocess and Biosystems Engineering, Springer Science and Business Media LLC, Bd. 31, Heft 3, S. 155-161, unter URL: https://dx.doi.org/10.1007/s00449-008-0198-4, unter URL: 10.1007/s00449-008-0198-4

Hydroxynitrile Lyase in Organic Solvent-Free Systems to Overcome Thermodynamic Limitations

von Langermann, Jan; Mell, Annett; Paetzold, Eckhard; Daußmann, Thomas; Kragl, Udo

In: Advanced Synthesis & Catalysis, Wiley, Bd. 349, Heft 8-9, S. 1418-1424, unter URL: https://dx.doi.org/10.1002/adsc.200700016, unter URL: 10.1002/adsc.200700016