Prof. Bommhardt

apl. Prof. Dr. rer. nat. habil. Ursula Bommhardt
Institut für Molekulare und Klinische Immunologie (IMKI)
Fax: +49 391 67 15852
apl. Prof. Dr. rer. nat. habil. Ursula Bommhardt

Institut für Molekulare und Klinische Immunologie (IMKI)
Fax: +49 391 67 15852
Abgeschlossene Projekte
- Die Funktion von NMDA-Rezeptoren bei der Reifung und Aktivierung von T-Zellen
Laufzeit: 01.01.2010 - 31.12.2013 - Die Funktion von PKB/Akt bei der Anergieinduktion und der Immunantwort in infektiösen und autoimmunen Erkrankungen
Laufzeit: 01.07.2005 - 30.06.2009 - Biochemische und molekularbiologische Untersuchungen zur Funktion von PKB bei der T-Zellreifung und T-Zellaktivierung
Laufzeit: 01.03.2006 - 28.02.2009 - Die Funktion von PKB/Akt bei der T-Zellreifung und T-Zellaktivierung DFG-FOR 521
Laufzeit: 01.12.2007 - 30.11.2008 - Proteinkinase B (PKB)/Akt: ein Schlüsselprotein für die Funktion und Transformation von T-Lymphozyten
Laufzeit: 01.10.2004 - 01.10.2006
2017
Abstrakt
Insights into the mechanism of action of insulin-like growth factor-1 and insulin in human T cells in vitro
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 26.2017, 3, P081 (OP06/06), S. E35; http://onlinelibrary.wiley.com/doi/10.1111/exd.13280/full
Insights into the mechanism of action of isotretinoin in human sebocytes in vitro
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 26.2017, 3, P082, S. E35-E36; http://onlinelibrary.wiley.com/doi/10.1111/exd.13280/full
Begutachteter Zeitschriftenartikel
Effects of isotretinoin on the phosphoinositide-3-kinase/Akt/FoxO1 pathway and molecular functions of SZ95 sebocytes in vitro
In: Journal of clinical & experimental dermatology research - Los Angeles, CA: Omics international, Bd. 8.2017, 3, Art.-Nr. 1000399, insges. 12 S.; http://dx.doi.org/10.4172/2155-9554.1000399
Insulin and insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro
In: Dermato-endocrinology - Austin, Tex: Landes Bioscience, Bd. 9.2017, Art.-Nr. e1356518, insges. 13 S.; http://dx.doi.org/10.1080/19381980.2017.1356518
2016
Begutachteter Zeitschriftenartikel
Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness
In: OncoTarget : open access impact journal. - [S.l.] : Impact Journals LLC, Bd. 7.2016, 33, S. 53797-53807
2015
Abstrakt
Effects of isotretinoin on FoxO1 transcriptional regulation and molecular functions of SZ95 sebocytes
In: Experimental dermatology : the official journal of the European Immunodermatology Society. - Oxford : Wiley-Blackwell; Bd. 24.2015, 3, P068, S. E12
Begutachteter Zeitschriftenartikel
Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro
In: Molecular and cellular endocrinology. - Amsterdam [u.a.] : Elsevier Science, Bd. 415.2015, S. 32-44
Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage
In: European journal of immunology. - Weinheim : Wiley-VCH, Bd. 45.2015, 5, S. 1326-1338
VGF expression by T lymphocytes in patients with Alzheimer's disease
In: OncoTarget : open access impact journal. - [S.l.] : Impact Journals LLC, Bd. 6.2015, 17, S. 14843-14851
2014
Abstrakt
Critical role of thymocyte-derived brain-derived neurotrophic factor in T cell maturation
In: Journal of neuroimmunology : official journal of the International Society for Neuroimmunology. - Amsterdam [u.a.] : Elsevier Science, Bd. 275.2014, 1/2, S. 202-203
Begutachteter Zeitschriftenartikel
Age-related increase of VGF-expression in T lymphocytes
In: Aging. - [S.l.] : Impact Journals, LLC, Bd. 6.2014, 6, S. 440-453
Immunosuppression by N-Methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells
In: Molecular and cellular biology. - Washington, DC : Soc, Bd. 34.2014, 5, S. 820-831
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells
In: Cell communication and signaling. - London : Biomed Central; Bd. 12.2014, Art.-Nr. 75, insges. 13 S.
Dissertation
Crosstalk between NMDAR antagonists and potassium channels in murine and human lymphocytes
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014; 92 Bl.: graph. Darst.; 30 cm
2013
Abstrakt
Interleukin-7-mediated NFAT activation sets the threshold for T cell development
In: Cytokine. - London : Academic Press; Bd. 63.2013, 3, Abs. 196, S. 289
Begutachteter Zeitschriftenartikel
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development
In: Nature immunology - New York, NY: SpringerNature, Bd. 14.2013, 2, S. 127-135; http://dx.doi.org/10.1038/ni.2507
2012
Dissertation
Proteinkinase B- und TGFβ1-Signalwege - Untersuchungen zu ihrer Interaktion bei der Th-Zelldifferenzierung
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2012; 143 Bl.: graph. Darst.
Originalartikel in begutachteter internationaler Zeitschrift
Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function
In: European journal of immunology. - Weinheim : Wiley VCH, Bd. 42.2012, 12, S. 3381-3393
2011
Dissertation
Einfluss von Proteinkinase B (PKB/Akt) auf Differenzierungsprozesse von T-Helferzellen und den Verlauf der Experimentellen Autoimmunen Enzephalomyelitis (EAE)
In: Magdeburg Univ., Fak. für Naturwiss., Diss., 2011, III, 104 Bl., graph. Darst., 30 cm
Originalartikel in begutachteter internationaler Zeitschrift
NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network
In: The journal of experimental medicine. - New York, NY : Rockefeller Univ. PressThe journal of experimental medicine <New York, NY>, Bd. 208.2011, 4, S. 823-839
2010
Dissertation
Cross-talk of protein kinase B (PKB/Akt) with the transcription factor NFAT and the Src kinase Fyn in T lymphocytes
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2010; III, 116 Bl.: graph. Darst.; 30 cm
Originalartikel in begutachteter internationaler Zeitschrift
Hedgehog signalling in T-cell development: A non-redundant role for Gli1
In: Cell cycle . - Georgetown, Tex. : Landes Bioscience, Bd. 9.2010, 22, S. 4428
Hedgehog signalling in T-cell development: A non-redundant role for Gli1.
In: Cell Cycle. 2010 Nov 15;9(22):4433-4432.
2009
Originalartikel in begutachteter internationaler Zeitschrift
Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNF[alpha]-induced apoptosis in colorectal tumor cells
In: The American journal of pathology . - Bethesda, Md. : American Society for Investigative Pathology, Bd. 175.2009, 2, S. 557-570
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 10, S. 6124-6134
2008
Originalartikel in begutachteter internationaler Zeitschrift
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 181.2008, 12, S. 8267-8277
2007
Originalartikel in begutachteter internationaler Zeitschrift
A logical model provides insights into T cell receptor signaling
In: Public Library of Science : PLoS Computational Biology . - San Francisco, Calif. : Public Library of Science, Bd. 3.2007, 8, insges. 11 S.; Abstract unter URL: http://dx.doi.org/10.1371/journal.pcbi.0030163
Glis: novel modulators of TCR signaling?
In: Blood: the journal of hematology - Washington, DC: American Society of Hematology, Bd. 109.2007, 9, S. 3618-3619; http://bloodjournal.hematologylibrary.org/content/vol109/issue9/
[Gamma]c cytokines provide multiple homeostatic signals to naive CD4+ T cells
In: European journal of immunology - Weinheim: Wiley VCH, Bd. 37.2007, 9, S. 2606-2616; http://www3.interscience.wiley.com/cgi-bin/abstract/114801695/ABSTRACT
2006
Originalartikel in begutachteter internationaler Zeitschrift
PKB rescues Calcineurin/NFAT-induced arrest of Rag expression and Pre-T cell differentiation
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md: American Association of Immunologists, Bd. 177.2006, 7, S. 4567-4576; http://www.jimmunol.org/cgi/content/abstract/177/7/4567
- Dr. Michael Kreutz, IfN
- Prof. E. Serfling, Würzburg
- T-Zellreifung
- T-Zellaktivierung- und differenzierung: Th17, Treg...
- Signaltransduktion in T-Zellen, ins. PKB/Akt-Signalgebung
- Autoimmunität und Tumorgenese