Publikationen
2024
Begutachteter Zeitschriftenartikel
Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry
Bhuria, Vikas; Franz, Tobias; Baldauf, Conny; Böttcher, Martin; Chatain, Nicolas; Koschmieder, Steffen; Brümmendorf, Tim Henrik; Mougiakakos, Dimitrios; Schraven, Burkhart; Kahlfuß, Sascha; Fischer, Thomas
In: Cell communication and signaling - London : Biomed Central, Bd. 22 (2024), Artikel 186, insges. 22 S.
Leucine-rich glioma-inactivated 1 (LGI1) protein stimulates proliferation and IL-10 production in peripheral blood mononuclear cells of patients with LGI1 antibody-mediated autoimmune encephalitis in vitro
Goihl, Alexander; Reinhold, Dirk; Reinhold, Annegret; Schraven, Burkhart; Körtvélyessy, Péter
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 25 (2024), Heft 5, Artikel 2581, insges. 8 S.
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia
Haage, Tobias Ronny; Charakopoulos, Emmanouil; Bhuria, Vikas; Baldauf, Conny K.; Korthals, Mark; Handschuh, Juliane; Müller, Peter; Li, Juan; Harit, Kunjan; Nishanth, Gopala; Frey, Stephanie; Böttcher, Martin; Fischer, Klaus-Dieter; Dudeck, Jan; Dudeck, Anne; Lipka, Daniel; Schraven, Burkhart; Green, Tony; Müller, Andreas Johann; Mougiakakos, Dimitrios; Fischer, Thomas
In: Journal of hematology & oncology - London : Biomed Central, Bd. 17 (2024), S. 1-23, Artikel 43, insges. 23 S. [Gesehen am 18.11.2024]
Combined immunodeficiency caused by a novel nonsense mutation in LCK
Keller, Bärbel; Kfir-Erenfeld, Shlomit; Matusewicz, Paul; Hartl, Frederike; Lev, Atar; Lee, Yu Nee; Simon, Amos J.; Stauber, Tali; Elpeleg, Orly; Somech, Raz; Stepensky, Polina; Minguet, Susana; Schraven, Burkhart; Warnatz, Klaus
In: Journal of clinical immunology - Dordrecht [u.a.] : Springer Science + Business Media B.V, Bd. 44 (2024), Artikel 4, insges. 17 S.
2023
Abstract
Proteomic profiling and cytokine analysis reveals molecular signatures and inflammatory factors associated with thrombosis in JAK2-V617F positive myeloproliferative neoplasm (MPN) cohorts
Bhuria, Vikas; Ham, Marco Adrianus; Vogel, Katrin; Waldleben, Ana; Zeremski, Vanja; Böttcher, Martin; Brunner-Weinzierl, Monika; Mougiakakos, Dimitrios; Schraven, Burkhart; Jänsch, Lothar; Fischer, Thomas
In: Blood - Washington, DC : American Society of Hematology, Bd. 142 (2023), Heft Supplement 1, Artikel 6340, insges. 2 S.
Dependence of pathogenic T helper cells on lipid receptors during house dust mite allergic airway inflammation
Krone, Anna; Schreiber, Simon; Negele, Jonas; Franz, Tobias; Kotrba, Johanna; Marks, Anna; Roder, Marc; Sammt, Anja; Jantz-Naeem, Nouria; Garbers, Christoph; Geffers, Robert; Schraven, Burkhart; Müller, Andreas Johann; Dudeck, Anne; Kahlfuß, Sascha
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 53 (2023), Heft Suppl. 2, S. 377, Artikel P 391
The CALRdel52 mutation reduces adhesion of granulocytes to E-selectin - implications for thromboembolic risk
Charakopoulos, Emmanouil; Haage, Tobias Ronny; Bhuria, Vikas; Böttcher, Martin; Schraven, Burkhart; Mougiakakos, Dimitrios; Fischer, Thomas
In: Oncology research and treatment - Basel : Karger, Bd. 46 (2023), Heft suppl 5, S. 107-108, Artikel V668
JAK2-V617F promotes up-regulation of pro-inflammatory cytokines including IL-1 upon adhesion-induced activation of β1/β2 Integrins
Baldauf, Conny K.; Charakopoulos, Emmanouil; Böttcher, Martin; Zeremski, Vanja; Mougiakakos, Dimitrios; Schraven, Burkhart; Fischer, Thomas
In: Blood - Washington, DC : American Society of Hematology, Bd. 142 (2023), Heft Supplement 1, Artikel 2749, insges. 3 S.
Begutachteter Zeitschriftenartikel
Antibody properties associate with clinical phenotype in LGI1 encephalitis
Ludewig, Susann; Salzburger, Leonie; Goihl, Alexander; Rohne, Jana; Leypoldt, Frank; Bittner, Daniel Markus; Düzel, Emrah; Schraven, Burkhart; Reinhold, Dirk; Korte, Martin; Körtvélyessy, Péter
In: Cells - Basel : MDPI, Bd. 12 (2023), Heft 2, Artikel 282, insges. 15 S.
Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults
Raschick, Matthias; Richter, Anni; Fischer, Larissa; Knopf, Lea; Schult, Annika; Yakupov, Renat; Behnisch, Gusalija; Guttek, Karina; Düzel, Emrah; Dunay, Ildikò Rita; Seidenbecher, Constanze; Schraven, Burkhart; Reinhold, Dirk; Schott, Björn H.
In: Journal of neural transmission - Wien [u.a.] : Springer, Bd. 130 (2023), Heft 8, S. 989-1002
Patterns of allergic sensitization in adults with severe asthma - the ATLAS non-interventional study
Lücke, Eva Kristin; Schraven, Burkhart; Borucki, Katrin; Lux, Anke; Reinhold, Dirk; Wu, Qingyu; Schreiber, Jens
In: Journal of asthma - Philadelphia, Pa. : Taylor & Francis, Bd. 60 (2023), Heft 11, S. 2021-2029
Zinc aspartate induces proliferation of resting and antigen-stimulated human PBMC under high-density cell culture condition
Guttek, Karina; Reinhold, Annegret; Grüngreiff, Kurt; Schraven, Burkhart; Reinhold, Dirk
In: Journal of trace elements in medicine and biology - München : Elsevier, Bd. 77 (2023), Artikel 127152
Allgemeine Kenntnisse zu häufig angewandten Testverfahren in der rheumatologisch-immunologischen Diagnostik und Forschung - General knowledge of frequently applied test procedures in rheumatological and immunological diagnostics and research
Reinhold, Dirk; Reinhold, Annegret; Schraven, Burkhart; Feist, Eugen
In: Zeitschrift für Rheumatologie - Darmstadt : Steinkopff, Bd. 82 (2023), Heft 4, S. 278-284
Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate
Baars, Iris; Jaedtka, Moritz; Dewitz, Leon-Alexander; Fu, Yan; Franz, Tobias; Mohr, Juliane; Gintschel, Patricia; Berlin, Hannes; Degen, Angelina; Freier, Sandra; Rygol, Stefan; Schraven, Burkhart; Kahlfuß, Sascha; Zandbergen, Ger; Müller, Andreas Johann
In: JCI insight - Ann Arbor, Michigan : JCI Insight, Bd. 8 (2023), Heft 14, Artikel e169020, insges. 20 S.
TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment
Jantz-Naeem, Nouria; Böttcher-Loschinski, Romy; Borucki, Katrin; Mitchell-Flack, Marisa; Böttcher, Martin; Schraven, Burkhart; Mougiakakos, Dimitrios; Kahlfuß, Sascha
In: Frontiers in oncology - Lausanne : Frontiers Media, Bd. 13 (2023), Artikel 1060112, insges. 11 S.
How ITD insertion sites orchestrate the biology and disease of FLT3-ITD-mutated acute myeloid leukemia
Haage, Tobias Ronny; Schraven, Burkhart; Mougiakakos, Dimitrios; Fischer, Thomas
In: Cancers - Basel : MDPI, Bd. 15 (2023), Heft 11, Artikel 2991, insges. 15 S.
2022
Abstract
IgE-mediated sensitization towards frequent and rare allergens in severe asthmatics - the ATLAS project
Schreiber, Jens; Thurm, Christoph; Reinhold, Dirk; Luecke, Eva; Schraven, Burkhart; Wu, Qingyu; Lux, Anke; Mailänder, Claudia
In: American journal of respiratory and critical care medicine - New York, NY : American Thoracic Society, Bd. 205 (2022), Artikel A5703, insges. 1 S.
Effector function of natural killer cells is suppressed in acute myeloid leukemia
Höchst, Bastian; Baumann, Tobias; Rothfuß, C.; Donakonda, Sainitin; Brauchle, Bettina; Marcinek, Anetta; Urban, Christian; Mergner, J.; Kearney, C.; Hecker, Judith; Götze, Katharina; Pedde, Anna-Marie; Bücklein, Veit Leonhard; Böttcher, Jan; Jacobs, Roland; Simeoni, Luca; Schraven, Burkhart; Pichlmair, Andreas; Subklewe, Marion; Knolle, Percy A.
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft Suppl. 1, S. 401-402, Artikel P 290
Begutachteter Zeitschriftenartikel
Y192 within the SH2 domain of Lck regulates TCR signaling downstream of PLC-γ1 and thymic selection
Kästle, Matthias; Merten, Camilla; Hartig, Roland; Plaza Sirvent, Carlos; Schmitz, Ingo; Bommhardt, Ursula; Schraven, Burkhart; Simeoni, Luca
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 13, insges. 15 S.
Genetic knock-out of TNFR1 and TNFR2 in a JAK2-V617F polycythemia vera mouse model. Letter
Müller, Peter; Baldauf, Conny K.; Haage, Tobias Ronny; Charakopoulos, Emmanouil; Böttcher, Martin; Bhuria, Vikas; Mougiakakos, Dimitrios; Schraven, Burkhart; Fischer, Thomas
In: HemaSphere - Hoboken : John Wiley & Sons Ltd., Bd. 6 (2022), Heft 5, Artikel e717, insges. 4 S.
A cysteine residue within the kinase domain of Zap70 regulates Lck activity and proximal TCR signaling
Schultz, Annika; Schnurra, Marvin; El-Bizri, Ali; Woessner, Nadine M.; Hartmann, Sara; Hartig, Roland; Minguet, Susana; Schraven, Burkhart; Simeoni, Luca
In: Cells - Basel: MDPI, 2012, Bd. 11 (2022), 17, insges. 13 S.
Robust induction of neutralizing antibodies against the SARS-CoV-2 Delta variant after homologous Spikevax or heterologous Vaxzevria-Spikevax vaccination
Hammerschmidt, Swantje Iris Anna-Dorothea; Thurm, Christoph; Bos̆njak, Berislav; Bernhardt, Günter; Reinhold, Annegret; Willenzon, Stefanie; Ritter, Christiane; Reinhold, Dirk; Schraven, Burkhart; Förster, Reinhold
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft 2, S. 356-359
Thromboinflammation in myeloproliferative neoplasms (MPN) - a puzzle still to be solved
Bhuria, Vikas; Baldauf, Conny K.; Schraven, Burkhart; Fischer, Thomas
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 6, insges. 21 S.
T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation
Cammann, Clemens; Israel, Nicole; Frentzel, Sarah; Jeron, Andreas; Topfstedt, Eylin; Schüler, Thomas; Simeoni, Luca; Zenker, Martin; Fehling, Hans Joerg; Schraven, Burkhart; Bruder, Dunja; Seifert, Ulrike
In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 13 (2022), Artikel 958616, insges. 15 S.
Ionic mitigation of CD4 + T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc
Krone, Anna; Fu, Yanpeng; Schreiber, Simon; Kotrba, Johanna; Borde, Loisa; Nötzold, Aileen; Thurm, Christoph; Negele, Jonas; Franz, Tobias; Stegemann-Koniszewski, Sabine; Schreiber, Jens; Garbers, Christoph; Shukla, Aniruddh; Geffers, Robert; Schraven, Burkhart; Reinhold, Dirk; Dudeck, Anne; Reinhold, Annegret; Müller, Andreas Johann; Kahlfuß, Sascha
In: Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature, Bd. 12 (2022), Artikel 1943, insges. 14 S.
IL-13 determines specific IgE responses and SARS-CoV-2 immunity after mild COVID-19 and novel mRNA vaccination
Meltendorf, Stefan; Vogel, Katrin; Thurm, Christoph; Prätsch, Florian; Reinhold, Annegret; Färber, Jacqueline; Heuft, Hans-Gert; Kaasch, Achim; Hachenberg, Thomas; Weinzierl, Stefan; Schraven, Burkhart; Reinhold, Dirk; Brunner-Weinzierl, Monika; Lingel, Holger
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 52 (2022), Heft 12, S. 1972-1979
Homologous and heterologous anti-COVID-19 vaccination does not induce new-onset formation of autoantibodies typically accompanying lupus erythematodes, rheumatoid arthritis, celiac disease and antiphospholipid syndrome
Thurm, Christoph; Reinhold, Annegret; Borucki, Katrin; Kahlfuß, Sascha; Feist, Eugen; Schreiber, Jens; Reinhold, Dirk; Schraven, Burkhart
In: Vaccines - Basel: MDPI, 2013, Bd. 10 (2022), 2, insges. 16 S.
Dissertation
Regulation of T cell activation and T cell development via the conserved tyrosine 192 within the SH2 domain of the Src family kinase p56Lck
Kästle, Matthias; Schraven, Burkhart
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Naturwissenschaften 2022, XV, 150 Seiten [Literaturverzeichnis: Seite 136-150]
Nicht begutachteter Zeitschriftenartikel
Anämie-Prävalenz der älteren Bevölkerung in Sachsen-Anhalt
Mikuško, Martin; Bartsch, Rainer; Wolleschak, Denise; Wehde, Natalie; Lux, Anke; Kropf, Siegfried; Schraven, Burkhart; Mougiakakos, Dimitrios; Fischer, Thomas
In: Ärzteblatt Sachsen-Anhalt - offizielles Mitteilungsblatt der Ärztekammer Sachsen-Anhalt - Magdeburg: Ärztekammer Sachsen-Anhalt, Bd. 33 (2022), 6, S. 21-25
2021
Abstract
Peripheral mast cell-derived RANKL is a prerequisite for lymphocyte egress from distant lymph nodes
Katsoulis-Dimitriou, Konstantinos; Umer, Waqar; Haffner-Luntzer, Melanie; Edler, Hanna; Baumgart, Kathleen; Schraven, Burkhart; Fröbel, Julia; Ignatius, Anita; Dudeck, Jan; Dudeck, Anne
In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 51 (2021), Suppl. 1, S. 35
Begutachteter Zeitschriftenartikel
The multiple roles of the cytosolic adapter proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -mediated signaling events
Dadwal, Nirdosh; Mix, Charlie; Reinhold, Annegret; Witte, Amelie; Freund, Christian; Schraven, Burkhart; Kliche, Stefanie
In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 12 (2021), Artikel 703534, insges. 14 S.
Pitavastatin is a highly potent inhibitor of T-cell proliferation
Voss, Linda; Guttek, Karina; Reddig, Annika; Reinhold, Annegret; Voss, Martin; Simeoni, Luca; Schraven, Burkhart; Reinhold, Dirk
In: Pharmaceuticals - Basel : MDPI, Bd. 14 (2021), Heft 8, Artikel 727, insges. 19 S.
Zinc aspartate induces IL-16 secretion and apoptosis in human T cells
Reinhold, Dirk; Guttek, Karina; Reddig, Annika; Voss, Linda; Schubert, Claudia; Kahlfuß, Sascha; Grüngreiff, Kurt; Schraven, Burkhart; Reinhold, Annegret
In: Biomedicines - Basel : MDPI, Bd. 9 (2021), Heft 3, Artikel 246, insges. 11 S.
Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation
Dudeck, Jan; Kotrba, Johanna; Immler, Roland Thomas; Hoffmann, Aaron; Voss, Martin; Alexakē, Basileia-Ismēnē; Morton, Lorena; Jahn, Stephan René; Katsoulis-Dimitriou, Konstantinos; Winzer, Simon; Kollias, Georg; Fischer, Thomas; Nedospasov, Sergei A.; Dunay, Ildikò Rita; Chavakis, Triantafyllos; Müller, Andreas Johann; Schraven, Burkhart; Sperandio, Markus; Dudeck, Anne
In: Immunity - [Cambridge, Mass.]: Cell Press, Bd. 54 (2021), 3, S. 468-483.e5
The activity and stability of p56Lck and TCR signaling do not depend on the co-chaperone Cdc37
Kowallik, Sarah; Kritikos, Andreas; Kästle, Matthias; Thurm, Christoph; Schraven, Burkhart; Reinhold, Dirk; Simeoni, Luca
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 22 (2021), Heft 1, Artikel 126, insges. 12 S.
ABC transporters in T cell-mediated physiological and pathological immune responses
Thurm, Christoph; Schraven, Burkhart; Kahlfuß, Sascha
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 17, insges. 10 S.
Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection
Kleinholz, Corinna L.; Riek-Burchardt, Monika; Seiß, Elena Anne; Amore, Jonas; Gintschel, Patricia; Philipsen, Lars; Bousso, Philippe; Relja, Borna; Schraven, Burkhart; Handschuh, Juliane; Mohr, Juliane; Müller, Andreas Johann
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 11 (2021), insges. 12 S.
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells
Formaglio, Pauline; Alabdullah, Mohamad; Siokis, Anastasios; Handschuh, Juliane; Sauerland, Ina; Fu, Yan; Krone, Anna; Gintschel, Patricia; Stettin, Juliane; Heyde, Sandrina; Mohr, Juliane; Philipsen, Lars; Schröder, Anja; Robert, Philippe A.; Zhao, Gang; Khailaie, Sahamoddin; Dudeck, Anne; Bertrand, Jessica; Späth, Gerald F.; Kahlfuß, Sascha; Bousso, Philippe; Schraven, Burkhart; Hühn, Jochen; Binder, Sebastian; Meyer-Hermann, Michael; Müller, Andreas Johann
In: Immunity - [Cambridge, Mass.] : Cell Press, Bd. 54 (2021), Heft 12, S. 2724-2739.e10
Enhanced susceptibility of ADAP-deficient mice to Listeria monocytogenes infection is associated with an altered phagocyte phenotype and function
Böning, Martha A. L.; Parzmair, Gerald P.; Jeron, Andreas; Düsedau, Henning Peter; Kershaw, Olivia; Xu, Baolin; Relja, Borna; Schlüter, Dirk; Dunay, Ildikò Rita; Reinhold, Annegret; Schraven, Burkhart; Bruder, Dunja
In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 12 (2021), Artikel 724855, insges. 20 S.
Screening of FDA-approved drug library identifies adefovir dipivoxil as highly potent inhibitor of T cell proliferation
Voss, Linda; Guttek, Karina; Reddig, Annika; Reinhold, Annegret; Voss, Martin; Schraven, Burkhart; Reinhold, Dirk
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 11 (2021), insges. 16 S.
Cooperative interaction of Nck and Lck orchestrates optimal TCR signaling
Hartl, Frederike; Ngoenkam, Jatuporn; Beck-García, Esmeralda; Cerqueira, Liz; Wipa, Piyamaporn; Paensuwan, Pussadee; Suriyaphol, Prapat; Mishra, Pankaj; Schraven, Burkhart; Günther, Stefan; Pongcharoen, Sutatip; Schamel, Wolfgang; Minguet, Susana
In: Cells - Basel: MDPI, 2012, Bd. 10 (2021), 4, insges. 13 S.
Metabolic interdependency of Th2 cell-mediated type 2 immunity and the tumor microenvironment
Schreiber, Simon; Hammers, Christoph; Kaasch, Achim; Schraven, Burkhart; Dudeck, Anne; Kahlfuß, Sascha
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 12 (2021), insges. 12 S.
Nicht begutachteter Zeitschriftenartikel
ADAP's intrinsically disordered region is an actin sponge regulating T cell motility
Dadwal, Nirdosh; Degen, Janine; Sticht, Jana; Hilal, Tarek; Wegner, Tatjana; Reichardt, Peter; Lyck, Ruth; Abadier, Michael; Hons, Miroslas; Mix, Charlie; Kuropka, Benno; Stephanowitz, Heike; Liu, Fan; Schraven, Burkhart; Wülfing, Christoph; Kliche, Stefanie; Freund, Christian
In: bioRxiv beta - Cold Spring Harbor : Cold Spring Harbor Laboratory, NY . - 2021, insges. 20 S.
2020
Begutachteter Zeitschriftenartikel
Serum and CSF cytokine levels mirror different neuroimmunological mechanisms in patients with LGI1 and Caspr2 encephalitis
Körtvélyessy, Péter; Goihl, Alexander; Guttek, Karina; Schraven, Burkhart; Prüß, Harald; Reinhold, Dirk
In: Cytokine - Oxford [u.a.] : Elsevier - Vol. 135.2020, 155226
Kv1.3 potassium channels - promising therapeutic targets in hematological malignancies
Lowinus, Theresa; Bose, Tanima; Simeoni, Luca; Schraven, Burkhart; Bommhardt, Ursula
In: Journal of cellular signaling - Wilmington: Scientific Archives LLC, 2020, Bd. 1 (2020), 3, S. 79-86
Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal
Baumann, Tobias; Dunkel, Andreas; Schmid, Christian; Schmitt, Sabine; Hiltensperger, Michael; Lohr, Kerstin; Laketa, Vibor; Donakonda, Sainitin; Ahting, Uwe; Lorenz-Depiereux, Bettina; Heil, Jan Erik; Schredelseker, Johann; Simeoni, Luca; Fecher, Caroline; Körber, Nina; Bauer, Tanja; Hüser, Norbert; Hartmann, Daniel; Laschinger, Melanie; Eyerich, Kilian; Eyerich, Stefanie; Anton, Martina; Streeter, Matthew; Wang, Tina; Schraven, Burkhart; Spiegel, David; Assaad, Farhah; Misgeld, Thomas; Zischka, Hans; Murray, Peter J.; Heine, Annkristin; Heikenwälder, Mathias; Korn, Thomas; Dawid, Corinna; Hofmann, Thomas F.; Knolle, Percy A.; Höchst, Bastian
In: Nature immunology - London: Springer Nature Limited, Bd. 21 (2020), 5, S. 555-566, insges. 12 S.
Ratio and index of neurofilament light chain indicate its origin in GuillainBarré Syndrome
Körtvélyessy, Péter; Kuhle, Jens; Düzel, Emrah; Vielhaber, Stefan; Schmidt, Christian; Heinius, Annika; Leypoldt, Frank; Schraven, Burkhart; Reinhold, Dirk; Leppert, David; Goihl, Alexander
In: Annals of Clinical and Translational Neurology - Chichester [u.a.] : Wiley, Bd. 7 (2020), Heft 11, S. 2213-2220
ADAP promotes degranulation and migration of NK cells primed during in vivo Listeria monocytogenes infection in mice
Böning, Martha A. L.; Trittel, Stephanie; Riese, Peggy; Ham, Marco Adrianus; Heyner, Maxi; Voss, Martin; Parzmair, Gerald P.; Klawonn, Frank; Jeron, Andreas; Guzmán, Carlos; Jänsch, Lothar; Schraven, Burkhart; Reinhold, Annegret; Bruder, Dunja
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Vol. 10.2020, Art.-Nr. 3144, insgesamt 16 Seiten
Tyrosine 192 within the SH2 domain of the Srcprotein tyrosine kinase p56Lck regulates Tcell activation independently of Lck/CD45 interactions
Kästle, Matthias; Merten, Camilla; Hartig, Roland; Kaehne, Thilo; LiaunardyJopeace, Ardiyanto; Woessner, Nadine M.; Schamel, Wolfgang; James, John; Minguet, Susana; Simeoni, Luca; Schraven, Burkhart
In: Cell communication and signaling - London: Biomed Central, 2003, Vol. 18.2020, Art.-Nr. 183, insgesamt 18 Seiten
2019
Abstract
Regulation of Lck activity via a highly conserved cysteine residue within the kinase domain
Kritikos, Andreas; Kowallik, Sarah; Schraven, Burkhart; Simeoni, Luca
In: European journal of immunology - Weinheim : Wiley-VCH - Bd. 49.2019, Suppl. 1, P231, Seite 194-195
Regulating microvesicle transport at the immunological synapse
Ham, Marco; Amsberg, Nicole; Reinking, Janne; Philipsen, Lars; Müller, Andreas Johann; Hühn, Jochen; Schraven, Burkhart; Jänsch, Lothar
In: European journal of immunology: basic, clinical, translational - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 1, P379, Seite 281
A highly conserved tyrosine residue within the SH2 domain of Lck regulates T-cell development and activation
Kästle, Matthias; Merten, Camilla; Simeoni, Luca; Schraven, Burkhart
In: European journal of immunology - Weinheim : Wiley-VCH - Bd. 49.2019, Suppl. 1, P208, Seite 182
Inflammatory CD11c+ monocytes constitute a main reservoir for high proliferation and cell-to-cell transmission of Leishmania major
Heyde, Sandrina; Philipsen, Lars; Formaglio, Pauline; Fu, Yan; Baars, Iris; Höbbel, Guido; Kleinholz, Corinna L.; Seiß, Elena Anne; Stettin, Juliane; Gintschel, Patricia; Dudeck, Anne; Bousso, Philippe; Schraven, Burkhart; Müller, Andreas Johann
In: European journal of immunology: basic, clinical, translational - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 3, P0943, S. 1195
Cytokine release, degranulation and migratory capacity of NK cells depends on ADAP during Listeria monocytogenes infection of mice
Böning, Martha A. L.; Parzmair, Gerald P.; Jeron, Andreas; Riese, Peggy; Trittel, Stephanie; Heyner, Maxi; Voss, Martin; Jänsch, Lothar; Guzmán, Carlos; Schraven, Burkhart; Reinhold, Annegret; Bruder, Dunja
In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 1, SAT2, Seite 2-3
Begutachteter Zeitschriftenartikel
Characterization of mice with a platelet-specific deletion of the adapter molecule ADAP
Rudolph, Jochen M.; Guttek, Karina; Weitz, Gabriele; Meinke, Clara Antonia; Kliche, Stefanie; Reinhold, Dirk; Schraven, Burkhart; Reinhold, Annegret
In: Molecular and cellular biology - Washington, DC : Soc - Bd. 39.2019, 9, Art.-Nr. e00365-18, insges. 16 S.
Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils
Seiß, Elena Anne; Krone, Anna; Formaglio, Pauline; Goldmann, Oliver; Engelmann, Susanne; Schraven, Burkhart; Medina, Eva; Müller, Andreas Johann
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 9.2019, Art.-Nr. 5703, insges. 10 S.
Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling
Lowinus, Theresa; Heidel, Florian; Bose, Tanima; Nimmagadda, Subbaiah Chary; Schnöder, Tina; Cammann, Clemens; Schmitz, Ingo; Seifert, Ulrike; Fischer, Thomas; Schraven, Burkhart; Bommhardt, Ursula
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 17.2019, Art.-Nr. 5, insges. 13 S.
Beyond TCR signaling - emerging functions of Lck in cancer and immunotherapy
Bommhardt, Ursula; Schraven, Burkhart; Simeoni, Luca
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 14, Art.-Nr. 3500, insges. 18 S.
Immune cell-type specific ablation of adapter protein ADAP differentially modulates EAE
Rudolph, Jochen M.; Meinke, Clara; Voss, Martin; Guttek, Karina; Kliche, Stefanie; Reinhold, Dirk; Schraven, Burkhart; Reinhold, Annegret
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 10.2019, Art.-Nr. 2343, insges. 13 S.
Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency
Dudeck, Jan; Froebel, Julia; Kotrba, Johanna; Lehmann, Christian H.K.; Dudziak, Diana; Speier, Stephan; Nedospasov, Sergei A.; Schraven, Burkhart; Dudeck, Anne
In: The journal of allergy and clinical immunology - Amsterdam [u.a.]: Elsevier, Bd. 143.2019, 5, S. 1849-1864.e4
2018
Abstract
Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells
Mix, Charlie; Waldt, Natalie; Seifert, Anke; Demiray, Yunus Emre; Reichardt, Peter; Reinhold, Annegret; Freund, Christian; Müller, Andreas Johann; Schraven, Burkhart; Stork, Oliver; Kliche, Stefanie
In: European journal of immunology - Weinheim : Wiley-VCH - Bd. 49.2019, Suppl. 1, P214, Seite 185-186
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
Raza, Syed Ahsan; Albrecht, Anne; Çalişkan, Gürsel; Müller, Bettina; Demiray, Yunus Emre; Ludewig, Susann; Meis, Susanne; Faber, Nicolai; Hartig, Roland; Schraven, Burkhart; Leßmann, Volkmar; Schwegler, Herbert; Stork, Oliver
In: 11th FENS Forum of Neuroscience - FENS - 2018, Abstract 3915 [Forum: 11th FENS Forum of Neuroscience, Berlin, Germany, 7-11 July 2018]
Begutachteter Zeitschriftenartikel
Beware the intruder - real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo
Neumann, Jens; Henneberg, Sophie; Kenne, Susanne; Nolte, Niklas; Müller, Andreas Johann; Schraven, Burkhart; Görtler, Michael; Reymann, Klaus G.; Gunzer, Matthias; Riek-Burchardt, Monika
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 13.2018, 3, Art.-Nr. e0193970, insges. 9 S.
CD45 in human physiology and clinical medicine
Rheinländer, Andreas; Schraven, Burkhart; Bommhardt, Ursula
In: Immunology letters - Amsterdam [u.a.]: Elsevier Science, Bd. 196.2018, S. 22-32
JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation
Edelmann, Bärbel; Gupta, Nibedita; Schnöder, Tina; Oelschlegel, Anja Maria; Shahzad, Khurrum; Goldschmidt, Jürgen; Philipsen, Lars; Weinert, Sönke; Ghosh, Aniket; Saalfeld, Felix C.; Nimmagadda, Subbaiah Chary; Müller, Peter; Braun-Dullaeus, Rüdiger C.; Mohr, Juliane; Wolleschak, Denise; Kliche, Stefanie; Amthauer, Holger; Heidel, Florian; Schraven, Burkhart; Isermann, Berend; Müller, Andreas Johann; Fischer, Thomas
In: The journal of clinical investigation - Ann Arbor, Mich.: ASCJ, 1924, Bd. 128 (2018), 10, S. 4359-4371
Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells
Waldt, Natalie; Seifert, Anke; Demiray, Yunus Emre; Devroe, Eric; Turk, Benjamin E.; Reichardt, Peter; Mix, Charlie; Reinhold, Annegret; Freund, Christian; Müller, Andreas Johann; Schraven, Burkhart; Stork, Oliver; Kliche, Stefanie
In: Frontiers in immunology - Lausanne : Frontiers Media - Bd. 9.2018, Art.-Nr. 2852, insges. 16 S.
CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission
Heyde, Sandrina; Philipsen, Lars; Formaglio, Pauline; Fu, Yan; Baars, Iris; Höbbel, Guido; Kleinholz, Corinna L.; Seiß, Elena Anne; Stettin, Juliane; Gintschel, Patricia; Dudeck, Anne; Bousso, Philippe; Schraven, Burkhart; Müller, Andreas Johann
In: PLoS pathogens/ Public Library of Science - Lawrence, Kan.: PLoS, 2005, Bd. 14.2018, 10, Art.-Nr. e1007374, insges. 30 S.
2017
Begutachteter Zeitschriftenartikel
A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity
Thurm, Christoph; Poltorak, Mateusz Pawel; Reimer, Elisa; Brinkmann, Melanie M.; Leichert, Lars I.; Schraven, Burkhart; Simeoni, Luca
In: OncoTarget - [S.l.]: Impact Journals LLC, 2010, Bd. 8 (2017), 19, S. 30805-30816
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
Raza, Ahsan Syed; Albrecht, Anne; Çalişkan, Gürsel; Müller, Bettina; Demiray, Yunus Emre; Ludewig, Susann; Meis, Susanne; Faber, Nicolai; Hartig, Roland; Schraven, Burkhart; Leßmann, Volkmar; Schwegler, Herbert; Stork, Oliver
In: Nature Communications - [London] : Nature Publishing Group UK - Vol. 8.2017, Art. 189, insgesamt 15 S.
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Ranjan, Satish; Goihl, Alexander; Kohli, Shrey; Gadi, Ihsan; Pierau, Mandy; Shahzad Hussain, Khurrum; Gupta, Dheerendra; Bock, Fabian; Wang, Hongjie; Shaikh, Haroon; Kähne, Thilo; Reinhold, Dirk; Bank, Ute; Zenclussen, Ana Claudia; Niemz, Jana; Schnöder, Tina; Brunner-Weinzierl, Monika; Fischer, Thomas; Kalinski, Thomas; Schraven, Burkhart; Luft, Thomas; Hühn, Jochen; Naumann, Michael; Heidel, Florian; Isermann, Berend
In: Nature Communications - [London] : Nature Publishing Group UK - 8(2017) Artikel-Nummer 311, 16 Seiten
JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1
Gupta, Nibedita; Edelmann, Bärbel; Schnöder, Tina; Saalfeld, Felix C.; Wolleschak, Denise; Kliche, Stefanie; Schraven, Burkhart; Heidel, Florian; Fischer, Thomas
In: Leukemia - London: Springer Nature, 1997, Bd. 31 (2017), 5, S. 1223-1226
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling
Philipsen, Lars; Reddycherla, Amarendra Varma; Hartig, Roland; Gumz, Janine; Kästle, Matthias; Kritikos, Andreas; Poltorak, Mateusz Pawel; Prokazov, Yury; Turbin, Evgeny; Weber, André; Zuschratter, Werner; Schraven, Burkhart; Simeoni, Luca; Müller, Andreas Johann
In: Science signaling: the signal transduction knowledge environment - Washington, DC [u.a.]: Assoc., Bd. 10.2017, 462, insges. 14 S.
D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes
Witte, Amelie; Meineke, Bernhard; Sticht, Jana; Philipsen, Lars; Kuropka, Benno; Müller, Andreas Johann; Freund, Christian; Schraven, Burkhart; Kliche, Stefanie
In: Molecular and cellular biology - London : Taylor & Francis - Bd. 37.2017, 7, Seite e.00509-e.00516
2016
Abstract
LPS stimulation induces ROS formation, apoptosis, DNA damage and oxidation of cysteine residues in FLT3-ITD positive cell lines resulting in FLT3-tyrosine kinase inhibitor resistance
Müller, Christian; Schnöder, Tina; Simeoni, Luca; Heidel, Florian; Thurm, Christoph; Schraven, Burkhart; Fischer, Thomas
In: Haematologica: journal of the European Hematology Association - Pavia: Ferrata-Storti Foundation, 2014, Bd. 101.2016, s1, Abs. E877, S. 360
Reactive oxygen species (ROS) modulates sensitivity to FLT3-tyrosine kinase inhibitors in murine and human FLT3-ITD positive AML cell lines
Müller, Christian; Simeoni, Luca; Heidel, Florian; Schraven, Burkhart; Fischer, Thomas
In: Haematologica: journal of the European Hematology Association - Pavia: Ferrata-Storti Foundation, 2014, Bd. 101.2016, s1, Abs. E885, S. 362-363
Begutachteter Zeitschriftenartikel
Early changes in the metabolic profile of activated CD8+ T cells
Cammann, Clemens; Rath, Alexander; Reichl, Udo; Lingel, Holger; Brunner-Weinzierl, Monika; Simeoni, Luca; Schraven, Burkhart; Lindquist, Jonathan A.
In: BMC cell biology - London : BioMed Central - Bd. 17.2016, Art.-Nr. 28, insges. 11 S.
ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens
Parzmair, Gerald P.; Gereke, Marcus; Haberkorn, Oxana; Annemann, Michaela; Podlasly, Lisa; Kliche, Stefanie; Reinhold, Annegret; Schraven, Burkhart; Bruder, Dunja
In: Journal of leukocyte biology - Hoboken, NJ: Wiley, 1984, Bd. 101.2017, 2, S. 407-419[Im Titel ist "+" hochgestellt]
Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness
Lowinus, Theresa; Bose, Tanima; Busse, Stefan Gregor; Busse, Mandy; Reinhold, Dirk; Schraven, Burkhart; Bommhardt, Ursula H. H.
In: OncoTarget - [S.l.]: Impact Journals LLC, 2010, Bd. 7 (2016), 33, S. 53797-53807
Atypical I[kappa]B proteins in immune cell differentiation and function
Annemann, Michaela; Plaza Sirvent, Carlos; Schuster, Marc; Katsoulis-Dimitriou, Konstantinos; Kliche, Stefanie; Schraven, Burkhart; Schmitz, Ingo
In: Immunology letters - Amsterdam [u.a.] : Elsevier Science, Bd. 171 (2016), S. 26-35
Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling
Kuropka, Benno; Schraven, Burkhart; Kliche, Stefanie; Krause, Eberhard; Freund, Christian
In: Expert review of proteomics - Abingdon : Taylor & Francis Group, Bd. 13 (2016), Heft 6, S. 545-554
Normal development and function of T cells in proline rich 7 (Prr7) deficient mice
Hrdinka, Matous; Sudan, Kritika; Just, Sissy; Drobek, Ales; Stepanek, Ondrej; Schlüter, Dirk; Reinhold, Dirk; Jordan, Bryen A.; Gintschel, Patricia; Schraven, Burkhart; Kreutz, Michael R.
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 11 (2016), 9, Art.-Nr. e0162863, insges. 15 S.
2015
Begutachteter Zeitschriftenartikel
Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
Neumann, Jens; Riek-Burchardt, Monika; Herz, Josephine; Döppner, Thorsten Roland; König, Rebecca; Hütten, Heiko; Etemire, Eloho; Männ, Linda; Klingberg, Anika; Fischer, Thomas; Görtler, Michael; Heinze, Hans-Jochen; Reichardt, Peter; Schraven, Burkhart; Hermann, Dirk Matthias; Reymann, Klaus G.; Gunzer, Matthias
In: Acta neuropathologica - Berlin: Springer, Bd. 129 (2015), 2, S. 259-277
Catchup - a mouse model for imaging-based tracking and modulation of neutrophil granulocytes
Hasenberg, Anja; Hasenberg, Mike; Männ, Linda; Neumann, Franziska; Borkenstein, Lars; Stecher, Manuel; Kraus, Andreas; Engel, Daniel R.; Klingberg, Anika; Seddigh, Pegah; Abdullah, Zeinab; Klebow, Sabrina; Engelmann, Swen; Reinhold, Annegret; Brandau, Sven; Seeling, Michaela; Waisman, Ari; Schraven, Burkhart; Göthert, Joachim Rudolf; Nimmerjahn, Falk; Gunzer, Matthias
In: Nature methods - London [u.a.]: Nature Publishing Group, 2004, Bd. 12.2015, 5, S. 445-452
Analysis of phosphorylation-dependent protein interactions of adhesion and degranulation promoting adaptor protein (ADAP) reveals novel interaction partners required for chemokine-directed T cell migration
Kuropka, Benno; Witte, Amelie; Sticht, Jana; Waldt, Natalie; Majkut, Paul; Hackenberger, Christian; Schraven, Burkhart; Krause, Eberhard; Kliche, Stefanie; Freund, Christian
In: Molecular & cellular proteomics - Bethesda, Md. : The American Society for Biochemistry and Molecular Biology, Bd. 14 (2015), Heft 11, S. 2961-2972
T cells and reactive oxygen species
Belikov, Aleksey V.; Schraven, Burkhart; Simeoni, Luca
In: Journal of biomedical science: an international and Asian forum for high-impact biomedical research - London: BioMed Central, Bd. 22.2015, Art.-Nr. 85, insges. 11 S.
Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells
Vogel, Stephanie; Grabski, Elena; Buschjäger, Daniela; Klawonn, Frank; Döring, Marius; Wang, Junxi; Fletcher, Erika; Bechmann, Ingo Jürgen; Witte, Torsten; Durisin, Martin; Schraven, Burkhart; Mangsbo, Sara M.; Schönfeld, Kurt; Czeloth, Niklas; Kalinke, Ulrich
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 5.2015, Art.-Nr. 18308, insges. 11 S.
The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis
Engelmann, Swen; Togni, Mauro; Kliche, Stefanie; Reinhold, Dirk; Schraven, Burkhart; Reinhold, Annegret
In: Critical reviews in immunology - Boca Raton, Fla. : CRC Press, Bd. 35 (2015), Heft 1, S. 1-14
Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function
Perner, Florian; Schnöder, Tina; Ranjan, Satish; Wolleschak, Denise; Ebert, Carolin; Pils, Marina C.; Frey, Stephanie; Polanetzki, Anja; Fahldieck, Corinna; Schönborn, Uta; Schraven, Burkhart; Isermann, Berend; Fischer, Thomas; Heidel, Florian
In: Leukemia - London: Springer Nature, Bd. 30 (2016), 4, S. 991-995
MiR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells
Reddycherla, Amarendra Varma; Meinert, Ines; Reinhold, Annegret; Reinhold, Dirk; Schraven, Burkhart; Simeoni, Luca
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 10.2015, 4, Art. e0125311, insges. 17 S.
2014
Begutachteter Zeitschriftenartikel
Immunosuppression by N-Methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells
Kahlfuß, Sascha; Simma, Narasimhulu; Mankiewicz, Judith; Bose, Tanima; Lowinus, Theresa; Klein-Heßling, Stefan; Sprengel, Rolf; Schraven, Burkhart; Heine, Martin; Bommhardt, Ursula
In: Molecular and cellular biology - Washington, DC: Soc., Bd. 34 (2014), 5, S. 820-831, insges. 12 S.
TCR-triggered extracellular superoxide production is not required for T-cell activation
Belikov, Aleksey V.; Schraven, Burkhart; Simeoni, Luca
In: Cell communication and signaling. - London : Biomed Central; Bd. 12.2014, Art.-Nr. 50, insges. 10 S.
Sos1 regulates sustained TCR-mediated Erk activation
Poltorak, Mateusz; Meinert, Ines; Stone, James C.; Schraven, Burkhart; Simeoni, Luca
In: European journal of immunology. - Weinheim : Wiley-VCH, Bd. 44.2014, 5, S. 1535-1540
Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation
Harder, Thomas; Guttek, Karina; Philipsen, Lars; Simeoni, Luca; Schraven, Burkhart; Reinhold, Dirk
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 12.2014, Art.-Nr. 74, insges. 8 S.
Tetanus toxoid-pulsed monocyte vaccination for augmentation of collateral vessel growth
Herold, Jörg; Francke, Alexander; Weinert, Soenke; Schmeisser, Alexander; Hebel, Katrin; Schraven, Burkhart; Roehl, Friedich-Wilhelm; Strasser, Ruth H.; Braun-Dullaeus, Ruediger C.
In: Journal of the American Heart Association - New York, NY : Association - Bd. 3.2014, 2, Art.-Nr. e000611, insges. 12 S.
Hippocampus-dependent learning in SKAP-HOM deficient mice
Fiedler, Anna; Grecksch, Gisela; Reinhold, Annegret; Schraven, Burkhart; Becker, Axel
In: Behavioural brain research: an international journal - Amsterdam: Elsevier, Bd. 270 (2014), S. 125-130
Negative interactions and feedback regulations are required for transient cellular response
Mobashir, Mohammad; Madhusudhan, Thati; Isermann, Berend; Beyer, Tilo; Schraven, Burkhart
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 4.2014, Art.-Nr. 3718, insges. 8 S.
Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function
Wolleschak, Denise; Mack, Thomas S.; Perner, Florian; Frey, Stephanie; Schnöder, Tina; Wagner, Marie-Christine; Höding, Christine; Pils, Marina C.; Parkner, Andreas; Kliche, Stefanie; Schraven, Burkhart; Hebel, Katrin; Brunner-Weinzierl, Monika; Ranjan, Satish; Isermann, Berend; Lipka, Daniel; Fischer, Thomas; Heidel, Florian
In: Haematologica - Pavia : Ferrata Storti Foundation - Bd. 99.2014, 6, S. e90-e93
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells
Simma, Narasimhulu; Bose, Tanima; Kahlfuß, Sascha; Mankiewicz, Judith; Lowinus, Theresa; Lühder, Fred; Schüler, Thomas; Schraven, Burkhart; Heine, Martin; Bommhardt, Ursula
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 12.2014, Art.-Nr. 75, insges. 13 S.
2013
Begutachteter Zeitschriftenartikel
Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation
Arndt, Börge; Poltorak, Mateusz; Kowtharapu, Bhavani Shankar; Reichardt, Peter; Philipsen, Lars; Lindquist, Jonathan A.; Schraven, Burkhart; Simeoni, Luca
In: Journal of immunological methods: JIM - Amsterdam [u.a.]: Elsevier, Bd. 387 (2013), 1/2, S. 276-283
TCR activation kinetics and feedback regulation in primary human T cells
Poltorak, Mateusz; Arndt, Börge; Kowtharapu, Bhavani Shankar; Reddycherla, Amarendra V.; Witte, Vanessa Alexandra; Lindquist, Jonathan A.; Schraven, Burkhart; Simeoni, Luca
In: Cell communication and signaling - London: Biomed Central, Bd. 11.2013, Art.-Nr. 4, insges. 22 S.
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells
Smida, Michal; Cammann, Clemens; Gurbiel, Slavyana; Kerstin, Nadja; Lingel, Holger; Lindquist, Sabine; Simeoni, Luca; Brunner-Weinzierl, Monika; Suchanek, Miloslav; Schraven, Burkhart; Lindquist, Jonathan A.
In: Cell communication and signaling - London : Biomed Central - Bd. 11.2013, Art.-Nr. 28, insges. 13 S.
Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters
Philipsen, Lars; Engels, Thomas; Schilling, Kerstin; Gurbiel, Slavyana; Fischer, Klaus-Dieter; Tedford, Kerry; Schraven, Burkhart; Gunzer, Matthias; Reichardt, Peter
In: Molecular & cellular proteomics - Bethesda, Md.: The American Society for Biochemistry and Molecular Biology, Bd. 12 (2013), 9, S. 2551-2567
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation
Stirnweiss, Anja; Hartig, Roland; Gieseler, Steffi; Lindquist, Jonathan A.; Reichardt, Peter; Philipsen, Lars; Simeoni, Luca; Poltorak, Mateusz; Merten, Camilla; Zuschratter, Werner; Prokazov, Yury; Paster, Wolfgang; Stockinger, Hannes; Harder, Thomas; Gunzer, Matthias; Schraven, Burkhart
In: Science signaling - Washington, DC [u.a.]: Assoc., Bd. 6.2013, 263 ra13, insges. 11 S.
Discrete, qualitative models of interaction networks
Ballerstein, Kathrin; Haus, Utz-Uwe; Lindquist, Jonathan Axel; Beyer, Tilo; Schraven, Burkhart; Weismantel, Robert
In: Frontiers in bioscience / Scholar - Searington, NY: Bioscience Research Institute (BRI), part of IMR Press, Bd. S5.2013, 1, S. 149-166
Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX
Arndt, Börge; Kalinski, Thomas; Reinhold, Dirk; Thielitz, Anja; Roessner, Albert; Schraven, Burkhart; Simeoni, Luca
In: Journal of leukocyte biology - Bethesda, Md. : FASEB, Bd. 93 (2013), Heft 3, S. 353-362
T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice
Engelmann, Swen; Togni, Mauro; Reinhold, Dirk; Thielitz, Anja; Reichardt, Peter; Kliche, Stefanie; Schraven, Burkhart; Reinhold, Annegret
In: The journal of immunology - Bethesda, Md: Soc, Bd. 191 (2013), 10, S. 4950-4959
Cross-talk between the signalling pathways of the receptor for interleukin 2 and the T-cell antigen in human T-blasts
Hristov, Kroum; Lindquist, Jonathan; Schraven, Burkhart
In: Acta medica Bulgarica - Sofia : Medicina i Fizkultura, Bd. 40 (2013), Heft 1, S. 76-83
2012
Anderes Material
Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.
Arndt, Boerge; Poltorak, Mateusz; Kowtharapu, Bhavani S; Reichardt, Peter; Phillipsen, Lars; Lindquist, Jonathan A; Schraven, Burkhart; Simeoni, Luca
In: Journal of immunological methods, Vol. , ISSN 1872-7905, 2012, 10.1016/j.jim.2012.11.006
Buchbeitrag
SKAP2/SCAP2 (Src kinase-associated phosphoprotein 2)
Reinhold, Annegret; Schraven, Burkhart L.
In: Choi, Sangdun: : Encyclopedia of signaling molecules. - New York, NY [u.a.] : Springer, S. 1736-1740, 2012
Begutachteter Zeitschriftenartikel
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
Warnecke, Nicole; Poltorak, Mateusz; Kowtharapu, Bhavani S; Arndt, Boerge; Stone, James C; Schraven, Burkhart; Simeoni, Luca
In: EMBO reports, Vol. 13, ISSN 1469-3178, , 10.1038/embor.2012.17
Originalartikel in begutachteter internationaler Zeitschrift
Re-stimulation of T-cell antigen receptor and regulation of the tyrosine phosphorylation in peripheral T-cells
Hristov, Kroum; Lindquist, Jonathan; Schraven, Burkhart
In: Acta medica Bulgarica: AMB / Medical Academy, Sofia - Sofia: Medicina i Fizkultura, Bd. XXXIX. 2012, 2, S. 11-22
Simulated Evolution of Signal Transduction Networks
Mobashir, Mohammad; Schraven, Burkhart; Beyer, Tilo
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 7.2012, 12, insges. 10 S.
Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases
Linka, René M.; Risse, S. L.; Bienemann, K.; Werner, Markus; Linka, Yvonne; Krux, Frank; Synaeve, Cindy; Deenen, René; Ginzel, Sebastian; Dvorsky, Radovan; Gombert, Michael; Halenius, Anne; Hartig, Roland; Helminen, Merja; Fischer, Alain; Stepensky, Polina; Vettenranta, Kim; Köhrer, Karl; Ahmadian, M. Reza; Laws, Hans-Jürgen; Fleckenstein, Bernhard; Jumaa, Hassan; Latour, Sylvain; Schraven, Burkhart; Borkhardt, Arndt
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 26.2012, 5, S. 963-971
First insight into the kinome of human regulatory T cells
König, Sebastian; Probst-Kepper, Michael; Reinl, Tobias; Jeron, Andreas; Hühn, Jochen; Schraven, Burkhart; Jänsch, Lothar
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 7.2012, 7, Art.-Nr. e40896, insges. 12 S.
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells
Warnecke, Nicole; Poltorak, Mateusz; Kowtharapu, Bhavani Shankar; Arndt, Börge; Stone, James C.; Schraven, Burkhart; Simeoni, Luca
In: EMBO reports / publ. for EMBO/ European Molecular Biology Organization - Weinheim: Wiley, Bd. 13 (2012), 4, S. 386-391
CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules
Kliche, Stefanie; Worbs, Tim; Wang, Xiaoqian; Degen, Janine; Patzak, Irene Maria; Meineke, Bernhard; Togni, Mauro; Moser, Markus; Reinhold, Annegret; Kiefer, Friedemann; Freund, Christian; Förster, Reinhold; Schraven, Burkhart
In: Blood - Washington, DC : American Society of Hematology, Bd. 119 (2012), Heft 3, S. 777-785
Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function
Pierau, Mandy; Na, Shin-Young; Simma, Narasimhulu; Lowinus, Theresa; Marx, Alexander; Schraven, Burkhart; Bommhardt, Ursula H.
In: European journal of immunology - Weinheim: Wiley, Bd. 42 (2012), 12, S. 3381-3393
Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function
Pierau, Mandy; Na, Shin-Young; Simma, Narasimhulu; Lowinus, Theresa; Marx, Alexander; Schraven, Burkhart; Bommhardt, Ursula H.
In: European journal of immunology - Weinheim : Wiley, Bd. 42 (2012), Heft 12, S. 3381-3393, insges. 13 S.
An inhibitor study of interleukin 2 receptor (IL2R) signalling mechanisms in human T-lymphoblasts
Hristov, Kroum; Lindquist, Jonathan; Schraven, Burkhart
In: Dokladi na Bălgarskata Akademija na Naukite/ Bălgarska akademija na naukite - Sofija: Akademija, Bd. 65 (2012), 1, S. 53-62
The adapter protein ADAP is required for selected dendritic cell functions
Togni, Mauro; Engelmann, Swen; Reinhold, Dirk; Schraven, Burkhart; Reinhold, Annegret
In: Cell communication and signaling - London : Biomed Central - Bd. 10.2012, Art. 14, insges. 10 S.
Emerging roles of ADAP, SKAP55, and SKAP-HOM for integrin and NF-[kappa]B signaling in T cells
Witte, Amelie; Degen, Janine; Baumgart, Kathleen; Waldt, Natalie; Kuropka, Benno; Freund, Christian; Schraven, Burkhart; Kliche, Stefanie
In: Journal of clinical & cellular immunology - Sunnyvale, Calif. : OMICS Publishing Group - Bd. 3.2012, Nr. S12, Artikel-Nr.002, insges. 8 S.
2011
Originalartikel in begutachteter internationaler Zeitschrift
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates Src kinase activity in brain maturation
Lindquist, Sabine; Karitkina, Diana; Langnäse, Kristina; Posevitz-Fejfár, Anita; Schraven, Burkhart; Xavier, Ramnik; Seed, Brian; Lindquist, Jonathan A.
In: PLOS ONE - San Francisco, California, US : PLOS - Bd. 6.2011, 9, Art.-Nr. e23978 insges. 14 S.
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling
Arndt, Börge; Krieger, Tina; Kalinski, Thomas; Thielitz, Anja; Reinhold, Dirk; Roessner, Albert; Schraven, Burkhart; Simeoni, Luca
In: PLOS ONE - San Francisco, California, US : PLOS - Bd. 6.2011, 9, Art.-Nr. e23761 insges. 7 S.
Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo
Hasenberg, Mike; Köhler, Anja; Bonifatius, Susanne; Borucki, Katrin; Riek-Burchardt, Monika; Achilles, Julia; Männ, Linda; Baumgart, Kathleen; Schraven, Burkhart; Gunzer, Matthias
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 6, 2011, 2, Art. e17314, insges. 11 S.
Protocol optimization for DOK2 immunoprecipitation from murine splenic and thymic T-cell preparations
Hristov, Kroum; Lindquist, Jonathan A.; Schraven, Burkhart
In: Dokladi na Bălgarskata Akademija na Naukite / Bălgarska akademija na naukite - Sofija : Akademija, Bd. 64 (2011), Heft 7, S. 979-986
Integrating signals from the T-cell receptor and the interleukin-2 receptor
Beyer, Tilo; Busse, Mandy; Hristov, Kroum; Gurbiel, Slavyana; Smida, Michal; Haus, Utz-Uwe; Ballerstein, Kathrin; Pfeuffer, Frank; Weismantel, Robert; Schraven, Burkhart; Lindquist, Jonathan A.
In: PLoS Computational Biology - San Francisco, Calif: Public Library of Science, Bd. 7.2011, 8, Art. e1002121, insges. 15 S.
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands
Köhler, Anja; Filippo, Katia; Hasenberg, Mike; Brandt, Cindy; Nye, Emma; Hosking, Martin P.; Lane, Thomas E.; Männ, Linda; Ransohoff, Richard M.; Hauser, Anja E.; Winter, Oliver; Schraven, Burkhart; Geiger, Hartmut; Hogg, Nancy; Gunzer, Matthias
In: Blood: the journal of hematology / American Society of Hematology. William Dameshek, founding ed. - Washington, DC: American Society of Hematology, Bd. 117 (2011), 16, S. 4349-4357
The SLP-76 Src homology 2 domain is required for T cell development and activation
Burns, Jeremy C.; Corbo, Evann; Degen, Janine; Gohil, Mercy; Anterasian, Christine; Schraven, Burkhart; Koretzky, Gary A.; Kliche, Stefanie; Jordan, Martha S.
In: The journal of immunology. - Bethesda, Md : American Assoc. of Immunologists, Bd. 187.2011, 9, S. 4459-4466
2010
Originalartikel in begutachteter internationaler Zeitschrift
Stoichiometry and intracellular fate of TRIM-containing TCR complexes
Swamy, Mahima; Siegers, Gabrielle M; Fiala, Gina J; Molnar, Eszter; Dopfer, Elaine P; Fisch, Paul; Schraven, Burkhart; Schamel, Wolfgang W. A.
In: Cell communication and signaling . - London : Biomed Central, Bd. 8.2010, insges. 10 S.; Abstract
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells
Sylvester, Marc; Kliche, Stefanie; Lange, Sabine; Geithner, Sabine; Klemm, Clementine; Schlosser, Andreas; Großmann, Arndt; Stelzl, Ulrich; Schraven, Burkhart; Krause, Eberhard; Freund, Christian
In: PLOS ONE - San Francisco, California, US : PLOS - Vol. 5, 2010, 7, Art. e11708, insges. 11 S.
Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells
Rieke, Cornelia; Kähne, Thilo; Schweitzer, Katrin; Schraven, Burkhart; Wienands, Jürgen; Engelke, Michael; Naumann, Michael
In: Cellular signalling - Amsterdam : Elsevier, Bd. 22 (2010), Heft 3, S. 395-403
Nicht begutachteter Zeitschriftenartikel
Exploring the immune system - systems biology research networks in quest for new therapy options
Höfer, Thomas; Lindquist, Jonathan; Schraven, Burkhart; Schamel, Wolfgang
In: Systembiologie.de - Heidelberg : Dt. Krebsforschungszentrum, Abt. Theoret. Bioinformatik . - 2010, Heft 1, S. 51-55
2009
Originalartikel in begutachteter internationaler Zeitschrift
Cannabinoid receptor type 1 and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling
Börner, Christine; Smida, Michal; Höllt, Volker; Schraven, Burkhart; Kraus, Jürgen
In: The journal of biological chemistry . - Bethesda, Md. : ASBMB, Bd. 284.2009, 51, S. 35450-35460
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
Pierau, Mandy; Engelmann, Swen; Reinhold, Dirk; Lapp, Thabo; Schraven, Burkhart; Bommhardt, Ursula
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 10, S. 6124-6134
Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
Linnemann, Carsten; Schildberg, Frank A.; Schurich, Anna; Diehl, Linda; Hegenbarth, Silke I.; Endl, Elmar; Lacher, Svenja K.; Müller, Christa E.; Frey, Jürgen; Simeoni, Luca; Schraven, Burkhart; Wohlleber, Dirk; Knolle, Percy A.
In: Immunology - Oxford [u.a.] : Wiley-Blackwell - Bd. 128.2009, 1,Pt.2, S. e728-e737
Systematic amino acid substitutions improved efficiency of GD2-peptide mimotope vaccination against neuroblastoma
Bleeke, Matthias; Fest, Stefan; Hübener, Nicole; Landgraf, Christiane; Schraven, Burkhart; Gaedicke, Gerhard; Volkmer, Rudolf; Lode, Holger N.
In: The European journal of cancer - Amsterdam [u.a.] : Elsevier, Bd. 45 (2009), Heft 16, S. 2915-2921
Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells
Horn, Jessica; Wang, Xiaoqian; Reichardt, Peter; Stradal, Theresia; Warnecke, Nicole; Simeoni, Luca; Gunzer, Matthias; Yablonski, Deborah; Schraven, Burkhart; Kliche, Stefanie
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 183.2009, 9, S. 5756-5767
Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo
Reinhold, Annegret; Reimann, Sibylle; Reinhold, Dirk; Schraven, Burkhart; Togni, Mauro
In: Journal of leukocyte biology - Bethesda, Md. : FASEB, Bd. 86 (2009), Heft 1, S. 61-71
Mechanisms of opioid-mediated inhibition of human T cell receptor signaling
Börner, Christine; Warnick, Beate; Smida, Michal; Hartig, Roland; Lindquist, Jonathan; Schraven, Burkhart; Höllt, Volker; Kraus, Jürgen
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 2, S. 882-889
2008
Herausgeberschaft
Sparking signals - kinases as molecular signaltransducers and pharmacological drug targets in inflammation
Baier, Gottfried; Schraven, Burkhart
In: Heidelberg [u.a.]: Springer, 2008, XIV, 185 S. - (Ernst Schering Foundation symposium proceedings; 2007,3), ISBN: 3-540-73500-3 Kongress: Symposium. Ernst Schering Foundation Potsdam 2007.06.20-22[Literaturangaben]
Originalartikel in begutachteter internationaler Zeitschrift
Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts
Tauzin, Sebastien; Ding, Heidrun; Khatib, Karim; Ahmad, Ishtiaq; Burdevet, Dimitri; Echten-Deckert, Gerhild van; Lindquist, Jonathan; Schraven, Burkhart; Din, Nasir-ud-; Borisch, Bettina; Hoessli, Daniel C.
In: Blood . - Washington, DC : American Society of Hematology, Bd. 111.2008, 4, S. 2310-2320
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
Veracini, Laurence; Simon, Valérie; Richard, Véronique; Schraven, Burkhart; Horejsi, Vaclav; Roche, Serge; Benistant, Christine
In: The journal of cell biology . - New York, NY : Rockefeller Univ. Press, Bd. 182.2008, 3, S. 603-614
SIT and TRIM determine T cell fate in the thymus
Kölsch, Uwe; Schraven, Burkhart; Simeoni, Luca
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 181.2008, 9, S. 5930-5939
A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration
Posevitz-Fejfár, Anita; Smida, Michal; Kliche, Stefanie; Hartig, Roland; Schraven, Burkhart; Lindquist, Jonathan A.
In: European journal of immunology - Weinheim : Wiley, Bd. 38 (2008), Heft 1, S. 250-259
CD28 superagonists: what makes the difference in humans?
Schraven, Burkhart; Kalinke, Ulrich
In: Immunity - Cambridge, Mass. : Cell Press, Bd. 28 (2008), Heft 5, S. 591-595
Regulation of T cell homeostasis by the transmembrane adaptor protein SIT
Posevitz, Vilmos; Arndt, Börge; Krieger, Tina; Warnecke, Nicole; Schraven, Burkhart; Simeoni, Luca
In: The journal of immunology : official journal of the American Association of Immunologists. - Bethesda, Md : American Assoc. of Immunologists, Bd. 180.2008, 3, S. 1634-1642
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells
Bekeredjian-Ding, Isabelle; Marshall, Anne; Schiller, Martin; Heyder, Petra; Lorenz, Hanns-Martin; Schraven, Burkhart; Bommhardt, Ursula; Heeg, Klaus
In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 181 (2008), Heft 12, S. 8267-8277, insges. 11 S. [Gefördert durch: Deutsche Forschungsgemeinschaft Grants BO1054/2-1 and LO 437/5-3; Im Titel ist + hochgestellt]
T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional [mu]-opioid receptors
Börner, Christine; Kraus, Jürgen; Bedini, Andrea; Schraven, Burkhart; Höllt, Volker
In: Molecular pharmacology - Bethesda, Md. : American Society for Pharmacology and Experimental Therapeutics, Bd. 74 (2008), Heft 2, S. 496-504
Signaling signatures and functional properties of antihuman CD28 superagonistic antibodies
Waibler, Zoe; Sender, Linda Y.; Merten, Camilla; Hartig, Roland; Kliche, Stefanie; Gunzer, Matthias; Reichardt, Peter; Kalinke, Ulrich; Schraven, Burkhart
In: PLOS ONE - San Francisco, California, US : PLOS - Bd. 3.2008, 3, Art. e1708, insges. 13 S.
Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells
Wang, Xiaoqian; Simeoni, Luca; Lindquist, Jonathan A.; Saez-Rodriguez, Julio; Ambach, Andreas; Gilles, Ernst D.; Kliche, Stefanie; Schraven, Burkhart
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 180.2008, 10, S. 6703-6712
Originalartikel in begutachteter zeitschriftenartiger Reihe
Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins
Simeoni, Luca; Lindquist, Jonathan A.; Smida, Michal; Witte, Vanessa Alexandra; Arndt, Börge; Schraven, Burkhart
In: Inhibition of immune cell function - Oxford : Blackwell Munksgaard , 2008 ; Cooper, Max D., Bd. 224 (2008), S. 215-228
Systems biology of T cell activation
Lindquist, Jonathan A.; Schraven, Burkhart
In: Sparking signals - kinases as molecular signaltransducers and pharmacological drug targets in inflammation - Berlin : Springer , 2008, S. 43-61
2007
Herausgeberschaft
Immunoreceptors & integrins
Schraven, Burkhart
In: Munksgaard: Blackwell, 2007, 264 S., Ill., graph. Darst. - (Immunological reviews; 218)
Immunoreceptors & integrins
Schraven, Burkhart
In: Munksgaard: Blackwell, 2007, 264 S. - (Immunological reviews; 218) [Literaturangaben]
Originalartikel in begutachteter internationaler Zeitschrift
Impact of HMG-CoA reductase inhibition on brain pathology
Zipp, Frauke; Waiczies, Sonia; Aktaş, Orhan; Neuhaus, Oliver; Hemmer, Bernhard; Schraven, Burkhart; Nitsch, Robert; Hartung, Hans-Peter
In: Trends in pharmacological sciences - Amsterdam : Cell Press, Bd. 28 (2007), Heft 7, S. 342-349
Deletion of the LIME adaptor protein minimally affects T and B cell development and function
Grégoire, Claude; Simova, Sarka; Wang, Ying; Sansoni, Amandine; Richelme, Sylvie; Schmidt-Giese, Anja; Simeoni, Luca; Angelisova, Pavla; Reinhold, Dirk; Schraven, Burkhart; Horejsi, Vaclav; Malissen, Bernard; Malissen, Marie
In: European journal of immunology - Weinheim: Wiley, Bd. 37 (2007), 11, S. 3259-3269
A logical model provides insights into T cell receptor signaling
Sáez Rodríguez, Julio; Simeoni, Luca; Lindquist, Jonathan A.; Hemenway, Rebecca; Bommhardt, Ursula; Arndt, Börge; Haus, Utz-Uwe; Weismantel, Robert; Gilles, Ernst D.; Klamt, Steffen; Schraven, Burkhart
In: PLoS Computational Biology - San Francisco, Calif: Public Library of Science, Bd. 3(2007), 8, insges. 11 S.
A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains - blocking Ras activation
Smida, Michal; Posevitz-Fejfár, Anita; Horejsi, Vaclav; Schraven, Burkhart; Lindquist, Jonathan A.
In: Blood: the journal of hematology / American Society of Hematology. William Dameshek, founding ed. - Washington, DC: American Society of Hematology, Bd. 110 (2007), 2, S. 596-605
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
Ménasché, Gaël; Kliche, Stefanie; Chen, Emily J. H.; Stradal, Theresia; Schraven, Burkhart; Koretzky, Gary
In: Molecular and cellular biology: MCB / American Society for Microbiology - Washington, DC: American Society for Microbiology, Bd. 27 (2007), 11, S. 4070-4081
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes
Davidson, Dominique; Schraven, Burkhart; Veillette, André
In: Molecular and cellular biology: MCB / American Society for Microbiology - Washington, DC: American Society for Microbiology, Bd. 27 (2007), 5, S. 1960-1973
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes
Davidson, Dominique; Schraven, Burkhart; Veillette, André
In: Molecular and cellular biology - Washington, DC : American Society for Microbiology, Bd. 27 (2007), Heft 5, S. 1960-1973
TGF-[beta]1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
Preller, Vera; Gerber, Annegret; Wrenger, Sabine; Togni, Mauro; Marguet, Didier; Tadje, Janine; Lendeckel, Uwe; Röcken, Christoph; Faust, Jürgen; Neubert, Klaus; Schraven, Burkhart; Martin, Roland; Ansorge, Siegfried; Brocke, Stefan; Reinhold, Dirk
In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 178 (2007), Heft 7, S. 4632-4640
Fyn regulates the duration of TCR engagement needed for commitment to effector function
Filby, Andrew; Seddon, Benedict; Kleczkowska, Joanna; Salmond, Robert; Tomlinson, Peter; Smida, Michal; Lindquist, Jonathan A.; Schraven, Burkhart; Zamoyska, Rose
In: The journal of immunology - Rockville, Md. : American Association of Immunologists, Bd. 179 (2007), Heft 7, S. 4635-4644
Impact of HMG-CoA reductase inhibition on brain pathology
Zipp, Frauke; Waiczies, Sonia; Aktaş, Orhan; Neuhaus, Oliver; Hemmer, Bernhard; Schraven, Burkhart; Nitsch, Robert; Hartung, Hans-Peter
In: Trends in pharmacological sciences: TIPS ; including toxicological sciences - Amsterdam: Cell Press, Bd. 28 (2007), 7, S. 342-349
In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction
Jordan, Martha S.; Maltzman, Jonathan S.; Kliche, Stefanie; Shabason, Jacob; Smith, Jennifer E.; Obstfeld, Amrom; Schraven, Burkhart; Koretzky, Gary A.
In: European journal of immunology - Weinheim: Wiley, Bd. 37 (2007), 10, S. 2961-2972
TGF-[beta]1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
Preller, Vera; Gerber, Annegret; Wrenger, Sabine; Togni, Mauro; Marguet, Didier; Tadje, Janine; Lendeckel, Uwe; Röcken, Christoph; Faust, Jürgen; Neubert, Klaus; Schraven, Burkhart; Martin, Roland; Ansorge, Siegfried; Brocke, Stefan; Reinhold, Dirk
In: The journal of immunology - Rockville, Md.: American Association of Immunologists, Bd. 178 (2007), 7, S. 4632-4640
In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction
Jordan, Martha S.; Maltzman, Jonathan S.; Kliche, Stefanie; Shabason, Jacob; Smith, Jennifer E.; Obstfeld, Amrom; Schraven, Burkhart; Koretzky, Gary A.
In: European journal of immunology - Weinheim : Wiley, Bd. 37 (2007), Heft 10, S. 2961-2972
Deletion of the LIME adaptor protein minimally affects T and B cell development and function
Grégoire, Claude; Simova, Sarka; Wang, Ying; Sansoni, Amandine; Richelme, Sylvie; Schmidt-Giese, Anja; Simeoni, Luca; Angelisova, Pavla; Reinhold, Dirk; Schraven, Burkhart; Horejsi, Vaclav; Malissen, Bernard; Malissen, Marie
In: European journal of immunology - Weinheim : Wiley, Bd. 37 (2007), Heft 11, S. 3259-3269
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
Ménasché, Gaël; Kliche, Stefanie; Chen, Emily J. H.; Stradal, Theresia; Schraven, Burkhart; Koretzky, Gary
In: Molecular and cellular biology - Washington, DC : American Society for Microbiology, Bd. 27 (2007), Heft 11, S. 4070-4081
ADAP is required for normal [alpha]IIb[beta]3 activation by VWF/GP Ib-IX-V and other agonists
Kasirer-Friede, Ana; Moran, Barry; Nagrampa-Orje, Jennifer; Swanson, Ken; Ruggeri, Zaverio M.; Schraven, Burkhart; Neel, Benjamin G.; Koretzky, Gary; Shattil, Sanford J.
In: Blood: the journal of hematology / American Society of Hematology. William Dameshek, founding ed. - Washington, DC: American Society of Hematology, Bd. 109 (2007), 3, S. 1018-1025
Fyn regulates the duration of TCR engagement needed for commitment to effector function
Filby, Andrew; Seddon, Benedict; Kleczkowska, Joanna; Salmond, Robert; Tomlinson, Peter; Smida, Michal; Lindquist, Jonathan A.; Schraven, Burkhart; Zamoyska, Rose
In: The journal of immunology - Rockville, Md.: American Association of Immunologists, Bd. 179 (2007), 7, S. 4635-4644
Originalartikel in begutachteter zeitschriftenartiger Reihe
Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap 1 effector molecules
Ménasché, Gaël; Kliche, Stefanie; Bezman, Natalie; Schraven, Burkhart
In: Immunoreceptors & integrins - Munksgaard : Blackwell , 2007 ; Schraven, Burkhart, Bd. 218 (2007), S. 82-91
Immunoreceptors and integrins
Schraven, Burkhart; Reth, Michael
In: Immunoreceptors & integrins - Munksgaard : Blackwell , 2007 ; Schraven, Burkhart, Bd. 218 (2007), S. 5-8
Immunoreceptors and integrins
Schraven, Burkhart; Reth, Michael
In: Immunoreceptors & integrins - Munksgaard: Blackwell, 2007; Schraven, Burkhart, Bd. 218 (2007), S. 5-8
Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap 1 effector molecules
Ménasché, Gaël; Kliche, Stefanie; Bezman, Natalie; Schraven, Burkhart
In: Immunoreceptors & integrins - Munksgaard: Blackwell, 2007; Schraven, Burkhart, Bd. 218 (2007), S. 82-91
2006
Herausgeberschaft
Cell communication in nervous and immune system
Gundelfinger, Eckart D.; Seidenbecher, Constanze; Schraven, Burkhart
In: Heidelberg: Springer, 2006, XIV, 313 S. - (Results and problems in cell differentiation; 43), ISBN: 3-540-36828-0, 978-3-540-36828-1 EUR 160.45 (freier Pr.), sfr 254.00 (freier Pr.)
Cell communication in nervous and immune system
Gundelfinger, Eckart D.; Seidenbecher, Constanze; Schraven, Burkhart
In: Heidelberg: Springer, 2006, XIV, 313 S., Ill., graph. Darst., 24 cm - (Results and problems in cell differentiation; 43)
Originalartikel in begutachteter internationaler Zeitschrift
Lipid-binding hSH3 domains in immune cell adapter proteins
Heuer, Katja; Sylvester, Marc; Kliche, Stefanie; Pusch, Rico; Thiemke, Katharina; Schraven, Burkhart; Freund, Christian
In: Journal of molecular biology - Amsterdam [u.a.] : Elsevier, Bd. 361 (2006), Heft 1, S. 94-104
Fatal neonatal-onset mitochondrial respiratory chain disease with T cell immunodeficiency
Reichenbach, Janine; Schubert, Ralf; Horvàth, Rita; Petersen, Jens; Fütterer, Nancy; Malle, Elisabeth; Stumpf, Andreas; Gebhardt, Boris R.; Koehl, Ulrike; Schraven, Burkhart; Zielen, Stefan
In: Pediatric research - New York : Springer Nature, Bd. 60 (2006), Heft 3, S. 321-326
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1
Kliche, Stefanie; Breitling, Dennis; Togni, Mauro; Pusch, Rico; Heuer, Katja; Wang, Xiaoqian; Freund, Christian; Kasirer-Friede, Ana; Menasche, Gael; Koretzky, Gary A.; Schraven, Burkhart
In: Molecular and cellular biology: MCB / American Society for Microbiology - Washington, DC: American Society for Microbiology, Bd. 26 (2006), 19, S. 7130-7144
Lipid-binding hSH3 domains in immune cell adapter proteins
Heuer, Katja; Sylvester, Marc; Kliche, Stefanie; Pusch, Rico; Thiemke, Katharina; Schraven, Burkhart; Freund, Christian
In: Journal of molecular biology / ed.-in-chief J. C. Kendrew - Amsterdam [u.a.]: Elsevier, Bd. 361 (2006), 1, S. 94-104
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1
Kliche, Stefanie; Breitling, Dennis; Togni, Mauro; Pusch, Rico; Heuer, Katja; Wang, Xiaoqian; Freund, Christian; Kasirer-Friede, Ana; Menasche, Gael; Koretzky, Gary A.; Schraven, Burkhart
In: Molecular and cellular biology - Washington, DC : American Society for Microbiology, Bd. 26 (2006), Heft 19, S. 7130-7144
Normal T-cell development and immune functions in TRIM-deficient mice
Kölsch, Uwe; Arndt, Börge; Reinhold, Dirk; Lindquist, Jonathan A.; Jüling, Nicole; Kliche, Stefanie; Pfeffer, Klaus; Bruyns, Eddy; Schraven, Burkhart; Simeoni, Luca
In: Molecular and cellular biology: MCB / American Society for Microbiology - Washington, DC: American Society for Microbiology, Bd. 26 (2006), Heft 9, S. 3639-3648
Fatal neonatal-onset mitochondrial respiratory chain disease with T cell immunodeficiency
Reichenbach, Janine; Schubert, Ralf; Horvàth, Rita; Petersen, Jens; Fütterer, Nancy; Malle, Elisabeth; Stumpf, Andreas; Gebhardt, Boris R.; Koehl, Ulrike; Schraven, Burkhart; Zielen, Stefan
In: Pediatric research: official journal of the Society for Pediatric Research, the American Pediatric Society, and the European Society for Paedriatic Research - New York: Springer Nature, Bd. 60 (2006), 3, S. 321-326
Normal T-cell development and immune functions in TRIM-deficient mice
Kölsch, Uwe; Arndt, Börge; Reinhold, Dirk; Lindquist, Jonathan A.; Jüling, Nicole; Kliche, Stefanie; Pfeffer, Klaus; Bruyns, Eddy; Schraven, Burkhart; Simeoni, Luca
In: Molecular and cellular biology - Washington, DC : American Society for Microbiology, Bd. 26 (2006), Heft 9, S. 3639-3648
Originalartikel in begutachteter zeitschriftenartiger Reihe
CD26/DP IV in T cell activation and autoimmunity
Preller, Vera; Gerber, Annegret; Togni, Mauro; Wrenger, Sabine; Schraven, Burkhart; Röcken, Christoph; Marguet, Didier; Ansorge, Siegfried; Brocke, Stefan; Reinhold, Dirk
In: Dipeptidyl aminopeptidases - New York: Springer Science + Business Media, 2006 . - 2006, S. 187-193
CD26/DP IV in T cell activation and autoimmunity
Preller, Vera; Gerber, Annegret; Togni, Mauro; Wrenger, Sabine; Schraven, Burkhart; Röcken, Christoph; Marguet, Didier; Ansorge, Siegfried; Brocke, Stefan; Reinhold, Dirk
In: Dipeptidyl aminopeptidases - basic science and clinical applications , 1. Ed. - New York : Springer Science + Business Media , 2006, S. 187-193
2005
Originalartikel in begutachteter internationaler Zeitschrift
Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
Togni, Mauro; Swanson, K.; Reimann, Sibylle; Kliche, Stefanie; Pearce, A.; Simeoni, Luca; Reinhold, Dirk; Wienands, J.; Neel, B.; Schraven, Burkhart; Gerber, Annegret
In: Mol. Cell. Biol. 25(2005), Nr. 18, S. 8052 - 8063
Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.
Wang, Y.; Horvath, O.; Hamm-Baarke, Andrea; Richelme, M.; Grgoire, C.; Schraven, Burkhart; ...,
In: Mol. Cell. Biol. 25(2005), Nr. 11, S. 4455 - 4465
The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.
Simeoni, Luca; Posevitz, Vilmos; Koelsch, Uwe; Meinert, Ines; Bruyns, E.; Pfeffer, K.; Reinhold, Dirk; Schraven, Burkhart
In: Mol. Cell. Biol. 25(2005), Nr. 17, S. 7557 - 7568
Right time, right place : the organization of membrane proximal signaling.
Simeoni, Luca; Smida, Michal; Posevitz, Vilmos; Schraven, Burkhart; Lindquist, Jonathan
In: Semin. Immunol. 17(2005), Nr. 1, S. 35 - 49
2004
Originalartikel in begutachteter internationaler Zeitschrift
The role of adaptor proteins in lymphocyte activation.
Togni, Mauro; Lindquist, Jonathan; Gerber, Annegret; Koelsch, Uwe; Hamm-Baarke, Andrea; Kliche, Stefanie; Schraven, Burkhart
In: Mol. Immunol. 41(2004), Nr. 6-7, S. 615 - 630
Shp2 regulates Src family kinase activity and Ras/Erk activation by controlling Csk recruitment.
Zhang, S.; Yang, W.; Kontaridis, M.; Schraven, Burkhart; Philips, M.; Neel, B.
In: Mol. Cell 13(2004), Nr. 3, S. 341 - 355
A novel flow cytometric assay focusing on perforin release mechanisms of cytotoxic T lymphocytes.
Weren, Andrea; Bonnekoh, Bernd; Schraven, Burkhart; Gollnick, Harald; Ambach, Andreas
In: J. Immunol. Methods 289(2004), Nr. 1-2, S. 17 - 26
Expression of cell surface antigens in diabetic patients and healthy controls after injury.
Lobmann, Ralf; Ittenson, Annelore; Schiweck, S.; Motzkau, Markus; Schraven, Burkhart; Winckler, Stephan; Lehnert, Hendrik
In: Diabetes Nutr. Metab. 17(2004), Nr. 4, S. 244 - 246
Transmembrane adapters : structure, biochemistry and biology.
Kliche, Stefanie; Lindquist, Jonathan; Schraven, Burkhart
In: Semin. Immunol. 16(2004), Nr. 6, S. 367 - 377
Grb2 and the non-T cell activation linker NTAL constitute a Ca2+-regulating signal circuit in B lymphocytes.
Stork, B.; Engelke, M.; Frey, J.; Horejs¡, V.; Hamm-Baarke, Andrea; Schraven, Burkhart; Kurosaki, T.; Wienands, J.
In: Immunity 21(2004), Nr. 5, S. 681 - 691
Adaptors and linkers in T and B cells.
Simeoni, Luca; Kliche, Stefanie; Lindquist, Jonathan; Schraven, Burkhart
In: Curr. Opin. Immunol. 16(2004), Nr. 3, S. 304 - 313
Transmembrane adaptor proteins : organizers of immunoreceptor signalling.
Horejs¡, V.; Zhang, W.; Schraven, Burkhart
In: Nat. Rev. Immunol. 4(2004), Nr. 8, S. 603 - 616
Nicht begutachteter Zeitschriftenartikel
Grundsätzliches und Neues aus der Immunologie.
Schraven, Burkhart
In: Dtsch. Z. Klin. Forsch. 8(2004), Nr. 9/10, [8 S.]
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