Prof. Stork

Prof. Dr. sc. nat. habil. Oliver Stork
Institut für Biologie (IBIO)
Aktuelle Projekte
- DFG 488/8-1 - Zur Rolle von Filamin A bei integrinabhängigem Dendritenwachstum und hippokampalen Funktionen
Laufzeit: 01.06.2022 - 31.05.2025 - SFB 1436/1 - Z01 "Functional neural circuit analysis and small animal imaging in vivo"
Laufzeit: 01.01.2021 - 31.12.2024 - SFB 1436/1 - TP MGK / IRTG
Laufzeit: 01.01.2021 - 31.12.2024 - SBF 1436/1 - A07 "Molecular & cellular determinants of neural resources - Orexinergic modulation of neural resource"
Laufzeit: 31.01.2021 - 31.12.2024 - DFG 488/9-1 - NPY-vermittelte Autophagie und die Stressadaptation hippokampaler Schaltkreise - TP RP9
Laufzeit: 15.11.2021 - 14.11.2024 - DZP-CIRC: Schaltkreise der (Fehl-)Anpassung des Verhaltens: Mikro- und Mesoschaltungsplastizität in frühen Widrigkeiten und Traumata
Laufzeit: 01.12.2022 - 31.12.2023 - GRK 2413/1 - SynAge TP02 - "Autophagy mechanisms in the aging hippocampus" (1. Förderperiode)
Laufzeit: 01.01.2019 - 30.06.2023 - Dopaminerge Modulation der Schaltungsanregbarkeit und Plastizität in der lateralen Amygdala.
Laufzeit: 01.01.2020 - 30.06.2023 - GeNeRARe - Deutsches Forschungsnetzwerk für RASopathien
Laufzeit: 01.07.2019 - 30.06.2023 - GRK 2413/1 - SynAge TP10 - "Hippocampal interneuron circuits during cognitive decline" (1. Förderperiode)
Laufzeit: 01.01.2019 - 30.06.2023
Abgeschlossene Projekte
- ADAPtive T Zell Migration ins gestresste Hirn
Laufzeit: 01.01.2018 - 30.06.2022 - ABINEP M2-project 5: Modulation verhaltensrelevanter Oszillationen durch Interneuron-Netzwerke
Laufzeit: 01.02.2017 - 30.05.2022 - CBBS Science Campus: Elucidating the role of ventral hippocampal network oscillations in fear memory persistence
Laufzeit: 01.04.2018 - 31.05.2021 - DENDRITISCHE VERZWEIGUNG VON NEURONEN: SUBSTRAT-SPEZIFITÄT DURCH NDR2 UND PRÄZISE KONTROLLE DURCH FILAMIN A.
Laufzeit: 01.02.2017 - 30.04.2021 - SBF 1436/1 Start-up Funding - A07 "Molecular & cellular determinants of neural resources - Orexinergic modulation of neural resource"
Laufzeit: 01.07.2020 - 31.12.2020 - SFB 1436/1 Start-up funding - Z01 "Functional neural circuit analysis and small animal imaging in vivo"
Laufzeit: 01.07.2020 - 31.12.2020 - CBBS - Life Cell Imaging System
Laufzeit: 01.09.2019 - 31.12.2020 - CBBS ScienceCampus -"Elucidating the role of ventral hippocampal network oscillations in fear memory persistence" (Funded by the Leibniz Association, grant ID: SAS-2015-LIN-LWC) -- € 80,000
Laufzeit: 01.06.2018 - 01.03.2020 - GABAerger Interneurone als Vermittler kognitiver Flexibilität
Laufzeit: 01.01.2016 - 31.12.2019 - Vulnerabilität und Resilienz gegen pathologisches Furchtgedächtnis - die Rolle neuropeptiderger Modulation im Gyrus Dentatus
Laufzeit: 01.02.2016 - 31.07.2019 - Deutsches Forschungsnetzwerk für RASopathien: Kognitive Funktionen in Mausmodellen
Laufzeit: 01.02.2016 - 31.01.2019 - Monoaminergic IMPACT on Neuronal Circuits - a Leibniz Postdoctoral Network (LPN)
Laufzeit: 01.07.2015 - 31.12.2018 - Die Rolle der Serin/Threonin Kinase Ndr2 bei integrinvermittelter neuronaler Plastizität und Lernen
Laufzeit: 01.01.2015 - 30.06.2018 - ERARE - Verbund: Präklinische Entwicklung therapeutischer Ansätze für Träger einer Prämutation im Fragilen X Gen (Drug FXSPreMut)
Laufzeit: 01.03.2015 - 31.03.2018 - Proteindegradierung in Furchtgedächtnis und PTBS: Rolle der Ubiquitin Ligase Praja1
Laufzeit: 01.10.2013 - 31.03.2017 - Zelluläre Mechanismen integrinvermittelter neuronaler Differenzierung
Laufzeit: 01.01.2015 - 31.12.2016 - E-RARE-Verbund: Entwicklung therapeutischer Interventionen im Fragilen X assoziierten Tremor und Ataxie Syndrom (Cure-FXTAS)
Laufzeit: 01.05.2013 - 30.04.2016 - Funktion GABAerger Interneurone des amygdalo- hippokampalen Systems in der Balance von aversiver Motivation und Verhaltensinhibition
Laufzeit: 01.01.2012 - 31.12.2015 - GABAerge Interneurone bei der Furchtkonditionierung: Rolle synaptischer GAD- Expression
Laufzeit: 01.04.2011 - 31.03.2015 - Role of the hippocampal GABA system in the development of post-traumatic stress symptoms
Laufzeit: 01.02.2010 - 31.01.2015 - Regulation von Aktinfilamentdynamik und aktinvermittelten Transportprozessen durch RhoGEFs und assoziierte Kinasen in T-Zellen und Neuronen
Laufzeit: 01.04.2010 - 30.09.2014 - Modulation des „Inside-out/Outside-in Signalings“ von Integrinen in der immunologischen und der neuronalen Synapse
Laufzeit: 01.01.2010 - 30.06.2014 - GABAerge Mechanismen bei der Milderung stressinduzierter Effekte
Laufzeit: 01.03.2011 - 30.11.2013 - E-RARE Verbund: Rho Signalwege als Ziel neuer therapeutischer Strategien im fragilen X-Syndrom. Auswirkungen pharmakologischer Interventionen auf die Gedächtnisbildung und -speicherung im genetischen Mausmodell (CURE-FXS), Teilprojekt Magdeburg
Laufzeit: 01.05.2010 - 31.08.2013 - Epigenetische Mechanismen der Posttraumatischen Belastungsstörung
Laufzeit: 01.01.2010 - 31.12.2011 - GABAerge Neurone als Schnittstellen amygdalo-hippokampaler Interaktionen bei der Gedächtnisbildung
Laufzeit: 01.01.2008 - 31.12.2011 - Bedeutung Ndr2-vermittelter Signaltransduktion und Mikrofilament-dynamik für die Gedächtniskonsolidierung
Laufzeit: 01.01.2007 - 31.05.2010 - Aktivierungsmechanismen der Serin/Threonin Kinase Ndr2 und ihre Auswirkungen auf Aktin-vermittelte strukturelle Prozesse in neuronalen Zellen
Laufzeit: 01.10.2005 - 31.03.2010 - Einfluss von Stressfaktoren auf die Entwicklung corticaler Netzwerke: Zelluläre Mechanismen und Reversibilität CRH-induzierter synaptischer Plastizität
Laufzeit: 01.01.2007 - 31.12.2009 - Molekulare Analyse struktureller und funktioneller Prozesse der Amygdala mit Bezug zu erlernter und pathopsychologischer Veränderungen emotionaler Informationsverarbeitung
Laufzeit: 01.04.2003 - 31.03.2007 - Molekulare Mechanismen konditionierter Furcht: Expression und Wirkung von Neuropeptiden
Laufzeit: 01.01.2003 - 31.12.2005
2022
Abstract
Choosing memory retrieval strategies - a critical role for inhibition in the dentate gyrus
In: FENS Forum - FENS, 2022 . - 2022
Filamin A modulates dendritic branching via integrin-akt axis and actin cytoskeleton
In: FENS Forum - FENS, 2022 . - 2022
Trehalose increases TFEB and autophagic flux in the dorsal hippocampus, and produces changes in exploratory behaviour in old mice
In: FENS Forum - FENS, 2022 . - 2022
Begutachteter Zeitschriftenartikel
Allostatic gene regulation of inhibitory synaptic factors in the rat ventral hippocampus in a juvenile/adult stress model of psychopathology
In: European journal of neuroscience - Oxford [u.a.]: Wiley, 1989, Bd. 55 (2022), 9/10, S. 2142-2153
Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus
In: Brain, behavior and immunity - Orlando, Fla. [u.a.]: Elsevier, Bd. 99 (2022), S. 203-217
Choosing memory retrieval strategies - a critical role for inhibition in the dentate gyrus
In: Neurobiology of Stress - Amsterdam [u.a.]: Elsevier, 2015, Bd. 20 (2022), insges. 11 S.
Comparison of three common inbred mouse strains reveals substantial differences in hippocampal GABAergic interneuron populations and in vitro network oscillations
In: Authorea - Hoboken: Authorea . - 2022, insges. 22 S.
Early life stress exacerbates behavioural and neuronal alterations in adolescent male mice lacking methyl-CpG binding protein 2 (Mecp2)
In: Frontiers in behavioral neuroscience - Lausanne: Frontiers Research Foundation, Bd. 16 (2022), insges. 16 S.
Fear engrams and NPYergic circuit in the dorsal dentate gyrus determine remote fear memory generalization
In: bioRxiv beta - Cold Spring Harbor: Cold Spring Harbor Laboratory, NY . - 2022, insges. 28 S.
MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice
In: Journal of neurodevelopmental disorders - New York, NY: Springer, Bd. 13 (2022), 1, insges. 12 S.
2021
Abstract
Sex differences in emotional information processing in the GAD65 knock out model of heightened stress susceptibility
In: Neuroforum - Berlin: De Gruyter, 2003, Bd. 27 (2021), 1, Supplement, insges. 1 S.
The functional effects of the Rasopathy-related KRASV14l mutation in the brain
In: Neuroforum - Berlin: De Gruyter, 2003, Bd. 27 (2021), 1, Supplement, insges. 1 S.
Begutachteter Zeitschriftenartikel
Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 11 (2021), insges. 12 S.
Reducing glutamic acid decarboxylase in the dorsal dentate gyrus attenuates juvenile stress induced emotional and cognitive deficits
In: Neurobiology of Stress - Amsterdam [u.a.]: Elsevier, 2015, Bd. 15 (2021), insges. 12 S.
Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats
In: Nature Communications - [London]: Nature Publishing Group UK, Bd. 12 (2021), insges. 17 S.
The presynaptic scaffold protein Bassoon in forebrain excitatory neurons mediates hippocampal circuit maturation - potential involvement of TrkB signalling
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 15, insges. 15 S.
To err is (not only) human - mechanisms of post-error attentional regulation illuminated in mice
In: Neuron - [Cambridge, Mass.]: Cell Press, Bd. 109 (2021), 7, S. 1074-1076
Transgenic modeling of Ndr2 gene amplification reveals disturbance of hippocampus circuitry and function
In: iScience - Amsterdam: Elsevier, 2018, Bd. 24 (2021), 8, insges. 23 S.
Dissertation
Involvement of TRPC4 and TRPC5 channels in persistent firing in the hippocampus and in the medial entorhinal cortex
In: Magdeburg, 2021, 212 Blätter, Illustrationen, Diagramme, 30 cm
NDR2 and filamin A as modulators of integrin activation during dendritic growth
In: Magdeburg, 2021, xi, 143 Blätter, Illustrationen, Diagramme, 30 cm
2020
Begutachteter Zeitschriftenartikel
Dietary phytoestrogens modulate aggression and activity in social behavior circuits of male mice
In: Hormones and behavior - Orlando, Fla.: Acad. Press, Volume 119 (2019), Artikel 104637, 2020
Glutamic acid decarboxylase 67 haplodeficiency in mice - consequences of postweaning social isolation on behavior and changes in brain neurochemical systems
In: Brain structure & function - Berlin: Springer, 2007, Bd. 225.2020, 6, S. 1719-1742
Hippocampal GABAergic interneurons and their co-localized neuropeptides in stress vulnerability and resilience
In: Neuroscience & biobehavioral reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 122 (2021), S. 229-244
Male-specific features are reduced in Mecp2-null mice - analyses of vasopressinergic innervation, pheromone production and social behaviour
In: Brain structure & function - Berlin: Springer, Bd. 225.2020, 7, S. 2219-2238
Region-specific involvement of interneuron subpopulations in trauma-related pathology and resilience
In: Neurobiology of disease - Orlando, Fla.: Academic Press, 1994, Bd. 143.2020, Art.-Nr. 104974, insgesamt 11 Seiten
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus
In: Neuropsychopharmacology - London: Springer Nature, Bd. 45 (2020), 12, S. 2120-2130
Buchbeitrag
Active resilience in response to traumatic stress
In: Stress resilience: molecular and behavioral aspects / edited by Alon Chen: molecular and behavioral aspects - London, United Kingdom: Elsevier/Academic Press, 2020 . - 2020, S. 95-106
Dissertation
Reversibility of the pathology in a mouse model of fragile X-associated tremor/ataxia syndrome - exploring time-dependence and intervention strategies
In: Magdeburg, 2020, xii, 116, A-O Blätter, Illustrationen, Diagramme, 30 cm ; [Literaturverzeichnis: Blatt 105-116]
2019
Abstract
A depletion of dietary phytoestrogen in the adult C57BL/6 mice affects contextual fear and hippocampal plasticity
In: 37th Göttingen Neurobiology Conference: 13th Göttingen Meeting of the German Neuroscience Society, March 20 - 23, 2019 : proceedings - Neurowissenschaftliche Gesellschaft, 2019, 2019, Artikel T25-14C - (Neuroforum, Band 25, Suppl. 1)
Augmented ventral hippocampal network oscillations in mouse strains with elevated anxiety and impaired fear extinction
In: 37th Göttingen Neurobiology Conference: 13th Göttingen Meeting of the German Neuroscience Society, March 20 - 23, 2019 : proceedings - Neurowissenschaftliche Gesellschaft, 2019, 2019, Artikel T25-7A - (Neuroforum, Band 25, Suppl. 1)
Behavioral analysis of conditional knockout mice for a presynaptic active zone protein Bassoon in excitatory, inhibitory and dopaminergic nerve terminals
In: 37th Göttingen Neurobiology Conference: 13th Göttingen Meeting of the German Neuroscience Society, March 20 - 23, 2019 : proceedings - Neurowissenschaftliche Gesellschaft, 2019, 2019, Artikel T25-2A - (Neuroforum, Band 25, Suppl. 1)
Changes in hippocampal network oscillations and single cell properties of GAD65 KO mice-a model of reduced GABAergic synthesis
In: 37th Göttingen Neurobiology Conference: 13th Göttingen Meeting of the German Neuroscience Society, March 20 - 23, 2019 : proceedings - Neurowissenschaftliche Gesellschaft, 2019, 2019, Artikel T23-6C - (Neuroforum, Band 25, Suppl. 1)
Disruption in the hippocampal network function in inducible FMR1 premutation mice
In: 37th Göttingen Neurobiology Conference: 13th Göttingen Meeting of the German Neuroscience Society, March 20 - 23, 2019 : proceedings - Neurowissenschaftliche Gesellschaft, 2019, 2019, Artikel T11-16B - (Neuroforum, Band 25, Suppl. 1)
Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase
In: 37th Göttingen Neurobiology Conference: 13th Göttingen Meeting of the German Neuroscience Society, March 20 - 23, 2019 : proceedings - Neurowissenschaftliche Gesellschaft, 2019 - 13th Göttingen Meeting of the German Neuroscience Society, March 20 - 23, 2019 : proceedings, 2019, Artikel T13-1A - (Neuroforum, Band 25, Suppl. 1)
Role of Ndr2 kinase in substrate-specific neurite growth and spine development
In: 37th Göttingen Neurobiology Conference: 13th Göttingen Meeting of the German Neuroscience Society, March 20 - 23, 2019 : proceedings - Neurowissenschaftliche Gesellschaft, 2019, 2019, Artikel T2-1B - (Neuroforum, Band 25, Suppl. 1)
Begutachteter Zeitschriftenartikel
Depletion of dietary phytoestrogens reduces hippocampal plasticity and contextual fear memory stability in adult male mouse
In: Nutritional neuroscience - Abingdon, Oxon: Routledge, Taylor and Francis Group, 1998 . - 2019
Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system
In: Brain structure & function - Berlin: Springer, Bd. 224 (2019), 4, S. 1647-1658
Persistent increase in ventral hippocampal long-term potentiation by juvenile stress - a role for astrocytic glutamine synthetase
In: Glia - Bognor Regis [u.a.]: Wiley-Liss, Bd. 67 (2019), 12, S. 2279-2293
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, Volume 10.2019, article number 5448, insgesamt 17 Seiten
The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Volume 9 (2019), article number 13513, insgesamt 11 Seiten
Dissertation
Roles of the Hippo pathway kinase Ndr2 in neural development and behavior
In: Magdeburg, 2019, xii, 87 Blätter, Illustrationen, Diagramme, 30 cm ; [Literaturverzeichnis: Blatt 76-86]
Herausgeberschaft
Circadian rhythms in regulation of brain processes and role in psychiatric disorders
In: New York, NY: Hindawi, 2018, 1 Online-Ressource
Research topic "learning and memory"
In: Lausanne: Frontiers Research Foundation, 2019, 1 Online-Ressource
2018
Abstract
Augmented hippocampal network oscillations in a mouse model of reduced GABA synthesis
In: 11th FENS Forum of Neuroscience - FENS, 2018, 2018, Abstract 1179
Conditional knockout of active zone protein Bassoon in forebrain excitatory synapses display altered dentate gyrus maturation and dentate gyrus-dependent learning
In: 11th FENS Forum of Neuroscience: 7-11 July 2018, Berlin, Germany ; abstracts - FENS, 2018, 2018, Abstract 1067
Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells
In: European journal of immunology: basic, clinical, translational - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 1, P214, Seite 185-186
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
In: 11th FENS Forum of Neuroscience: 7-11 July 2018, Berlin, Germany ; abstracts - FENS, 2018, 2018, Abstract 3915
Reduction of hippocampal plasticity and contextual fear memory in the adult male mouse by depletion of dietary phyto-oestrogens
In: 11th FENS Forum of Neuroscience: 7-11 July 2018, Berlin, Germany ; abstracts - FENS, 2018, 2018, Abstract 989
Role of Ndr2, a serine/threonine kinase, on the mossy fiber development and its contribution to the Pallister-Killian Syndrome
In: 11th FENS Forum of Neuroscience: 7-11 July 2018, Berlin, Germany ; abstracts - FENS, 2018, 2018, Abstract 2490
Substrate-specific neurite growth controlled by Ndr2 kinase through α1 integrin expression
In: 11th FENS Forum of Neuroscience: 7-11 July 2018, Berlin, Germany ; abstracts - FENS, 2018, 2018, Abstract 389
Begutachteter Zeitschriftenartikel
Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance
In: Brain structure & function - Berlin: Springer, 2007, Bd. 223.2018, 7, S. 3423-3445
Animal models of PTSD - a challenge to be met
In: Molecular psychiatry - London: Macmillan, Bd. 24 (2019), 8, S. 1135-1156, 2018
Caldendrin directly couples postsynaptic calcium signals to actin remodeling in dendritic spines
In: Neuron - [Cambridge, Mass.]: Cell Press, Bd. 97.2018, 5, S. 994-996
Circadian rhythms in regulation of brain processes and role in psychiatric disorders
In: Neural plasticity - New York, NY: Hindawi, Volume 2018 (2018), article ID 5892657, insgesamt 3 Seiten
Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 9.2018, Art.-Nr. 2852, insges. 16 S.
GAD65 promoter polymorphism rs2236418 modulates harm avoidance in women via inhibition/excitation balance in the rostral ACC
In: The journal of neuroscience: the official journal of the Society for Neuroscience - Washington, DC: Soc., 1981, Bd. 38.2018, 22, S. 5067-5077
Hippocampal network oscillations as mediators of behavioural metaplasticity - insights from emotional learning
In: Neurobiology of learning and memory - Orlando, Fla.: Academic Press, 1995 . - 2018, insges. 17 S.
Hippocampal network oscillations at the interplay between innate anxiety and learned fear
In: Psychopharmacology - Berlin: Springer, Bd. 236 (2018), 1, S. 321-338
Ndr2 kinase controls neurite outgrowth and dendritic branching through [alpha]1 integrin expression
In: Frontiers in molecular neuroscience - Lausanne: Frontiers Research Foundation, Bd. 11.2018, Art.-Nr. 66, insges. 11 S.
Dissertation
Role of HIPP cells in the dentate gyrus during fear memory formation
In: Magdeburg, 2017, xii, 119 Blätter, Illustrationen ; [Literaturverzeichnis: Blatt 84-104]
2017
Abstract
Region specific metabolic correlates contribute to gene and sex relationship of transitional anxiety phenotypes
In: Biological psychiatry: a journal of psychiatric neuroscience ; a publication of the Society of Biological Psychiatry - Amsterdam [u.a.]: Elsevier Science, 1985, Bd. 81.2017, 10, Suppl., Abs. 579, S. S234
Begutachteter Zeitschriftenartikel
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy
In: PLoS Genetics/ Public Library of Science - San Francisco, Calif.: Public Library of Science, 2005, Bd. 13.2017, 3, Art.-Nr. e1006684, insges. 37 S.
Circadian rhythms in fear conditioning - an overview of behavioral, brain system, and molecular interactions
In: Neural plasticity - New York, NY: Hindawi, insges. 12 S., 2017
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, Vol. 8.2017, Art. 189, insgesamt 15 S.
Neurobiological consequences of juvenile stress - a GABAergic perspective on risk and resilience
In: Neuroscience & biobehavioral reviews: official journal of the International Behavioral Neuroscience Society - Amsterdam [u.a.]: Elsevier Science - official journal of the International Behavioral Neuroscience Society, Vol. 74.2017, Part A, S. 21-43
Receptor tyrosine kinase inhibition by regorafenib/sorafenib inhibits growth and invasion of meningioma cells
In: European journal of cancer - Amsterdam [u.a.]: Elsevier, 1965, Bd. 73.2017, S. 9-21
Selective rescue of heightened anxiety but not gait ataxia in a premutation 90CGG mouse model of Fragile X-associated tremor/ataxia syndrome
In: Human molecular genetics: HMG online - Oxford: Oxford Univ. Press, Bd. 26.2017, 11, S. 2133-2145
2016
Begutachteter Zeitschriftenartikel
A Jacob/Nsmf gene knockout results in hippocampal dysplasia and impaired BDNF signaling in dendritogenesis
In: PLoS Genetics: a peer-reviewed, open-access journal/ Public Library of Science - San Francisco, Calif.: Public Library of Science, 2005, Bd. 12.2016, 3, Art.-Nr. e1005907, insges. 32 S.
Identification of parvalbumin interneurons as cellular substrate of fear memory persistence
In: Cerebral cortex - Oxford: Oxford Univ. Press, Bd. 26 (2016), 5, S. 2325-2340
Integrin activation through the hematopoietic adapter molecule ADAP regulates dendritic development of hippocampal neurons
In: Frontiers in molecular neuroscience - Lausanne: Frontiers Research Foundation, Bd. 9 (2016), Art.-Nr. 91, insges. 14 S.
Quantitative proteomics reveals protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse
In: Behavioural brain research : an international journal. - Amsterdam : Elsevier, Bd. 303.2016, S. 208-217
Shifts in excitatory/inhibitory balance by juvenile stress - a role for neuron-astrocyte interaction in the dentate gyrus
In: Glia - Bognor Regis [u.a.]: Wiley-Liss, Bd. 64 (2016), 6, S. 911-922
2015
Begutachteter Zeitschriftenartikel
5-HT receptor-mediated modulation of granule cell inhibition after juvenile stress recovers after a second exposure to adult stress
In: Neuroscience - an international journal under the editorial direction of IBRO: an international journal under the editorial direction of IBRO - Amsterdam [u.a.]: Elsevier Science, Bd. 293.2015, S. 67-79
Contextual fear conditioning modulates hippocampal AMPA-, GluN1- and serotonin receptor 5-HT1A-containing receptor complexes
In: Behavioural brain research. - Amsterdam : Elsevier, Bd. 278.2015, S. 44-54
Differential modulation of synaptic plasticity and local circuit activity in the dentate gyrus and CA1 regions of the rat hippocampus by corticosterone
In: Stress: the international journal on the biology of stress - Abingdon: Taylor & Francis Group, Bd. 18.2015, 3, S. 319-327
Fear memory and the amygdala - Insights from a molecular perspective
In: Cell & tissue research - Berlin: Springer, Bd. 310.2015, 3, S. 271-277
Genetic analysis of the glyoxalase system in schizophrenia
In: Progress in neuro-psychopharmacology & biological psychiatry: an international research, review, and news journal - Amsterdam [u.a.]: Elsevier Science, Bd. 59.2015, S. 105-110
Identification and characterization of GABAergic projection neurons from ventral hippocampus to amygdala
In: Brain Sciences - Basel: MDPI AG, Bd. 5 (2015), 3, S. 299-317
Individual phases of contextual fear conditioning differentially modulate dorsal and ventral hippocampal GluA1-3, GluN1-containing receptor complexes and subunits
In: Hippocampus - New York, NY [u.a.]: Wiley, Bd. 25.2015, 12, S. 1501-1516
Limbic encephalitis - potential impact of adaptive autoimmune inflammation on neuronal circuits of the amygdala
In: Frontiers in neurology - Lausanne: Frontiers Research Foundation, Vol. 6.2015, Art. 171, insgesamt 10 S.
Long-term changes in the CA3 associative network of fear-conditioned mice
In: Stress: the international journal on the biology of stress - Abingdon: Taylor & Francis Group - the international journal on the biology of stress, Bd. 18 (2015), 2, S. 188-197
The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology
In: Genes, brain and behavior: official journal of IBANGS - International Behavioural and Neural Genetics Society - Copenhagen [u.a.]: Blackwell Munksgaard, 2002, Bd. 14.2015, 1, S. 37-45
Timing of presentation and nature of stimuli determine retroactive interference with social recognition memory in mice
In: Physiology & behavior: official journal of the International Behavioral Neuroscience Society - Amsterdam [u.a.]: Elsevier Science, Bd. 143 (2015), S. 10-14
Transcriptional regulation of glutamic acid decarboxylase in the male mouse amygdala by dietary phyto-oestrogens
In: Journal of neuroendocrinology: the official journal of the European Neuroendocrine Association and the British Neuroendocrine Group - Oxford [u.a.]: Wiley-Blackwell, Bd. 27.2015, 4, S. 285-292
2014
Begutachteter Zeitschriftenartikel
Amygdala activation and GABAergic gene expression in hippocampal sub-regions at the interplay of stress and spatial learning
In: Frontiers in behavioral neuroscience. - Lausanne : Frontiers Research Foundation; Vol. 8.2014, Art. 3, insgesamt 8 S.
GAD65 haplodeficiency conveys resilience in animal models of stress-induced psychopathology
In: Frontiers in behavioral neuroscience. - Lausanne : Frontiers Research Foundation; Vol. 8.2014, Art. 265, insgesamt 10 S.
Glutamic acid decarboxylase 67 haplodeficiency impairs social behavior in mice
In: Genes, brain and behavior - Copenhagen [u.a.]: Blackwell Munksgaard, 2002, Bd. 13.2014, 4, S. 439-450
Hippocampal protein kinase C family members in spatial memory retrieval in the mouse
In: Behavioural brain research. - Amsterdam : Elsevier, Bd. 258.2014, S. 202-207
NCAM deficiency in the mouse forebrain impairs innate and learned avoidance behaviours
In: Genes, brain and behavior. - Copenhagen [u.a.] : Blackwell Munksgaard, Bd. 13.2014, 5, S. 468-477
Networks of protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6j mouse
In: Behavioural brain research - Amsterdam: Elsevier, Bd. 280 (2015), S. 45-50, 2014
The GABA-synthetic enzyme GAD65 controls circadian activation of conditioned fear pathways
In: Behavioural brain research. - Amsterdam : Elsevier, Bd. 260.2014, S. 92-100
The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology
In: Genes, brain and behavior. - Copenhagen [u.a.] : Blackwell Munksgaard, 2014
The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth
In: The journal of neuroscience - Washington, DC: Soc, 1981, Bd. 34.2014, 15, S. 5342-5354
Dissertation
Modulation of social and emotional behaviors by glutamic acid decarboxylase (GAD) and phytoestrogens
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014, XIV, 199 S., Ill., graph. Darst., 21 cm
2013
Begutachteter Zeitschriftenartikel
Circadian modulation of anxiety - a role for somatostatin in the amygdala
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Vol. 8.2013, 12, Art. e84668, insgesamt 12 S.
Distinct set of kinases induced after retrieval of spatial memory discriminate memory modulation processes in the mouse hippocampus
In: Hippocampus - New York, NY [u.a.]: Wiley, 1991, Bd. 23.2013, 8, S. 672-683
Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model
In: The journal of neuroscience: the official journal of the Society for Neuroscience - Washington, DC: Soc., 1981, Bd. 33.2013, 38, S. 15259-15271
Long-lasting increase of corticosterone after fear memory reactivation - anxiolytic effects and network activity modulation in the ventral hippocampus
In: Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology - London: Springer Nature - official publication of the American College of Neuropsychopharmacology, Bd. 38 (2013), 3, S. 386-394
Role of stress system disturbance and enhanced novelty response in spatial learning of NCAM-deficient mice
In: Stress: the international journal on the biology of stress - Abingdon: Taylor & Francis Group, 1996, Bd. 16.2013, 6, S. 638-646
Stress-induced metaplasticity - from synapses to behavior
In: Neuroscience - an international journal under the editorial direction of IBRO: an international journal under the editorial direction of IBRO - Amsterdam [u.a.]: Elsevier Science, 1976, Bd. 250.2013, S. 112-120
The ubiquitin ligase praja1 reduces NRAGE expression and inhibits neuronal differentiation of PC12 cells
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Vol. 8.2013, 5, Art. e63067, insgesamt 8 S.
mTORC1 inhibitors suppress meningioma growth in mouse models
In: Clinical cancer research - Philadelphia, Pa. [u.a.]: AACR, Bd. 19 (2013), 5, S. 1180-1189
2012
Begutachteter Zeitschriftenartikel
Are NCAM deficient mice an animal model for schizophrenia?
In: Frontiers in behavioral neuroscience . - Lausanne : Frontiers Research Foundation, Bd. 6.2012, insges. 9 S.
Originalartikel in begutachteter internationaler Zeitschrift
Synaptology of ventral CA1 and subiculum projections to the basomedial nucleus of the amygdala in the mouse: relation to GABAergic interneurons
In: Brain structure & function. - Berlin : Springer, Bd. 217.2012, 1, S. 5-17
2011
Dissertation
Die funktionelle Bedeutung der Serin/Threonin-Kinase Ndr2 in Integrin-Signalwegen für die Differenzierung neuronaler Zellen
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2011, XIV, 143 S., graph. Darst.
Originalartikel in begutachteter internationaler Zeitschrift
Neuropeptide S-mediated facilitation of synaptic transmission enforces subthreshold theta oscillations within the lateral amygdala
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 6.2011, 3, Artikel-Nr. e18020 insges. 10 S.
2010
Dissertation
Molecular mechanisms of classical fear conditioning - GABAergic factors and their role in fear-related network activities
In: Magdeburg Univ., Fak. für Naturwiss., Diss., 2010, 132 Bl., graph. Darst., 30 cm
Originalartikel in begutachteter internationaler Zeitschrift
Disruption of fear memory consolidation and reconsolidation by actin filament arrest in the basolateral amygdala
In: Neurobiology of learning and memory: an interdisciplinary journal - Amsterdam: Elsevier, 1995, Bd. 94.2010, 2, S. 117-126
Role of the neural cell adhesion molecule (NCAM) in amygdalo-hippocampal interactions and salience determination of contextual fear memory
In: The international journal of neuropsychopharmacology - Oxford: Oxford Univ. Press, 1998, Bd. 13.2010, 5, S. 661-674
2009
Originalartikel in begutachteter internationaler Zeitschrift
Behavioral effects and pattern of brain c-fos mRNA induced by 2,5-dihydro-2,4,5-trimethylthiazoline, a component of fox feces odor in GAD67-GFP knock-in C57BL/6 mice
In: Behavioural brain research . - Amsterdam : Elsevier, Bd. 202.2009, 2, S. 218-224
Deficiency of the 65 kDa isoform of glutamic acid decarboxylase impairs extinction of cued but not contextual fear memory
In: The journal of neuroscience: the official journal of the Society for Neuroscience - Washington, DC: Society for Neuroscience, SfN, Bd. 29 (2009), 50, S. 15713-15720
2008
Originalartikel in begutachteter internationaler Zeitschrift
Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of pavlovian fear memory
In: Learning & memory . - Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, Bd. 15.2008, 3, S. 163-171
Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 3.2008, 7, Art.e2695, insges. 11 S.
Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity
In: Learning & memory: molecules, cells, systems, and behavior - Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, Bd. 15 (2008), 4, S. 252-260
2007
Originalartikel in begutachteter internationaler Zeitschrift
Dissociated theta phase synchronization in amygdalo-hippocampal circuits during various stages of fear memory
In: European journal of neuroscience . - Oxford : Blackwell Science, Bd. 25.2007, 6, S. 1823-1831
Theta resynchronization during reconsolidation of remote contextual fear memory
In: Neuroreport . - London : Lippincott Williams & Wilkins, Bd. 18.2007, 11, S. 1107-1111
2006
Begutachteter Zeitschriftenartikel
Genes and neurons - molecular insights to fear and anxiety
In: Genes, brain and behavior: official journal of IBANGS - International Behavioural and Neural Genetics Society - Copenhagen [u.a.]: Blackwell Munksgaard, Bd. 5.2006, 2, S. 34-47
Originalartikel in begutachteter internationaler Zeitschrift
Genes and neurons - molecular insights to fear and anxiety
In: Genes, brain and behavior . - Oxford : Blackwell Munksgaard, Bd. 5.2006, S. 34-47
2005
Originalartikel in begutachteter internationaler Zeitschrift
Theta activity in neurons and networks of the amygdala related to long-term fear memory.
In: Hippocampus 15(2005), Nr. 7, S. 874 - 880
2004
Begutachteter Zeitschriftenartikel
Corrigendum to Generalisation of conditioned fear and its behavioural expression in mice - [Behav Brain Res 145 (2003) 99111]
In: Behavioural brain research : an international journal. - Amsterdam : Elsevier, Bd. 151.2004, 1/2, S. 337
Originalartikel in begutachteter internationaler Zeitschrift
Neuronal functions of the novel serine/threonine kinase Ndr2.
In: J. Biol. Chem. 279(2004), Nr. 44, S. 45773 - 45781
2003
Begutachteter Zeitschriftenartikel
Altered conditioned fear behavior in glutamate decarboxylase 65 null mutant mice
In: Genes, brain and behavior : official journal of IBANGS - International Behavioural and Neural Genetics Society. - Copenhagen [u.a.] : Blackwell Munksgaard, Bd. 2.2003, 2, S. 65-70
Originalartikel in begutachteter internationaler Zeitschrift
Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval.
In: Science 301(2003), Nr. 5634, S. 846 - 850
Cell adhesion molecules: Key players in memory consolidation?.
In: News Physiol. Sci. 18(2003), S. 147 - 150
Contribution of NR2B subunits to synaptic transmission in amygdaloid interneurons.
In: J. Neurosci. 23(2003), Nr. 7, S. 2549 - 2556
Generalisation of conditioned fear and its behavioural expression in mice.
In: Behav. Brain Res. 145(2003), S. 89 - 98
Genes and mechanisms in the amygdala involved in the formation of fear memory.
In: Ann. N.Y. Acad. Sci. 985(2003), S. 92 - 105
2002
Begutachteter Zeitschriftenartikel
Resistance to alcohol withdrawal-induced behaviour in Fyn transgenic mice and its reversal by ifenprodil
In: Brain research / Molecular brain research. - Amsterdam [u.a.] : Elsevier, Bd. 105.2002, 1/2, S. 126-135
Originalartikel in begutachteter internationaler Zeitschrift
Fear memory and the amygdala: insights from a molecular perspective.
In: Cell Tissue Res. 310(2002), S. 271 - 277
Reduction of extracellular GABA in the mouse amygdala during and following confrontation with a conditioned fear stimulus.
In: Neurosci. Lett. 327(2002), S. 138 - 142
2001
Originalartikel in begutachteter internationaler Zeitschrift
Identification of genes expressed in the amygdala during the formation of fear memory.
In: Learn. Mem. 8(2001), Nr. 4, S. 209 - 219
- Prof. Dr. Rüdiger Linke, Uni Magdeburg
- Prof. Dr. Herbert Schwegler, Uni Magdeburg
- Gundelfinger, Dr. Eckart, Leibniz Institut Magdebrug
- Institut für Physiologie
- Kreutz, Dr. Michael, Leibniz Institut Magdeburg
- Seidenbecher, Dr. Constanze, Leibniz Institut Magdeburg
- Hukema, Dr. Renate, Erasmus Medical Center Rotterdam
- Heinze, Dr. Hans-Jochen, Magdeburg
- Dr. Stefanie Kliche, Institut für Molekulare und Klinische Immunologie, OVGU
- DZNE (Deutsches Zentrum für neurodegenerative Erkrankungen)
- Prof. Dr. Anna Fejtova, Universität Erlangen-Nürnberg
- Prof. Dr. Gal Richter-Levin, Universität Haifa
- Prof. A. Albrecht, Institut für Anatomie, FME, OVGU Magdeburg
- Charlet-Berguerand, Dr. Nicolas, IGBMC Illkirch
- Prof. Dr. Alexander Dityatev, DZNE Magdeburg
- Prof. Dr. Martin Zener, Uni Magdeburg
- Dr. Thomas Munsch, Institut für Physiologie, OVGU Magdeburg
- Prof. Dr. Christian Freund, FU Berlin
- Prof. Dr. Daniela Dieterich, Otto-von-Guericke-Universität Magdeburg
- Ohl, Dr. Frank, Leibniz Institut Magdeburg
- Sobzak, Dr. Krysztof, Adam Mickiewicz University Waswas, Poland
- Martinat, Dr. Cecile, INSERM Desbrueres
- Afonso, Dr. Nuno, TechnoPhage
- Prof. Dr. Martin Zenker, OVGU Magdeburg
- Prof. Dr. Volkmar Leßmann, OVGU Magdeburg
- Kreutz, Dr. Michael, Leibniz Institut für Neurobiologie Magdeburg
- Dr. Thomas Munsch, Institut für Physiologie
- Untersuchung von affektivem Verhalten im Mausmodell
- Untersuchung von Lernen und Gedächtnis im Mausmodell
- Verhaltensgenetik, transgene Mäuse
- stereotaktische Substanzapplikation
Zellbiologie / Biochemie:
- Zelllinien und akut dissoziierte neuronale Zellen
- Untersuchung neuronaler Differenzierung in Kultur
- Entwicklung viraler und nichtviraler Transfektionstechniken
Gewebsanalytik:
- funktionelle Genomik: differentielle Klonierung, Genexpressionsanalysen mit laser capture und qPCR
- Proteinexpression, -lokalisation und -interaktion
- Morphologische Analysen, immunhistochemische Techniken
- Angstmodelle (L/D, Offenfeld, erhöhtes Pluslabyrinth, ..)
- Gedächtnisanalysen (Furchtkonditionierung, Objekterkennung)
- Depressionsmodelle (Anhedonie, Porsolt-Test, ...)
Molekulare Analysen
- mRNA Quantifizierung in definierten Hirnarealen / Zellpopulationen
1986 | Abitur am Städtischen Gymnasium Löhne | |
1986-88 | Zivildienst, Evangelische Jugendhilfe Schweicheln | |
1988-93 | Biologiestudium an der Universität Bielefeld | |
1992-93 | Anfertigung einer Diplomarbeit unter Anleitung von Prof. Dr. Dr. K. Obata im Laboratory of Neurochemistry, National Institute for Physiological Sciences, Okazaki, Japan. Titel: "Induktion von Tyrosin Hydroxylase Genexpression durch Haloperidol und Auswirkungen auf die zelluläre Verteilung von Tyrosin Hydroxylase mRNA und Protein in der Substantia nigra der Ratte" Juli 1993 Diplom (Note: sehr gut) | |
1993-94 | "Guest Researcher" im Laboratory of Neurochemistry, National Institute for Physiological Sciences, Okazaki, Japan Forschungsthema: Genexpressionsregulation in der Substantia nigra | |
1994-97 | Anfertigung einer Dissertation unter Anleitung von Prof. Dr. M. Schachner, Abteilung für Neurobiologie der Eidgenössischen Technischen Hochschule Zürich. Titel: "Roles of the Neural Cell Adhesion Molecule (NCAM) and its synapse-specific isoform (NCAM 180) in information processing in the central nervous system and in control of behaviour | |
1997 | Promotion zum Doctor scientarium naturalium | |
1997-99 | "Postdoctoral Fellow" in der Abteilung von Prof. Dr. Dr. K. Obata, National Institute for Physiological Sciences, Okazaki, Japan. Forschungsthema: molekulare Prozesse der Furchtkonditionierung | |
2000-01 | Wissenschaftlicher Mitarbeiter am Institut für Physiologie der Otto-von-Guericke Universität Magdeburg (Prof. Dr. H.-C. Pape) Forschungsthema: molekulare, zelluläre und systemphysiologische Prozesse der Furchtkonditionierung | |
2001-07 | Hochschulassistent und Leiter der Nachwuchsgruppe "Genetische Grundlagen von Emotionalverhalten , ibid. | |
2005 | JSPS "Short-term fellow" an der Gunma Universität, Maebashi, Japan | |
2005 | Habilitation und venia legendi für das Fach Physiologie an der Otto-von-Guericke Universität Magdeburg | |
2007-08 | Vertretungsprofessur am Lehrstuhl Molekulare Neurobiologie, Institut für Biologie, Otto-von-Guericke Universität Magdeburg | |
2008-20 2012 seit 2016 seit 2020 | W2 Professur am Lehrstuhl Genetik & Molekulare Neurobiologie, Institut für Biologie, Otto-von-Guericke Universität Magdeburg Guest Researcher am Center for Genomic Regulation Barcelona Ko-Direktor, Center of Behavioral Brain Sciences Magdeburg W3 Professur am Lehrstuhl Genetik & Molekulare Neurobiologie, Institut für Biologie, Otto-von-Guericke Universität Magdeburg |