Prof. Schraven

Prof. Dr. med. Burkhart Schraven
Institut für Molekulare und Klinische Immunologie (IMKI)
Aktuelle Projekte
- Landesforschergruppen SI-2 und SI-3
Laufzeit: 01.01.2015 - 31.12.2024
Abgeschlossene Projekte
- SFB 854, TP19: Regulation of the Src-family kinase Lck by posttranslational modification and TCR/Lck interactions
Laufzeit: 01.01.2018 - 30.06.2022 - Sonderforschungsbereich 854: Molekulare Organisation der Zellulären Kommunikation im Immunsystem Sprecher: Schraven, Burkhart; Prof. Dr. Projekthomepage:, http://www.sfb854.de, , Finanzierung: Deutsche Forschungsgemeinschaft (DFG) ; 01.01.2018 bis 31.12.2021 Forschergruppen: Gesundheitscampus Immunologie, Infektiologie und Inflammation (GC-I³)
Laufzeit: 01.01.2018 - 30.06.2022 - "Autonomie im Alter" - "Immuntherapeutika - Entwicklung neuartiger präventiver und/oder therapeutischer Wirkprinzipien zur Minimierung entzündlicher Erkrankungen"
Laufzeit: 01.04.2019 - 31.03.2022 - Molekulare Organisation der Zellulären Kommunikation im Immunsystem
Laufzeit: 01.01.2014 - 31.12.2017 - Zentrale Verwaltung und Koordination DFG FOR 521
Laufzeit: 15.01.2007 - 14.01.2010 - Herstellung monoklonaler Antikörper DFG FOR 521
Laufzeit: 15.01.2007 - 14.01.2010 - Zellbiologische, biochemische und molekular biologische Untersuchungen zur Rolle des Adaptorproteins SKAP HOM bei der Integrin - vermittelten Adhäsion
Laufzeit: 01.10.2005 - 31.05.2009 - N2-Signalübertragende Netzwerke TP 11: Molekulare Mechanismen der sequentiellen Aktivierung der Src-Kinasen Lck und Fyn in den lipid-rafts muriner CD4+ T-Lymphozyten
Laufzeit: 01.07.2005 - 30.06.2008 - N2 TP 7: Funktionelle Analyse signalübertragender Proteinkomplexe in Lipid-raft-Strukturen Helicobacter pylori-infizierter Epithelzellen
Laufzeit: 01.07.2005 - 30.06.2008 - N2 TP 5: Molekulare Analyse der zellbiologischen Funktion des survival promoting peptide Y-P30
Laufzeit: 01.07.2005 - 30.06.2008 - N2 TP 4: Untersuchungen zur Funktion des µ-Opiatrezeptors in immunkompetenten Zellen
Laufzeit: 01.07.2005 - 30.06.2008 - Die Bedeutung des transmembranösen Adapterproteins TRIM für die Aufrechterhaltung der immunologischen Homöostase im peripheren Immunsystem und im Verdauungstrakt
Laufzeit: 01.09.2004 - 31.08.2007 - Identifizierung der Signaltransduktionswege bei der SDF-1-vermittelten Adhäsion und Migration von T-Zellen
Laufzeit: 01.01.2004 - 31.12.2006 - Untersuchungen zur Regulation der MHC:Peptid induzierten MAP Kinase Kaskade im Hinblick auf die Signaldynamik in T-Lymphozyten
Laufzeit: 01.10.2004 - 31.12.2006 - Herstellung monoklonaler Antikörper (mAK) mit Spezifität für die Tyrosinphosphorylierungsstellen zytoplasmatischer und transmembranöser Adapterproteine
Laufzeit: 01.10.2004 - 30.09.2006 - Zentrale Verwaltung und Koordination der DFG-Forschergruppe 521
Laufzeit: 01.10.2004 - 30.09.2006 - "Molekulare, biochemische, funktionelle charakterisierung von NAP und pp36"
Laufzeit: 01.02.2003 - 28.02.2006 - Molekulare, biochemische und funktionelle Charakterisierung von TRIM (T-Cell Receptor Interacting Molecule)
Laufzeit: 01.04.2001 - 31.03.2003
2022
Abstract
IgE-mediated sensitization towards frequent and rare allergens in severe asthmatics - the ATLAS project
In: American journal of respiratory and critical care medicine - New York, NY: American Thoracic Society, 1959, Bd. 205 (2022), insges. 1 S.
Begutachteter Zeitschriftenartikel
Homologous and heterologous anti-COVID-19 vaccination does not induce new-onset formation of autoantibodies typically accompanying lupus erythematodes, rheumatoid arthritis, celiac disease and antiphospholipid syndrome
In: Vaccines - Basel: MDPI, 2013, Bd. 10 (2022), 2, insges. 16 S.
Ionic mitigation of CD4 + T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 12 (2022), insges. 14 S.
Robust induction of neutralizing antibodies against the SARS-CoV-2 Delta variant after homologous Spikevax or heterologous Vaxzevria-Spikevax vaccination
In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 52 (2022), 2, S. 356-359
2021
Abstract
Peripheral mast cell-derived RANKL is a prerequisite for lymphocyte egress from distant lymph nodes
In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 51 (2021), Suppl. 1, S. 35
Begutachteter Zeitschriftenartikel
ABC transporters in T cell-mediated physiological and pathological immune responses
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 17, insges. 10 S.
Cooperative interaction of Nck and Lck orchestrates optimal TCR signaling
In: Cells - Basel: MDPI, 2012, Bd. 10 (2021), 4, insges. 13 S.
Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation
In: Immunity - [Cambridge, Mass.]: Cell Press, Bd. 54 (2021), 3, S. 468-483.e5
Enhanced susceptibility of ADAP-deficient mice to Listeria monocytogenes infection is associated with an altered phagocyte phenotype and function
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 12 (2021), insges. 20 S.
Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 11 (2021), insges. 12 S.
Metabolic interdependency of Th2 cell-mediated type 2 immunity and the tumor microenvironment
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 12 (2021), insges. 12 S.
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells
In: Immunity - [Cambridge, Mass.]: Cell Press, 1994, Bd. 54 (2021), 12, S. 2724-2739.e10
Pitavastatin is a highly potent inhibitor of T-cell proliferation
In: Pharmaceuticals - Basel: MDPI, 2004, Bd. 14 (2021), 8, insges. 19 S.
Screening of FDA-approved drug library identifies adefovir dipivoxil as highly potent inhibitor of T cell proliferation
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 11 (2021), insges. 16 S.
Simulation of a batch crystallizer using a multi-scale approach in time and space
In: Chemical engineering science - Amsterdam [u.a.]: Elsevier Science, Volume 232 (2021), article 116344
The activity and stability of p56Lck and TCR signaling do not depend on the co-chaperone Cdc37
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 1, insges. 12 S.
Zinc aspartate induces IL-16 secretion and apoptosis in human T cells
In: Biomedicines - Basel: MDPI, 2013, Bd. 9 (2021), 3, insges. 11 S.
2020
Begutachteter Zeitschriftenartikel
ADAP promotes degranulation and migration of NK cells primed during in vivo Listeria monocytogenes infection in mice
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Vol. 10.2020, Art.-Nr. 3144, insgesamt 16 Seiten
Kv1.3 potassium channels - promising therapeutic targets in hematological malignancies
In: Journal of cellular signaling - Wilmington: Scientific Archives LLC, 2020, Bd. 1 (2020), 3, S. 79-86
Ratio and index of neurofilament light chain indicate its origin in GuillainBarré Syndrome
In: Annals of Clinical and Translational Neurology - Chichester [u.a.]: Wiley, 2013, Bd. 7 (2020), 11, S. 2213-2220
Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal
In: Nature immunology - London: Springer Nature Limited, Bd. 21 (2020), 5, S. 555-566, insges. 12 S.
Serum and CSF cytokine levels mirror different neuroimmunological mechanisms in patients with LGI1 and Caspr2 encephalitis
In: Cytokine - Oxford [u.a.]: Elsevier, Vol. 135.2020, 155226
Tyrosine 192 within the SH2 domain of the Srcprotein tyrosine kinase p56Lck regulates Tcell activation independently of Lck/CD45 interactions
In: Cell communication and signaling - London: Biomed Central, 2003, Vol. 18.2020, Art.-Nr. 183, insgesamt 18 Seiten
2019
Abstract
A highly conserved tyrosine residue within the SH2 domain of Lck regulates T-cell development and activation
In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 49.2019, Suppl. 1, P208, Seite 182
Cytokine release, degranulation and migratory capacity of NK cells depends on ADAP during Listeria monocytogenes infection of mice
In: European journal of immunology - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 1, SAT2, Seite 2-3
Inflammatory CD11c+ monocytes constitute a main reservoir for high proliferation and cell-to-cell transmission of Leishmania major
In: European journal of immunology: basic, clinical, translational - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 3, P0943, S. 1195
Regulating microvesicle transport at the immunological synapse
In: European journal of immunology: basic, clinical, translational - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 1, P379, Seite 281
Regulation of Lck activity via a highly conserved cysteine residue within the kinase domain
In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 49.2019, Suppl. 1, P231, Seite 194-195
Begutachteter Zeitschriftenartikel
Beyond TCR signaling - emerging functions of Lck in cancer and immunotherapy
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 14, Art.-Nr. 3500, insges. 18 S.
Characterization of mice with a platelet-specific deletion of the adapter molecule ADAP
In: Molecular and cellular biology - Washington, DC: Soc, Bd. 39.2019, 9, Art.-Nr. e00365-18, insges. 16 S.
Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency
In: The journal of allergy and clinical immunology - Amsterdam [u.a.]: Elsevier, Bd. 143.2019, 5, S. 1849-1864.e4
Immune cell-type specific ablation of adapter protein ADAP differentially modulates EAE
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 10.2019, Art.-Nr. 2343, insges. 13 S.
Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 9.2019, Art.-Nr. 5703, insges. 10 S.
Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 17.2019, Art.-Nr. 5, insges. 13 S.
2018
Abstract
Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells
In: European journal of immunology: basic, clinical, translational - Weinheim: Wiley-VCH, 1971, Bd. 49.2019, Suppl. 1, P214, Seite 185-186
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
In: 11th FENS Forum of Neuroscience: 7-11 July 2018, Berlin, Germany ; abstracts - FENS, 2018, 2018, Abstract 3915
Begutachteter Zeitschriftenartikel
Beware the intruder - real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 13.2018, 3, Art.-Nr. e0193970, insges. 9 S.
CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission
In: PLoS pathogens/ Public Library of Science - Lawrence, Kan.: PLoS, 2005, Bd. 14.2018, 10, Art.-Nr. e1007374, insges. 30 S.
CD45 in human physiology and clinical medicine
In: Immunology letters - Amsterdam [u.a.]: Elsevier Science, Bd. 196.2018, S. 22-32
Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 9.2018, Art.-Nr. 2852, insges. 16 S.
JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation
In: The journal of clinical investigation: JCI ; the publication of the American Society for Clinical Investigation - Ann Arbor, Mich.: ASCJ, 1924, Bd. 128 (2018), 10, S. 4359-4371
2017
Begutachteter Zeitschriftenartikel
A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity
In: OncoTarget - [S.l.]: Impact Journals LLC, 2010, Bd. 8 (2017), 19, S. 30805-30816
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, 8(2017) Artikel-Nummer 311, 16 Seiten
D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes
In: Molecular and cellular biology: MCB - Washington, DC: Soc., Bd. 37.2017, 7, Seite e.00509-e.00516
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling
In: Science signaling: the signal transduction knowledge environment - Washington, DC [u.a.]: Assoc., Bd. 10.2017, 462, insges. 14 S.
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, Vol. 8.2017, Art. 189, insgesamt 15 S.
JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1
In: Leukemia - London: Springer Nature, 1997, Bd. 31 (2017), 5, S. 1223-1226
2016
Abstract
LPS stimulation induces ROS formation, apoptosis, DNA damage and oxidation of cysteine residues in FLT3-ITD positive cell lines resulting in FLT3-tyrosine kinase inhibitor resistance
In: Haematologica: journal of the European Hematology Association - Pavia: Ferrata-Storti Foundation, 2014, Bd. 101.2016, s1, Abs. E877, S. 360
Reactive oxygen species (ROS) modulates sensitivity to FLT3-tyrosine kinase inhibitors in murine and human FLT3-ITD positive AML cell lines
In: Haematologica: journal of the European Hematology Association - Pavia: Ferrata-Storti Foundation, 2014, Bd. 101.2016, s1, Abs. E885, S. 362-363
Begutachteter Zeitschriftenartikel
ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens
In: Journal of leukocyte biology - Hoboken, NJ: Wiley, 1984, Bd. 101.2017, 2, S. 407-419
Atypical I[kappa]B proteins in immune cell differentiation and function
In: Immunology letters - Amsterdam [u.a.]: Elsevier Science, 1979, Bd. 171.2016, S. 26-35
Early changes in the metabolic profile of activated CD8+ T cells
In: BMC cell biology - London: BioMed Central, 2000, Bd. 17.2016, Art.-Nr. 28, insges. 11 S.
Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness
In: OncoTarget - [S.l.]: Impact Journals LLC, 2010, Bd. 7 (2016), 33, S. 53797-53807
Normal development and function of T cells in proline rich 7 (Prr7) deficient mice
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 11 (2016), 9, Art.-Nr. e0162863, insges. 15 S.
Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling
In: Expert review of proteomics - Abingdon: Taylor & Francis Group, 2004, Bd. 13.2016, 6, S. 545-554
2015
Begutachteter Zeitschriftenartikel
Analysis of phosphorylation-dependent protein interactions of adhesion and degranulation promoting adaptor protein (ADAP) reveals novel interaction partners required for chemokine-directed T cell migration
In: Molecular & cellular proteomics: MCP - Bethesda, Md: The American Society for Biochemistry and Molecular Biology, 2002, Bd. 14.2015, 11, S. 2961-2972
Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 5.2015, Art.-Nr. 18308, insges. 11 S.
Catchup - a mouse model for imaging-based tracking and modulation of neutrophil granulocytes
In: Nature methods - London [u.a.]: Nature Publishing Group, 2004, Bd. 12.2015, 5, S. 445-452
MiR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 10.2015, 4, Art. e0125311, insges. 17 S.
Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function
In: Leukemia: normal and malignant hemopoiesis ; a peer-reviewed journal - London: Springer Nature, 1997, Bd. 30.2016, 4, S. 991-995
T cells and reactive oxygen species
In: Journal of biomedical science: an international and Asian forum for high-impact biomedical research - London: BioMed Central, Bd. 22.2015, Art.-Nr. 85, insges. 11 S.
The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis
In: Critical reviews in immunology - Boca Raton, Fla: CRC Press, Bd. 35.2015, 1, S. 1-14
Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
In: Acta neuropathologica - Berlin: Springer, 1961, Bd. 129.2015, 2, S. 259-277
2014
Begutachteter Zeitschriftenartikel
Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function
In: Haematologica: journal of the European Hematology Association : journal of the Ferrata Storti Foundation - Pavia: Ferrata Storti Foundation, Bd. 99.2014, 6, S. e90-e93
Hippocampus-dependent learning in SKAP-HOM deficient mice
In: Behavioural brain research: an international journal - Amsterdam: Elsevier, Bd. 270 (2014), S. 125-130
Immunosuppression by N-Methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells
In: Molecular and cellular biology - Washington, DC: Soc., Bd. 34 (2014), 5, S. 820-831, insges. 12 S.
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 12.2014, Art.-Nr. 75, insges. 13 S.
Negative interactions and feedback regulations are required for transient cellular response
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 4.2014, Art.-Nr. 3718, insges. 8 S.
Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 12.2014, Art.-Nr. 74, insges. 8 S.
Sos1 regulates sustained TCR-mediated Erk activation
In: European journal of immunology. - Weinheim : Wiley-VCH, Bd. 44.2014, 5, S. 1535-1540
TCR-triggered extracellular superoxide production is not required for T-cell activation
In: Cell communication and signaling. - London : Biomed Central; Bd. 12.2014, Art.-Nr. 50, insges. 10 S.
Tetanus toxoid-pulsed monocyte vaccination for augmentation of collateral vessel growth
In: Journal of the American Heart Association : JAHA. - New York, NY : Association; Bd. 3.2014, 2, Art.-Nr. e000611, insges. 12 S.
2013
Begutachteter Zeitschriftenartikel
Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation
In: Journal of immunological methods: JIM - Amsterdam [u.a.]: Elsevier, Bd. 387 (2013), 1/2, S. 276-283
Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX
In: Journal of leukocyte biology. - Bethesda, Md : FASEB, Bd. 93.2013, 3, S. 353-362
Cross-talk between the signalling pathways of the receptor for interleukin 2 and the T-cell antigen in human T-blasts
In: Acta medica Bulgarica: AMB / Medical Academy, Sofia - Sofia: Medicina i Fizkultura, Bd. 40 (2013), 1, S. 76-83
Discrete, qualitative models of interaction networks
In: Frontiers in bioscience / Scholar - Searington, NY: Bioscience Research Institute (BRI), part of IMR Press, Bd. S5.2013, 1, S. 149-166
Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters
In: Molecular & cellular proteomics - Bethesda, Md.: The American Society for Biochemistry and Molecular Biology, Bd. 12 (2013), 9, S. 2551-2567
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 11.2013, Art.-Nr. 28, insges. 13 S.
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation
In: Science signaling - Washington, DC [u.a.]: Assoc., Bd. 6.2013, 263 ra13, insges. 11 S.
T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice
In: The journal of immunology - Bethesda, Md: Soc, Bd. 191 (2013), 10, S. 4950-4959
TCR activation kinetics and feedback regulation in primary human T cells
In: Cell communication and signaling - London: Biomed Central, Bd. 11.2013, Art.-Nr. 4, insges. 22 S.
2012
Anderes Material
Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.
In: Journal of immunological methods, Vol. , ISSN 1872-7905, 2012, 10.1016/j.jim.2012.11.006
Begutachteter Zeitschriftenartikel
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
In: EMBO reports, Vol. 13, ISSN 1469-3178, , 10.1038/embor.2012.17
Buchbeitrag
SKAP2/SCAP2 (Src kinase-associated phosphoprotein 2)
In: Choi, Sangdun: : Encyclopedia of signaling molecules. - New York, NY [u.a.] : Springer, S. 1736-1740, 2012
Originalartikel in begutachteter internationaler Zeitschrift
An inhibitor study of interleukin 2 receptor (IL2R) signalling mechanisms in human T-lymphoblasts
In: Dokladi na Bălgarskata Akademija na Naukite. - Sofija : Akademija, Bd. 65.2012, 1, S. 53-62
CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules
In: Blood: the journal of hematology / American Society of Hematology. William Dameshek, founding ed.: the journal of hematology - Washington, DC: American Society of Hematology, Bd. 119 (2012), 3, S. 777-785
Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function
In: European journal of immunology - Weinheim: Wiley, Bd. 42 (2012), 12, S. 3381-3393
Emerging roles of ADAP, SKAP55, and SKAP-HOM for integrin and NF-[kappa]B signaling in T cells
In: Journal of clinical & cellular immunology - Sunnyvale, Calif.: OMICS Publishing Group, Bd. 3.2012, Nr. S12, Artikel-Nr.002, insges. 8 S.
First insight into the kinome of human regulatory T cells
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 7.2012, 7, Art.-Nr. e40896, insges. 12 S.
Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 26.2012, 5, S. 963-971
Re-stimulation of T-cell antigen receptor and regulation of the tyrosine phosphorylation in peripheral T-cells
In: Acta medica Bulgarica: AMB / Medical Academy, Sofia - Sofia: Medicina i Fizkultura, Bd. XXXIX. 2012, 2, S. 11-22
Simulated Evolution of Signal Transduction Networks
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 7.2012, 12, insges. 10 S.
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells
In: EMBO reports / publ. for EMBO/ European Molecular Biology Organization - Weinheim: Wiley, Bd. 13 (2012), 4, S. 386-391
The adapter protein ADAP is required for selected dendritic cell functions
In: Cell communication and signaling. - London : Biomed Central; Bd. 10.2012, Art. 14, insges. 10 S.
2011
Originalartikel in begutachteter internationaler Zeitschrift
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands
In: Blood: the journal of hematology - Washington, DC: American Society of Hematology, 1946, Bd. 117.2011, 16, S. 4349-4357
Integrating signals from the T-cell receptor and the interleukin-2 receptor
In: PLoS Computational Biology - San Francisco, Calif: Public Library of Science, 2005, Bd. 7.2011, 8, Art. e1002121, insges. 15 S.
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates Src kinase activity in brain maturation
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 6.2011, 9, Art.-Nr. e23978 insges. 14 S.
Protocol optimization for DOK2 immunoprecipitation from murine splenic and thymic T-cell preparations
In: Dokladi na Bălgarskata Akademija na Naukite. - Sofija : Akademija, Bd. 64.2011, 7, S. 979-986
Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 6, 2011, 2, Art. e17314, insges. 11 S.
The SLP-76 Src homology 2 domain is required for T cell development and activation
In: The journal of immunology. - Bethesda, Md : American Assoc. of Immunologists, Bd. 187.2011, 9, S. 4459-4466
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 6.2011, 9, insges. 7 S.
2010
Nicht begutachteter Zeitschriftenartikel
Exploring the immune system - systems biology research networks in quest for new therapy options
In: Systembiologie.de: das Magazin für systembiologische Forschung in Deutschland - Heidelberg: Dt. Krebsforschungszentrum, Abt. Theoret. Bioinformatik, 2010 . - 2010, 1, S. 51-55
Originalartikel in begutachteter internationaler Zeitschrift
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells
In: Public Library of Science : PLoS one . - Lawrence, Kan. : PLoS, Bd. 5.2010, 7, insges. 11 S.
Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells
In: Cellular signalling - Amsterdam: Elsevier, Bd. 22 (2010), 3, S. 395-403
Stoichiometry and intracellular fate of TRIM-containing TCR complexes
In: Cell communication and signaling . - London : Biomed Central, Bd. 8.2010, insges. 10 S.
2009
Originalartikel in begutachteter internationaler Zeitschrift
Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
In: Immunology - Oxford [u.a.]: Wiley-Blackwell, 1958, Bd. 128.2009, 1,Pt.2, S. e728-e737
Cannabinoid receptor type 1 and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling
In: The journal of biological chemistry . - Bethesda, Md. : ASBMB, Bd. 284.2009, 51, S. 35450-35460
Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo
In: Journal of leukocyte biology . - Bethesda, Md. : FASEB, Bd. 86.2009, 1, S. 61-71
Mechanisms of opioid-mediated inhibition of human T cell receptor signaling
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 2, S. 882-889
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 10, S. 6124-6134
Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 183.2009, 9, S. 5756-5767
Systematic amino acid substitutions improved efficiency of GD2-peptide mimotope vaccination against neuroblastoma
In: The European journal of cancer: EJC ; the official journal of EORTC, European Organization for Research and Treatment of Cancer, ESO, European School of Oncology, EACR, European Association for Cancer Research, FECS, Federation of European Cancer Societies - Amsterdam [u.a.]: Elsevier, 1965, Bd. 45.2009, 16, S. 2915-2921
2008
Herausgeberschaft
Sparking signals - kinases as molecular signaltransducers and pharmacological drug targets in inflammation
In: Heidelberg [u.a.]: Springer, 2008, XIV, 185 S., Ill., graph. Darst., 22 cm - (Ernst Schering Foundation symposium proceedings; 2007,3) ; Kongress: Symposium. Ernst Schering Foundation (Potsdam : 2007.06.20-22)
Originalartikel in begutachteter internationaler Zeitschrift
A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration
In: European journal of immunology . - Weinheim : Wiley VCH, Bd. 38.2008, 1, S. 250-259
CD28 superagonists: what makes the difference in humans?
In: Immunity . - Cambridge, Mass. : Cell Press, Bd. 28.2008, 5, S. 591-595
Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 180.2008, 10, S. 6703-6712
Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts
In: Blood . - Washington, DC : American Society of Hematology, Bd. 111.2008, 4, S. 2310-2320
Regulation of T cell homeostasis by the transmembrane adaptor protein SIT
In: The journal of immunology : official journal of the American Association of Immunologists. - Bethesda, Md : American Assoc. of Immunologists, Bd. 180.2008, 3, S. 1634-1642
SIT and TRIM determine T cell fate in the thymus
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 181.2008, 9, S. 5930-5939
Signaling signatures and functional properties of antihuman CD28 superagonistic antibodies
In: PLoS one . - Lawrence, Kan. : PLoS, Bd. 3.2008, 3, insges. 13 S.
T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional [mu]-opioid receptors
In: Molecular pharmacology . - Bethesda, Md. : American Society for Pharmacology and Experimental Therapeutics, ISSN 0026-895x, Bd. 74.2008, 2, S. 496-504
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells
In: The journal of immunology - Rockville, Md.: American Association of Immunologists, Bd. 181 (2008), 12, S. 8267-8277
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
In: The journal of cell biology . - New York, NY : Rockefeller Univ. Press, Bd. 182.2008, 3, S. 603-614
Originalartikel in begutachteter zeitschriftenartiger Reihe
Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins
In: Inhibition of immune cell function / Max D. Cooper guest ed. - Oxford: Blackwell Munksgaard, 2008; Cooper, Max D., Bd. 224 (2008), S. 215-228
Systems biology of T cell activation
In: Sparking signals . - Berlin [u.a.] : Springer, ISBN 978-3-540-73500-7, S. 43-61
2007
Herausgeberschaft
Immunoreceptors & integrins
In: Munksgaard: Blackwell, 2007, 264 S., Ill., graph. Darst. - (Immunological reviews; 218) ; [Literaturangaben]
Originalartikel in begutachteter internationaler Zeitschrift
A logical model provides insights into T cell receptor signaling
In: PLoS Computational Biology - San Francisco, Calif: Public Library of Science, Bd. 3(2007), 8, insges. 11 S.
A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains - blocking Ras activation
In: Blood: the journal of hematology - Washington, DC: American Society of Hematology, 1946, Bd. 110.2007, 2, S. 596-605
ADAP is required for normal [alpha]IIb[beta]3 activation by VWF/GP Ib-IX-V and other agonists
In: Blood: the journal of hematology - Washington, DC: American Society of Hematology, 1946, Bd. 109.2007, 3, S. 1018-1025
Deletion of the LIME adaptor protein minimally affects T and B cell development and function
In: European journal of immunology - Weinheim: Wiley VCH, 1971, Bd. 37.2007, 11, S. 3259-3269
Fyn regulates the duration of TCR engagement needed for commitment to effector function
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, 1916, Bd. 179.2007, 7, S. 4635-4644
Impact of HMG-CoA reductase inhibition on brain pathology
In: Trends in pharmacological sciences: TIPS ; including toxicological sciences - Amsterdam: Cell Press, 1979, Bd. 28.2007, 7, S. 342-349
In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction
In: European journal of immunology - Weinheim: Wiley VCH, 1971, Bd. 37.2007, 10, S. 2961-2972
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes
In: Molecular and cellular biology: MCB - Washington, DC: American Society for Microbiology, 1981, Bd. 27.2007, 5, S. 1960-1973
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
In: Molecular and cellular biology: MCB - Washington, DC: American Society for Microbiology, 1981, Bd. 27.2007, 11, S. 4070-4081
TGF-[beta]1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md.: American Association of Immunologists, Bd. 178 (2007), 7, S. 4632-4640
Originalartikel in begutachteter zeitschriftenartiger Reihe
Immunoreceptors and integrins
In: Immunoreceptors & integrins - Munksgaard: Blackwell, 2007, Bd. 218.2007, S. 5-8
Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap 1 effector molecules
In: Immunoreceptors & integrins - Munksgaard: Blackwell, 2007, Bd. 218.2007, S. 82-91
2006
Herausgeberschaft
Cell communication in nervous and immune system
In: Heidelberg: Springer, 2006, XIV, 313 S., Ill., graph. Darst., 24 cm - (Results and problems in cell differentiation; 43), 978-3-540-36828-1 EUR 160.45 (freier Pr.), sfr 254.00 (freier Pr.)
Originalartikel in begutachteter internationaler Zeitschrift
Fatal neonatal-onset mitochondrial respiratory chain disease with T cell immunodeficiency
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Lipid-binding hSH3 domains in immune cell adapter proteins
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Normal T-cell development and immune functions in TRIM-deficient mice
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The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1
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Originalartikel in begutachteter zeitschriftenartiger Reihe
CD26/DP IV in T cell activation and autoimmunity
In: Dipeptidyl aminopeptidases - New York: Springer Science + Business Media, 2006 . - 2006, S. 187-193
2005
Originalartikel in begutachteter internationaler Zeitschrift
Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
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Right time, right place : the organization of membrane proximal signaling.
In: Semin. Immunol. 17(2005), Nr. 1, S. 35 - 49
Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.
In: Mol. Cell. Biol. 25(2005), Nr. 11, S. 4455 - 4465
The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.
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2004
Nicht begutachteter Zeitschriftenartikel
Grundsätzliches und Neues aus der Immunologie.
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Originalartikel in begutachteter internationaler Zeitschrift
A novel flow cytometric assay focusing on perforin release mechanisms of cytotoxic T lymphocytes.
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Adaptors and linkers in T and B cells.
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Expression of cell surface antigens in diabetic patients and healthy controls after injury.
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Grb2 and the non-T cell activation linker NTAL constitute a Ca2+-regulating signal circuit in B lymphocytes.
In: Immunity 21(2004), Nr. 5, S. 681 - 691
Shp2 regulates Src family kinase activity and Ras/Erk activation by controlling Csk recruitment.
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The role of adaptor proteins in lymphocyte activation.
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Transmembrane adapters : structure, biochemistry and biology.
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Transmembrane adaptor proteins : organizers of immunoreceptor signalling.
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2003
Nicht begutachteter Zeitschriftenartikel
Perioperative Immunmodulation beim Nierenzellkarzinom.
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Originalartikel in begutachteter internationaler Zeitschrift
LIME : a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
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The activation of Csk by CD4 interferes with TCR-mediated activatory signaling.
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Transmembrane adapters : attractants for cytoplasmic effectors.
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Originalartikel in begutachteter nationaler Zeitschrift
Neue immologische Signale aus Magdeburg.
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2002
Originalartikel in begutachteter internationaler Zeitschrift
Adapters in lymphocyte signaling.
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Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein.
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Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin- mediated phospholipase Cg2 regulation in platelets.
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Non-T cell activation linker (NTAL) : a transmembrane adaptor protein involved in immunoreceptor signaling.
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Process outgrowth of oligodendrocytes is promoted by interaction of Fyn kinase with the cytoskeletal protein Tau.
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- Universität Freiburg, Biologische Fakultät, Prof. Dr rer. nat. Wolfgang Schamel
- Immunologie
- Molekulare Zellbiologie
- Immunologie
- Molekulare Zellbiologie
1. Universitäre Ausbildung
1980-1986 Studium des Faches Medizin, Universität Mainz
1978-1980 Studium des Faches Agrarwissenschaften, Universität Göttingen
2. Akademische und sonstige Qualifikationen
2020 Zusatzbezeichnung ¿Immunologie¿ im Rahmen der Facharztweiterbildung
2001 Facharzt fürTransfusionsmedizin und Immunhämatologie
2001 C4-Professor für Immunologie, OvGU Magdeburg
1997 Venia legendi für das Fach Immunologie, Universität Heidelberg
1997 Habilitation für das Fach Immunologie: Universität Heidelberg,
1988 Doktorprüfung (Dr. med.): Immunologie, Universität Mainz/Innere Medizin I,
1986 Approbation
3. Berufliche Laufbahn
2007-2018 Leiter (in Nebentätigkeit) der Abteilung Immunkontrolle (IMMK) am Helmholtz-Institut für Infektionsforschung (HZI), Braunschweig
seit 2001 Direktor (C4/W3) des Instituts für Molekulare and Klinische Immunologie an der Medizinischen Fakultät der OvGU Magdeburg
1995-2001 Arbeitsgruppenleiter an der Medizinischen Fakultät, Universität Heidelberg, Institut für Immunologie and Serologie
1988-1995 Postdoctorand am DKFZ, Heidelberg, seit 1991 als Arbeitsgruppenleiter
1987-1988 Wissenschaftlicher Assistent am Uniklinkum Mainz
4. Weitere Qualifikationen
seit 2016 Mitglied derJury des Galenus von Pergamon-Preises
seit 2010 Sprecher des DFG-Sonderforschungsbereiches 854
2007-2020 Prodekan für Forschung und Mitglied des Fakultätsvorstandes der Medizinischen Fakultät
2010 Otto-von-Guericke Forschungspreis der OvGU Magdeburg (zusammen mit E. Gundelfinger und M. Naumann)
2004-2016 Beiratsmitglied der Deutschen Gesellschaft für Immunologie (DGfI)
2003-2012 Fachkollegiat des DFG-Fachkollegiums ¿Zellbiologie¿
2004-2009 Sprecher der DFG-Forschergruppe 521 (FOR521)
2003 Ernennung zum ¿Fachimmunologen¿, der Deutschen Gesellsch. f. Immunol. (DGfI)
2001-2004 Sprecher des BMBF-Forschungszentrums ¿Immunologie, MD-Halle, Sachsen-Anhalt¿