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Prof. Schraven

Prof. Dr. med. Burkhart Schraven

Medizinische Fakultät
Institut für Molekulare und Klinische Immunologie (IMKI)
Haus 26, Leipziger Str. 44, 39120, Magdeburg,
Tel.: +49 391 67 15800
Fax: +49 391 67 15852

Prof. Dr. med. Burkhart Schraven

Medizinische Fakultät
Institut für Molekulare und Klinische Immunologie (IMKI)
Haus 26, Leipziger Str. 44, 39120, Magdeburg,
Tel.: +49 391 67 15800
Fax: +49 391 67 15852
Projekte

Aktuelle Projekte

Abgeschlossene Projekte

Publikationen

2017

Begutachteter Zeitschriftenartikel
Parzmair, Gerald P.;  Gereke, Marcus;  Haberkorn, Oxana;  Annemann, Michaela;  Podlasly, Lisa;  Kliche, Stefanie;  Reinhold, Annegret;  Schraven, Burkhart;  Bruder, Dunja 

ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens
In: Journal of leukocyte biology: JLB - Bethesda, Md: Soc. for Leukocyte Biology, Bd. 101.2017, 2, S. 407-419; http://dx.doi.org/10.1189/jlb.1A0216-090RR

Ranjan, Satish;  Goihl, Alexander;  Kohli, Shrey;  Gadi, Ihsan;  Pierau, Mandy;  Shahzad, Khurrum;  Gupta, Dheerendra;  Bock, Fabian Maximilian;  Wang, Hongjie;  Shaikh, Haroon;  Kähne, Thilo;  Reinhold, Dirk;  Bank, Ute;  Zenclussen, Ana Claudia;  Niemz, Jana;  Schnöder, Tina;  Brunner-Weinzierl, Monika;  Fischer, Thomas;  Kalinski, Thomas;  Schraven, Burkhart;  Luft, Thomas;  Hühn, Jochen;  Naumann, Michael;  Heidel, Florian;  Isermann, Berend 

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
In: Nature Communications - [London]: Nature Publishing Group UK, Bd. 8.2017, Art.-Nr. 311, insges. 16 S.; http://dx.doi.org/10.1038/s41467-017-00169-4

Witte, Amelie;  Meineke, Bernhard;  Sticht, Jana;  Philipsen, Lars;  Kuropka, Benno;  Müller, Andreas J.;  Freund, Christian;  Schraven, Burkhart;  Kliche, Stefanie 

D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes
In: Molecular and cellular biology: MCB - Washington, DC: Soc, Bd. 37.2017, 7, Seite e.00509-e.00516; http://dx.doi.org/10.1128/MCB.00509-16

Philipsen, Lars;  Reddycherla, Amarendra Varma;  Hartig, Roland;  Gumz, Janine;  Kästle, Matthias;  Kritikos, Andreas;  Poltorak, Mateusz P.;  Prokazov, Yury;  Turbin, Evgeny;  Weber, André;  Zuschratter, Werner;  Schraven, Burkhart;  Simeoni, Luca;  Müller, Andreas J. 

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling
In: Science signaling: the signal transduction knowledge environment - Washington, DC [u.a.]: Assoc, Bd. 10.2017, 462, insges. 14 S.; http://dx.doi.org/10.1126/scisignal.aaf4736

Raza, Ahsan Syed;  Albrecht, Anne;  Çaliş  kan, Gürsel;  Müller, Bettina;  Demiray, Yunus Emre;  Ludewig, Susann;  Meis, Susanne;  Faber, Nicolai;  Hartig, Roland;  Schraven, Burkhart;  Leßmann, Volkmar;  Schwegler, Herbert;  Stork, Oliver 

HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
In: Nature Communications - [London]: Nature Publishing Group UK, Vol. 8.2017, Art. 189, insgesamt 15 S.; http://dx.doi.org/10.1038/s41467-017-00205-3

Gupta, Nibedita;  Edelmann, Bärbel;  Schnöder, Tina;  Saalfeld, Felix C.;  Wolleschak, Denise;  Kliche, Stefanie;  Schraven, Burkhart;  Heidel, Florian;  Fischer, Thomas 

JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - London: Springer Nature, Bd. 31.2017, 5, S. 1223-1226; http://dx.doi.org/10.1038/leu.2017.26

2016

Abstrakt
Müller, Christian;  Schnöder, Tina;  Simeoni, Luca;  Heidel, Florian;  Thurm, Christoph;  Schraven, Burkhart;  Fischer, Thomas 

LPS stimulation induces ROS formation, apoptosis, DNA damage and oxidation of cysteine residues in FLT3-ITD positive cell lines resulting in FLT3-tyrosine kinase inhibitor resistance
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 101.2016, s1, Abs. E877, S. 360

Müller, Christian;  Simeoni, Luca;  Heidel, Florian;  Schraven, Burkhart;  Fischer, Thomas 

Reactive oxygen species (ROS) modulates sensitivity to FLT3-tyrosine kinase inhibitors in murine and human FLT3-ITD positive AML cell lines
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 101.2016, s1, Abs. E885, S. 362-363

Begutachteter Zeitschriftenartikel
Annemann, Michaela;  Plaza-Sirvent, Carlos;  Schuster, Marc;  Katsoulis-Dimitriou, Konstantinos;  Kliche, Stefanie;  Schraven, Burkhart;  Schmitz, Ingo 

Atypical I[kappa]B proteins in immune cell differentiation and function
In: Immunology letters. - Amsterdam [u.a.] : Elsevier Science, Bd. 171.2016, S. 26-35

Cammann, Clemens;  Rath, Alexander;  Reichl, Udo;  Lingel, Holger;  Brunner-Weinzierl, Monika;  Simeoni, Luca;  Schraven, Burkhart;  Lindquist, Jonathan A. 

Early changes in the metabolic profile of activated CD8+ T cells
In: BMC cell biology. - London : BioMed Central; Bd. 17 (2016), Art.-Nr. 28, insges. 11 S.

Lowinus, Theresa;  Bose, Tanima;  Busse, Stefan;  Busse, Mandy;  Reinhold, Dirk;  Schraven, Burkhart;  Bommhardt, Ursula H. H. 

Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness
In: OncoTarget : open access impact journal. - [S.l.] : Impact Journals LLC, Bd. 7.2016, 33, S. 53797-53807

Hrdinka , Matous;  Sudan, Kritika;  Just, Sissy;  Drobek, Ales;  Stepanek, Ondrej;  Schlüter, Dirk;  Reinhold, Dirk;  Jordan, Bryen A.;  Gintschel, Patricia;  Schraven, Burkhart;  Kreutz, Michael R. 

Normal development and function of T cells in proline rich 7 (Prr7) deficient mice
In: PLoS one. - Lawrence, Kan : PLoS; Bd. 11 (2016), 9, Art.-Nr. e0162863, insges. 15 S.

Kuropka, Benno;  Schraven, Burkhart;  Kliche, Stefanie;  Krause, Eberhard;  Freund, Christian 

Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling
In: Expert review of proteomics. - Abingdon : Taylor & Francis Group, Bd. 13.2016, 6, S. 545-554

2015

Begutachteter Zeitschriftenartikel
Kuropka, Benno;  Witte, Amelie;  Sticht, Jana;  Waldt, Natalie;  Majkut, Paul;  Hackenberger, Christian P. R.;  Schraven, Burkhart;  Krause, Eberhard;  Kliche, Stefanie;  Freund, Christian 

Analysis of phosphorylation-dependent protein interactions of adhesion and degranulation promoting adaptor protein (ADAP) reveals novel interaction partners required for chemokine-directed T cell migration
In: Molecular & cellular proteomics : MCP. - Bethesda, Md : The American Society for Biochemistry and Molecular Biology, Bd. 14.2015, 11, S. 2961-2972

Vogel, Stephanie;  Grabski, Elena;  Buschjäger, Daniela;  Klawonn, Frank;  Döring, Marius;  Wang, Junxi;  Fletcher, Erika;  Bechmann, Ingo;  Witte, Torsten;  Durisin, Martin;  Schraven, Burkhart;  Mangsbo, Sara M.;  Schönfeld, Kurt;  Czeloth, Niklas;  Kalinke, Ulrich 

Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells
In: Scientific reports. - London : Nature Publishing Group; Bd. 5.2015, Art.-Nr. 18308, insges. 11 S.

Hasenberg, Anja;  Hasenberg, Mike;  Männ, Linda;  Neumann, Franziska;  Borkenstein, Lars;  Stecher, Manuel;  Kraus, Andreas;  Engel, Daniel R.;  Klingberg, Anika;  Seddigh, Pegah;  Abdullah, Zeinab;  Klebow, Sabrina;  Engelmann, Swen;  Reinhold, Annegret;  Brandau, Sven;  Seeling, Michaela;  Waisman, Ari;  Schraven, Burkhart;  Göthert, Joachim R.;  Nimmerjahn, Falk;  Gunzer, Matthias 

Catchup - a mouse model for imaging-based tracking and modulation of neutrophil granulocytes
In: Nature methods : techniques for life scientists and chemists. - London [u.a.] Nature Publishing Group, Bd. 12.2015, 5, S. 445-452

Reddycherla, Amarendra V.;  Meinert, Ines;  Reinhold, Annegret;  Reinhold, Dirk;  Schraven, Burkhart;  Simeoni, Luca 

MiR-20a inhibits TCR-mediated signaling and cytokine production in human naïve CD4+ T cells
In: PLoS one. - Lawrence, Kan : PLoS; Bd. 10.2015, 4, Art. e0125311, insges. 17 S.

Perner, Florian;  Schnöder, Tina M.;  Ranjan, Satish;  Wolleschak, Denise;  Ebert, Carolin;  Pils, Marina C.;  Frey, Stephanie;  Polanetzki, Anja;  Fahldieck, Corinna;  Schönborn, Uta;  Schraven, Burkhart;  Isermann, Berend;  Fischer, Thomas;  Heidel, Florian H. 

Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function
In: Leukemia : normal and malignant hemopoiesis ; a peer-reviewed journal. - Basingstoke : Nature Publ. Group, Bd. 30.2016, 4, S. 991-995

Belikov, Aleksey V.;  Schraven, Burkhart;  Simeoni, Luca 

T cells and reactive oxygen species
In: Journal of biomedical science : an international and Asian forum for high-impact biomedical research. - London : BioMed Central; Bd. 22.2015, Art.-Nr. 85, insges. 11 S.

Engelmann, Swen;  Togni, Mauro;  Kliche, Stefanie;  Reinhold, Dirk;  Schraven, Burkhart;  Reinhold, Annegret 

The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis
In: Critical reviews in immunology. - Boca Raton, Fla : CRC Press, Bd. 35.2015, 1, S. 1-14

Neumann, Jens;  Riek-Burchardt, Monika;  Herz, Josephine;  Doeppner, Thorsten R.;  König, Rebecca;  Hütten, Heiko;  Etemire, Eloho;  Männ, Linda;  Klingberg, Anika;  Fischer, Thomas;  Görtler, Michael W.;  Heinze, Hans-Jochen;  Reichardt, Peter;  Schraven, Burkhart;  Hermann, Dirk M.;  Reymann, Klaus G.;  Gunzer, Matthias 

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
In: Acta neuropathologica. - Berlin : Springer, Bd. 129.2015, 2, S. 259-277

2014

Begutachteter Zeitschriftenartikel
Wolleschak, Denise;  Mack, Thomas S.;  Perner, Florian;  Frey, Stephanie;  Schnoeder, Tina M.;  Wagner, Marie-Christine;  Höding, Christine;  Pils, Marina C.;  Parkner, Andreas;  Kliche, Stefanie;  Schraven, Burkhart;  Hebel, Katrin;  Brunner-Weinzierl, Monika;  Ranjan, Satish;  Isermann, Berend;  Lipka, Daniel B.;  Fischer, Thomas;  Heidel, Florian H. 

Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function
In: Haematologica, the hematology journal : official organ of the European Hematology Association. - Pavia : Ferrata Storti Foundation; Bd. 99.2014, 6, S. e90-e93

Fiedler, Anna;  Grecksch, Gisela;  Reinhold, Annegret;  Schraven, Burkhart;  Becker, Axel 

Hippocampus-dependent learning in SKAP-HOM deficient mice
In: Behavioural brain research : an international journal. - Amsterdam : Elsevier, Bd. 270.2014, S. 125-130

Kahlfuß, Sascha;  Simma, Narasimhulu;  Mankiewicz, Judith;  Bose, Tanima;  Lowinus, Theresa;  Klein-Hessling, Stefan;  Sprengel, Rolf;  Schraven, Burkhart;  Heine, Martin;  Bommhardt, Ursula 

Immunosuppression by N-Methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells
In: Molecular and cellular biology. - Washington, DC : Soc, Bd. 34.2014, 5, S. 820-831

Simma, Narasimhulu;  Bose, Tanima;  Kahlfuß, Sascha;  Mankiewicz, Judith;  Lowinus, Theresa;  Lühder, Fred;  Schüler, Thomas;  Schraven, Burkhart;  Heine, Martin;  Bommhardt, Ursula 

NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells
In: Cell communication and signaling. - London : Biomed Central; Bd. 12.2014, Art.-Nr. 75, insges. 13 S.

Mobashir, Mohammad;  Madhusudhan, Thati;  Isermann, Berend;  Beyer, Tilo;  Schraven, Burkhart 

Negative interactions and feedback regulations are required for transient cellular response
In: Scientific reports. - London : Nature Publishing Group; Bd. 4.2014, Art.-Nr. 3718, insges. 8 S.

Harder, Thomas;  Guttek, Karina;  Philipsen, Lars;  Simeoni, Luca;  Schraven, Burkhart;  Reinhold, Dirk 

Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation
In: Cell communication and signaling. - London : Biomed Central; Bd. 12.2014, Art.-Nr. 74, insges. 8 S.

Poltorak, Mateusz;  Meinert, Ines;  Stone, James C.;  Schraven, Burkhart;  Simeoni, Luca 

Sos1 regulates sustained TCR-mediated Erk activation
In: European journal of immunology. - Weinheim : Wiley-VCH, Bd. 44.2014, 5, S. 1535-1540

Belikov, Aleksey V.;  Schraven, Burkhart;  Simeoni, Luca 

TCR-triggered extracellular superoxide production is not required for T-cell activation
In: Cell communication and signaling. - London : Biomed Central; Bd. 12.2014, Art.-Nr. 50, insges. 10 S.

Herold, Joerg;  Francke, Alexander;  Weinert, Soenke;  Schmeisser, Alexander;  Hebel, Katrin;  Schraven, Burkhart;  Roehl, Friedich-Wilhelm;  Strasser, Ruth H.;  Braun-Dullaeus, Ruediger C. 

Tetanus toxoid-pulsed monocyte vaccination for augmentation of collateral vessel growth
In: Journal of the American Heart Association : JAHA. - New York, NY : Association; Bd. 3.2014, 2, Art.-Nr. e000611, insges. 12 S.

2013

Begutachteter Zeitschriftenartikel
Arndt, Börge;  Poltorak, Mateusz;  Kowtharapu, Bhavani S.;  Reichardt, Peter;  Philipsen, Lars;  Lindquist, Jonathan A.;  Schraven, Burkhart;  Simeoni, Luca 

Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation
In: Journal of immunological methods. - Amsterdam [u.a.] : Elsevier, Bd. 387.2013, 1/2, S. 276-283

Arndt, Börge;  Kalinski, Thomas;  Reinhold, Dirk;  Thielitz, Anja;  Roessner, Albert;  Schraven, Burkhart;  Simeoni, Luca 

Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX
In: Journal of leukocyte biology. - Bethesda, Md : FASEB, Bd. 93.2013, 3, S. 353-362

Hristov, Kroum;  Lindquist, Jonathan;  Schraven, Burkhart 

Cross-talk between the signalling pathways of the receptor for interleukin 2 and the T-cell antigen in human T-blasts
In: Acta medica Bulgarica. - Sofia : Medicina i Fizkultura, Bd. 40.2013, 1, S. 76-83

Ballerstein, Kathrin;  Haus, Utz-Uwe;  Lindquist, Jonathan Axel;  Beyer, Tilo;  Schraven, Burkhart;  Weismantel, Robert 

Discrete, qualitative models of interaction networks
In: Frontiers in bioscience. - Searington, NYFrontiers in bioscience / Scholar edition, Bd. 5.2013, 1, S. 149-166

Philipsen, Lars;  Engels, Thomas;  Schilling, Kerstin;  Gurbiel, Slavyana;  Fischer, Klaus-Dieter;  Tedford, Kerry;  Schraven, Burkhart;  Gunzer, Matthias;  Reichardt, Peter 

Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters
In: Molecular & cellular proteomics. - Bethesda, Md : The American Society for Biochemistry and Molecular Biology, Bd. 12.2013, 9, S. 2551-2567

Smida, Michal;  Cammann, Clemens;  Gurbiel, Slavyana;  Kerstin, Nadja;  Lingel, Holger;  Lindquist, Sabine;  Simeoni, Luca;  Brunner-Weinzierl, Monika C.;  Suchanek, Miloslav;  Schraven, Burkhart;  Lindquist, Jonathan A. 

PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells
In: Cell communication and signaling. - London : Biomed Central; Bd. 11.2013, Art.-Nr. 28, insges. 13 S.

Stirnweiss, Anja;  Hartig, Roland;  Gieseler, Steffi;  Lindquist, Jonathan A.;  Reichardt, Peter;  Philipsen, Lars;  Simeoni, Luca;  Poltorak, Mateusz;  Merten, Camilla;  Zuschratter, Werner;  Prokazov, Yury;  Paster, Wolfgang;  Stockinger, Hannes;  Harder, Thomas;  Gunzer, Matthias;  Schraven, Burkhart 

T cell activation results in conformational changes in the Src family kinase Lck to induce its activation
In: Science signaling. - Washington, DC [u.a.] : Assoc, Bd. 6.2013, 263, insges. 11 S.

Engelmann, Swen;  Togni, Mauro;  Reinhold, Dirk;  Thielitz, Anja;  Reichardt, Peter;  Kliche, Stefanie;  Reinhold, Dirk;  Schraven, Burkhart;  Reinhold, Annegret 

T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice
In: The journal of immunology. - Bethesda, Md : Soc, Bd. 191.2013, 10, S. 4950-4959

Poltorak, Mateusz;  Arndt, Börge;  Kowtharapu, Bhavani S.;  Reddycherla, Amarendra V.;  Witte, Vanessa;  Lindquist, Jonathan A.;  Schraven, Burkhart;  Simeoni, Luca 

TCR activation kinetics and feedback regulation in primary human T cells
In: Cell communication and signaling. - London : Biomed Central, Bd. 11.2013, insges. 22 S.

2012

Anderes Material
Arndt, Boerge;  Poltorak, Mateusz;  Kowtharapu, Bhavani S;  Reichardt, Peter;  Phillipsen, Lars;  Lindquist, Jonathan A;  Schraven, Burkhart;  Simeoni, Luca 

Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.
In: Journal of immunological methods, Vol. , ISSN 1872-7905, 2012, 10.1016/j.jim.2012.11.006

Begutachteter Zeitschriftenartikel
Warnecke, Nicole;  Poltorak, Mateusz;  Kowtharapu, Bhavani S;  Arndt, Boerge;  Stone, James C;  Schraven, Burkhart;  Simeoni, Luca 

TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
In: EMBO reports, Vol. 13, ISSN 1469-3178, , 10.1038/embor.2012.17

Buchbeitrag
Reinhold, Annegret;  Schraven, Burkhart L. 

SKAP2/SCAP2 (Src kinase-associated phosphoprotein 2)
In: Choi, Sangdun: : Encyclopedia of signaling molecules. - New York, NY [u.a.] : Springer, S. 1736-1740, 2012

Originalartikel in begutachteter internationaler Zeitschrift
Hristov, Kroum;  Lindquist, Jonathan;  Schraven, Burkhart 

An inhibitor study of interleukin 2 receptor (IL2R) signalling mechanisms in human T-lymphoblasts
In: Dokladi na Bălgarskata Akademija na Naukite. - Sofija : Akademija, Bd. 65.2012, 1, S. 53-62

Kliche, Stefanie;  Worbs, Tim;  Wang, Xiaoqian;  Degen, Janine;  Patzak, Irene;  Meineke, Bernhard;  Togni, Mauro;  Moser, Markus;  Reinhold, Annegret;  Kiefer, Friedemann;  Freund, Christian;  Förster, Reinhold;  Schraven, Burkhart 

CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules
In: Blood. - Washington, DC : American Society of Hematology, Bd. 119.2012, 3, S. 777-785

Pierau, Mandy;  Na, Shin-Young;  Simma, Narasimhulu;  Lowinus, Theresa;  Marx, Alexander;  Schraven, Burkhart;  Bommhardt, Ursula H. 

Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function
In: European journal of immunology. - Weinheim : Wiley VCH, Bd. 42.2012, 12, S. 3381-3393

Witte, Amelie;  Degen, Janine;  Baumgart, Kathleen;  Waldt, Natalie;  Kuropka, Benno;  Freund, Christian;  Schraven, Burkhart;  Kliche, Stefanie 

Emerging roles of ADAP, SKAP55, and SKAP-HOM for integrin and NF-[kappa]B signaling in T cells
In: Journal of Clinical & Cellular Immunology. - Sunnyvale, Calif : OMICS Publishing Group, Bd. 3.2012, 12, insges. 8 S.

König, Sebastian;  Probst-Kepper, Michael;  Reinl, Tobias;  Jeron, Andreas;  Hühn, Jochen;  Schraven, Burkhart;  Jänsch, Lothar 

First insight into the kinome of human regulatory T cells
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 7.2012, 7, insges. 12 S.

Linka, René M.;  Risse, S. L.;  Bienemann, K.;  Werner, Markus;  Linka, Yvonne;  Krux, Frank;  Synaeve, Cindy;  Deenen, René;  Ginzel, Sebastian;  Dvorsky, Radovan;  Gombert, Michael;  Halenius, Anne;  Hartig, Roland;  Helminen, Merja;  Fischer, Alain;  Stepensky, Polina;  Vettenranta, Kim;  Köhrer, Karl;  Ahmadian, M. Reza;  Laws, Hans-Jürgen;  Fleckenstein, Bernhard;  Jumaa, Hassan;  Latour, Sylvain;  Schraven, Burkhart;  Borkhardt, Arndt 

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 26.2012, 5, S. 963-971

Hristov, Kroum;  Lindquist, Jonathan;  Schraven, Burkhart 

Re-stimulation of T-cell antigen receptor and regulation of the tyrosine phosphorylation in peripheral T-cells
In: Acta medica Bulgarica. - Sofia : Medicina i Fizkultura, Bd. 39.2012, 2, S. 11-22

Mobashir, Mohammad;  Schraven, Burkhart;  Beyer, Tilo 

Simulated Evolution of Signal Transduction Networks
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 7.2012, 12, insges. 10 S.

Warnecke, Nicole;  Poltorak, Mateusz;  Kowtharapu, Bhavani S.;  Arndt, Börge;  Stone, James C.;  Schraven, Burkhart;  Simeoni, Luca 

TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells
In: EMBO reports. - London : Nature Publ. Group, Bd. 13.2012, 4, S. 386-391

Togni, Mauro;  Engelmann, Swen;  Reinhold, Dirk;  Schraven, Burkhart;  Reinhold, Annegret 

The adapter protein ADAP is required for selected dendritic cell functions
In: Cell communication and signaling. - London : Biomed Central; Bd. 10.2012, Art. 14, insges. 10 S.

2011

Originalartikel in begutachteter internationaler Zeitschrift
Köhler, Anja;  Filippo, Katia De;  Hasenberg, Mike;  Brandt, Cindy van den;  Nye, Emma;  Hosking, Martin P.;  Lane, Thomas E.;  Männ, Linda;  Ransohoff, Richard M.;  Hauser, Anja E.;  Winter, Oliver;  Schraven, Burkhart;  Geiger, Hartmut;  Hogg, Nancy;  Gunzer, Matthias 

G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands
In: Blood. - Washington, DC : American Society of Hematology, Bd. 117.2011, 16, S. 4349-4357

Beyer, Tilo;  Busse, Mandy;  Hristov, Kroum;  Gurbiel, Slavyana;  Smida, Michal;  Haus, Utz-Uwe;  Ballerstein, Kathrin;  Pfeuffer, Frank;  Weismantel, Robert;  Schraven, Burkhart;  Lindquist, Jonathan A. 

Integrating signals from the T-cell receptor and the interleukin-2 receptor
In: PLoS Computational Biology. - San Francisco, Calif : Public Library of Science, Bd. 7.2011, 8, insges. 15 S.

Lindquist, Sabine;  Karitkina, Diana;  Langnäse, Kristina;  Posevitz-Fejfar, Anita;  Schraven, Burkhart;  Xavier, Ramnik;  Seed, Brian;  Lindquist, Jonathan A. 

Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates Src kinase activity in brain maturation
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 6.2011, 9, insges. 14 S.

Hristov, Kroum;  Lindquist, Jonathan A.;  Schraven, Burkhart 

Protocol optimization for DOK2 immunoprecipitation from murine splenic and thymic T-cell preparations
In: Dokladi na Bălgarskata Akademija na Naukite. - Sofija : Akademija, Bd. 64.2011, 7, S. 979-986

Hasenberg, Mike;  Köhler, Anja;  Bonifatius, Susanne;  Borucki, Katrin;  Riek-Burchardt, Monika;  Achilles, Julia;  Männ, Linda;  Baumgart, Kathleen;  Schraven, Burkhart;  Gunzer, Matthias 

Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 6.2011, 2, insges. 11 S.

Burns, Jeremy C.;  Corbo, Evann;  Degen, Janine;  Gohil, Mercy;  Anterasian, Christine;  Schraven, Burkhart;  Koretzky, Gary A.;  Kliche, Stefanie;  Jordan, Martha S. 

The SLP-76 Src homology 2 domain is required for T cell development and activation
In: The journal of immunology. - Bethesda, Md : American Assoc. of Immunologists, Bd. 187.2011, 9, S. 4459-4466

Arndt, Börge;  Krieger, Tina;  Kalinski, Thomas;  Thielitz, Anja;  Reinhold, Dirk;  Roessner, Albert;  Schraven, Burkhart;  Simeoni, Luca 

The transmembrane adaptor protein SIT inhibits TCR-mediated signaling
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 6.2011, 9, insges. 7 S.

2010

Nicht begutachteter Zeitschriftenartikel
Höfer, Thomas;  Lindquist, Jonathan;  Schraven, Burkhart;  Schamel, Wolfgang 

Exploring the immune system - systems biology research networks in quest for new therapy options
In: Systembiologie.de . - Heidelberg : Dt. Krebsforschungszentrum, Abt. Theoret. Bioinformatik, 1, S. 51-55

Originalartikel in begutachteter internationaler Zeitschrift
Sylvester, Marc;  Kliche, Stefanie;  Lange, Sabine;  Geithner, Sabine;  Klemm, Clementine;  Schlosser, Andreas;  Großmann, Arndt;  Stelzl, Ulrich;  Schraven, Burkhart;  Krause, Eberhard;  Freund, Christian 

Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells
In: Public Library of Science : PLoS one . - Lawrence, Kan. : PLoS, Bd. 5.2010, 7, insges. 11 S.; Abstract unter URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011708

Rieke, Cornelia;  Kähne, Thilo;  Schweitzer, Katrin;  Schraven, Burkhart;  Wienands, Jürgen;  Engelke, Michael;  Naumann, Michael 

Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells
In: Cellular signalling . - Amsterdam : Elsevier, Bd. 22.2010, 3, S. 395-403

Swamy, Mahima;  Siegers, Gabrielle M;  Fiala, Gina J;  Molnar, Eszter;  Dopfer, Elaine P;  Fisch, Paul;  Schraven, Burkhart;  Schamel, Wolfgang W. A. 

Stoichiometry and intracellular fate of TRIM-containing TCR complexes
In: Cell communication and signaling . - London : Biomed Central, Bd. 8.2010, insges. 10 S.; Abstract unter URL: http://www.biosignaling.com/content/8/1/5/abstract

2009

Originalartikel in begutachteter internationaler Zeitschrift
Linnemann, Carsten;  Schildberg, Frank A.;  Schurich, Anna;  Diehl, Linda;  Hegenbarth, Silke I.;  Endl, Elmar;  Lacher, Svenja;  Müller, Christa E.;  Frey, Jürgen;  Simeoni, Luca;  Schraven, Burkhart;  Stabenow, Dirk;  Knolle, Percy A. 

Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
In: Immunology . - Oxford [u.a.] : Wiley-Blackwell, Bd. 128.2009, 1, S. 728-737; Abstract unter URL: http://www3.interscience.wiley.com/journal/122186133/abstract

Börner, Christine;  Smida, Michal;  Höllt, Volker;  Schraven, Burkhart;  Kraus, Jürgen 

Cannabinoid receptor type 1 and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling
In: The journal of biological chemistry . - Bethesda, Md. : ASBMB, Bd. 284.2009, 51, S. 35450-35460

Reinhold, Annegret;  Reimann, Sibylle;  Reinhold, Dirk;  Schraven, Burkhart;  Togni, Mauro 

Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo
In: Journal of leukocyte biology . - Bethesda, Md. : FASEB, Bd. 86.2009, 1, S. 61-71

Börner, Christine;  Warnick, Beate;  Smida, Michal;  Hartig, Roland;  Lindquist, Jonathan;  Schraven, Burkhart;  Höllt, Volker;  Kraus, Jürgen 

Mechanisms of opioid-mediated inhibition of human T cell receptor signaling
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 2, S. 882-889

Pierau, Mandy;  Engelmann, Swen;  Reinhold, Dirk;  Lapp, Thabo;  Schraven, Burkhart;  Bommhardt, Ursula 

Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 10, S. 6124-6134

Horn, Jessica;  Wang, Xiaoqian;  Reichardt, Peter;  Stradal, Theresia E. B.;  Warnecke, Nicole;  Simeoni, Luca;  Gunzer, Matthias;  Yablonski, Deborah;  Schraven, Burkhart;  Kliche, Stefanie 

Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 9, S. 5756-5767

Bleeke, Matthias;  Fest, Stefan;  Hübener, Nicole;  Landgraf, Christiane;  Schraven, Burkhart;  Gaedicke, Gerhard;  Volkmer, Rudolf;  Lode, Holger N. 

Systematic amino acid substitutions improved efficiency of GD2-peptide mimotope vaccination against neuroblastoma
In: The European journal of cancer . - Amsterdam [u.a.] : Elsevier, Bd. 45.2009, 16, S. 2915-2921

2008

Herausgeberschaft
Baier, Gottfried;  Schraven, Burkhart 

Sparking signals - kinases as molecular signaltransducers and pharmacological drug targets in inflammation
In: Berlin [u.a.]: Springer, 2008; XIV, 185 S.: Ill., graph. Darst.; 22 cm - (Ernst Schering Foundation symposium proceedings; 2007,3), ISBN 978-3-540-73500-7 ; Kongress: Symposium. Ernst Schering Foundation; (Potsdam) : 2007.06.20-22 ; [Literaturangaben]

Originalartikel in begutachteter internationaler Zeitschrift
Posevitz-Fejfár, Anita;  Smída, Michal;  Kliche, Stefanie;  Hartig, Roland;  Schraven, Burkhart;  Lindquist, Jonathan 

A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration
In: European journal of immunology . - Weinheim : Wiley VCH, Bd. 38.2008, 1, S. 250-259

Schraven, Burkhart;  Kalinke, Ulrich 

CD28 superagonists: what makes the difference in humans?
In: Immunity . - Cambridge, Mass. : Cell Press, Bd. 28.2008, 5, S. 591-595

Wang, Xiaoqian;  Simeoni, Luca;  Lindquist, Jonathan A.;  Saez-Rodriguez, Julio;  Ambach, Andreas;  Gilles, Ernst D.;  Kliche, Stefanie;  Schraven, Burkhart 

Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 180.2008, 10, S. 6703-6712

Tauzin, Sebastien;  Ding, Heidrun;  Khatib, Karim;  Ahmad, Ishtiaq;  Burdevet, Dimitri;  Echten-Deckert, Gerhild van;  Lindquist, Jonathan;  Schraven, Burkhart;  Din, Nasir-ud-;  Borisch, Bettina;  Hoessli, Daniel C. 

Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts
In: Blood . - Washington, DC : American Society of Hematology, Bd. 111.2008, 4, S. 2310-2320

Posevitz, Vilmos;  Arndt, Börge;  Krieger, Tina;  Warnecke, Nicole;  Schraven, Burkhart;  Simeoni, Luca 

Regulation of T cell homeostasis by the transmembrane adaptor protein SIT
In: The journal of immunology : official journal of the American Association of Immunologists. - Bethesda, Md : American Assoc. of Immunologists, Bd. 180.2008, 3, S. 1634-1642

Kölsch, Uwe;  Schraven, Burkhart;  Simeoni, Luca 

SIT and TRIM determine T cell fate in the thymus
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 181.2008, 9, S. 5930-5939

Waibler, Zoe;  Sender, Linda Y.;  Merten, Camilla;  Hartig, Roland;  Kliche, Stefanie;  Gunzer, Matthias;  Reichardt, Peter;  Kalinke, Ulrich;  Schraven, Burkhart 

Signaling signatures and functional properties of antihuman CD28 superagonistic antibodies
In: PLoS one . - Lawrence, Kan. : PLoS, Bd. 3.2008, 3, insges. 13 S.; Abstract unter URL: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2246163&rendertype=abstract

Börner, Christine;  Kraus, Jürgen;  Bedini, Andrea;  Schraven, Burkhart;  Höllt, Volker 

T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional [mu]-opioid receptors
In: Molecular pharmacology . - Bethesda, Md. : American Society for Pharmacology and Experimental Therapeutics, ISSN 0026-895x, Bd. 74.2008, 2, S. 496-504

Bekeredjian-Ding, Isabelle;  Doster, Anne;  Schiller, Martin;  Heyder, Petra;  Lorenz, Hanns-Martin;  Schraven, Burkhart;  Bommhardt, Ursula;  Heeg, Klaus 

TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 181.2008, 12, S. 8267-8277

Veracini, Laurence;  Simon, Valérie;  Richard, Véronique;  Schraven, Burkhart;  Horejsi, Vaclav;  Roche, Serge;  Benistant, Christine 

The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
In: The journal of cell biology . - New York, NY : Rockefeller Univ. Press, Bd. 182.2008, 3, S. 603-614

Originalartikel in begutachteter zeitschriftenartiger Reihe
Simeoni, Luca;  Lindquist, Jonathan;  Smida, Michal;  Witte, Vanessa;  Arndt, Börge;  Schraven, Burkhart 

Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins
In: Inhibition of immune cell function . - Oxford : Blackwell Munksgaard, Bd. 224.2008, S. 215-228

Lindquist, Jonathan;  Schraven, Burkhart 

Systems biology of T cell activation
In: Sparking signals . - Berlin [u.a.] : Springer, ISBN 978-3-540-73500-7, S. 43-61

2007

Herausgeberschaft
Schraven, Burkhart 

Immunoreceptors & integrins
In: Immunological reviews; 218; Munksgaard: Blackwell; 264 S.: Ill., graph. Darst., 2007 ; [Literaturangaben]

Originalartikel in begutachteter internationaler Zeitschrift
Saez-Rodriguez, Julio;  Simeoni, Luca;  Lindquist, Jonathan;  Hemenway, Rebecca;  Bommhardt, Ursula;  Arndt, Börge;  Haus, Utz-Uwe;  Weismantel, Robert;  Gilles, Ernst D.;  Klamt, Steffen;  Schraven, Burkhart 

A logical model provides insights into T cell receptor signaling
In: Public Library of Science : PLoS Computational Biology . - San Francisco, Calif. : Public Library of Science, Bd. 3.2007, 8, insges. 11 S.; Abstract unter URL: http://dx.doi.org/10.1371/journal.pcbi.0030163

Smída, Michal;  Posevitz-Fejfár, Anita;  Horejsi, Vaclav;  Schraven, Burkhart;  Lindquist, Jonathan 

A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains - blocking Ras activation
In: Blood . - Washington, DC : American Society of Hematology, Bd. 110.2007, 2, S. 596-605

Kasirer-Friede, Ana;  Moran, Barry;  Nagrampa-Orje, Jennifer;  Swanson, Ken;  Ruggeri, Zaverio M.;  Schraven, Burkhart;  Neel, Benjamin G.;  Koretzky, Gary;  Shattil, Sanford J. 

ADAP is required for normal [alpha]IIb[beta]3 activation by VWF/GP Ib-IX-V and other agonists
In: Blood . - Washington, DC : American Society of Hematology, Bd. 109.2007, 3, S. 1018-1025

Grégoire, Claude;  Simova, Sarka;  Wang, Ying;  Sansoni, Amandine;  Richelme, Sylvie;  Schmidt-Giese, Anja;  Simeoni, Luca;  Angelisova, Pavla;  Reinhold, Dirk;  Schraven, Burkhart;  Horejsi, Vaclav;  Malissen, Bernard;  Malissen, Marie 

Deletion of the LIME adaptor protein minimally affects T and B cell development and function
In: European journal of immunology . - Weinheim : Wiley VCH, Bd. 37.2007, 11, S. 3259-3269

Filby, Andrew;  Seddon, Benedict;  Kleczkowska, Joanna;  Salmond, Robert;  Tomlinson, Peter;  Smída, Michal;  Lindquist, Jonathan;  Schraven, Burkhart;  Zamoyska, Rose 

Fyn regulates the duration of TCR engagement needed for commitment to effector function
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 179.2007, 7, S. 4635-4644

Zipp, Frauke;  Waiczies, Sonia;  Aktas, Orhan;  Neuhaus, Oliver;  Hemmer, Bernhard;  Schraven, Burkhart;  Nitsch, Robert;  Hartung, Hans-Peter 

Impact of HMG-CoA reductase inhibition on brain pathology
In: Trends in pharmacological sciences . - Amsterdam : Cell Press, Bd. 28.2007, 7, S. 342-349

Jordan, Martha S.;  Maltzman, Jonathan S.;  Kliche, Stefanie;  Shabason, Jacob;  Smith, Jennifer E.;  Obstfeld, Amrom;  Schraven, Burkhart;  Koretzky, Gary A. 

In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction
In: European journal of immunology . - Weinheim : Wiley VCH, Bd. 37.2007, 10, S. 2961-2972

Davidson, Dominique;  Schraven, Burkhart;  Veillette, André 

PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes
In: Molecular and cellular biology . - Washington, DC : American Society for Microbiology, Bd. 27.2007, 5, S. 1960-1973

Ménasché, Gaël;  Kliche, Stefanie;  Chen, Emily J. H.;  Stradal, Theresia E. B.;  Schraven, Burkhart;  Koretzky, Gary 

RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
In: Molecular and cellular biology . - Washington, DC : American Society for Microbiology, Bd. 27.2007, 11, S. 4070-4081

Preller, Vera;  Gerber, Annegret;  Wrenger, Sabine;  Togni, Mauro;  Marguet, Didier;  Tadje, Janine;  Lendeckel, Uwe;  Röcken, Christoph;  Faust, Jürgen;  Neubert, Klaus;  Schraven, Burkhart;  Martin, Roland;  Ansorge, Siegfried;  Brocke, Stefan;  Reinhold, Dirk 

TGF-[beta]1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 178.2007, 7, S. 4632-4640

Originalartikel in begutachteter zeitschriftenartiger Reihe
Schraven, Burkhart;  Reth, Michael 

Immunoreceptors and integrins
In: Immunoreceptors & integrins . - Munksgaard : Blackwell, Bd. 218.2007, S. 5-8

Ménasché, Gaël;  Kliche, Stefanie;  Bezman, Natalie;  Schraven, Burkhart 

Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap 1 effector molecules
In: Immunoreceptors & integrins . - Munksgaard : Blackwell, Bd. 218.2007, S. 82-91

2006

Herausgeberschaft
Gundelfinger, Eckart D.;  Seidenbecher, Constanze I.;  Schraven, Burkhart 

Cell communication in nervous and immune system
In: Results and problems in cell differentiation; 43

Originalartikel in begutachteter internationaler Zeitschrift
Reichenbach, Janine;  Schubert, Ralf;  Horvàth, Rita;  Petersen, Jens;  Fütterer, Nancy;  Malle, Elisabeth;  Stumpf, Andreas;  Gebhardt, Boris R.;  Koehl, Ulrike;  Schraven, Burkhart;  Zielen, Stefan 

Fatal neonatal-onset mitochondrial respiratory chain disease with T cell immunodeficiency
In: Pediatric research . - Baltimore, Md. [u.a.] : Lippincott Williams & Wilkins, Bd. 60.2006, 3, S. 321-326

Heuer, Katja;  Sylvester, Marc;  Kliche, Stefanie;  Pusch, Rico;  Thiemke, Katharina;  Schraven, Burkhart;  Freund, Christian 

Lipid-binding hSH3 domains in immune cell adapter proteins
In: Journal of molecular biology . - Amsterdam [u.a.] : Elsevier, Bd. 361.2006, 1, S. 94-104

Kölsch, Uwe;  Arndt, Börge;  Reinhold, Dirk;  Lindquist, Jonathan;  Jüling, Nicole;  Kliche, Stefanie;  Pfeffer, Klaus;  Bruyns, Eddy;  Schraven, Burkhart;  Simeoni, Luca 

Normal T-cell development and immune functions in TRIM-deficient mice
In: Molecular and cellular biology . - Washington, DC : American Society for Microbiology, Bd. 26.2006, 9, S. 3639-3648

Kliche, Stefanie;  Breitling, Dennis;  Togni, Mauro;  Pusch, Rico;  Heuer, Katja;  Wang, Xiaoqian;  Freund, Christian;  Kasirer-Friede, Ana;  Menasche, Gael;  Koretzky, Gary A.;  Schraven, Burkhart 

The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1
In: Molecular and cellular biology . - Washington, DC : American Society for Microbiology, Bd. 26.2006, 19, S. 7130-7144

Originalartikel in begutachteter zeitschriftenartiger Reihe
Preller, Vera;  Gerber, Annegret;  Togni, Mauro;  Wrenger, Sabine;  Schraven, Burkhart;  Röcken, Christoph;  Marguet, Didier;  Ansorge, Siegfried;  Brocke, Stefan;  Reinhold, Dirk 

CD26/DP IV in T cell activation and autoimmunity
In: Dipeptidyl aminopeptidases . - New York : Springer Science + Business Media, ISBN 0-387-29058-3, S. 187-193

2005

Originalartikel in begutachteter internationaler Zeitschrift
Togni, Mauro;  Swanson, K. (ext.);  Reimann, Sibylle;  Kliche, Stefanie;  Pearce, A. (ext.);  Simeoni, Luca;  Reinhold, Dirk;  Wienands, J. (ext.);  Neel, B. (ext.);  Schraven, Burkhart;  Gerber, Annegret 

Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
In: Mol. Cell. Biol. 25(2005), Nr. 18, S. 8052 - 8063

Simeoni, Luca;  Smida, Michal;  Posevitz, Vilmos;  Schraven, Burkhart;  Lindquist, Jonathan 

Right time, right place : the organization of membrane proximal signaling.
In: Semin. Immunol. 17(2005), Nr. 1, S. 35 - 49

Wang, Y. (ext.);  Horvath, O. (ext.);  Hamm-Baarke, Andrea;  Richelme, M. (ext.);  Grgoire, C. (ext.);  Schraven, Burkhart;  ..., (ext.);   

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.
In: Mol. Cell. Biol. 25(2005), Nr. 11, S. 4455 - 4465

Simeoni, Luca;  Posevitz, Vilmos;  Koelsch, Uwe;  Meinert, Ines;  Bruyns, E. (ext.);  Pfeffer, K. (ext.);  Reinhold, Dirk;  Schraven, Burkhart 

The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.
In: Mol. Cell. Biol. 25(2005), Nr. 17, S. 7557 - 7568

2004

Nicht begutachteter Zeitschriftenartikel
Schraven, Burkhart 

Grundsätzliches und Neues aus der Immunologie.
In: Dtsch. Z. Klin. Forsch. 8(2004), Nr. 9/10, [8 S.]

Originalartikel in begutachteter internationaler Zeitschrift
Weren, Andrea;  Bonnekoh, Bernd;  Schraven, Burkhart;  Gollnick, Harald;  Ambach, Andreas 

A novel flow cytometric assay focusing on perforin release mechanisms of cytotoxic T lymphocytes.
In: J. Immunol. Methods 289(2004), Nr. 1-2, S. 17 - 26

Simeoni, Luca;  Kliche, Stefanie;  Lindquist, Jonathan;  Schraven, Burkhart 

Adaptors and linkers in T and B cells.
In: Curr. Opin. Immunol. 16(2004), Nr. 3, S. 304 - 313

Lobmann, Ralf;  Ittenson, Annelore;  Schiweck, S.;  Motzkau, Markus;  Schraven, Burkhart;  Winckler, Stephan;  Lehnert, Hendrik 

Expression of cell surface antigens in diabetic patients and healthy controls after injury.
In: Diabetes Nutr. Metab. 17(2004), Nr. 4, S. 244 - 246

Stork, B. (ext.);  Engelke, M. (ext.);  Frey, J. (ext.);  Horejs¡, V. (ext.);  Hamm-Baarke, Andrea;  Schraven, Burkhart;  Kurosaki, T. (ext.);  Wienands, J. (ext.) 

Grb2 and the non-T cell activation linker NTAL constitute a Ca2+-regulating signal circuit in B lymphocytes.
In: Immunity 21(2004), Nr. 5, S. 681 - 691

Zhang, S. (ext.);  Yang, W. (ext.);  Kontaridis, M. (ext.);  Schraven, Burkhart;  Philips, M. (ext.);  Neel, B. (ext.);   

Shp2 regulates Src family kinase activity and Ras/Erk activation by controlling Csk recruitment.
In: Mol. Cell 13(2004), Nr. 3, S. 341 - 355

Togni, Mauro;  Lindquist, Jonathan;  Gerber, Annegret;  Koelsch, Uwe;  Hamm-Baarke, Andrea;  Kliche, Stefanie;  Schraven, Burkhart 

The role of adaptor proteins in lymphocyte activation.
In: Mol. Immunol. 41(2004), Nr. 6-7, S. 615 - 630

Kliche, Stefanie;  Lindquist, Jonathan;  Schraven, Burkhart 

Transmembrane adapters : structure, biochemistry and biology.
In: Semin. Immunol. 16(2004), Nr. 6, S. 367 - 377

Horejs¡, V. (ext.);  Zhang, W. (ext.);  Schraven, Burkhart 

Transmembrane adaptor proteins : organizers of immunoreceptor signalling.
In: Nat. Rev. Immunol. 4(2004), Nr. 8, S. 603 - 616

2003

Nicht begutachteter Zeitschriftenartikel
Boehm, Malte;  Klatte, T.;  Ittenson, Annelore;  Roehl, Friedrich Wilhelm;  Ansorge, Siegfried;  Schraven, Burkhart;  Allhoff, Ernst Peter 

Perioperative Immunmodulation beim Nierenzellkarzinom.
In: Tumorzentrum aktuell(2003), Nr. 2, S. 10 - 18

Originalartikel in begutachteter internationaler Zeitschrift
Brdickov , N. (ext.);  Brdicka, T. (ext.);  Schmidt, Peter;  Simeoni, Luca;  Kliche, Stefanie;  Merten, Camilla;  Schraven, Burkhart;  Horejs¡, V. (ext.);   

LIME : a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
In: J. Exp. Med. 198(2003), Nr. 10, S. 1453 - 1462

Marinari, B. (ext.);  Simeoni, Luca;  Schraven, Burkhart;  Piccolella, E. (ext.);  Tuosto, L. (ext.) 

The activation of Csk by CD4 interferes with TCR-mediated activatory signaling.
In: Eur. J. Immunol. 33(2003), Nr. 9, S. 2609 - 2618

Lindquist, Jonathan;  Simeoni, Luca;  Schraven, Burkhart 

Transmembrane adapters : attractants for cytoplasmic effectors.
In: Immunol. Rev. 191(2003), Nr. 1, S. 165 - 182

Originalartikel in begutachteter nationaler Zeitschrift
Schraven, Burkhart 

Neue immologische Signale aus Magdeburg.
In: Magdeburger Wissenschaftsjournal [Magdeburg] 8(2003), Nr. 1/2, S. 29 - 44

2002

Originalartikel in begutachteter internationaler Zeitschrift
Leo, A. (ext.);  Wienands, J. (ext.);  Baier, G. (ext.);  Horejsi, V. (ext.);  Schraven, Burkhart 

Adapters in lymphocyte signaling.
In: J. Clin. Invest. 109(2002), Nr. 3, S. 301 - 309

Fortin, M. (ext.);  Steff, A.M. (ext.);  Felberg, J. (ext.);  Ding, I.;  Schraven, Burkhart;  Johnson, P. (ext.);  Hugo, P. (ext.) 

Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein.
In: J. Immunol. 168(2002), S. 6084 - 6089

Wonerow, P. (ext.);  Obergfell, A. (ext.);  Wilde, J. (ext.);  Bobe, R. (ext.);  Asazuma, N. (ext.);  Brdika, T. (ext.);  Leo, A. (ext.);  Schraven, Burkhart;  Hoeji, V. (ext.);  Shattil, S. (ext.);  Watson, S. (ext.) 

Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin- mediated phospholipase Cg2 regulation in platelets.
In: Biochem. J. 364(2002), S. 755 - 765

Brdicka, T. (ext.);  Imrich, M. (ext.);  Schmidt, Peter;  Brdickov , N. (ext.);  Horv th, O. (ext.);  Simeoni, Luca;  Oesterreicher, J. (ext.);  Aguado, E. (ext.);  Malissen, M. (ext.);  Schraven, Burkhart;  Horejs¡, V. (ext.);   

Non-T cell activation linker (NTAL) : a transmembrane adaptor protein involved in immunoreceptor signaling.
In: J. Exp. Med. 196(2002), Nr. 12, S. 1617 - 1626

Klein, C. (ext.);  Kraemer, E.M. (ext.);  Cardine, A.M. (ext.);  Schraven, Burkhart;  Brandt, R.;  Trotter, J. (ext.) 

Process outgrowth of oligodendrocytes is promoted by interaction of Fyn kinase with the cytoskeletal protein Tau.
In: J. Neurosci. 22(2002), Nr. 3, S. 698 - 707

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  • Molekulare Zellbiologie
Vita
Burkhart Schraven leitet die Abteilung "Immunkontrolle" am HZI und ist gleichzeitig Direktor des Instituts für Molekulare und Klinische Immunologie und Lehrstuhlinhaber für das Fach Immunologie an der Medizinischen Fakultät der Otto-von-Guericke-Universität Magdeburg. Er studierte Humanmedizin an den Universitäten Mainz, Bonn und Bochum und promovierte über "Etablierung von in vitro Systemen zur Analyse der T- und B-Zell Interaktion." Nach seiner Habilitation im Fach "Immunologie" an der Medizinischen Fakultät der Universität Heidelberg zum Thema "Molekulare Analyse des CD2 Rezeptorkomplexes in humanen T-Lymphozyten" wechselte er nach Magdeburg, um dort den Direktorenposten des Instituts für Immunologie zu übernehmen. Zudem ist er seit 2007 Prodekan für Forschung an der Medizinischen Fakultät der Otto-von-Guericke-Universität Magdeburg und seit 2010 Sprecher des DFG-Sonderforschungsbereiches 854 "Molekulare Organisation der zellulären Kommunikation im Immunsystem". An dem Sonderforschungsbereich beteiligen sich auch Gruppen des HZI mit zwei Teilprojekten. Gemeinsam möchten HZI und OVGU die seit 2007 bestehende Kooperation weiter ausbauen. Hierzu wurde 2008 im Rahmen eines gemeinsamen durchgeführten Berufungsverfahrens die W2-Professur "Systemorientierte Immunologie und Entzündungsforschung" eingerichtet, die der Abteilumg Immunkontrolle zugeordnet ist.
presse
Burkhart Schraven untersucht Fragestellungen der Molekularen und Klinischen Immunologie an der Otto-von-Guericke-Universität Magdeburg. Was passiert, wenn sich das Immunsystem mit Bakterien, Pilzen, Viren oder körperfremden Substanzen auseinandersetzt? Welche Signalwege und –komponenten werden angeschaltet und wie „reden“ die Signalmoleküle miteinander, um die Immunantwort zu steuern? Die biochemischen Reaktionen, die ablaufen, wenn ein Organismus “Gefahr“oder „Fremd“ erkennt sind sehr komplex. Da wird in und auf Zellen migriert, angeheftet, ausgebaut und umgebaut, mit dem Ziel den eigenen Organismus vor Krankheit und Schaden zu schützen. Mit vereinten Kräften untersuchen Wissenschaftler des Instituts für Molekulare und Klinische Immunologie der Medizinischen Fakultät der Otto-von-Guericke Universität Magdeburg und des HZI in interdisziplinären Projekten wer dabei mit wem und vor allem wie interagiert.

Letzte Änderung: 28.08.2017 - Ansprechpartner:

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