Prof. Schaper

Prof. Dr. rer. nat. Fred Schaper
Systembiologie
Aktuelle Projekte
- Programm Forschungsgroßgeräte - Zellsorter INST 272/284-1 FUGG
Laufzeit: 16.07.2020 - 15.07.2030 - Intravascular crosstalk of interleukin-6 and therapeutic glucocorticoids in SARS-CoV2 infection
Laufzeit: 01.01.2022 - 31.12.2024
Abgeschlossene Projekte
- Kontrolle der entzündlichen Zytokinantwort durch Stress
Laufzeit: 01.09.2014 - 30.09.2018 - InTraSig:Entwicklung einer personalisierten Anti-Entzündungstherapie zur Inhibition des Interleukin-6-Trans-Signalwegs
Laufzeit: 01.09.2014 - 31.12.2017 - JAK-Sys; Aufklärung der dysbalancierten Signaltransduktion durch JAK2-V617F in myeloproliferativen Neoplasien mittels qualitativer und quantitativer Modellierungsansätze
Laufzeit: 01.01.2013 - 31.07.2016 - Dynamik und Mechanismen der Interleukin-6-Rezeptoraktivierung
Laufzeit: 01.01.2013 - 31.12.2013 - Signal Transduktion von JAK2-V617F
Laufzeit: 01.01.2012 - 31.12.2012 - Adapter proteins as a central regulator of the dynamics of cytokine signaling
Laufzeit: 01.02.2010 - 31.12.2011 - Balance of MAPK-activation and the initiation of the JAK/STAT pathway in interleukin-6 signal transduction
Laufzeit: 23.07.2010 - 31.12.2011 - Funktionsdefinition der Protein-Tyrosinphosphatase SHP2 in der Interleukin-6 Signaltransduktion
Laufzeit: 01.10.2007 - 30.09.2011 - Cross-talk von NF-kB, Glucokorticoiden und STAT3 während der Akut-Phase Reaktion
Laufzeit: 01.07.2008 - 30.06.2011 - IL-6-vermittelte, STAT-unabhängige Signalwege
Laufzeit: 01.07.2008 - 31.01.2011 - Untersuchungen zum cross-talk zwischen IL-6-Typ-Zytokinen und dem Wachstumsfaktor PDGF: die Rolle der SOCS3-Phosphorylierung
Laufzeit: 01.08.2005 - 30.04.2009 - IL-6-vermittelte, STAT-unabhängige Signalwege
Laufzeit: 01.07.2005 - 30.06.2008 - Untersuchungen zur dualen Funktion von NF-kB für die Regulation STAT3-abhängiger Gene
Laufzeit: 01.07.2005 - 30.06.2008 - Untersuchungen zur dualen Funktion von NF-kB für die Regulation STAT3-abhängiger Gene
Laufzeit: 01.07.2002 - 30.06.2005 - Signaltransduktion der Interleukin-6-Typ-Zytokin-vermittelten Migration von T-Zellen
Laufzeit: 01.07.2002 - 30.06.2005 - Negative Regulation der Interleukin-6-Signaltransduktion
Laufzeit: 01.07.2002 - 30.06.2005 - IL-6 Signaltransduktion während der Akutphase-Antwort der Leber
Laufzeit: 01.07.1999 - 30.06.2002 - Untersuchungen zur dualen Funktion von NF -kB für die Regulation STAT3-abhängiger Gene
Laufzeit: 01.04.2002 - 30.06.2002 - Signaltransduktion der Interleukin-6-Typ-Zytokin-vermittelten Migration von T-Zellen
Laufzeit: 01.12.2000 - 30.06.2002 - Studien zur Interleukin-6 und Hepatocyte Growth Factor (HGF)-Signaltransduktion während der Akutphase-Antwort der Leber
Laufzeit: 01.02.1997 - 30.06.1999
2022
Abstract
Non-canonical STAT3 function reduces REDD1 transcription
In: 4th International Conference on Cytokines in Cancer, 2022 . - 2022, insges. 1 S.
STAT3-mediated reduction of REDD1 expression - Novel insights into crosstalk of inflammatory- and stress-signalling
In: 25th Jubilee Meeting on Singal Transduction - Signal Transduction Society, 2022 . - 2022, S. 49
SARS-CoV2-induced vascular inflammation a battlefield for IL-6
In: 25th Jubilee Meeting on Singal Transduction - Signal Transduction Society, 2022 . - 2022, S. 104
Begutachteter Zeitschriftenartikel
Non-canonical STAT3 function reduces REDD1 transcription
In: The FEBS journal/ Vereinigung der Europäischen Biochemischen Gesellschaften - Oxford [u.a.]: Wiley-Blackwell . - 2022, insges. 34 S.
All-in-one superparamagnetic and SERS-active niosomes for dual-targeted in vitro detection of breast cancer cells
In: Sensors & Diagnostics/ Royal Society of Chemistry - London: RSC Publishing . - 2022, insges. 16 S.
Decoding cellular communication - an information theoretic perspective on cytokine and endocrine signaling
In: Current opinion in endocrine and metabolic research - Amsterdam: Elsevier . - 2022
Buchbeitrag
Mediatoren
In: Löffler/Petrides Biochemie und Pathobiochemie - Berlin, Heidelberg: Springer Berlin Heidelberg; Heinrich, Peter C. . - 2022, S. 527-532
Rezeptoren und ihre Signaltransduktion
In: Löffler/Petrides Biochemie und Pathobiochemie - Berlin, Heidelberg: Springer Berlin Heidelberg; Heinrich, Peter C. . - 2022, S. 533-571
Prinzipien zellulärer Kommunikation
In: Löffler/Petrides Biochemie und Pathobiochemie - Berlin, Heidelberg: Springer Berlin Heidelberg; Heinrich, Peter C. . - 2022, S. 513-526
2021
Begutachteter Zeitschriftenartikel
Glucocorticoids attenuate interleukin6induced cFos and Egr1 expression and impair neuritogenesis in PC12 cells
In: Journal of neurochemistry - Oxford: Wiley-Blackwell, Bd. 157 (2021), 3, S. 532-549
The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling
In: Cell communication and signaling - London: Biomed Central, Bd. 19 (2021), 1, insges. 19 S.
2019
Begutachteter Zeitschriftenartikel
Robustness and information transfer within IL-6-induced JAK/STAT signalling
In: Communications biology - London: Springer Nature, Vol. 2.2019, Art. 27, insgesamt 14 S.
The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner
In: Cell communication and signaling - London: Biomed Central, Volume 17 (2019), Article 135, insgesamt 23 Seiten
Intragenic regulation of SOCS3 isoforms
In: Cell communication and signaling - London: Biomed Central, Volume 17 (2019), 1, Artikel 70, insgesamt 15 Seiten
Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression - fusing experimental insights and dynamic modelling
In: Cell communication and signaling - London: Biomed Central, Vol. 17.2019, 1, Art. 17:46, insgesamt 21 Seiten
Designing optimal experiments to discriminate interaction graph models
In: IEEE ACM transactions on computational biology and bioinformatics - New York, NY: IEEE, Bd. 16 (2019), 3, S. 925-935
2018
Begutachteter Zeitschriftenartikel
Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, Vol. 9.2018, 1, Art. 168, insgesamt 17 S.
2017
Begutachteter Zeitschriftenartikel
The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, Bd. 35 (2017), S. 37-47
2016
Abstract
Expression level of JAK2-V617F determines sensitivity to tyrosine kinase inhibitor Ruxolitinib in HEK293 Flp-In cells and can be augmented by treatment with inhibitors of PI3K/Akt pathway in JAK2-V617F - positive murine progenitor cells
In: Oncology research and treatment - Basel: Karger, 2014, Bd. 39.2016, Suppl. 3, Abs. P510, Seite 148-149
Begutachteter Zeitschriftenartikel
Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-Inhibitor REDD1 in a STAT3-dependent manner
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, 1989, Bd. 28.2016, 8, S. 907-916
2015
Begutachteter Zeitschriftenartikel
Systems biology of IL-6, IL-12 family cytokines
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 595-602
"Family reunion" - a structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 471-474
A two-level approach for fusing early signaling events and long term cellular responses
In: IFAC-PapersOnLine/ Internationale Förderung für Automatische Lenkung - Frankfurt: Elsevier, 2015, Bd. 48.2015, 8, S. 1228-1233
Interleukin-6: Biology, signaling and strategies of blockade
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 475-487
MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, 1989, Bd. 27.2014, 2, S. 340-352, 2015
2014
Buchbeitrag
Mediatoren
In: Löffler/Petrides Biochemie und Pathobiochemie. - Berlin [u.a.] : Springer, S. 407-410, 2014
Rezeptoren und ihre Signaltransduktion
In: Löffler/Petrides Biochemie und Pathobiochemie. - Berlin [u.a.] : Springer, S. 411-441, 2014
Prinzipien zellulärer Kommunikation
In: Löffler/Petrides Biochemie und Pathobiochemie. - Berlin [u.a.] : Springer, S. 395-406, 2014
2013
Begutachteter Zeitschriftenartikel
JAK/STAT signalling - an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, 2005, Bd. 9.2013, S. 1290-1307
Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domains point mutations associated with Noonan syndrome and leukemia
In: Journal of proteomics - New York, NY [u.a.]: Elsevier, 2008, Bd. 84.2013, S. 132-147
mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice
In: The journal of clinical investigation: JCI : the publication of the American Society for Clinical Investigation - Ann Arbor, Mich: ASCJ, 1924, Bd. 123.2013, 2, S. 767-781
JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells
In: JAK-STAT - London: Taylor & Francis Group, 2012, Bd. 2.2013, 3, insges. 13 S.
Buchbeitrag
Determination of protein turnover rates in the JAK/STAT pathway using a radioactive pulse-chase approach
In: JAK-STAT signalling: methods and protocols / ed. by Sandra E. Nicholson and Nicos A. Nicola: methods and protocols - New York [u.a.]: Humana Pr., 2013 . - 2013, S. 69-80 - (Methods in molecular biology; 967)
2012
Buchbeitrag
JAK-STAT signalling as example for a database-supported modular modelling concept
In: Gilbert, David: : Computational Methods in Systems Biology. - Berlin : Springer, S. 362-365, 2012 - (Lecture Notes in Bioinformatics; 7605)
Originalartikel in begutachteter internationaler Zeitschrift
Hepatic acute phase proteins - regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kB-dependent signaling
In: European journal of cell biology. - Amsterdam : Elsevier, Bd. 91.2012, 6/7, S. 496-505
Glucocorticoids increase interleukin-6 dependent gene induction by interfering with the expression of the SOCS 3 feedback inhibitor
In: Hepatology. - Hoboken, NJ : Wiley Interscience, Bd. 55.2012, 1, S. 256-266
Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling
In: Molecular BioSystems. - Cambridge : Royal Society of Chemistry, 8, S. 2119-2134, 2012
Interleukin-6 signalling - more than Jaks and STATs
In: European journal of cell biology. - Amsterdam : Elsevier, Bd. 91.2012, 6/7, S. 486-495
Plasticity and cross-talk of Interleukin 6-type cytokines
In: Cytokine & growth factor reviews - Oxford [u.a.]: Elsevier, 1996, Bd. 23.2012, 3, S. 85-97
2011
Originalartikel in begutachteter internationaler Zeitschrift
Glucagon counteracts interleukin-6-dependent gene expression by redundant action of EPAC and PKA
In: Biological chemistry - Berlin [u.a.]: de Gruyter, Bd. 392.2011, S. 1123-1134
A simple work flow for biologically inspired model reduction - application to early JAK-STAT signaling
In: BMC systems biology - London: BioMed Central, Bd. 5.2011, 30, insges. 30 S.
Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, Bd. 7.2011, 12, S. 3253-3270
Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini
In: PLoS biology - Lawrence, KS: PLoS, Bd. 9.2011, 2
2010
Originalartikel in begutachteter internationaler Zeitschrift
Cross-regulation of cytokine signalling - pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation
In: Journal of cell science . - Cambridge : Company of Biologists Limited, Bd. 123.2010, 6, S. 947-959
2009
Begutachteter Zeitschriftenartikel
A new mechanism for the regulation of Gab1 recruitment to the plasma membrane
In: J Cell Sci, Volume 122, Issue Pt 1, Pages: 55-64, 2009
Originalartikel in begutachteter internationaler Zeitschrift
Signal transduction - receptors, mediators, and genes
In: Science signaling - Washington, DC [u.a.]: Assoc, 2008, Bd. 2.2009, 63, insges. 4 S.
Signal transduction in the footsteps of Goethe and Schiller
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 7.2009, Art. 2, insges. 6 S.
2008
Begutachteter Zeitschriftenartikel
Interleukin-6 acts in the fashion of a classical chemokine on monocytic cells by inducing integrin activation, cell adhesion, actin polymerization, chemotaxis, and transmigration
In: J Leukoc Biol, Volume 84, Issue 6, Pages: 1521-9; 2008
Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation
In: Biochem J, Volume 412, Issue 1, Pages: 65-72, 2008
SHPS-1/SIRP1alpha contributes to interleukin-6 signalling
In: Cell Signal, Volume 20, Issue 7, Pages: 1385-91, 2008
2007
Begutachteter Zeitschriftenartikel
Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene
In: Cell Signal, Volume 19, Issue 9, Pages: 1866-78, 2007
Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade
In: J Immunol, Volume 178, Issue 5, Pages: 2813-26, 2007
2006
Begutachteter Zeitschriftenartikel
Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130
In: Cell Signal, Volume 18, Issue 1, Pages: 40-9, 2006
Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism
In: J Biol Chem, Volume 281, Issue 13, Pages: 8458-68, 2006
Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes
In: J Hepatol, Volume 45, Issue 1, Pages: 72-80, 2006
Lehrbuch
Kapitel 25: Kommunikation zwischen Zellen: Extrazelluläre Signalmoleküle, Rezeptoren und Signaltransduktion
In: in: Löffler, G., Petrides, P.E., Heinrich, P.C. (eds.): Biochemie und Pathobiochemie 8. Auflage. Springer-Verlag Berlin Heidelberg, 2006, pp 755-807
2005
Begutachteter Zeitschriftenartikel
The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling
In: Cell Signal, Volume 17, Issue 5, Pages: 559-69, 2005
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases
In: J Biol Chem, Volume 280, Issue 36, Pages: 31478-88, 2005
Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo
In: J Hepatol, Volume 43, Issue 4, Pages: 704-10, 2005
2004
Begutachteter Zeitschriftenartikel
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
In: Biochem J, Volume 378, Issue Pt 2, Pages: 449-60, 2004
Interleukin-6 is a direct mediator of T cell migration
In: Eur J Immunol, Volume 34, Issue 10, Pages: 2895-906, 2004
Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression
In: J Biol Chem, Volume 279, Issue 43, Pages: 45279-89, 2004
Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK
In: J Biol Chem, Volume 279, Issue 42, Pages: 44093-100, 2004
2003
Begutachteter Zeitschriftenartikel
IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3
In: Faseb J, Volume 17, Issue 3, Pages: 488-90, 2003
TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex
In: J Immunol, Volume 171, Issue 1, Pages: 257-66, 2003
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
In: Biochem J, Volume 374, Issue Pt 1, Pages: 1-20, 2003
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
In: J Biol Chem, Volume 278, Issue 1, Pages: 661-71, 2003
Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
In: J Immunol, Volume 170, Issue 6, Pages: 3263-72, 2003
Lehrbuch
Kapitel 28: Endokrine Funktionen II: Zytokine
In: in: Löffler, G., Petrides, P.E. (eds.): Biochemie und Pathobiochemie 7. Auflage. Springer-Verlag Berlin Heidelberg, 2003, pp. 813-835
2001
Begutachteter Zeitschriftenartikel
The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B
In: J Immunol, Volume 167, Issue 3, Pages: 1469-1481, 2001
The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription
In: Biol Chem, Volume 382, Issue 10, Pages: 1447-53, 2001
Expression of suppressors of cytokine signaling during liver regeneration
In: J Clin Invest, Volume 107, Issue 10, Pages: 1285-92, 2001
Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited
In: Eur J Biochem, Volume 268, Issue 24, Pages: 6401-7, 2001
Termination and modulation of IL-6-type cytokine signaling
In: Adv Exp Med Biol, Volume 495, Pages: 153-60, 2001
A completely foreign receptor can mediate an interferon-gamma-like response
In: Embo J, Volume 20, Issue 19, Pages: 5431-42, 2001
2000
Begutachteter Zeitschriftenartikel
Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation
In: J Immunol, Volume 165, Issue 5, Pages: 2535-43, 2000
A new peptide-affinity tag for the detection and affinity purification of recombinant proteins with a monoclonal antibody
In: J Immunol Methods, Volume 240, Issue 1-2, Pages: 165-83, 2000
Cytoplasmic STAT proteins associate prior to activation
In: Biochem J, Volume 345 Pt 3, Pages: 417-21, 2000
Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor
In: J Biol Chem, Volume 275, Issue 52, Pages: 40742-8, 2000
Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies
In: J Biol Chem, Volume 275, Issue 7, Pages: 4579-86, 2000
The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3
In: Embo J, Volume 19, Issue 21, Pages: 5845-55, 2000
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
In: J Biol Chem, Volume 275, Issue 17, Pages: 12848-56, 2000
The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction
In: Journal of Immunology 164, Issue 2, Pages: 848-54, 2000
Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA
In: FEBS Lett, Volume 478, Issue 1-2, Pages: 100-4, 2000
The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130
In: J Biol Chem, 275, Issue 25, Pages: 18810-17, 2000
1999
Begutachteter Zeitschriftenartikel
LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
In: FEBS Letters 463 (3) , pp. 365-370, 1999
Characterization and binding specificity of the monomeric STAT3-SH2 domain
In: Journal of Biological Chemistry 274 (3) , pp. 1342-1348, 1999
Different protein turnover of interleukin-6-type cytokine signalling components
In: European Journal of Biochemistry 265 (1) , pp. 251-257, 1999
Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor.
In: Biochemical Journal 339 (1) , pp. 15-19, 1999
1998
Begutachteter Zeitschriftenartikel
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
In: Biochemical J. 224 (2) , pp. 297-314, 1998
In vivo formation of IRF-1 homodimers
In: Biochimie 80 (8-9) , pp. 659-664, 1998
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
In: Biochemical Journal 335 (3) , pp. 557-565, 1998
Functional domains of interferon regulatory factor 1 (IRF-1)
In: Biochemical Journal 335 (1) , pp. 147-157, 1998
Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130
In: FEBS Letters 441 (2) , pp. 231-234, 1998
1997
Begutachteter Zeitschriftenartikel
Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes
In: FEBS Letters 405 (1) , pp. 99-103, 1997
Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA
In: Journal of Biological Chemistry 272 (15) , pp. 9785-9792, 1997
1996
Begutachteter Zeitschriftenartikel
Regulation of cell growth by IRF-1 in BHK-21 cells
In: Cytotechnology 22 (1-3) , pp. 147-156, 1996
1995
Begutachteter Zeitschriftenartikel
Identification of mammalian cell clones exhibiting highly regulated expression from inducible promoters
In: Trends in Genetics 11 , pp. 219-220, 1995
IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR
In: Oncogene 11 (3) , pp. 439-445, 1995
Proliferation control of mammalian cells by the tumor suppressor IRF-1
In: Cytotechnology 18 (1-2) , pp. 67-75, 1995
1994
Begutachteter Zeitschriftenartikel
A multifunctional vector family for gene expression in mammalian cells
In: Gene 149 , pp. 387-388, 1994
A new hybrid promoter directs transcription at identical start points in mammalian cells and in vitro
In: Gene 149 , pp. 389-390, 1994
1993
Begutachteter Zeitschriftenartikel
Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes
In: Nucleic Acids Research 21 (12) , pp. 2881-2889, 1993
- Conaris Research Institute AG, Kiel
- Prof. Dr. Stephan Feller, Martin-Luther-Universität, Halle
- Prof. Dr. Rolf Findeisen, Otto-von-Guericke Universität Magdeburg
- Prof. Dr. Thomas Fischer, Otto-von-Guericke Universität Magdeburg
- PD Dr. Claude Haan, University Luxembourg
- Prof. Dr. Raymond Kaempfer, Hebrew University, Jerusalem, Israel
- Prof. Dr. Steffen Klamt, Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg
- Prof. Dr. Martin Mönnigmann, Ruhr Universität, Bochum
- Prof. Dr. Timothy M. Palmer, University of Bradford, UK
- Prof. Dr. Stefan Rose-John, Christian-Albrechts-Universität Kiel
- Prof. Dr. Jürgen Scheller, Heinrich-Heine-Universität Düsseldorf
- Jun.-Prof. Dr. Steffen Waldherr, Institut für Automatisierungstechnik, OvGU
- Prof. Dr. Dagmar Wirth, Helmholtz Zentrum für Infektionsforschung, Braunschweig
- Prof. Dr. Dagmar Wirth
- Signaltransduktion
- Zytokine
- Cross-Talk
- Interleukin-6
- Interleukin-1
- Adapterproteine
- Phosphatasen
- Regulationsnetzwerke
- Signaltransduktion
- Zytokine
- Cross-Talk
- Interleukin-6
- Interleukin-1
- Adapterproteine
- Phosphatasen
- Regulationsnetzwerke
- 1965, Germany
Languages:
- German, English
Education:
- Academic studies of Biology, Technical University of Braunschweig (1985-1992)
- Diploma thesis: "Mutagenesis studies on phosphorylation of the transcription factor IRF-1", National Institute for Biotechnology (GBF), Braunschweig, Germany 1992
Professional Career:
- Ph.D. thesis: "Phosphorylation and dimerization of the transcription factor IRF-1", National Institute for Biotechnology (GBF), Braunschweig, Germany, 1996
- PostDoc: National Institute for Biotechnology (GBF), Braunschweig, Germany, 1995-1996
- Scientific Assistant: Dept. of Biochemistry, Technical University Aachen (RWTH), Germany, 1996-2000
- Assistant Professor (Akad. Rat): Dept. of Biochemistry, Technical University Aachen (RWTH), Germany, 2000-2004
- Habilitation (venia legendi) Biochemistry and Molecular Biology, Technical University Aachen (RWTH), Germany, 2002
- Akademischer Oberrat: Dept. of Biochemistry, Technical University Aachen (RWTH), Germany, 2004-2010
- Adjunct Professor (apl. Prof.): Dept. of Biochemistry and Molecular Biology, Technical University Aachen (RWTH), Germany, 2005-2010
- Full Professer (Univ.-Prof., W3) and Chair of the Department of Systems Biology, Otto-von-Guericke-University (OvGU), Magdeburg, Germany, since 2010
- Dean of Studies (Faculty of Life Sciences), since 2016
Awards:
- Technical University of Braunschweig: Braunschweiger Bürgerpreis Naturwissenschaften, 1992
- Minerva-Foundation Fellowship: Technion - Israel Institute of Technology, Haifa, Israel, 1993
- RWTH-Aachen: Friedrich-Wilhelm-Habilitationspreis, 2003