Robustness and information transfer within IL-6-induced JAK/STAT signalling
In: Communications biology - London: Springer Nature, Vol. 2.2019, Art. 27, insgesamt 14 S.

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner
In: Cell communication and signaling - London: Biomed Central, Volume 17 (2019), Article 135, insgesamt 23 Seiten

Intragenic regulation of SOCS3 isoforms
In: Cell communication and signaling - London: Biomed Central, Volume 17 (2019), 1, Artikel 70, insgesamt 15 Seiten

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression - fusing experimental insights and dynamic modelling
In: Cell communication and signaling - London: Biomed Central, Vol. 17.2019, 1, Art. 17:46, insgesamt 21 Seiten

Designing optimal experiments to discriminate interaction graph models
In: IEEE ACM transactions on computational biology and bioinformatics - New York, NY: IEEE, Bd. 16.2019, 3, S. 925-935

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability
In: Nature Communications - [London]: Nature Publishing Group UK, Vol. 9.2018, 1, Art. 168, insgesamt 17 S.

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, Bd. 35.2017, S. 37-47

Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-Inhibitor REDD1 in a STAT3-dependent manner
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, Bd. 28.2016, 8, S. 907-916

Systems biology of IL-6, IL-12 family cytokines
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 595-602

"Family reunion" - a structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 471-474

A two-level approach for fusing early signaling events and long term cellular responses
In: IFAC-PapersOnLine/ Internationale Förderung für Automatische Lenkung - Frankfurt: Elsevier, Bd. 48.2015, 8, S. 1228-1233

Interleukin-6: Biology, signaling and strategies of blockade
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 475-487

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, Bd. 27.2014, 2, S. 340-352, 2015

Mediatoren
In: Löffler/Petrides Biochemie und Pathobiochemie. - Berlin [u.a.] : Springer, S. 407-410, 2014

Rezeptoren und ihre Signaltransduktion
In: Löffler/Petrides Biochemie und Pathobiochemie. - Berlin [u.a.] : Springer, S. 411-441, 2014

Prinzipien zellulärer Kommunikation
In: Löffler/Petrides Biochemie und Pathobiochemie. - Berlin [u.a.] : Springer, S. 395-406, 2014

JAK/STAT signalling - an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology
In: Molecular BioSystems. - Cambridge : Royal Society of Chemistry, Bd. 9.2013, S. 1290-1307

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domains point mutations associated with Noonan syndrome and leukemia
In: Journal of proteomics. - New York, NY [u.a.] : Elsevier, Bd. 84.2013, S. 132-147

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice
In: The journal of clinical investigation : JCI ; the publication of the American Society for Clinical Investigation. - Ann Arbor, Mich : ASCJ, Bd. 123.2013, 2, S. 767-781

JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells
In: JAK-STAT. - Austin, Tex : Landes Bioscience, Bd. 2.2013, 3, insges. 13 S.

Determination of protein turnover rates in the JAK/STAT pathway using a radioactive pulse-chase approach
In: JAK-STAT signalling : methods and protocols. - New York [u.a.] : Humana Pr., S. 69-80, 2013 - (Methods in molecular biology; 967)

JAK-STAT signalling as example for a database-supported modular modelling concept
In: Gilbert, David: : Computational Methods in Systems Biology. - Berlin : Springer, S. 362-365, 2012 - (Lecture Notes in Bioinformatics; 7605)

Hepatic acute phase proteins - regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kB-dependent signaling
In: European journal of cell biology. - Amsterdam : Elsevier, Bd. 91.2012, 6/7, S. 496-505

Glucocorticoids increase interleukin-6 dependent gene induction by interfering with the expression of the SOCS 3 feedback inhibitor
In: Hepatology. - Hoboken, NJ : Wiley Interscience, Bd. 55.2012, 1, S. 256-266

Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling
In: Molecular BioSystems. - Cambridge : Royal Society of Chemistry, 8, S. 2119-2134, 2012

Interleukin-6 signalling - more than Jaks and STATs
In: European journal of cell biology. - Amsterdam : Elsevier, Bd. 91.2012, 6/7, S. 486-495

Plasticity and cross-talk of Interleukin 6-type cytokines
In: Cytokine & growth factor reviews. - Oxford [u.a.] : Elsevier, Bd. 23.2012, 3, S. 85-97

Glucagon counteracts interleukin-6-dependent gene expression by redundant action of EPAC and PKA
In: Biological chemistry - Berlin [u.a.]: de Gruyter, Bd. 392.2011, S. 1123-1134

A simple work flow for biologically inspired model reduction - application to early JAK-STAT signaling
In: BMC systems biology - London: BioMed Central, Bd. 5.2011, 30, insges. 30 S.

Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, Bd. 7.2011, 12, S. 3253-3270

Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini
In: PLoS biology - Lawrence, KS: PLoS, Bd. 9.2011, 2

Cross-regulation of cytokine signalling - pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation
In: Journal of cell science . - Cambridge : Company of Biologists Limited, Bd. 123.2010, 6, S. 947-959

A new mechanism for the regulation of Gab1 recruitment to the plasma membrane
In: J Cell Sci, Volume 122, Issue Pt 1, Pages: 55-64, 2009

Signal transduction - receptors, mediators, and genes
In: Science signaling . - Washington, DC [u.a.] : Assoc., Bd. 2.2009, 63, insges. 4 S.

Signal transduction in the footsteps of Goethe and Schiller
In: Cell communication and signaling . - London : Biomed Central, Bd. 7.2009, insges. 6 S.

Interleukin-6 acts in the fashion of a classical chemokine on monocytic cells by inducing integrin activation, cell adhesion, actin polymerization, chemotaxis, and transmigration
In: J Leukoc Biol, Volume 84, Issue 6, Pages: 1521-9; 2008

Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation
In: Biochem J, Volume 412, Issue 1, Pages: 65-72, 2008

SHPS-1/SIRP1alpha contributes to interleukin-6 signalling
In: Cell Signal, Volume 20, Issue 7, Pages: 1385-91, 2008

Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene
In: Cell Signal, Volume 19, Issue 9, Pages: 1866-78, 2007

Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade
In: J Immunol, Volume 178, Issue 5, Pages: 2813-26, 2007

Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130
In: Cell Signal, Volume 18, Issue 1, Pages: 40-9, 2006

Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism
In: J Biol Chem, Volume 281, Issue 13, Pages: 8458-68, 2006

Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes
In: J Hepatol, Volume 45, Issue 1, Pages: 72-80, 2006

Kapitel 25: Kommunikation zwischen Zellen: Extrazelluläre Signalmoleküle, Rezeptoren und Signaltransduktion
In: in: Löffler, G., Petrides, P.E., Heinrich, P.C. (eds.): Biochemie und Pathobiochemie 8. Auflage. Springer-Verlag Berlin Heidelberg, 2006, pp 755-807

The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling
In: Cell Signal, Volume 17, Issue 5, Pages: 559-69, 2005

Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases
In: J Biol Chem, Volume 280, Issue 36, Pages: 31478-88, 2005

Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo
In: J Hepatol, Volume 43, Issue 4, Pages: 704-10, 2005

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
In: Biochem J, Volume 378, Issue Pt 2, Pages: 449-60, 2004

Interleukin-6 is a direct mediator of T cell migration
In: Eur J Immunol, Volume 34, Issue 10, Pages: 2895-906, 2004

Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression
In: J Biol Chem, Volume 279, Issue 43, Pages: 45279-89, 2004

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK
In: J Biol Chem, Volume 279, Issue 42, Pages: 44093-100, 2004

IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3
In: Faseb J, Volume 17, Issue 3, Pages: 488-90, 2003

TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex
In: J Immunol, Volume 171, Issue 1, Pages: 257-66, 2003

Principles of interleukin (IL)-6-type cytokine signalling and its regulation
In: Biochem J, Volume 374, Issue Pt 1, Pages: 1-20, 2003

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
In: J Biol Chem, Volume 278, Issue 1, Pages: 661-71, 2003

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
In: J Immunol, Volume 170, Issue 6, Pages: 3263-72, 2003

Kapitel 28: Endokrine Funktionen II: Zytokine
In: in: Löffler, G., Petrides, P.E. (eds.): Biochemie und Pathobiochemie 7. Auflage. Springer-Verlag Berlin Heidelberg, 2003, pp. 813-835

The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B
In: J Immunol, Volume 167, Issue 3, Pages: 1469-1481, 2001

The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription
In: Biol Chem, Volume 382, Issue 10, Pages: 1447-53, 2001

Expression of suppressors of cytokine signaling during liver regeneration
In: J Clin Invest, Volume 107, Issue 10, Pages: 1285-92, 2001

Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited
In: Eur J Biochem, Volume 268, Issue 24, Pages: 6401-7, 2001

Termination and modulation of IL-6-type cytokine signaling
In: Adv Exp Med Biol, Volume 495, Pages: 153-60, 2001

A completely foreign receptor can mediate an interferon-gamma-like response
In: Embo J, Volume 20, Issue 19, Pages: 5431-42, 2001

Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation
In: J Immunol, Volume 165, Issue 5, Pages: 2535-43, 2000

A new peptide-affinity tag for the detection and affinity purification of recombinant proteins with a monoclonal antibody
In: J Immunol Methods, Volume 240, Issue 1-2, Pages: 165-83, 2000

Cytoplasmic STAT proteins associate prior to activation
In: Biochem J, Volume 345 Pt 3, Pages: 417-21, 2000

Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor
In: J Biol Chem, Volume 275, Issue 52, Pages: 40742-8, 2000

Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies
In: J Biol Chem, Volume 275, Issue 7, Pages: 4579-86, 2000

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3
In: Embo J, Volume 19, Issue 21, Pages: 5845-55, 2000

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
In: J Biol Chem, Volume 275, Issue 17, Pages: 12848-56, 2000

The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction
In: Journal of Immunology 164, Issue 2, Pages: 848-54, 2000

Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA
In: FEBS Lett, Volume 478, Issue 1-2, Pages: 100-4, 2000

The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130
In: J Biol Chem, 275, Issue 25, Pages: 18810-17, 2000

LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
In: FEBS Letters 463 (3) , pp. 365-370, 1999

Characterization and binding specificity of the monomeric STAT3-SH2 domain
In: Journal of Biological Chemistry 274 (3) , pp. 1342-1348, 1999

Different protein turnover of interleukin-6-type cytokine signalling components
In: European Journal of Biochemistry 265 (1) , pp. 251-257, 1999

Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor.
In: Biochemical Journal 339 (1) , pp. 15-19, 1999

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
In: Biochemical J. 224 (2) , pp. 297-314, 1998

In vivo formation of IRF-1 homodimers
In: Biochimie 80 (8-9) , pp. 659-664, 1998

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
In: Biochemical Journal 335 (3) , pp. 557-565, 1998

Functional domains of interferon regulatory factor 1 (IRF-1)
In: Biochemical Journal 335 (1) , pp. 147-157, 1998

Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130
In: FEBS Letters 441 (2) , pp. 231-234, 1998

Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes
In: FEBS Letters 405 (1) , pp. 99-103, 1997

Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA
In: Journal of Biological Chemistry 272 (15) , pp. 9785-9792, 1997

Regulation of cell growth by IRF-1 in BHK-21 cells
In: Cytotechnology 22 (1-3) , pp. 147-156, 1996

Identification of mammalian cell clones exhibiting highly regulated expression from inducible promoters
In: Trends in Genetics 11 , pp. 219-220, 1995

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR
In: Oncogene 11 (3) , pp. 439-445, 1995

Proliferation control of mammalian cells by the tumor suppressor IRF-1
In: Cytotechnology 18 (1-2) , pp. 67-75, 1995

A multifunctional vector family for gene expression in mammalian cells
In: Gene 149 , pp. 387-388, 1994

A new hybrid promoter directs transcription at identical start points in mammalian cells and in vitro
In: Gene 149 , pp. 389-390, 1994

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes
In: Nucleic Acids Research 21 (12) , pp. 2881-2889, 1993