Prof. Heike Walles

Aktuelle Projekte
- Stimulate 2 - Teilprojekt Immunoprofiling
Laufzeit: 01.10.2020 - 30.09.2025 - Zeitaufgelöste Raman- und metabolische Spektroskopie-Untersuchungen zur Detektion, Identifikation und Behandlungskontrolle mikrobieller Aktivität bei chronischer Inflammation und Kanzerogenese (TIRAMISU) - Teilvorhaben: 3D Gewebemodelle des Rachenraums FKZ: 13N15789
Laufzeit: 01.08.2021 - 31.07.2024 - Aerosolentstehung in der Lunge und Einkapselung von Viren WA2915/12-1
Laufzeit: 01.05.2021 - 30.04.2024
Abgeschlossene Projekte
- Effect of HZI compounds on autophagy in engineered tissue culture models
Laufzeit: 01.12.2019 - 30.09.2020 - Core Facility Tissue Engineering
Laufzeit: 01.01.2019 - 31.12.2019
2022
Buchbeitrag
Bacterial nanocellulose-based grafts for cell colonization studies - an in vitro bioreactor perfusion model
In: Methods in molecular biology - Totowa, NJ: Humana Press, Bd. 2436 (2022), S. 205-222
2021
Abstract
Biocompatibility of pure refractory metals and their combination as high entropy alloys
In: Intermetallics 2021 - International Conference, 4th till 8th October 2021 : Educational Center Kloster Banz, Germany : programme and abstracts - Jena, Germany: Conventus Congressmanagement & Marketing GmbH, 2021; Krüger, Manja . - 2021, S. 172-173
Protein coating of bacterial nanocellulose small diameter vascular grafts leads to improved endothelialization
In: The thoracic and cardiovascular surgeon - Stuttgart: Thieme, 1953, Bd. 69 (2021), S01, insges. 1 S.
Begutachteter Zeitschriftenartikel
Biological models of the lower human airways - challenges and special requirements of human 3D barrier models for biomedical research
In: Pharmaceutics - Basel: MDPI, 2009, Bd. 13 (2021), 12, insges. 13 S.
Comparative evaluation on impacts of fibronectin, heparinchitosan, and albumin coating of bacterial nanocellulose small-diameter vascular grafts on endothelialization in vitro
In: Nanomaterials - Basel: MDPI, 2011, Bd. 11 (2021), 8, insges. 24 S.
In vitro skin culture media influence the viability and inflammatory response of primary macrophages
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 11 (2021), 1, insges. 11 S.
Refractory metal coated alumina foams as support material for stem cell and fibroblasts cultivation
In: Materials - Basel: MDPI, Bd. 14 (2021), 11
Sevoflurane exerts protective effects in murine peritonitis-induced sepsis via hypoxia-inducible factor 1α/adenosine A2B receptor signaling
In: Anesthesiology - Hagerstown, Md.: Lippincott Williams & Wilkins, Bd. 135 (2021), S. 136-150
The influence of differently functionalized nanodiamonds on proliferation, apoptosis and EMT/MET phenomena in 2D and 3D tumor cell cultures
In: Journal of materials chemistry / B - London [u.a.]: RSC, Bd. 9 (2021), 45, S. 9395-9405
Toward allogenizing a xenograft - xenogeneic cardiac scaffolds recellularized with human-induced pluripotent stem cells do not activate human naive neutrophils
In: Journal of biomedical materials research / B - Hoboken, NJ: Wiley, Bd. 110 (2021), 3, S. 691-701
Triple co-culture and perfusion bioreactor for studying the interaction between Neisseria gonorrhoeae and neutrophils - a novel 3D tissue model for bacterial infection and immunity
In: Journal of tissue engineering - London: Sage, Bd. 12 (2021), insges. 12 S.
2020
Begutachteter Zeitschriftenartikel
A three-dimensional intestinal tissue model reveals factors and small regulatory RNAs important for colonization with Campylobacter jejuni
In: PLoS pathogens/ Public Library of Science - Lawrence, Kan.: PLoS, Volume 16(2020), issue 2, article e1008304, 35 Seiten
An advanced human intestinal coculture model reveals compartmentalized host and pathogen strategies during salmonella infection
In: mBio - Washington, DC: American Society for Microbiology, Volume 11(2020), issue 1, article e03348-19, 19 Seiten
Biomimetic in vitro test system for evaluation of dental implant materials
In: Dental materials: official publication of the Academy of Dental Materials - Amsterdam: Elsevier, Bd. 36.2020, 8, S. 1059-1070
Connecting cancer pathways to tumor engines - a stratification tool for colorectal cancer combining human in vitro tissue models with boolean in silico models
In: Cancers - Basel: MDPI, Volume 12(2020), issue 1, article 28, 27 Seiten
Development of a bioreactor system for preendothelialized cardiac patch generation with enhanced viscoelastic properties by combined collagen I compression and stromal cell culture
In: Journal of tissue engineering and regenerative medicine - Hoboken, NJ [u.a.]: Wiley . - 2020
Inflammation-induced tissue damage mimicking GvHD in human skin models as test-platform for immunotherapeutics
In: Alternatives to animal experimentation: ALTEX ; a quarterly journal for new paths in biomedical science ; official organ of CAAT (Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore), EUSAAT (European Society for Alternatives to Animal Testing, Vienna), t4 (Transatlantic Think Tank of Toxicology, Baltimore, Constance, Utrecht) - Heidelberg: Springer, Bd. 37.2020, 3, S. 429-440
Matrix decoded - a pancreatic extracellular matrix with organ specific cues guiding human iPSC differentiation
In: Biomaterials: biomaterials reviews online - Amsterdam [u.a.]: Elsevier Science, Volume 244(2020), article 119766, 18 Seiten
Modular micro-physiological human tumor/tissue models based on decellularized tissue for improved preclinical testing
In: Alternatives to animal experimentation - Heidelberg: Springer, Bd. 38 (2020), 2, S. 289-306
Nanotopographical coatings induce an early phenotype-specific response of primary material-resident M1 and M2 macrophages
In: Materials - Basel: MDPI, Volume 13(2020), issue 5, article 1142, 20 Seiten
Regulatory-compliant validation of a highly sensitive qPCR for biodistribution assessment of hemophilia a patient cells
In: Molecular therapy. Methods & clinical development - New York, NY: Nature Publishing Group, Bd. 18.2020, S. 176-188
2019
Abstract
Effects of commensal biofilms on a peri-implant mucosa in a three dimensional model
In: Biomedical engineering: joint journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering - Berlin [u.a.]: de Gruyter, 1998, Volume 64(2019), issue S1, Seite 63
Generation of porous 3D-scaffolds based on electrospun nanofibers
In: Biomedical engineering: joint journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering - Berlin [u.a.]: de Gruyter, 1998, Volume 64(2019), issue S1, Seite 59
Begutachteter Zeitschriftenartikel
A coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals after topical exposure
In: Toxicology in vitro: official journal of the European Society of Toxicology in Vitro - Amsterdam [u.a.]: Elsevier Science, 1987, Bd. 57.2019, S. 62-66
An in vitro model mimics the contact of biomaterials to blood components and the reaction of surrounding soft tissue
In: Acta biomaterialia - [Amsterdam]: Elsevier, 2005, Bd. 89.2019, S. 227-241
Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Volume 9(2019), issue 1, article 12297, 12 Seiten
Biomimetic human tissue model for long-term study of neisseria gonorrhoeae infection
In: Frontiers in microbiology - Lausanne: Frontiers Media, 2010, Volume 10(2019), article 1740, 17 Seiten
Ciclopirox olamine promotes the angiogenic response of endothelial cells and mesenchymal stem cells
In: Clinical hemorheology and microcirculation: blood flow and vessels - Amsterdam [u.a.]: IOS Press, Bd. 73 (2019), 2, S. 317-328
Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model
In: Cellular microbiology - Oxford [u.a.]: Wiley-Blackwell, 1999, Volume 21(2019), issue 10, article e13078, 12 Seiten
EZH2 inhibition in ewing sarcoma upregulates G D2 expression for targeting with gene-modified T cells
In: Molecular therapy: official journal of the American Society of Gene Therapy - Amsterdam: Elsevier, 2000, Bd. 27.2019, 5, S. 933-946
Follistatin effects in migration, vascularization, and osteogenesis in vitro and bone repair in vivo
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, 2013, Volume 7(2019), article 38, 14 Seiten
Linking two worlds in polymer chemistry - the influence of block uniformity and dispersity in amphiphilic block copolypeptoids on their selfassembly
In: Biopolymers - New York, NY: Wiley, 1963, Volume 110(2019), issue 4, article e23259, 14 Seiten
Obstructed defecation-an enteric neuropathy? - an exploratory study of patient samples
In: International journal of colorectal disease: clinical and molecular gastroenterology and surgery - Berlin: Springer, Bd. 34.2019, 1, S. 193-196
ROR1-CAR T cells are effective against lung and breast cancer in advanced microphysiologic 3D tumor models
In: JCI insight - Ann Arbor, Michigan: JCI Insight, 2016, Volume 4(2019), issue 18, article e126345, 15 Seiten
Reepithelialization in focus - non-invasive monitoring of epidermal wound healing in vitro
In: Biosensors and bioelectronics: the principal international journal devoted to research, design development and application of biosensors and bioelectronics - Amsterdam [u.a.]: Elsevier Science, 1989, Volume 142(2019), article 111555
Spin echo based cardiac diffusion imaging at 7T - an ex vivo study of the porcine heart at 7T and 3T
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Volume 14(2019), issue 3, article e0213994, 20 Seiten
2018
Begutachteter Zeitschriftenartikel
A combined tissue-engineered/in silico signature tool patient stratification in lung cancer
In: Molecular oncology - Hoboken, NJ: John Wiley & Sons, Inc., 2007, Bd. 12.2018, 8, S. 1264-1285, insges. 22 S.
A standardized method based on pigmented epidermal models evaluates sensitivity against UV-irradiation
In: Alternatives to animal experimentation: ALTEX ; a quarterly journal for new paths in biomedical science ; official organ of CAAT (Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore), EUSAAT (European Society for Alternatives to Animal Testing, Vienna), t4 (Transatlantic Think Tank of Toxicology, Baltimore, Constance, Utrecht) - Heidelberg: Springer, 1984, Bd. 35.2018, 3, S. 390-396
Advanced therapy medicinal products - a guide for bone Marrow-derived MSC application in bone and cartilage tissue engineering
In: Tissue engineering / B - Larchmont, NY: Liebert, 2008, Bd. 24.2018, 2, S. 155-169
Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet
In: Molecular metabolism: official journal of the German Center for Diabetes Research (DZD) - Oxford [u.a.]: Elsevier, 2012, Bd. 13.2018, S. 67-76
Corrigendum: Rapid analysis of cellnanoparticle interactions using singlecell raman trapping microscopy
In: Angewandte Chemie / International edition: a journal of the Gesellschaft Deutscher Chemiker - Weinheim: Wiley-VCH, 1962, Bd. 57.2018, 47, S. 15305
Evaluation of a miniaturized biologically vascularized scaffold in vitro and in vivo
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Volume 8(2018), issue 1, article 4719, 13 Seiten
Physical contact between mesenchymal stem cells and endothelial precursors induces distinct signatures with relevance to the very early phase of regeneration
In: Journal of cellular biochemistry - New York, NY: Wiley-Liss, 1972, Bd. 119.2018, 11, S. 9122-9140
Rapid analysis of cell-nanoparticle interactions using single-cell raman trapping microscopy
In: Angewandte Chemie / International edition: a journal of the Gesellschaft Deutscher Chemiker - Weinheim: Wiley-VCH, 1962, Bd. 57.2018, 18, S. 4946-4950
Recombinant collagen I peptide microcarriers for cell expansion and their potential use as cell delivery system in a bioreactor model
In: JoVE. Video journal - [S.l.], 2006, Volume 132(2018), article 57363, 11 Seiten
Replacing the Draize eye test - impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Volume 8(2018), article 15049, 13 Seiten
Site-directed immobilization of bone morphogenetic protein 2 to solid surfaces by click chemistry
In: JoVE. Video journal - [S.l.], 2006, Volume 133(2018), article e56616, 8 Seiten
Structure-Function relationships of equine menisci
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 13.2018, 3$YVolume 13(2018), issue 3, article e0194052
Tissue mimicry in morphology and composition promotes hierarchical matrix remodeling of invading stem cells in osteochondral and meniscus scaffolds
In: Advanced materials - Weinheim: Wiley-VCH, 1989, Volume 30(2018), issue 28, article 1706754, 7 Seiten
2017
Begutachteter Zeitschriftenartikel
An adherent mucus layer attenuates the genotoxic effect of colibactin
In: Cellular microbiology - Oxford [u.a.]: Wiley-Blackwell, 1999, Volume 20(2017), issue 2, article e12881, 10 Seiten
Deformation strain is the main physical driver for skeletal precursors to undergo osteogenesis in earlier stages of osteogenic cell maturation
In: Journal of tissue engineering and regenerative medicine - Hoboken, NJ [u.a.]: Wiley, 2007, Volume 12(2017), issue 3, Seiten e1474-e1479
NELL-1, HMGB1, and CCN2 enhance migration and vasculogenesis, but not osteogenic differentiation compared to BMP2
In: Tissue engineering / A - Larchmont, NY: Liebert, 2008, Bd. 24.2017, 3/4, S. 207-2018
- Photonscore GmbH (Photonscore
- Jun.-Prof. Dr. Fabian Denner (FVST - Lehrstuhl Mechanische Verfahrenstechnik)
- Omicron-Laserage Laserprodukte GmbH (Omicron)
- Prof. Dr. rer. nat. Claus-Dieter Ohl (FNW - Institut für Physik Abt. Physik der Weichen Materie)
- Leibniz Institute for Neurobiology Combinatorial NeuroImaging Core Facility (LIN CNI)
- Medical Faculty of the University Hospital Magdeburg - University Clinic for Otolaryngology, Head and Neck Surgery (UKM ENT)
- MedFact Engineering GmbH (MedFact)