Prof. Heike Walles

Prof. Dr. rer. biol hum. Heike Walles

Core Facility Tissue Engineering
Pfälzerstr. 2, 39106 Magdeburg, G28-107
Projekte
Publikationen

2021

Begutachteter Zeitschriftenartikel

Wacker, Max;  Riedel, Jan;  Walles, Heike;  Scherner, Maximilian Philipp;  Awad, George;  Varghese, Sam;  Schürlein, Sebastian;  Garke, Bernd;  Veluswamy, Priya;  Wippermann, Jens;  Hülsmann, Jörn 

Comparative evaluation on impacts of fibronectin, heparinchitosan, and albumin coating of bacterial nanocellulose small-diameter vascular grafts on endothelialization in vitro
In: Nanomaterials: open access journal - Basel: MDPI, 2011, Bd. 11 (2021), 8, insges. 24 S.

Hasemann, Georg;  Betke, Ulf;  Krüger, Manja;  Walles, Heike;  Scheffler, Michael 

Refractory metal coated alumina foams as support material for stem cell and fibroblasts cultivation
In: Materials - Basel: MDPI, Bd. 14 (2021), 11

2020

Begutachteter Zeitschriftenartikel

Alzheimer, Mona;  Svensson, Sarah L.;  König, Fabian;  Schweinlin, Matthias;  Metzger, Marco;  Walles, Heike;  Sharma, Cynthia M. 

A three-dimensional intestinal tissue model reveals factors and small regulatory RNAs important for colonization with Campylobacter jejuni
In: PLoS pathogens/ Public Library of Science - Lawrence, Kan.: PLoS, Volume 16(2020), issue 2, article e1008304, 35 Seiten

Schulte, Leon N.;  Schweinlin, Matthias;  Westermann, Alexander J.;  Janga, Harshavardhan;  Santos, Sara C.;  Appenzeller, Silke;  Walles, Heike;  Vogel, Jörg;  Metzger, Marco 

An advanced human intestinal coculture model reveals compartmentalized host and pathogen strategies during salmonella infection
In: mBio - Washington, DC: American Society for Microbiology, Volume 11(2020), issue 1, article e03348-19, 19 Seiten

Ehlicke, Franziska;  Berndt, Jonathan;  Marichikj, Nina;  Steinmüller-Nethl, Doris;  Walles, Heike;  Berndt, Ernst-Ulrich;  Hansmann, Jan 

Biomimetic in vitro test system for evaluation of dental implant materials
In: Dental materials: official publication of the Academy of Dental Materials - Amsterdam: Elsevier, Bd. 36.2020, 8, S. 1059-1070

Baur, Florentin;  Nietzer, Sarah L.;  Kunz, Meik;  Saal, Fabian;  Jeromin, Julian;  Matschos, Stephanie;  Linnebacher, Michael;  Walles, Heike;  Dandekar, Thomas;  Dandekar, Gudrun 

Connecting cancer pathways to tumor engines - a stratification tool for colorectal cancer combining human in vitro tissue models with boolean in silico models
In: Cancers - Basel: MDPI, Volume 12(2020), issue 1, article 28, 27 Seiten

Krziminski, Carolin;  Kammann, Sebastian;  Hansmann, Jan;  Edenhofer, Frank;  Dandekar, Gudrun;  Walles, Heike;  Leistner, Marcus 

Development of a bioreactor system for preendothelialized cardiac patch generation with enhanced viscoelastic properties by combined collagen I compression and stromal cell culture
In: Journal of tissue engineering and regenerative medicine - Hoboken, NJ [u.a.]: Wiley . - 2020

Wallstabe, Julia;  Bussemer, Lydia;  Groeber-Becker, Florian;  Freund, Lukas;  Alb, Miriam;  Dragan, Mariola;  Waaga-Gasser, Ana Maria;  Jakubietz, Rafael;  Kneitz, Hermann;  Rosenwald, Andreas;  Rebhan, Silke;  Walles, Heike;  Mielke, Stephan 

Inflammation-induced tissue damage mimicking GvHD in human skin models as test-platform for immunotherapeutics
In: Alternatives to animal experimentation: ALTEX ; a quarterly journal for new paths in biomedical science ; official organ of CAAT (Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore), EUSAAT (European Society for Alternatives to Animal Testing, Vienna), t4 (Transatlantic Think Tank of Toxicology, Baltimore, Constance, Utrecht) - Heidelberg: Springer, Bd. 37.2020, 3, S. 429-440

Berger, Constantin;  Bjørlykke, Yngvild;  Hahn, Lukas;  Mühlemann, Markus;  Kress, Sebastian;  Walles, Heike;  Luxenhofer, Robert;  Ræder, Helge;  Metzger, Marco;  Zdzieblo, Daniela 

Matrix decoded - a pancreatic extracellular matrix with organ specific cues guiding human iPSC differentiation
In: Biomaterials: biomaterials reviews online - Amsterdam [u.a.]: Elsevier Science, Volume 244(2020), article 119766, 18 Seiten

Schmitz, Tobias;  Jannasch, Maren;  Weigel, Tobias;  Moseke, Claus;  Gbureck, Uwe;  Groll, Jürgen;  Walles, Heike;  Hansmann, Jan 

Nanotopographical coatings induce an early phenotype-specific response of primary material-resident M1 and M2 macrophages
In: Materials - Basel: MDPI, Volume 13(2020), issue 5, article 1142, 20 Seiten

Bittorf, Patrick;  Bergmann, Thorsten;  Merlin, Simone;  Olgasi, Cristina;  Pullig, Oliver;  Sanzenbacher, Ralf;  Zierau, Martin;  Walles, Heike;  Follenzi, Antonia;  Braspenning, Joris 

Regulatory-compliant validation of a highly sensitive qPCR for biodistribution assessment of hemophilia a patient cells
In: Molecular therapy. Methods & clinical development - New York, NY: Nature Publishing Group, Bd. 18.2020, S. 176-188

2019

Abstract

Mikolai, C.;  Ingendoh-Tsakmakidis, A.;  Winkel, A.;  Kommerein, N.;  Falk, C. S.;  Rossi, A.;  Walles, Heike;  Stiesch, M. 

Effects of commensal biofilms on a peri-implant mucosa in a three dimensional model
In: Biomedical engineering: joint journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering - Berlin [u.a.]: de Gruyter, 1998, Volume 64(2019), issue S1, Seite 63

Weigel, T.;  Schmitz, T.;  Jannasch, M.;  Schürlein, S.;  Al Hijailan, R.;  Suliman, S.;  Walles, Heike;  Hansmann, J. 

Generation of porous 3D-scaffolds based on electrospun nanofibers
In: Biomedical engineering: joint journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering - Berlin [u.a.]: de Gruyter, 1998, Volume 64(2019), issue S1, Seite 59

Begutachteter Zeitschriftenartikel

Schellenberger, Mario T.;  Bock, Udo;  Hennen, Jennifer;  Groeber-Becker, Florian;  Walles, Heike;  Blömeke, Brunhilde 

A coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals after topical exposure
In: Toxicology in vitro: official journal of the European Society of Toxicology in Vitro - Amsterdam [u.a.]: Elsevier Science, 1987, Bd. 57.2019, S. 62-66

Jannasch, Maren;  Gaetzner, Sabine;  Groeber, Florian;  Weigel, Tobias;  Walles, Heike;  Schmitz, Tobias;  Hansmann, Jan 

An in vitro model mimics the contact of biomaterials to blood components and the reaction of surrounding soft tissue
In: Acta biomaterialia - [Amsterdam]: Elsevier, 2005, Bd. 89.2019, S. 227-241

Schwedhelm, Ivo;  Zdzieblo, Daniela;  Appelt-Menzel, Antje;  Berger, Constantin;  Schmitz, Tobias;  Schuldt, Bernhard;  Franke, Andre;  Müller, Franz-Josef;  Pless, Ole;  Schwarz, Thomas;  Wiedemann, Philipp;  Walles, Heike;  Hansmann, Jan 

Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Volume 9(2019), issue 1, article 12297, 12 Seiten

Heydarian, Motaharehsadat;  Yang, Tao;  Schweinlin, Matthias;  Steinke, Maria;  Walles, Heike;  Rudel, Thomas;  Kozjak-Pavlovic, Vera 

Biomimetic human tissue model for long-term study of neisseria gonorrhoeae infection
In: Frontiers in microbiology - Lausanne: Frontiers Media, 2010, Volume 10(2019), article 1740, 17 Seiten

Kremer, Antje;  Wußmann, Maximilian;  Herrmann, Marietta;  Raghunath, Michael;  Walles, Heike 

Ciclopirox olamine promotes the angiogenic response of endothelial cells and mesenchymal stem cells
In: Clinical hemorheology and microcirculation: blood flow and vessels - Amsterdam [u.a.]: IOS Press, Bd. 73 (2019), 2, S. 317-328

IngendohTsakmakidis, Alexandra;  Mikolai, Carina;  Winkel, Andreas;  Szafrański, Szymon P.;  Falk, Christine S.;  Rossi, Angela;  Walles, Heike;  Stiesch, Meike 

Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model
In: Cellular microbiology - Oxford [u.a.]: Wiley-Blackwell, 1999, Volume 21(2019), issue 10, article e13078, 12 Seiten

Kailayangiri, Sareetha;  Altvater, Bianca;  Lesch, Stefanie;  Balbach, Sebastian;  Göttlich, Claudia;  Kühnemundt, Johanna;  Mikesch, Jan-Henrik;  Schelhaas, Sonja;  Jamitzky, Silke;  Meltzer, Jutta;  Farwick, Nicole;  Greune, Lea;  Fluegge, Maike;  Kerl, Kornelius;  Lode, Holger N.;  Siebert, Nikolai;  Müller, Ingo;  Walles, Heike;  Hartmann, Wolfgang;  Rossig, Claudia 

EZH2 inhibition in ewing sarcoma upregulates G D2 expression for targeting with gene-modified T cells
In: Molecular therapy: official journal of the American Society of Gene Therapy - Amsterdam: Elsevier, 2000, Bd. 27.2019, 5, S. 933-946

Fahmy-Garcia, Shorouk;  Farrell, Eric;  Witte-Bouma, Janneke;  Robbesom-van den Berge, Iris;  Suarez, Melva;  Mumcuoglu, Didem;  Walles, Heike;  Kluijtmans, Sebastiaan G. J. M.;  Eerden, Bram C. J.;  Osch, Gerjo J. V. M.;  Leeuwen, Johannes P. T. M.;  Driel, Marjolein 

Follistatin effects in migration, vascularization, and osteogenesis in vitro and bone repair in vivo
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, 2013, Volume 7(2019), article 38, 14 Seiten

Gangloff, Niklas;  Höferth, Marcel;  Stepanenko, Vladimir;  Sochor, Benedikt;  Schummer, Bernhard;  Nickel, Joachim;  Walles, Heike;  Hanke, Randolf;  Würthner, Frank;  Zuckermann, Ronald N.;  Luxenhofer, Robert 

Linking two worlds in polymer chemistry - the influence of block uniformity and dispersity in amphiphilic block copolypeptoids on their selfassembly
In: Biopolymers - New York, NY: Wiley, 1963, Volume 110(2019), issue 4, article e23259, 14 Seiten

Kim, Mia;  Rosenbaum, Corinna;  Schlegel, Nicolas;  Grumaz, Christian;  Sohn, Kai;  Isbert, Christoph;  Walles, Heike;  Metzger, Marco 

Obstructed defecation-an enteric neuropathy? - an exploratory study of patient samples
In: International journal of colorectal disease: clinical and molecular gastroenterology and surgery - Berlin: Springer, Bd. 34.2019, 1, S. 193-196

Wallstabe, Lars;  Göttlich, Claudia;  Nelke, Lena C.;  Kühnemundt, Johanna;  Schwarz, Thomas;  Nerreter, Thomas;  Einsele, Hermann;  Walles, Heike;  Dandekar, Gudrun;  Nietzer, Sarah L.;  Hudecek, Michael 

ROR1-CAR T cells are effective against lung and breast cancer in advanced microphysiologic 3D tumor models
In: JCI insight - Ann Arbor, Michigan: JCI Insight, 2016, Volume 4(2019), issue 18, article e126345, 15 Seiten

Kiesewetter, Lisa;  Littau, Laura;  Walles, Heike;  Boccaccini, Aldo R.;  Groeber-Becker, Florian 

Reepithelialization in focus - non-invasive monitoring of epidermal wound healing in vitro
In: Biosensors and bioelectronics: the principal international journal devoted to research, design development and application of biosensors and bioelectronics - Amsterdam [u.a.]: Elsevier Science, 1989, Volume 142(2019), article 111555

Lohr, David;  Terekhov, Maxim;  Weng, Andreas Max;  Schroeder, Anja;  Walles, Heike;  Schreiber, Laura Maria 

Spin echo based cardiac diffusion imaging at 7T - an ex vivo study of the porcine heart at 7T and 3T
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Volume 14(2019), issue 3, article e0213994, 20 Seiten

2018

Begutachteter Zeitschriftenartikel

Göttlich, Claudia;  Kunz, Meik;  Zapp, Cornelia;  Nietzer, Sarah L.;  Walles, Heike;  Dandekar, Thomas;  Dandekar, Gudrun 

A combined tissue-engineered/in silico signature tool patient stratification in lung cancer
In: Molecular oncology - Hoboken, NJ: John Wiley & Sons, Inc., 2007, Bd. 12.2018, 8, S. 1264-1285, insges. 22 S.

Schmid, Freia F.;  Groeber-Becker, Florian;  Schwab, Stefanie;  Thude, Sibylle;  Goebeler, Matthias;  Walles, Heike;  Hansmann, Jan 

A standardized method based on pigmented epidermal models evaluates sensitivity against UV-irradiation
In: Alternatives to animal experimentation: ALTEX ; a quarterly journal for new paths in biomedical science ; official organ of CAAT (Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore), EUSAAT (European Society for Alternatives to Animal Testing, Vienna), t4 (Transatlantic Think Tank of Toxicology, Baltimore, Constance, Utrecht) - Heidelberg: Springer, 1984, Bd. 35.2018, 3, S. 390-396

Confalonieri, Davide;  Schwab, Andrea;  Walles, Heike;  Ehlicke, Franziska 

Advanced therapy medicinal products - a guide for bone Marrow-derived MSC application in bone and cartilage tissue engineering
In: Tissue engineering / B - Larchmont, NY: Liebert, 2008, Bd. 24.2018, 2, S. 155-169

Mühlemann, Markus;  Zdzieblo, Daniela;  Friedrich, Alexandra;  Berger, Constantin;  Otto, Christoph;  Walles, Heike;  Koepsell, Hermann;  Metzger, Marco 

Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet
In: Molecular metabolism: official journal of the German Center for Diabetes Research (DZD) - Oxford [u.a.]: Elsevier, 2012, Bd. 13.2018, S. 67-76

Steinke, Maria;  Zunhammer, Florian;  Chatzopoulou, Elisavet I.;  Teller, Henrik;  Schütze, Karin;  Walles, Heike;  Rädler, Joachim O.;  Grüttner, Cordula 

Corrigendum: Rapid analysis of cellnanoparticle interactions using singlecell raman trapping microscopy
In: Angewandte Chemie / International edition: a journal of the Gesellschaft Deutscher Chemiker - Weinheim: Wiley-VCH, 1962, Bd. 57.2018, 47, S. 15305

Kress, Sebastian;  Baur, Johannes;  Otto, Christoph;  Burkard, Natalie;  Braspenning, Joris;  Walles, Heike;  Nickel, Joachim;  Metzger, Marco 

Evaluation of a miniaturized biologically vascularized scaffold in vitro and in vivo
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Volume 8(2018), issue 1, article 4719, 13 Seiten

Hafen, Bettina;  Wiesner, Susanne;  Schlegelmilch, Katrin;  Keller, Alexander;  Seefried, Lothar;  Ebert, Regina;  Walles, Heike;  Jakob, Franz;  Schütze, Norbert 

Physical contact between mesenchymal stem cells and endothelial precursors induces distinct signatures with relevance to the very early phase of regeneration
In: Journal of cellular biochemistry - New York, NY: Wiley-Liss, 1972, Bd. 119.2018, 11, S. 9122-9140

Steinke, Maria;  Zunhammer, Florian;  Chatzopoulou, Elisavet I.;  Teller, Henrik;  Schütze, Karin;  Walles, Heike;  Rädler, Joachim O.;  Grüttner, Cordula 

Rapid analysis of cell-nanoparticle interactions using single-cell raman trapping microscopy
In: Angewandte Chemie / International edition: a journal of the Gesellschaft Deutscher Chemiker - Weinheim: Wiley-VCH, 1962, Bd. 57.2018, 18, S. 4946-4950

Suarez Muñoz, Melva;  Confalonieri, Davide;  Walles, Heike;  Dongen, Elisabeth M. W. M.;  Dandekar, Gudrun 

Recombinant collagen I peptide microcarriers for cell expansion and their potential use as cell delivery system in a bioreactor model
In: JoVE. Video journal - [S.l.], 2006, Volume 132(2018), article 57363, 11 Seiten

Lotz, C.;  Kiesewetter, L.;  Schmid, F. F.;  Hansmann, J.;  Walles, Heike;  Groeber-Becker, F. 

Replacing the Draize eye test - impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Volume 8(2018), article 15049, 13 Seiten

Siverino, Claudia;  Tabisz, Barbara;  Lühmann, Tessa;  Meinel, Lorenz;  Müller, Thomas;  Walles, Heike;  Nickel, Joachim 

Site-directed immobilization of bone morphogenetic protein 2 to solid surfaces by click chemistry
In: JoVE. Video journal - [S.l.], 2006, Volume 133(2018), article e56616, 8 Seiten

Ribitsch, Iris;  Peham, Christian;  Ade, Nicole;  Dürr, Julia;  Handschuh, Stephan;  Schramel, Johannes Peter;  Vogl, Claus;  Walles, Heike;  Egerbacher, Monika;  Jenner, Florien 

Structure-Function relationships of equine menisci
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 13.2018, 3$YVolume 13(2018), issue 3, article e0194052

Stuckensen, Kai;  Schwab, Andrea;  Knauer, Markus;  MuiñosLópez, Emma;  Ehlicke, Franziska;  Reboredo, Jenny;  GraneroMoltó, Froilán;  Gbureck, Uwe;  Prósper, Felipe;  Walles, Heike;  Groll, Jürgen 

Tissue mimicry in morphology and composition promotes hierarchical matrix remodeling of invading stem cells in osteochondral and meniscus scaffolds
In: Advanced materials - Weinheim: Wiley-VCH, 1989, Volume 30(2018), issue 28, article 1706754, 7 Seiten

2017

Begutachteter Zeitschriftenartikel

Reuter, Christian;  Alzheimer, Mona;  Walles, Heike;  Oelschlaeger, Tobias A. 

An adherent mucus layer attenuates the genotoxic effect of colibactin
In: Cellular microbiology - Oxford [u.a.]: Wiley-Blackwell, 1999, Volume 20(2017), issue 2, article e12881, 10 Seiten

RamaniMohan, RamKumar;  Schwedhelm, Ivo;  FinneWistrand, Anna;  Krug, Melanie;  Schwarz, Thomas;  Jakob, Franz;  Walles, Heike;  Hansmann, Jan 

Deformation strain is the main physical driver for skeletal precursors to undergo osteogenesis in earlier stages of osteogenic cell maturation
In: Journal of tissue engineering and regenerative medicine - Hoboken, NJ [u.a.]: Wiley, 2007, Volume 12(2017), issue 3, Seiten e1474-e1479

Fahmy-Garcia, Shorouk;  Driel, Marjolein;  Witte-Buoma, Janneke;  Walles, Heike;  Leeuwen, Johannes P.T.M.;  Osch, Gerjo J.V.M.;  Farrell, Eric 

NELL-1, HMGB1, and CCN2 enhance migration and vasculogenesis, but not osteogenic differentiation compared to BMP2
In: Tissue engineering / A - Larchmont, NY: Liebert, 2008, Bd. 24.2017, 3/4, S. 207-2018

Kooperationen
  • Photonscore GmbH (Photonscore
  • Jun.-Prof. Dr. Fabian Denner (FVST - Lehrstuhl Mechanische Verfahrenstechnik)
  • Omicron-Laserage Laserprodukte GmbH (Omicron)
  • Prof. Dr. rer. nat. Claus-Dieter Ohl (FNW - Institut für Physik Abt. Physik der Weichen Materie)
  • Leibniz Institute for Neurobiology Combinatorial NeuroImaging Core Facility (LIN CNI)
  • Medical Faculty of the University Hospital Magdeburg - University Clinic for Otolaryngology, Head and Neck Surgery (UKM ENT)
  • MedFact Engineering GmbH (MedFact)
Profil
Service
Vita
Presse

Letzte Änderung: 01.09.2021 - Ansprechpartner: Webmaster