Prof. Dr.- Ing. Reichl

Prof. Dr.-Ing. Udo Reichl
Fakultät für Verfahrens- und Systemtechnik (FVST)
Abgeschlossene Projekte
- de.NBI-Partner: MetaProteomanalyzer Service
Laufzeit: 01.11.2016 - 31.12.2021 - Biokatalysatoren in Bioreaktoren: Monitoring, Regelung und multikriterielle Optimierung von Biogasprozessen
Laufzeit: 01.06.2017 - 30.04.2021 - Biogas-Messprogramm III - Teil 2: Systemmikrobiologie; Teilvorhaben 3: Enzymatische Biodiversität
Laufzeit: 01.12.2015 - 30.11.2019 - e:Bio - Modul II - Verbundprojekt: CellSys - Systembiologischer Ansatz zur Entwicklung einer Produktionszelllinie für Influenzavakzine - Teilprojekt A
Laufzeit: 01.01.2013 - 31.08.2016 - Prozesskontrolle und Optimierung der Biogasproduktion mittels Metaproteomanalyse
Laufzeit: 01.08.2011 - 30.07.2014 - Prozessmikrobiologie in landwirtschaftlichen Biogasanlagen ¿ Ermittlung der mikrobiellen Diversität in Biogasanlagen sowie von hauptsächlichen verfahrenstechnischen Einflussfaktoren auf die Mikroflora (BIOGAS-BIOCOENOSIS)
Laufzeit: 01.11.2011 - 31.10.2013 - Analyse von Enzymaktivitäten und Durchführung von Gärversuchen
Laufzeit: 01.12.2012 - 01.03.2013 - Kultivierung und Infektion von CAP Zelllinien
Laufzeit: 01.08.2009 - 15.12.2012 - Einsatz synthetischer Liganden zur Aufreinigung salinsäurehaltiger, rekombinanter humaner Proteine und Impfstoff-Antigene
Laufzeit: 01.10.2008 - 31.03.2012 - Dynamics of Influenza A Virus Replication in Epithelial Cells
Laufzeit: 01.01.2007 - 31.12.2011 - FORSYS - Systemanalyse von Signal und Regulationsnetzwerken
Laufzeit: 01.01.2007 - 31.12.2011 - Dynamische Systeme in Biologie / Medizin und Prozesstechnik
Laufzeit: 01.06.2008 - 31.12.2011 - Purification and Characterization of Vaccinia virus with special emphasis on MVA-BN®
Laufzeit: 01.03.2007 - 30.09.2009 - Experimentelle Charakterisierung und Dynamik komplexer mikrobieller Gemeinschaften - Wachstumsanalyse einer Modellgemeinschaft mit Relevanz für die klinische Praxis
Laufzeit: 01.10.2005 - 31.03.2009 - Untersuchung des Einflusses von Genregulatorelementen auf die segregationale Plasmidstabilität und Modellierung von rekombinanten Fermentationsprozessen
Laufzeit: 01.01.2006 - 31.12.2007 - Charakterisierung eines automatischen, sterilen, totvolumenfreien Probenahme-Moduls für Bioreaktoren
Laufzeit: 01.05.2005 - 31.01.2006 - Weiterführung der Virusaufreinigung mittels Membranrekuperator
Laufzeit: 01.10.2005 - 31.12.2005 - Plasmidstabilität update
Laufzeit: 01.02.2005 - 31.12.2005 - Virusaufreinigung mitels Membranrekuperator
Laufzeit: 01.09.2005 - 30.11.2005 - Optimierungsstudie: Charakterisierung und Optimierung der MVA Vermehrung in primären HEF zur Herstellung von Impfstoffen
Laufzeit: 15.06.2004 - 15.06.2005 - Entwicklung eines Microcarrier-basierten Herstellungsverfahrens für einen Impfstoff gegen Schweine-Influenza
Laufzeit: 01.10.2004 - 30.05.2005 - Bioreaktor mit Sensorik
Laufzeit: 01.10.2004 - 31.12.2004 - Evaluation of membrane techniques in downstream processing of influenza virus
Laufzeit: 01.08.2004 - 30.11.2004 - Downstream Processing of Viral Vaccines
Laufzeit: 01.06.2004 - 30.11.2004 - Entwicklung und Erprobung von Prozessführungskonzepten zur Herstellung von inaktivierten Virusimpfstoffen
Laufzeit: 01.06.2001 - 31.05.2004 - Entwicklung eines Verfahrens für die großtechnische Herstellung von rekombinanten MVA als AIDS Vakzine in permanenten Hühnerembryofibroblasten
Laufzeit: 01.04.2003 - 31.01.2004 - Entwicklung eines serumfreien Kultivierungsverfahrens von primären Hühnerembryofibroblasten auf Microcarriern
Laufzeit: 01.02.2002 - 31.12.2003 - Entwicklung eines Herstellungsverfahrens für einen Impfstoff gegen Nerzenteritis
Laufzeit: 01.09.2002 - 31.10.2003
2022
Anderes Material
Impact of influenza A virus infection on growth and metabolism of suspension MDCK cells using a dynamic model
In: Metabolites - Basel: MDPI, 2011, Bd. 12 (2022), 3, insges. 27 S.
Begutachteter Zeitschriftenartikel
High-titer hepatitis C virus production in a scalable single-use high cell density bioreactor
In: Vaccines - Basel: MDPI, Bd. 10 (2022), 2, insges. 24 S.
2021
Begutachteter Zeitschriftenartikel
A high cell density perfusion process for Modified Vaccinia virus Ankara production - process integration with inline DNA digestion and cost analysis
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley . - 2021, insges. 15 S.
Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity
In: Cells - Basel: MDPI, 2012, Bd. 10 (2021), 7, insges. 14 S.
Associated viral gene transfer vectors by membrane-based steric exclusion chromatography
In: Human gene therapy - New York, NY: Liebert, 2021, insgesamt 16 Seiten
Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles
In: BMC biology - Berlin: Springer, Bd. 19 (2021)
Cell culture-based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 105 (2021), S. 72517264
Cell-free glycoengineering of the recombinant SARS-CoV-2 spike glycoprotein
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, 2013, Bd. 9 (2021), insges. 10 S.
Cell-free multi-enzyme synthesis and purification of uridine diphosphate galactose
In: ChemBioChem - Weinheim: Wiley-VCH, Bd. 22 (2021), S. 1-11
Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N-glycans
In: Microbial cell factories - London: Biomed Central, Bd. 20 (2021), S. 1-17
Comprehensive Nglycosylation analysis of the influenza A virus proteins HA and NA from adherent and suspension MDCK cells
In: The FEBS journal/ Vereinigung der Europäischen Biochemischen Gesellschaften - Oxford [u.a.]: Wiley-Blackwell . - 2021
Continuous purification of influenza A virus particles using pseudo-affinity membrane chromatography
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, Bd. 342 (2021), S. 139-148
Critical Assessment of MetaProteome Investigation (CAMPI) - a multi-laboratory comparison of established workflows
In: Nature Communications - [London]: Nature Publishing Group UK, Bd. 12 (2021), S. 1-15
Fecal metaproteomics reveals reduced gut inflammation and changed microbial metabolism following lifestyle-induced weight loss
In: Biomolecules - Basel: MDPI, 2011, Vol.11.2021, 5, 726, insgesamt 13 Seiten
Forschungsarbeiten am Institut für Verfahrenstechnik der OttovonGuerickeUniversität Magdeburg
In: Chemie - Ingenieur - Technik: CIT - Weinheim: Wiley-VCH Verl., Bd. 93 (2021), 3, S. 345-352
High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cells
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 105 (2021), 4, S. 1421-1434
Integrated cycles for urban biomass as a strategy to promote a CO2-neutral society - a feasibility study
In: Sustainability - Basel: MDPI, Bd. 13 (2021), 17, insges. 22 S.
MPA_Pathway_Tool - user-friendly, automatic assignment of microbial community data on metabolic pathways
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, Bd. 22 (2021), 20, insges. 12 S.
Multienzyme cascades for the in vitro synthesis of guanosine diphosphate Lfucose
In: ChemCatChem - Weinheim: WILEY-VCH Verlag, Bd. 13 (2021), insges. 11 S.
Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture
In: PLoS Computational Biology: a new community journal/ Public Library of Science - San Francisco, Calif.: Public Library of Science, Bd. 17 (2021), 9, insges. 28 S.
OP7, a novel influenza A virus defective interfering particle - production, purification, and animal experiments demonstrating antiviral potential
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 105 (2021), 1, S. 129-146
SARS-CoV-2 production in a scalable high cell density bioreactor
In: Vaccines - Basel: MDPI, Bd. 9 (2021), 7
Semi-continuous propagation of influenza A virus and its defective interfering particles - analyzing the dynamic competition to select candidates for antiviral therapy
In: Journal of virology - Baltimore, Md.: Soc., Bd. 95 (2021), 24$e01174-21, insges. 18 S.
Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteins
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 11 (2021)
Towards integrated production of an influenza A vaccine candidate with MDCK suspension cells
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley, Bd. 118 (2021), 10, S. 3996-4013
Tracking changes in adaptation to suspension growth for MDCK cells: cell growth correlates with levels of metabolites, enzymes and proteins
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 105 (2021), S. 1861-1874
Buchbeitrag
Correction to: Animal Cell Expression Systems
In: Advances in Glycobiotechnology - Cham: Springer International Publishing; Rapp, Erdmann . - 2021, S. 459-461
Dissertation
Metaproteomanalyse methanogener Mikrobiome aus Anreicherungskulturen im Labormaßstab
In: Magdeburg: Universitätsbibliothek, 2021, 1 Online-Ressource (IX, 123, A-J Seiten, 3,84 MB), Illustrationen
Herausgeberschaft
Advances in glycobiotechnology
In: Cham: Springer, 2021, viii, 461 Seiten, Illustrationen, Diagramme, 24 cm - (Advances in biochemical engineering/biotechnology; 175)
2020
Artikel in Zeitschrift
Synthesis of lipid-linked oligosaccharides by a compartmentalized multi-enzyme cascade for the in vitro N-glycosylation of peptides
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, 1984, Bd. 322 (2020), S. 54-65
Begutachteter Zeitschriftenartikel
A dynamic model linking cell growth to intracellular metabolism and extracellular byproduct accumulation
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley . - 2020, insges. 21 S.
Application of an nnclined settler for cell culture-based influenza A virus production in perfusion mode
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, Volume 8 (2020), article 672, insgesmat 13 Seiten
Impact of feeding and stirring regimes on the internal stratification of microbial communities in the fermenter of anaerobic digestion plants
In: Bioresource technology - Amsterdam [u.a.]: Elsevier Science, 314(2020), Artikel-Nummer 123679, 1 Online-Ressource, Illustrationen, Diagramme
Performance of an acoustic settler versus a hollow fiberbased ATF technology for influenza virus production in perfusion
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 104.2020, S. 4877-4888
Production of Modified Vaccinia Ankara virus by intensified cell cultures - a comparison of platform technologies for viral vector production
In: Biotechnology journal: BTJ ; systems & synthetic biology, nanobiotech, medicine - Weinheim: Wiley-VCH, 2020, Artikelnr. 2000024, insgesamt 10 Seiten
Single-cell analysis uncovers a vast diversity in intracellular viral defective interfering RNA content affecting the large cell-to-cell heterogeneity in influenza A virus replication
In: Viruses - Basel: MDPI, 12 (2020,1), Artikelnummer 71, 19 Seiten
Virus harvesting in perfusion culture - choosing the right type of hollow fiber membrane
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley, 2020, insgesamt 13 Seiten
Buchbeitrag
Perfusion control for high cell density cultivation and viral vaccine production
In: Animal Cell Biotechnology: Methods and Protocols - New York, NY: Springer US; Pörtner, Ralf . - 2020, S. 141-168
Dissertation
In-depth mass spectrometry-based glycoproteomics - advances in sample preparation, measurement and data-analysis of glycoproteins
In: Magdeburg, 2020, XI, 141 Seiten, Illustrationen, Diagramme, 30 cm ; [Literaturverzeichnis: Seite 118-133]
Intensified yellow fever and Zika virus production in animal cell culture
In: Magdeburg, 2020, XV, 175 Seiten, Illustrationen, Diagramme, 30 cm ; [Literaturverzeichnis: Seite 139-157]
Single-cell analysis of influenza A virus replication - sources of cell-to-cell heterogeneity and discoverey of a novel type of defective interfering particle
In: Magdeburg, 2020, XV, 155 Seiten, Illustrationen, Diagramme, 30 cm ; [Literaturverzeichnis: Seite 122-136]
2019
Abstract
Dialyseinduzierte Veränderungen im menschlichen Serum-Protein N-Glykosylation
In: Kongress für Nephrologie, 11. Jahrestagung der Deutschen Gesellschaft für Nephrologie: Die Nephrologie als ganzheitliche Disziplin in der Patientenversorgung : 10. 13. Oktober 2019 in Düsseldorf : Programm/ Kongress für Nephrologie, 2019, P256, S. 165
Begutachteter Zeitschriftenartikel
A novel type of influenza a virus-derived defective interfering particle with nucleotide substitutions in its genome
In: Journal of virology: publ. by the American Society for Microbiology - Baltimore, Md.: Soc., 1967, Bd. 93.2019, 4, Art.-Nr. e01786, insges. 24 Seiten
A robust and universal metaproteomics workflow for research studies and routine diagnostics within 24 h using phenol extraction, FASP digest, and the MetaProteomeAnalyzer
In: Frontiers in microbiology - Lausanne: Frontiers Media, 10 (2019), article 1883, insgesamt 20 Seiten
A system for production of defective interfering particles in the absence of infectious influenza A virus
In: PLOS ONE - San Francisco, California, US: PLOS, Vol. 14.2019, 3, Artikel e0212757, insgesamt 18 Seiten
Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the von Magnus effect
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, 14 (2019), 11, article e0224317, insgesamt 21 Seiten
Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1
In: Vaccine - Amsterdam: Elsevier, 1983, Bd. 37.2019, 47, S. 7019-7028
Enzymatic cascade synthesis provides novel linear human milk oligosaccharides as reference standards for xCGELIF based highthroughput analysis
In: Biotechnology journal - Weinheim: Wiley-VCH, Vol. 14 (2019), 3, Artikelnr. 1800305, insges. 9 Seiten
Enzymatic cascades for tailored 13 C 6 and 15 N enriched human milk oligosaccharides
In: Molecules: a journal of synthetic chemistry and natural product chemistry - Basel: MDPI, 1996, Volume 24 (2019), 19, Artikel 3482, insgesamt 21 Seiten
High titer MVA and influenza A virus production using a hybrid fed-batch/perfusion strategy with an ATF system
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 103 (2019), 7, S. 3025-3035
High-throughput serum N-glycomics - method comparison and application to study rheumatoid arthritis and pregnancy-associated changes
In: Molecular & cellular proteomics: MCP - Bethesda, Md: The American Society for Biochemistry and Molecular Biology, Bd. 18.2019, 1, S. 3-15
Hydrophobic-interaction chromatography for purification of influenza A and B virus
In: Journal of chromatography / B - New York, NY [u.a.]: Science Direct, Bd. 1117.2019, S. 103-117
Influenza A virus production in a single-use orbital shaken bioreactor with ATF or TFF perfusion systems
In: Vaccine - Amsterdam: Elsevier, Bd. 37.2019, 47, S. 7011-7018
Metaproteome analysis reveals that syntrophy, competition, and phage-host interaction shape microbial communities in biogas plants
In: Microbiome - London: Biomed Central . - 2019, insges. 17 S.
Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis
In: Journal of proteomics - New York, NY [u.a.]: Elsevier, 2008, Bd. 201.2019, S. 93-103
Production of Defective Interfering Particles of influenza A virus in parallel continuous cultures at two residence times - insights from qPCR measurements and viral dynamics modeling
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, 2013, Volume 7 (2019), Artikel 275, insgesamt 15 Seiten
RedCom - a strategy for reduced metabolic modeling of complex microbial communities and its application for analyzing experimental datasets from anaerobic digestion
In: PLoS Computational Biology/ Public Library of Science - San Francisco, Calif.: Public Library of Science, Vol. 15 (2019), 2, Artikel e1006759, insgesamt 32 Seiten
Semi-perfusion cultures of suspension MDCK cells enable high cell concentrations and efficient influenza A virus productionPK2.1
In: Vaccine - Amsterdam: Elsevier, Bd. 37 (2019), 47, S. 7003-7010
Use of sulfated cellulose membrane adsorbers for chromatographic purification of cell cultured-derived influenza A and B viruses
In: Separation and purification technology - Amsterdam [u.a.]: Elsevier Science, 1997, Bd. 226.2019, S. 350-358
Dissertation
Charakterisierung der Influenzavirus-Vermehrung in genetisch veränderten humanen Zelllinien zur Optimierung der Impfstoffproduktion
In: Magdeburg, 2019, XI, 173 Seiten, Illustrationen, Diagramme, 30 cm ; [Literaturverzeichnis: Seite 133-155]
2018
Artikel in Zeitschrift
One pot synthesis of GDP-mannose by a multi-enzyme cascade for enzymatic assembly of lipid-linked oligosaccharides
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley, 1959, Bd. 115 (2018), 1, S. 192-205
Begutachteter Zeitschriftenartikel
A multiscale model of influenza A virus replication covering highly different infection conditions in cell cultures
In: IFAC-PapersOnLine/ Internationale Förderung für Automatische Lenkung - Frankfurt: Elsevier, Bd. 51.2018, 19, S. 32-33
Cell culture-based production of defective interfering particles for influenza antiviral therapy
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 102.2018, 3, S. 1167-1177, 2017
Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, Bd. 283.2018, S. 120-129
High-cell-density cultivations to increase MVA virus production
In: Vaccine - Amsterdam: Elsevier, Bd. 36 (2018), 22, S. 3124-3133
Improvement of electrospray stability in negative ion mode for nano-PGC-LC-MS glycoanalysis via post-column make-up flow
In: Glycoconjugate journal: official journal of the International Glycoconjugate Organization - Dordrecht [u.a.]: Springer Science + Business Media B.V, Bd. 35.2018, 6, S. 499-509
MPA portable - a stand-alone software package for analyzing metaproteome samples on the go
In: Analytical chemistry - Columbus, Ohio: American Chemical Society, Bd. 90 (2018), 1, S. 685-689
Mathematical modeling as a tool to improve influenza vaccine production processes
In: IFAC-PapersOnLine/ Internationale Förderung für Automatische Lenkung - Frankfurt: Elsevier, Bd. 51.2018, 19, S. 1-4
Optimization of cell culture-derived influenza A virus particles purification using sulfated cellulose membrane adsorbers
In: Engineering in life sciences - Weinheim: Wiley-VCH, Bd. 18.2018, 1, S. 29-39
Process intensification of EB66® cell cultivations leads to high-yield yellow fever and Zika virus production
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 102.2018, 20, S. 8725-8737
Propagation of Brazilian Zika virus strains in static and suspension cultures using Vero and BHK cells
In: Vaccine - Amsterdam: Elsevier, 1983, Bd. 36.2018, 22, S. 3140-3145
Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths
In: Vaccine - Amsterdam: Elsevier, Bd. 36.2018, 22, S. 3153-3160
Purification of influenza viruslike particles using sulfated cellulose membrane adsorbers
In: Journal of chemical technology & biotechnology - Chichester: Wiley, Bd. 93.2018, 7, S. 1988-1996
SDSPAGE fractionation to increase metaproteomic insight into the taxonomic and functional composition of microbial communities for biogas plant samples
In: Engineering in life sciences - Weinheim: Wiley-VCH, Bd. 18.2018, 7, S. 498-509
The fine art of destruction - a guide to indepth glycoproteomic analyses-exploiting the diagnostic potential of fragment ions
In: Proteomics - Weinheim: Wiley VCH, 2001, Vol. 18.2018, 24, Art.-Nr. 1800282
Valorisation of deinking sludge as a substrate for lignocellulolytic enzymes production by Pleurotus ostreatus
In: Journal of cleaner production - Amsterdam [u.a.]: Elsevier Science, Vol. 197.2018, Part 1, S. 253-263
glyXtoolMS - an open-source pipeline for semiautomated analysis of glycopeptide mass spectrometry data
In: Analytical chemistry: the authoritative voice of the analytical community - Columbus, Ohio: American Chemical Society, 1947, Bd. 90.2018, 20, S. 11908-11916
2017
Begutachteter Zeitschriftenartikel
Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systems
In: PLoS one - Lawrence, Kan: PLoS, Bd. 12.2017, 8, Art.-Nr. e0182553, insges. 17 Seiten
Improvement of the glycoproteomic toolbox with the discovery of a unique C-terminal cleavage specificity of flavastacin for N-glycosylated asparagine
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 7.2017, Art.-Nr. 11419, insgesamt 9 Seiten
Influence of the production system on the surface properties of influenza A virus particles
In: Engineering in life sciences - Weinheim: Wiley-VCH, Bd. 17.2017, 10, S. 1071-1077
Proteotyping of laboratory-scale biogas plants reveals multiple steady-states in community composition
In: Anaerobe: the official journal of the Anaerobe Society of the Americas - London: Academic Press, Bd. 46.2017, S. 56-68
Specific ion effects on the particle size distributions of cell culturederived influenza A virus particles within the Hofmeister series
In: Engineering in life sciences - Weinheim: Wiley-VCH, Bd. 17.2017, 5, S. 470-478
Steric exclusion chromatography for purification of cell culture-derived influenza A virus using regenerated cellulose membranes and polyethylene glycol
In: Journal of chromatography / A: including electrophoresis, mass spectrometry and other separation and detection methods - New York, NY [u.a.]: Science Direct, Bd. 1483.2017, S. 110-119
Buchbeitrag
Animal cell expression systems
In: Advances in biochemical engineering, biotechnology - Berlin: Springer, S. 1-36, 2017
Dissertation
Charakterisierung von mikrobiellen Gemeinschaften aus Biogasanlagen mittels Metaproteomanalyse und Korrelationen der Ergebnisse zu den Prozessparametern
In: Magdeburg, 2017, XVII, 164, xxxvii Blätter, Illustrationen
2016
Begutachteter Zeitschriftenartikel
A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection
In: Vaccine - Amsterdam: Elsevier, 1983, Bd. 34.2016, 50, S. 6367-6374
A membrane-based purification process for cell culture-derived influenza A virus
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, 1984, Bd. 220.2016, S. 12-20
Binding kinetics and multi-bond : finding correlations by synthesizing interactions between ligand-coated bionanoparticles and receptor surfaces
In: Analytical biochemistry : methods in the biological sciences. - San Diego, Calif : Elsevier, Bd. 505.2016, S. 8-17
Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 100 (2016), 5, S. 2121-2132
Diagnostic concept for dynamically operated biogas production plants
In: Renewable energy - Amsterdam [u.a.]: Elsevier Science, Vol. 96.2016, Part A, S. 479-489
Early changes in the metabolic profile of activated CD8+ T cells
In: BMC cell biology - London: BioMed Central, 2000, Bd. 17.2016, Art.-Nr. 28, insges. 11 S.
Ezrin and HNRNP expression correlate with increased virus release rate and early onset of virus-induced apoptosis of MDCK suspension cells
In: Biotechnology journal : BTJ ; systems & synthetic biology, nanobiotech, medicine. - Weinheim : Wiley-VCH, Bd. 11.2016, 10, S. 1332-1342
Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital Disorder of glycosylation (PMM2-CDG)
In: Molecular & cellular proteomics : MCP. - Bethesda, Md : The American Society for Biochemistry and Molecular Biology, Bd. 15.2016, 4, S. 1435-1452
Impaired antiviral response of adenovirus-transformed cell lines supports virus replication
In: Journal of general virology: JGV - Reading: Soc., 1967, Bd. 97.2016, 2, S. 293-298
Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 100.2016, 16, S. 7181-7192
Metaproteomics applied to activated sludge for industrial wastewater treatment revealed a dominant methylotrophic metabolism of Hyphomicrobium zavarzinii
In: Microbial ecology - New York, NY: Springer, 1974 . - 2016
Predicting compositions of microbial communities from stoichiometric models with applications for the biogas process
In: Biotechnology for biofuels. - London : BioMed Central, Bd. 9.2016, 17, insges. 16 S.
Proteotyping of biogas plant microbiomes separates biogas plants according to process temperature and reactor type
In: Biotechnology for biofuels - London: BioMed Central, 2008, Bd. 9.2016, 1
Reprint of "Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs
In: Virus research : an international journal of molecular and cellular virology. - Amsterdam [u.a.] : Elsevier Science, Bd. 218.2016, S. 86-95
Sialic acid-specific affinity chromatography for the separation of erythropoietin glycoforms using serotonin as a ligand
In: Journal of chromatography / B - New York, NY [u.a.]: Science Direct, 1977, Bd. 1012/1013.2016, S. 193-203
Site-specific O-glycosylation analysis of human blood plasma proteins
In: Molecular & cellular proteomics: MCP - Bethesda, Md: The American Society for Biochemistry and Molecular Biology, 2002, Bd. 15.2016, 2, S. 624-641
Towards personalized diagnostics via longitudinal study of the human plasma N-glycome
In: Biochimica et biophysica acta / General subjects: BBA - Amsterdam [u.a.]: Elsevier, 1964, Bd. 1860.2016, 8, S. 1728-1738
2015
Begutachteter Zeitschriftenartikel
Bioreactor concepts for cell culture-based viral vaccine production
In: Expert review of vaccines - Abingdon, Oxon: Taylor & Francis, 2002, Bd. 14.2015, 9, S. 1181-1195
Colonic metaproteomic signatures of active bacteria and the host in obesity
In: Proteomics - Weinheim: Wiley VCH, 2001, Bd. 15.2015, 20, S. 3544-3552
Community shifts in a well-operating agricultural biogas plant - how process variations are handled by the microbiome
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 99 (2015), 18, S. 7791-7803
Comparison of influenza virus particle purification using magnetic sulfated cellulose particles with an established centrifugation method for analytics
In: Analytical chemistry : the authoritative voice of the analytical community. - Columbus, Ohio : American Chemical Society, Bd. 87.2015, 21, S. 10708-10711
Editorial: Can modern vaccine technology pursue the success of traditional vaccine manufacturing?
In: Biotechnology journal: BTJ : systems & synthetic biology, nanobiotech, medicine - Weinheim: Wiley-VCH, Bd. 10.2015, 5, S. 657-658
Exclusive decoration of simian immunodeficiency virus Env with high-mannose type N-glycans is not compatible with mucosal transmission in rhesus macaques
In: Journal of virology: publ. by the American Society for Microbiology - Baltimore, Md.: Soc., 1967, Bd. 89.2015, 22, S. 11727-11733
Fractionation of biogas plant sludge material improves metaproteomic characterization to investigate metabolic activity of microbial communities
In: Proteomics - Weinheim: Wiley VCH, Bd. 15 (2015), 20, S. 3585-3589
Metaproteomics of activated sludge from a wastewater treatment plant - a pilot study
In: Proteomics - Weinheim: Wiley VCH, Bd. 15 (2015), 20, S. 3596-3601
Metaproteomics of complex microbial communities in biogas plants
In: Microbial biotechnology - Oxford: Wiley-Blackwell, Bd. 8 (2015), 5, S. 749-763
Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs
In: Virus research: an international journal of molecular and cellular virology - Amsterdam [u.a.]: Elsevier Science, 1984, Bd. 213.2015, S. 90-99
Monitoring changes in proteome during stepwise adaptation of a MDCK cell line from adherence to growth in suspension
In: Vaccine - Amsterdam: Elsevier, 1983, Bd. 33.2015, 35, S. 4269-4280
Navigating through metaproteomics data - a logbook of database searching
In: Proteomics - Weinheim: Wiley VCH, 2001, Bd. 15.2015, 20, S. 3439-3453
Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, Vol. 6.2015, Art. 8938, insgesamt 12 S.
The MetaProteomeAnalyzer - a powerful open-source software suite for metaproteomics data analysis and interpretation
In: Journal of proteome research - Washington, DC: ACS Publications, Bd. 14 (2015), 3, S. 1557-1565
Dissertation
Population balance modeling of influenza A virus replication in MDCK cells during vaccine production
In: Magdeburg, Univ., Fak. für Elektrotechnik und Informationstechnik, Diss., 2015, X, 127 S., graph. Darst.
2014
Begutachteter Zeitschriftenartikel
A flow-through chromatography process for influenza A and B virus purification
In: Journal of virological methods - Amsterdam [u.a.]: Elsevier Science, Bd. 207.2014, S. 45-53
Avidity of influenza virus: Model-based identification of adsorption kinetics from surface plasmon resonance experiments
In: Journal of chromatography / A - New York, NY [u.a.]: Science Direct, Bd. 1326.2014, S. 125-129
Biological methanation of hydrogen within biogas plants - a model-based feasibility study
In: Applied energy - Amsterdam [u.a.]: Elsevier Science, Bd. 134 (2014), S. 413-425
Changes in intracellular metabolite pools during growth of adherent MDCK cells in two different media
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 98.2014, 1, S. 385-397
Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological
In: Molecular & cellular proteomics: MCP - Bethesda, Md: The American Society for Biochemistry and Molecular Biology, Bd. 13.2014, S. 1598-1610
Flow cytometric viability assessment of lactic acid bacteria starter cultures produced by fluidized bed drying
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 98.2014, 11, S. 4897-4909
Glycolysis is governed by growth regime and simple enzyme regulation in adherent MDCK cells
In: PLoS Computational Biology: a new community journal - San Francisco, Calif: Public Library of Science, Vol. 10.2014, 10, Art. e1003885, insgesamt 16 S.
High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells
In: Vaccine - Amsterdam: Elsevier, Bd. 32 (2014), 24, S. 2770-2781
Impact of cultivation conditions on N-glycosylation of influenza virus A hemagglutinin produced in MDCK cell culture
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley, 1959, Bd. 110.2014, 6, S. 1691-1703
Impact of defective interfering particles on virus replication and antiviral host response in cell culture-based influenza vaccine production
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 98.2014, 21, S. 8999-9008
Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactor
In: Vaccine - Amsterdam: Elsevier, 1983, Bd. 32.2014, 8, S. 1003-1011
Sample prefractionation with liquid isoelectric focusing enables in depth microbial metaproteome analysis of mesophilic and thermophilic biogas plants
In: Anaerobe - London: Academic Press, Bd. 29 (2014), S. 59-67
Species-specific viability analysis of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus in mixed culture by flow cytometry
In: BMC microbiology - London: BioMed Central, Bd. 14.2014, Art. 56, insgesamt 15 S.
The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis
In: BMC biotechnology - London: BioMed Central, Vol. 14.2014, Art. 72 insgesamt 14 S.
The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, Bd. 178.2014, S. 43-53
Buchbeitrag
Vaccine production - upstream processing with adherent or suspension cell lines
In: Animal Cell Biotechnology - Totowa, NJ: Humana Press, 2014 . - 2014, S. 371-393 - (Methods in Molecular Biology, Methods and Protocols; 1104)
Dissertation
Characterization of the avian designer cells AGE1.CR and AGE1.CR.plX considering growth, metabolism and production of influenza virus and Modified Vaccinia Virus Ankara (MVA)
In: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2014, IX, 178 S., Ill., graph. Darst., 30 cm
Impact of cultivation conditions on N-glycosylation of influenza A virus hemagglutinin, on quasispecies composition, and on immunogenicity of virus preparations
In: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2014, XVII, 159, S44 Bl., graph. Darst.
Habilitation
Improving industrial antibody manufacturing processes using animal cell culture technology
In: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Habil.-Schr., 2014, Getr. Zählung, Ill., graph. Darst., 30 cm
Herausgeberschaft
Large-Scale Networks in Engineering and Life Sciences
In: Cham: Birkhäuser, 2014, Online-Ressource (XIV, 388 p. 111 illus., 63 illus. in color, online resource) - (Springer eBook Collection; Mathematics and Statistics; SpringerLink; Bücher; Modeling and Simulation in Science, Engineering and Technology)
2013
Begutachteter Zeitschriftenartikel
Batch-to-batch variability of two human designer cell lines - AGE1.HN and AGE1.HN.AAT ; carried out by different laboratories under defined culture conditions using a mathematical model
In: Engineering in life sciences - Weinheim: Wiley-VCH, 2001, Bd. 13.2013, 6, S. 580-592
CAP, a new human suspension cell line for influenza virus production
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 97.2013, 1, S. 111-122, 2012
Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line
In: Vaccine. - Amsterdam : Elsevier, Bd. 31.2013, 48, S. 5693-5699
Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Vol. 8.2013, 9, Art. e72288, insgesamt 9 S.
Continuous purification of influenza virus using simulated moving bed chromatography
In: Journal of chromatography / A - New York, NY [u.a.]: Science Direct, Bd. 1307 (2013), S. 99-110
Development of a high-throughput glycoanalysis method for the characterization of oligosaccharides in human milk utilizing multiplexed capillary gel electrophoresis with laser-induced fluorescence detection
In: Electrophoresis. - Weinheim : Wiley-Blackwell, Bd. 34.2013, 16, S. 2323-2336
Distributed modeling of human influenza a virushost cell interactions during vaccine production
In: Biotechnology & bioengineering. - New York, NY [u.a.] : Wiley, Bd. 110.2013, 8, S. 2252-2266
Elements in the development of a production process for modified vaccinia virus ankara
In: Microorganisms. - Basel : MDPI, Bd. 1.2013, 1, S. 100-121
Evaluating differences of metabolic performances - statistical methods and their application to animal cell cultivations
In: Biotechnology & bioengineering. - New York, NY [u.a.] : Wiley, Bd. 110.2013, 10, S. 2633-2642
Herstellung moderner Grippeimpfstoffe
In: Chemie in unserer Zeit. - Weinheim : Wiley-VCH, Bd. 47.2013, 1, S. 12-22
Identification of growth phases and influencing factors in cultivation of AGE1.HN cells using set-based methods
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Vol. 8.2013, 8, Art. e68124, insgesamt 11 S.
Metagenome and metaproteome analyses of microbial communities in mesophilic biogas-producing anaerobic batch fermentations indicate concerted plant carbohydrate degradation
In: Systematic and applied microbiology - München: Elsevier, Bd. 36.2013, 5, S. 330-338
Metaproteome analysis of the microbial communities in agricultural biogas plants
In: New biotechnology - New York, NY [u.a.]: Elsevier, Bd. 30 (2013), 6, S. 614-622
Multiscale modeling of influenza A virus infection supports the development of direct-acting antivirals
In: PLoS Computational Biology: a new community journal/ Public Library of Science - San Francisco, Calif.: Public Library of Science, 2005, Bd. 9.2013, 11, Art. e1003372, insges. 13 S.
New method for density determination of nanoparticles using a CPS disc centrifuge
In: Colloids and surfaces. - Amsterdam [u.a.] : Elsevier ScienceColloids and surfaces / B, Bd. 104.2013, S. 27-31
PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia
In: Blood. - Stanford, Calif : HighWire Press, Bd. 112.2013, 6, S. 969-980
Proteome analysis of virushost cell interaction - rabies virus replication in Vero cells in two different media
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 97.2013, 12, S. 5493-5506
Proteomics in environmental and technical microbiology
In: Engineering in life sciences - Weinheim: Wiley-VCH, 2001, Bd. 14.2013, 1, S. 27-46
Searching for a needle in a stack of needles: challenges in metaproteomics data analysis
In: Molecular BioSystems. - Cambridge : Royal Society of Chemistry, Bd. 9.2013, 4, S. 578-585
Toward animal cell culturebased influenza vaccine design - viral hemagglutinin N-glycosylation markedly impacts immunogenicity
In: The journal of immunology - Bethesda, Md.: Soc., Bd. 190 (2013), 1, S. 220-230
glyXalign - high-throughput migration time alignment preprocessing of electrophoretic data retrieved via multiplexed capillary gel electrophoresis with laser-induced fluorescence detection-based glycoprofiling
In: Electrophoresis. - Weinheim : Wiley-Blackwell, Bd. 34.2013, 16, S. 2311-2315
Originalartikel in begutachteter internationaler Zeitschrift
The relation between growth phases, cell volume changes and metabolism of adherent cells during cultivation
In: Journal of biotechnology. - Amsterdam [u.a.] : Elsevier Science, Bd. 164.2013, 4, S. 489-499
2012
Abstract
Glycosylation matters - role of viral hemagglutinin N-glycosylation in immunogenicity
In: Immunology: an official journal of the British Society for Immunology - Oxford [u.a.]: Wiley-Blackwell, 1958, Vol. 137, 2012, Suppl. 1, Art. P1880, S. 760
Artikel in Kongressband
Distributed modeling and parameter estimation of influenza virus replication during vaccine production authors
In: Preprints MATHMOD 2012 Vienna: abstract volume - Vienna: ARGESIM, ARGE Simulation News, Vienna Univ. of Technology, insges. 6 S. - (ARGESIM report; 38)
Begutachteter Zeitschriftenartikel
A flow cytometric method for viability assessment of Staphylococcus aureus and Burkholderia cepacia in mixed culture
In: Cytometry / A - Hoboken, NJ: Wiley-Liss, Bd. 81.2012, 12, S. 1055-1066
Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture
In: Engineering in life sciences - Weinheim: Wiley-VCH, 2001, Bd. 12.2012, 5, S. 518-528
How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?
In: Biotechnology journal: BTJ : systems & synthetic biology, nanobiotech, medicine - Weinheim: Wiley-VCH, Bd. 7.2012, 12, S. 1522-1529
Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells
In: BMC biotechnology - London: BioMed Central, 12.2012, Art. 79, insgesamt 9 S.
Metaproteome analysis to determine the metabolically active part of a thermophilic microbial community producing biogas from agricultural biomass
In: Canadian journal of microbiology / publ. by the National Research Council of Canada - Plattsburgh, NY: NRC Research Press, 1954, Bd. 58.2012, 7, S. 917-922; =A http://dx.doi.org/10.1139/W2012-058
Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis
In: Journal of virology: publ. by the American Society for Microbiology - Baltimore, Md: Soc, Bd. 86.2012, 15, S. 7806-7817
Productivity, apoptosis, and infection dynamics of influenza A/PR/8 strains and A/PR/8-based reassortants
In: Vaccine - Amsterdam: Elsevier, Bd. 30.2012, 35, S. 5253-5261
Dissertation
Überwachung und Regelung von Hochzelldichtekultivierungen in der Influenza-Impfstoffproduktion
In: Zugl.: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2012: Aachen: Shaker, XI, 175 S., Ill., graph. Darst., 210 mm x 148 mm, 300 g - (Forschungsberichte aus dem Max-Planck-Institut für Dynamik komplexer technischer Systeme; 33)
Originalartikel in begutachteter internationaler Zeitschrift
Effect of the 3'-terminal truncation of the human interferon-gamma gene on plasmid segregation in escherichia coli
In: Biotechnology & biotechnological equipment: international scientific-theoretical and applied publication - London: Taylor and Francis, Bd. 26.2012, 2, S. 2930-2936
Impact of host cell line adaptation on quasispecies composition and glycosylation of influenza A virus hemagglutinin
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Vol. 6, 2012, 12, Art. e27989, insgesamt 10 S.
Proteomic tracking and analysis of a bacterial mixed culture
In: Proteomics: proteomics and systems biology - Weinheim: Wiley-VCH, 2001, Bd. 12.2012, 12, S. 1893-1901
Time-kill studies with a ceftazidime-treated mixed culture consisting of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus
In: Engineering in life sciences: Industry, Environment, Plant, Food - Weinheim: Wiley-Blackwell, Bd. 12.2012, 2, S. 188-197
Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host response
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 93.2012, 2, S. 601-611
2011
Dissertation
Molecular biological analysis of dynamic interactions between influenza viruses and host cells - host cell proteomes and viral replication dynamics
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2011, XVIII, 176 S., graph. Darst.
Originalartikel in begutachteter internationaler Zeitschrift
A novel concept combining experimental and mathematical analysis for the identification of unknown interspecies effects in a mixed culture
In: Biotechnology and bioengineering. - New York, NY [u.a.] : Wiley, Bd. 108.2011, 8, S. 1900-1911
Characterisation of cultivation of the human cell line AGE1.HN.AAT
In: BMC proceedings - London: BioMed Central, 2007, 2011 Suppl. 8, P87
Characterization of the human AGE1.HN cell line: a systems biology approach
In: BMC proceedings - London: BioMed Central, 2007, 2011, Suppl. 8, P78
Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture
In: BMC proceedings/ Biomed Central - London: BioMed Central, 2007, 2011, Suppl. 8, P47
Downstream processing of cell culture-derived virus particles
In: Expert review of vaccines. - London : Expert Reviews, Bd. 10.2011, 10, S. 1451-1475
Effects of a recombinant gene expression on ColE1-like plasmid segregation in Escherichia coli
In: BMC biotechnology. - London : BioMed Central, Bd. 11.2011, 18, insges. 12 S.
Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells
In: Vaccine. - Amsterdam : Elsevier, Bd. 29.2011, 41, S. 7125-7129
High-density microcarrier cell cultures for influenza virus production
In: Biotechnology progress. - Hoboken, NJ : Wiley, Bd. 27.2011, 1, S. 241-250
Impact of different influenza cultivation conditions on HA N-Glycosylation
In: BMC proceedings/ Biomed Central - London: BioMed Central, 2007, 2011, Suppl. 8, P113
Impact of influenza virus adaptation status on HA N-glycosylation patterns in cell culture-based vaccine production
In: Journal of carbohydrate chemistry - London [u.a.]: Taylor & Francis, 1982, Bd. 30.2011, 4/6, S. 281-290
Interspecies effects in a ceftazidime-treated mixed culture of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus: analysis at the single-species level
In: The journal of antimicrobial chemotherapy. - Oxford : Oxford Univ. Press, Bd. 66.2011, 1, S. 138-145
Metabolic adaptation of MDCK cells to different growth conditions - effects on catalytic activities of central metabolic enzymes
In: Biotechnology and bioengineering. - New York, NY [u.a.] : Wiley, Bd. 108.2011, 11, S. 2691-2704
Metaproteome analysis of sewage from membrane bioreactors
In: Proteomics. - Weinheim : Wiley-Blackwell, Bd. 11.2011, 13, S. 2738-2744
Originalartikel in begutachteter zeitschriftenartiger Reihe
Effect of influenza virus infection on key metabolic enzyme activities in MDCK cells
In: BMC proceedings. - London : BioMed Central, Bd. 5.2011, S. 4
Population balance modelling of influenza virus replication during vaccine production - influence of apoptosis
In: 21st European Symposium on Computer Aided Process Engineering ; Pt. B. - Amsterdam [u.a.] : Elsevier, S. 1336-1340, 2011 - (Computer-aided chemical engineering; 29) ; Kongress: ESCAPE; 21 (Chalkidiki, Greece) : 2011.05.29-06.01
2010
Originalartikel in begutachteter internationaler Zeitschrift
A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor
In: Vaccine. - Amsterdam : Elsevier, Bd. 28.2010, 38, S. 6256-6264
CFD-Modellierung der Zellkultivierung in Wave-Bioreaktoren
In: Chemie - Ingenieur - Technik . - Weinheim : Wiley-VCH Verl., Bd. 82.2010, 9, S. 1512
Capturing of cell culture-derived modified Vaccinia Ankara virus by ion exchange and pseudo-affinity membrane adsorbers
In: Biotechnology and bioengineering . - New York, NY [u.a.] : Wiley, Bd. 105.2010, 4, S. 761-769
Characterization of flow conditions in 2 L and 20 L wave bioreactors using computational fluid dynamics
In: Biotechnology progress . - Hoboken, NJ : Wiley, Bd. 26.2010, 1, S. 101-110
DNA depletion by precipitation in the purification of cell culture-derived influenza vaccines
In: Chemical engineering & technology: industrial chemistry, plant equipment, process engineering, biotechnology / Gesellschaft Deutscher Chemiker ; Deutsche Gesellschaft für Chemisches Apparatewesen, Chemische Technik und Biotechnologie, DECHEMA ; VDI-Gesellschaft Verfahrenstechnik und Chemieingenieurwesen, GVC: industrial chemistry, plant equipment, process engineering, biotechnology - Weinheim: Wiley-VCH, 1987, Bd. 33.2010, 6, S. 941-959
Differential activation of host cell signalling pathways through infection with two variants of influenza A/Puerto Rico/8/34 (H1N1) in MDCK cells
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 28.2010, 51, S. 8210-8218
Dynamics of bionanoparticle targeting in mixtures of human tumour cells by validated population balance modelling
In: Soft matter / publ. by the Royal Society of Chemistry - Cambridge: RSC Publ., 2005, Bd. 6.2010, 6, S. 1203-1216
Experimental characterization of flow conditions in 2 L and 20 L bioreactors with wave-induced motion
In: Biotechnology progress: a journal of food, pharmaceutical and bioengineering ; a publication of the American Chemical Society and the American Institute of Chemical Engineers - Hoboken, NJ: Wiley, 1985, Bd. 27.2011, 2, S. 402-409
Expression, purification, and characterization of a His 6-tagged glycerokinase from Pichia farinosa for enzymatic cycling assays in mammalian cells
In: Journal of biotechnology . - Amsterdam : Elsevier, Bd. 150.2010, 3, S. 396-403
High yields of influenza A virus in MadinDarby canine kidney cells are promoted by an insufficient interferon-induced antiviral state
In: The journal of general virology. - Reading : Society for General Microbiology, Bd. 91.2010, 7, S. 1754-1763
MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 88.2010, 2, S. 461-475
Measurement of key metabolic enzyme activities in mammalian cells using rapid and sensitive microplate-based assays
In: Biotechnology and bioengineering. - New York, NY [u.a.] : Wiley, Bd. 107.2010, 3, S. 566-581
Metabolic effects of influenza virus infection in cultured animal cells - intra- and extracellular metabolite profiling
In: BMC systems biology. - London : BioMed Central, Bd. 4.2010, 61, insges. 22 S.
Metaproteomanalyse von Klärschlamm aus Membranbioreaktoren
In: Chemie - Ingenieur - Technik . - Weinheim : Wiley-VCH Verl., Bd. 82.2010, 9, S. 1539
Purification of cell culture-derived modified vaccinia ankara virus by pseudo-affinity membrane adsorbers and hydrophobic interaction chromatography
In: Biotechnology and bioengineering. - New York, NY [u.a.] : Wiley, Bd. 107.2010, 2, S. 312-320
Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamics
In: Journal of virological methods. - Amsterdam : Elsevier, North-Holland Biomed. Press, Bd. 168.2010, 1/2, S. 63-71
Virushost cell interactions in vaccine production cell lines infected with different human influenza A virus variants: A proteomic approach
In: Journal of proteomics: official journal of the European Proteomics Association - Amsterdam [u.a.]: Elsevier, 2008, Bd. 73.2010, 9, S. 1656-1669
2009
Artikel in Kongressband
Flow characterization in wave bioreactors using computational fluid dynamics
In: 21th Meeting of the European Society for Animal Cell Technology \"Cellular Solutions for Clinical Challenges\", ESACT 2009 . - Dublin, insges. 17 S. ; Kongress: ESACT; 21 (Dublin) : 2009.06.07-10
Habilitation
Upstream processing issues in influenza vaccine production using animal cell technology
In: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Habil.-Schr., 2009, Getr. Zählung, Ill., graph. Darst., 21 cm
Originalartikel in begutachteter internationaler Zeitschrift
Atmospheric pressure free liquid infrared MALDI mass spectrometry - toward a combined ESI/MALDI-liquid chromatography interface
In: Analytical chemistry . - Washington, DC : Soc., Bd. 81.2009, 1, S. 443-452
Glycan analysis in cell culture-based influenza vaccine production - influence of host cell line strain on the glycosylation pattern of viral hemagglutinin
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 27.2009, 32, S. 4325-4336
Glycan analysis in cell culture-based influenza vaccine production: Influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 27.2009, 32, S. 4325-4336
Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine productionFlow cytometry and mathematical modeling
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 27.2009, 20, S. 2712-2722
New avian suspension cell lines provide production of influenza virus and MVA in serum-free media - studies on growth, metabolism and virus propagation
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 27.2009, 36, S. 4975-4982
Numerische und experimentelle Untersuchung der Fließbedingungen in Wave-Bioreaktoren
In: Chemie - Ingenieur - Technik . - Weinheim : Wiley-VCH Verl., Bd. 81.2009, 8, S. 1241
Purification of cell culture-derived influenza virus A/Puerto Rico/8/34 by membrane-based immobilized metal affinity chromatography
In: Journal of virological methods . - Amsterdam : Elsevier, North-Holland Biomed. Press, Bd. 161.2009, 2, S. 312-316
Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines
In: Proteomics . - Weinheim : Wiley VCH, Bd. 9.2009, 12, S. 3316-3327
Sulfated membrane adsorbers for economic pseudo-affinity capture of influenza virus particles
In: Biotechnology and bioengineering . - New York, NY [u.a.] : Wiley, Bd. 103.2009, 6, S. 1144-1154
2008
Originalartikel in begutachteter internationaler Zeitschrift
Auslegungsunterlagen für Bioreaktoren zur Maßstabsvergrößerung eines microcarrierbasierenden Virusproduktionsprozesses
In: Chemie - Ingenieur - Technik . - Weinheim : Wiley-VCH Verl., Bd. 80.2008, 6, S. 821-830
Comparison of metabolic flux distributions for MDCK cell growth in glutamine- and pyruvate-containing media
In: Biotechnology progress . - Hoboken, NJ : Wiley, Bd. 24.2008, 2, S. 311-320
Development and optimisation of a procedure for the production of parapoxvirus ovis by large-scale microcarrier cell culture in a non-animal, non-human and non-plant-derived medium
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 26.2008, 12, S. 1552-1565
Flow cytometric monitoring of influenza A virus infection in MDCK cells during vaccine production
In: BMC biotechnology . - London : BioMed Central, Bd. 8.2008, 45, insges. 23 S.
Mathematical model of growth and heterologous hantavirus protein production of the recombinant yeast saccharomyces cerevisiae
In: Engineering in life sciences . - Weinheim : Wiley-Blackwell, Bd. 8.2008, 4, S. 399-414
Metabolic flux model for an anchorage-dependent MDCK cell line - characteristic growth phases and minimum substrate consumption flux distribution
In: Biotechnology and bioengineering . - New York, NY [u.a.] : Wiley, Bd. 101.2008, 1, S. 135-152
Monitoring influenza virus content in vaccine production - precise assays for the quantitation of hemagglutination and neuraminidase activity
In: Biologicals: journal of the International Association of Biological Standardization - Amsterdam [u.a.]: Elsevier, 1990, Bd. 36.2008, 3, S. 145-161
N-glycan analysis by CGE-LIF - profiling influenza A virus hemagglutinin N-glycosylation during vaccine production
In: Electrophoresis: electrokinetics, fluidics, proteomics - Weinheim: Wiley-VCH, 1980, Bd. 29.2008, 20, S. 4203-4214
Profiling of external metabolites during production of hantavirus nucleocapsid protein with recombinant saccharomyces cerevisiae
In: Biotechnology letters. - Dordrecht [u.a.] : Kluwer Academic Publ., Bd. 30.2008, 3, S. 415-420
Segregated mathematical model for growth of anchorage-dependent MDCK cells in microcarrier culture
In: Biotechnology progress . - Hoboken, NJ : Wiley, Bd. 24.2008, 1, S. 110-119
Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells - optimization using experimental design
In: Analytical biochemistry . - San Diego, Calif. : Elsevier, Bd. 373.2008, 2, S. 349-369
Size-exclusion chromatography as a linear transfer system - purification of human influenza virus as an example
In: Journal of chromatography . - Amsterdam [u.a.] : Elsevier, Bd. 873.2008, 1, S. 102-112
Stochastic population balance modeling of influenza virus replication in vaccine production processes
In: Chemical engineering science. - Amsterdam : Elsevier, Bd. 63.2008, 1, S. 157-169
Stochastic population balance modeling of influenza virus replication in vaccine production processes. II. detailed description of the replication mechanism
In: Chemical engineering science. - Amsterdam : Elsevier, Bd. 63.2008, 8, S. 2299-2304
Originalartikel in begutachteter zeitschriftenartiger Reihe
Population balance modeling of influenza virus replication in MDCK cells during vaccine production
In: 18th European Symposium on Computer Aided Process Engineering. - Amsterdam [u.a.] : Elsevier, S. 133-138, 2008 - (Computer-aided chemical engineering; 25) ; Kongress: ESCAPE; 18 (Lyon) : 2008.06.01-04
2007
Buchbeitrag
Closed loop control of perfusion systems in high-density cell culture
In: Cell technology for cell products: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 / Hrsg. Rodney Smith: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 - Dordrecht: Springer Netherland . - 2007, S. 549-551 ; Kongress: European Society for Animal Cell Technology meeting 19 (Harrogate : 2005.06.05-08)
Dynamics of virus-host cell interaction
In: Bioinformatics - from genomes to therapies ; Vol. 2:Getting at the inner workings: molecular interactions - Weinheim: WILEY-VCH . - 2007, S. 861-898
Influenza vaccine - challanges in mammalian cell culture technology
In: Cell technology for cell products: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 / Hrsg. Rodney Smith: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 - Dordrecht: Springer Netherland . - 2007, S. 503-508 ; Kongress: European Society for Animal Cell Technology meeting 19 (Harrogate : 2005.06.05-08)
Monitoring cell physiology in influenza vaccine production by flow cytometry
In: Cell technology for cell products: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 / Hrsg. Rodney Smith: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 - Dordrecht: Springer Netherland . - 2007, S. 531-533 ; Kongress: European Society for Animal Cell Technology meeting 19 (Harrogate : 2005.06.05-08)
Monitoring of extracellular TCA cycle intermediates in mammalian cell culture
In: Cell technology for cell products: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 / Hrsg. Rodney Smith: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 - Dordrecht: Springer Netherland . - 2007, S. 603-605 ; Kongress: European Society for Animal Cell Technology meeting 19 (Harrogate : 2005.06.05-08)
Serum-free influenza vaccine production with MDCK cells in wave-bioreactor and 5L-stirred tank bioreactor
In: Cell technology for cell products: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 / Hrsg. Rodney Smith: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 - Dordrecht: Springer Netherland . - 2007, S. 563-565 ; Kongress: European Society for Animal Cell Technology meeting 19 (Harrogate : 2005.06.05-08)
Strategies for large scale production of Parapoxvirus Ovis NZ-2
In: Cell technology for cell products: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 / Hrsg. Rodney Smith: proceedings of the 19th ESACT meeting, Harrogate, UK, June 5-8, 2005 - Dordrecht: Springer Netherland . - 2007, S. 707-710 ; Kongress: European Society for Animal Cell Technology meeting 19 (Harrogate : 2005.06.05-08)
Vaccine production - state of the art and future needs in upstream processing
In: Animal cell biotechnology: methods and protocols / ed. by Ralf Pörtner: methods and protocols - Totowa, N.J.: Humana Press . - 2007, S. 457-473 - (Methods in biotechnology; 24)
Originalartikel in begutachteter internationaler Zeitschrift
Characterization of a three bacteria mixed culture in a chemostat - evaluation and application of a quantitative terminal-restriction fragment length polymorphism (T-RFLP) analysis for absolute and species specific cell enumeration
In: Biotechnology and bioengineering . - New York, NY [u.a.] : Wiley, Bd. 96.2007, 4, S. 738-756
Concentration polarization and nonequilibrium electroosmotic slip in dense multiparticle systems
In: Langmuir: the ACS journal of surfaces and colloids / American Chemical Society: the ACS journal of surfaces and colloids - Washington, DC: ACS Publ., Bd. 23 (2007), 18, S. 9271-9281
Direct capture of influenza A virus from cell culture supernatant with Sartobind anion-exchange membrane adsorbers
In: Journal of membrane science - Amsterdam: Elsevier, Bd. 299 (2007), 1/2, S. 251-260
Establishment of a mink enteritis vaccine production process in stirred-tank reactor and wave bioreactor microcarrier culture in 1-10 L scale
In: Vaccine - Amsterdam: Elsevier, Bd. 25 (2007), 20, S. 3987-3995
Hydrodynamic characteristics and expansion behavior of beds containing single and binary mixtures of particles
In: Industrial & engineering chemistry research: I & EC research ; a publication of the American Chemical Society for applied chemistry & chemical engineering - Washington, DC: ACS Publ., Bd. 46 (2007), 13, S. 4686-4694
Impact of adsorbents selection on capture efficiency of cell culture derived human influenza viruses
In: Journal of biotechnology - Amsterdam: Elsevier, Bd. 131 (2007), 3, S. 309-317
Lectin-affinity chromatography for downstream processing of MDCK cell culture derived human influenza A viruses
In: Vaccine - Amsterdam: Elsevier, Bd. 25 (2007), 5, S. 939-947
Profiling of external metabolites during production of hantavirus nucleocapsid protein with recombinant saccharomyces cerevisiae
In: Biotechnology letters - Dordrecht [u.a.]: Springer Science + Business Media B.V . - 2007, insges. 6 S.
2006
Originalartikel in begutachteter internationaler Zeitschrift
Coexistence in the chemostat as a result of metabolic by-products
In: Journal of mathematical biology - Berlin: Springer, Bd. 53.2006, 4, S. 556-584
Harvesting and concentration of human influenza - a virus produced in serum-free mammalian cell culture for the production of vaccines
In: Biotechnology and bioengineering - New York, NY [u.a.]: Wiley, Bd. 97.2007, 1, S. 73-85, 2006
High-performance anion-exchange chromatography using on-line electrolytic eluent generation for the determination of more than 25 intermediates from energy metabolism of mammalian cells in culture
In: Journal of chromatography / B - New York, NY [u.a.]: Science Direct, Bd. 843.2006, 2, S. 216-226
Purification of cell culture-derived human influenza a virius by size-exclusion and anion-exchange chromatography
In: Biotechnology and bioengineering - New York, NY [u.a.]: Wiley, Bd. 96.2007, 5, S. 932-944, 2006
2005
Buchbeitrag
Glutamine-free media for vaccine production processes.
In: Godia, Francesc (Hrsg.) ; Fussenegger, Martin (Hrsg.): Animal cell technology meets genomics ( 18th ESACT meeting Granada, Spain, May 11 - 14 2003). - proceedings. Dordrecht : Springer, 2005, S. 767 - 770 (ESACT 18)
Serum free cultivation of primary chicken embryo fibroblasts in microcarrier systems for vaccine production.
In: Godia, Francesc (Hrsg.) ; Fussenegger, Martin (Hrsg.): Animal cell technology meets genomics ( 18th ESACT meeting Granada, Spain, May 11 - 14 2003). - proceedings. Dordrecht : Springer, 2005, S. 771 - 774 (ESACT 18)
Originalartikel in begutachteter internationaler Zeitschrift
Downstream processing of MDCK cell-derived equine influenza virus.
In: Journal of Chromatography B [Amsterdam] 823(2005), S. 75 - 81
Mathematical model of influenza a virus production in large-scale microcarrier culture.
In: Biotechnology and bioengineering [New York, NY] 90(2005), Nr. 4, S. 46 - 58
Substitution of glutamine by pyruvate to reduce ammonia formation and groth inhibition of mammalian cells.
In: Biotechnology progress [New York, NY] 21(2005), S. 58 - 69
Tangential flow microfiltration and ultrafiltration for human influenza a virus concentration and purification.
In: Biotechnology and bioengineering [New York, NY] 92(2005), Nr. 2, S. 199 - 208
2004
Artikel in Kongressband
A mathematical model for the replication of influenza a virus in MDCK cells.
In: BioPerspectives 2004 : mit 22. DECHEMA-Jahrestagung der Biotechnologen (Wiesbaden, 4. - 6. Mai 2004). - Tagungshandbuch. Frankfurt am Main, 2004, S. 82
Originalartikel in begutachteter internationaler Zeitschrift
Amino acid analysis in mammalian cell culture media containing serum and high glucose concentrations by anion exchange chromatography and integrated pulsed amperometric detecion.
In: Analytical biochemistry [New York, NY] 335(2004), S. 119 - 125
Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture.
In: Vaccine [Amsterdam] 22(2004), S. 2202 - 2208
Neuraminidase activity assays for monitoring MDCK cell culture derived influenza virus.
In: Journal of virological methods [Amsterdam] 122(2004), S. 9 - 15
Structured model of influenza virus replication in MDCK cells.
In: Biotechnology and bioengineering [New York, NY] 88(2004), Nr. 1, S. 1 - 14
2003
Artikel in Kongressband
Animal cell cultures for the production of viral vaccines.
In: VDI-Gesellschaft (Veranst.) ; DECHEMA e. V. (Veranst.): GVC/DECHEMA : Vortrags- und Diskussionstagung (\"Zellkulturen : vom biologischen System zum Produktionsprozess\" Bad Dürkheim, 26. bis 28. Mai 2003). - Tagungsband. Bad Dürkheim, 2003, S. 32 - 35
Originalartikel in begutachteter internationaler Zeitschrift
Quantitative study of electrokinetic transport in porous media by confocal laser scanning microscopy.
In: Langmuir [Washington, DC] 19(2003), Nr. 11, S. 4527 - 4531
2002
Originalartikel in begutachteter internationaler Zeitschrift
Adaption of a fragment analysis technique to an automated high-throughput multicapillary electrophoresis device for the precise qualitative and quantitative characterization of microbial communities.
In: Electrophoresis [Weinheim] 23(2002), S. 1070 - 1079
2001
Buchbeitrag
Development of bioprocess concepts on vaccine production : influenza virus as an example.
In: Lindner-Olsson, E. (Hrsg.) ; Chatzissavidou, N. (Hrsg.) ; Lüllau, E. (Hrsg.): Animal cell technology : from target to market (17th ESACT meeting, Tylösand, Sweden, June 10-14, 2001). - proceedings. Dordrecht : Kluwer, 2001, S. 344 - 346
Originalartikel in begutachteter nationaler Zeitschrift
Systemorientierte Bioprozesstechnik : interdisziplinäre Forschung in Biologie, System- und Computerwissenschaften.
In: Magdeburger Wissenschaftsjournal [Magdeburg] 6(2001), Nr. 1/2, S. 29 - 36
2000
Buchbeitrag
ISCOM vaccines : antigen production and downstream processing.
In: Brunner, Herwig (Hrsg.): Biochemical engineering (4th International congress Stuttgart 17 and 18 February, 2000). - proceedings. Stuttgart : Fraunhofer-IRB-Verl., 2000, S. 314 - 318
1980 - 1987 | Studium Biologie, Diplom, Universität Saarbrücken |
1991 | Promotion am Institut für Systemdynamik der Universität Stuttgart, Abschluss: Doktoringenieur (Dr.-Ing.) |
1991 - 1992 | Wissenschaftlicher Mitarbeiter, Biotechnologie, University of British Columbia, Vancouver, Kanada |
1992 - 1993 | Wissenschaftlicher Mitarbeiter, Biotechnologie, Institut für Systemdynamik und Regelungstechnik, Universität Stuttgart |
1993 | Projektleiter ¿Mikrocarrier¿, Pitman-Moore GmbH, Burgwedel |
1993 - 1996 | Abteilungsleiter Virusproduktion, Pitman-Moore GmbH, Burgwedel |
1996 - 1999 | Stellvertretender Herstellungsleiter, Mallinckrodt Vet GmbH / Essex Animal Health, Burgwedel |
seit 1999 | o. Professor für Bioprozesstechnik, Otto-von-Guericke-Universität, Magdeburg |
seit 2000 | Wissenschaftliches Mitglied der Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
seit 2000 | Direktor am Max-Planck-Institut für Dynamik komplexer technischer Systeme, Abteilung System- und signalorientierte Bioprozesstechnik, Magdeburg |
2003 - 2004 | Geschäftsführender Leiter des Instituts für Verfahrenstechnik, Otto-von-Guericke-Universität, Magdeburg |
2005 - 2006 | Geschäftsführender Direktor am Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg |
seit 2005 | Mitglied der Perspektivenkommission der CPTS der Max-Planck-Gesellschaft |
2007 - 2013 | Sprecher der IMPRS ("International Max Planck Research School for Analysis, Design and Optimization in Chemical and Biochemical Process Engineering"), Magdeburg |
2009 - 2010 | Geschäftsführender Leiter des Instituts für Verfahrenstechnik, Otto-von-Guericke-Universität, Magdeburg |
2011 - 2012 | Geschäftsführender Direktor am Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg |
2017 - 2018 | Geschäftsführender Leiter des Instituts für Verfahrenstechnik, Otto-von-Guericke-Universität, Magdeburg |
2019 - 2020 | Geschäftsführender Direktor am Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg |