Prof. Bertrand

Prof. Dr. rer. nat. Jessica Bertrand
Orthopädische Universitätsklinik (KORT)
Aktuelle Projekte
- Abaksi- Antibakterielle Silber-Beschichtung von Endoprothesen
Laufzeit: 01.04.2021 - 01.04.2023 - Die Funktion von BCP Kristallen in der Regulation des chondrozytären Phänotyps in der Arthrose
Laufzeit: 01.03.2020 - 28.02.2023 - ROR2 blockade for cartilage regeneration and pain relief in osteoarthritis
Laufzeit: 01.01.2020 - 31.12.2022
Abgeschlossene Projekte
- ABINEP M3-project 3: Investigation of biofilms during septical prosthesis relaxation
Laufzeit: 01.04.2017 - 28.02.2022 - Untersuchung der zellulären Prozesse der Chondrokalzinose
Laufzeit: 01.06.2018 - 31.05.2020 - Regulation der phänotypischen Stabilität von Chondrozyten durch transmembrane Heparansulfat-Proteoglykane der Syndecan-Familie
Laufzeit: 01.05.2013 - 30.04.2018 - Mechanosensitive signalling complexes as early targets of post-traumatic osteoarthritis (OA)
Laufzeit: 01.01.2015 - 31.12.2017
2022
Begutachteter Zeitschriftenartikel
Microstructure-dependent crevice corrosion damage of implant materials CoCr28Mo6, TiAl6V4 and REX 734 under severe inflammatory conditions
In: Journal of biomedical materials research / B - Hoboken, NJ: Wiley, 1996, Bd. 110 (2022), 7, S. 1687-1704
Probing embryonic development enables the discovery of unique small-molecule bone morphogenetic protein potentiators
In: Journal of medicinal chemistry - Washington, DC: ACS, Bd. 65 (2022), 5, S. 3978-3990
Radiological changes in shoulder osteoarthritis and pain sensation correlate with patients age
In: Journal of orthopaedic surgery and research - London: Biomed Central, 2006, Bd. 17 (2022), insges. 9 S.
Dissertation
Der Einfluss von maritimen Wetterfaktoren auf Schmerz und Funktionsparameter bei Osteoarthrose
In: Magdeburg: Otto-von-Guericke-Universität Magdeburg, 2020, 1 ungezähltes Blatt, 3-80 Blätter, Diagramme, Formulare
2021
Abstract
Blocking ROR2 improves cartilage integrity and provides pain relief in osteoarthritis
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, 1939, Bd. 80 (2021), Suppl. 1, S. 120-121
Sensor-based measurement for advanced monitoring and early detection of PE wear in total knee arthroplasties
In: Biomedical engineering - Berlin [u.a.]: de Gruyter, 1998, Bd. 66 (2021), s1, S. S115
The gasotransmitter hydrogen sulfide (H2S) is protective against calcific tendinopathy (CT)
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, 1939, Bd. 80 (2021), Suppl. 1, S. 226
Begutachteter Zeitschriftenartikel
A novel alloy development approach - biomedical equiatomic Ta-Nb-Ti alloy
In: Metals - Basel: MDPI, 2011, Bd. 11 (2021), 11, insges. 12 S.
Aspect ratio of nano/microstructures determines Staphylococcus aureus adhesion on PET and titanium surfaces
In: Journal of applied microbiology - Oxford [u.a.]: Wiley-Blackwell, 1997, Bd. 131 (2021), 3, S. 1498-1514
Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 11 (2021), insges. 11 S.
Chondrocytes from osteoarthritic and chondrocalcinosis cartilage represent different phenotypes
In: Frontiers in cell and developmental biology - Lausanne: Frontiers Media, 2013, Bd. 9 (2021), insges. 9 S.
Effect of deep rolling on subsurface conditions of CoCr28Mo6 wrought alloy to improve the wear resistance of endoprostheses
In: Journal of the mechanical behavior of biomedical materials - Amsterdam [u.a.]: Elsevier, Bd. 118 (2021)
IL-17 regulates expression of cytokines in human osteoblasts rather than bone-specific genes
In: Osteologie: Organ der Deutschen Gesellschaft für Osteologie - Stuttgart: Thieme, Bd. 30 (2021), 1, S. 49-56
Long-term survival and failure analysis of anatomical stemmed and stemless shoulder arthroplasties
In: The bone & joint journal - London: British Editorial Society of Bone and Joint Surgery, Bd. 103-B (2021), 7, S. 1292-1300
Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice
In: Cell death & disease - London [u.a.]: Nature Publishing Group, 2010, Bd. 12 (2021), 5, insges. 13 S.
MMP-9 mediated Syndecan-4 shedding correlates with osteoarthritis severity
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, Bd. 29 (2021), 2, S. 280-289
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells
In: Immunity - [Cambridge, Mass.]: Cell Press, 1994, Bd. 54 (2021), 12, S. 2724-2739.e10
Sensor-based measurement for advanced monitoring and early detection of PE wear in total knee arthroplasties
In: Current directions in biomedical engineering - Berlin: De Gruyter, 2015, Bd. 7 (2021), 2, S. 283-286
Severe traumatic injury induces phenotypic and functional changes of neutrophils and monocytes
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd. 10 (2021), 18, insges. 19 S.
Syndecan-4 is increased in osteoarthritic knee, but not hip or shoulder, articular hypertrophic chondrocytes
In: Cartilage - London: Sage, Bd. 13 (2021), 2_suppl., S. 862S-871S
Synthesis of a lubricant to mimic the biorheological behavior of osteoarthritic and revision synovial fluid
In: Lubricants - Basel: MDPI, 2013, Bd. 9 (2021), 9, insges. 20 S.
The cytokine interleukin-11 crucially links bone formation, remodeling and resorption
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 60 (2021), S. 18-27
The gasotransmitter hydrogen sulfide (H2S) prevents pathologic calcification (PC) in cartilage
In: Antioxidants: open access journal - Basel: MDPI, 2013, Bd. 10 (2021), 9, insges. 18 S.
The role of calcium crystals and their effect on osteoarthritis pathogenesis
In: Best practice & research / Clinical rheumatology - London [u.a.]: Baillière Tindall, Bd. 35 (2021), 4
Dissertation
Vollautomatische Bestimmung von Hüfttotalendoprothesen-Parametern in routinemäßigen Röntgenbildern
In: Magdeburg, 2021, v, 171 Seiten, Illustrationen, Diagramme, 30 cm
2020
Abstract
Calcium pyrophosphate dihydrate (CPPD) crystals but not basic calcium phosphate (BCP) crystals induce syndecan-4 expression in cartilage
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, 1939, Vol. 79.2020, Suppl. 1, THU0435, S. 454-455
Chondrocalcinosis is associated with a specific effect on the chondrocyte phenotype that markedly differs from OA
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, 1939, Vol. 79.2020, Suppl. 1, AB0067, S. 1334
Inhibition des TLR-3 Signalwegs schützt vor post-traumatischer Arthrose
In: Zeitschrift für Orthopädie und Unfallchirurgie: Organ der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie - Stuttgart [u.a.]: Thieme, 2007, Bd. 158.2020, Suppl. 1, DKOU20-942, S. S199
Nekroptose in der Pathogenese der post-traumatischen Arthrose
In: Zeitschrift für Orthopädie und Unfallchirurgie: Organ der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie - Stuttgart [u.a.]: Thieme, 2007, Bd. 158.2020, Suppl. 1, DKOU20-1013, S. S216
Short term il1ra treatment reduces post-traumatic OA in mouse in vivo and, in vitro, in human cartilage
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Vol. 28.2020, Suppl. 1, S. S490
Begutachteter Zeitschriftenartikel
Antibacterial coating of Ti-6Al-4V surfaces using silver nano-powder mixed electrical discharge machining
In: Surface and coatings technology - Amsterdam [u.a.]: Elsevier Science, Bd.383.2020, Art.-Nr. 125254
Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, Bd. 79 (2020), 4, S. 481-489
BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, Bd. 79 (2020), 7, S. 975-984
Cartilage trauma induces necroptotic chondrocyte death and expulsion of cellular contents
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 12, Art.-Nr. 4204, insgesamt 14 Seiten
In vivo corrosion and damages in modular shoulder prostheses
In: Journal of biomedical materials research / B - Hoboken, NJ: Wiley, 1996, Bd. 108 (2020), 5, S. 1764-1778
Intraoperative assembly of anatomical shoulder prosthesis frequently results in malalignment of the modular taper junction
In: Journal of orthopaedic research - Hoboken, NJ [u.a.]: Wiley, 1983, Bd. 39 (2021), 11, S. 2485-2496
Microstructure and surface investigations of TiAl6V4 and CoCr28Mo6 orthopaedic femoral stems
In: IOP conference series / Materials science and engineering/ Institute of Physics - London [u.a.]: Institute of Physics, 2009, Vol. 882.2020, Paper 012004, insgesamt 16 Seiten
ROR2 blockade as a therapy for osteoarthritis
In: Science translational medicine: integrating medicine and science - Washington, DC: AAAS, 2009, Vol. 12.2020, 561, Art.-Nr. eaax3063
Retrieval study of commercially available knee implant coatings TiN, TiNbN and ZrN on TiAl6V4 and CoCr28Mo6
In: Journal of the mechanical behavior of biomedical materials - Amsterdam [u.a.]: Elsevier, Vol. 112.2020, Art.-Nr. 104034
The genetic variations associated with time to aseptic loosening after total joint arthroplasty
In: The journal of arthroplasty - Orlando, Fla.: Churchill Livingstone, Bd. 35 (2020), 4, S. 981-988
The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway against experimental osteoarthritis
In: Arthritis Research & Therapy - London: BioMed Central, 1999, Bd.22.2020, Art.-Nr. 49, insgesamt 12 Seiten
Tofacitinib and Baricitinib are taken up by different uptake mechanisms determining the efficacy of both drugs in RA
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 18, Art.-Nr. 6632, insgesamt 13 Seiten
2019
Abstract
BCP and CPPD crystals influence the chondrocyte phenotype in different ways
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, 1939, Bd. 78.2019, Suppl. 2, AB0086, S. 1506
Corrosion at modular taper junctions in anatomical shoulder prosthesis - a retrieval study
In: 5th Euro BioMAT 2019 - [Berlin: DGM e.V., 2019, 2019, Artikel B3.2: Session 2
Ex vivo Schadensanalyse an Konussteckverbindungen aus Co28Cr6Mo- und Ti6Al4V-Legierungen von anatomischen Schulterendoprothesen
In: WW WerkstoffWoche: 18.-20.09.2019, Dresden/ WerkstoffWoche - Sankt Augustin: Deutsche Gesellschaft für Materialkunde e.V., 2019 . - 2019, 2020
Inhibition of SDC4-LOX mediated extracellular matrix stiffening prevents chondrocyte differentiation in OA cartilage via increased YAP/TAZ signaling
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 27.2019, Suppl. 1, S. S150-S151
Matrix metalloproteinase mediated shedding of Syndecan-4 under osteoarthritis conditions
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 27.2019, Suppl. 1, S. S196-S197
Artikel in Zeitschrift
Notch-signaling activity determines uptake and biological effect of imatinib in systemic sclerosis dermal fibroblasts
In: The journal of investigative dermatology - Amsterdam: Elsevier, 1938, Bd. 139 (2019), 2, S. 439-447
Begutachteter Zeitschriftenartikel
Characteristics of different cathodic arc deposition coatings on CoCrMo for biomedical applications
In: Journal of the mechanical behavior of biomedical materials - Amsterdam [u.a.]: Elsevier, Bd. 97 (2019), S. 212-221
Ionic cobalt but not metal particles induces ROS generation in immune cells in vitro
In: Journal of biomedical materials research / B - Hoboken, NJ: Wiley, Bd. 107 (2019), 4, S. 1246-1253
Periprosthetic hypoxia as consequence of TRPM7 mediated cobalt influx in osteoblasts
In: Journal of biomedical materials research / B - Hoboken, NJ: Wiley, Bd. 107 (2019), 6, S. 1806-1813
Soluble syndecans - biomarkers for diseases and therapeutic options
In: British journal of pharmacology: BJP online - Malden, MA: Wiley, Bd. 176 (2019), 1, S. 67-81
Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis
In: Journal of autoimmunity - London: Academic Press, Bd.103.2019, Art.-Nr. 102288
2018
Abstract
BCP crystals drive chondrocyte hypertrophic differentiation via binding WNT ligands and activation of canonical WNT signaling
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, Bd. 26.2018, Suppl. 1, S. S62-S63
Differences in rheological properties between healthy, osteoarthritic and revision synovial fluid
In: ICoBT 2018: 4th International Conference on BioTribology, 26-29 September 2018, Montreal, Canada - Montreal, 2018, 2018, Poster-ID P27 ; [Konferenz: 4th International Conference on BioTribology, ICoBT 2018, Montreal, Canada, 26 - 29 September 2018]
Influence of cobalt (II) + and chromium (III)-ions on bone formation in human osteoblast-like cells in-vitro
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, Bd. 77.2018, Suppl. 2, AB0107, S. 1248-1249
Inhibition of the complement system component C5 as possible treatment in OA
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 26.2018, Suppl. 1, S. S108
Initial results on energy harvesting by exploiting the temperature gradient in hip implants
In: Biomedical engineering - Berlin [u.a.]: de Gruyter, Vol. 63.2018, Suppl.1, Abstract P 065, S. S364
Programmed cell death and toll-like receptor activation in articular cartilage
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, Bd. 26.2018, Suppl. 1, S. S70-S71
Transient receptor potential cation channel (TRPC6) as a regulator of CXCR2-mediated articular cartilage homeostasis
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, Bd. 26.2018, Suppl. 1, S. S96-S97
Begutachteter Zeitschriftenartikel
Calcification of the acetabular labrum of the hip - prevalence in the general population and relation to hip articular cartilage and fibrocartilage degeneration
In: Arthritis Research & Therapy - London: BioMed Central, Bd. 20.2018, Art.-Nr. 104, insges. 10 S.
Ceramic prosthesis surfaces induce an inflammatory cell response and fibrotic tissue changes
In: The bone & joint journal - London: British Editorial Society of Bone and Joint Surgery, Bd. 100-B.2018, 7, Seite 882-890
Differential effect of cobalt and chromium ions as well as CoCr particles on the expression of osteogenic markers and osteoblast function
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, Bd. 19.2018, 10, Art.-Nr. 3034, insges. 16 S.
Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, Bd. 26 (2018), 6, S. 818-823
The effects of cobalt and chromium ions on transforming growth factor-beta patterns and mineralization in human osteoblast-like MG63 and SaOs-2 cells
In: Journal of biomedical materials research / A - New York, NY [u.a.]: Wiley, Bd. 106.2018, 8, S. 2105-2115
The terminal complement pathway is activated in septic but not in aseptic shoulder revision arthroplasties
In: Journal of shoulder and elbow surgery - St. Louis, Mo.: Mosby, Bd. 27 (2018), 10, S. 1837-1844
2017
Abstract
Calcium crystals and their link to osteoarthritis
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, Bd. 76.2017, Suppl. 2, SP0057, S. 14
Nucleotide binding TLR dependent signalling cascades are activated upon cartilage trauma
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 25.2017, Suppl. 1, Abs. 264, S. S171
Shed syndecan 4 in synovial fluid as a biomarker for OA severity
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 25.2017, Suppl. 1, Abs. 119, S. S93-S94
Syndecan-4 deficiency affects extracellular matrix architecture of articular cartilage
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 25.2017, Suppl. 1, Abs. 211, S. S146
The role of transient receptor potential cation channel trpc6 activity in cxcr2-mediated chondrocyte phenotypic stability
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 25.2017, Suppl. 1, Abs. 16, S. S19
Artikel in Kongressband
Tribologische Charakterisierung natürlicher und künstlicher Gelenkoberflächen
In: Reibung, Schmierung und Verschleiß - Aachen: GfT Gesellschaft für Tribologie e.V.; Tribologie-Fachtagung (58.:2017), 2017, Art. 43, insgesamt 7 S.
Untersuchungs- und Prüfmethoden für funktionale Gelenkoberflächen
In: Sensitive Fertigungstechnik: Tagungsband der 4. Fachtagung 2017 / Harald Goldau, Ronny Stolze (Hrsg.): Tagungsband der 4. Fachtagung 2017/ Sensitive Fertigungstechnik: Tagungsband der 4. Fachtagung 2017 / Harald Goldau, Ronny Stolze (Hrsg.) - Aachen: Shaker Verlag; Goldau, Harald . - 2019, S. 179-184
Artikel in Zeitschrift
Importance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 7 (2017), S. 1258
Begutachteter Zeitschriftenartikel
Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin
In: Annals of the rheumatic diseases - London: BMJ Publ. Group, Bd. 76.2017, 2, S. 442-449
Buchbeitrag
Role of proteoglycans in osteoarthritis
In: Cartilage - Cham: Springer . - 2017, S. 63-80
2016
Abstract
Activation of the transient receptor potential cation channel TRPC6 is required for chondrocyte phenotypic stability
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 24.2016, Suppl. 1, Abs. 249, S. S152-S153
Altered matrix stiffness in decorin-null articular cartilage results in improved resistance to osteoarthritis induced by forced exercise
In: Osteoarthritis and cartilage. - [S.l.] : Elsevier; Bd. 24.2016, Suppl. 1, Abs. 214, S. S134
Pharmacological blockade of CAMKII is detrimental for osteoarthritis progression
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 24.2016, Suppl. 1, Abs. 243, S. S149
Role of toll like receptor 3 in cartilage homoeostasis during posttraumatic and degenerative osteoarthritis
In: Osteoarthritis and cartilage - [S.l.]: Elsevier, 1993, Bd. 24.2016, Suppl. 1, Abs. 124, S. S134-S135
Shed syndecan-4 in synovial fluid is a marker of osteoarthritis severity
In: Osteoarthritis and cartilage. - [S.l.] : Elsevier; Bd. 24.2016, Suppl. 1, Abs. 124, S. S81
Artikel in Zeitschrift
MATE1 regulates cellular uptake and sensitivity to imatinib in CML patients
In: Blood cancer journal- London [u.a.]: Nature Publishing Group, 2011, Bd. 6 (2016), Seite e470
Begutachteter Zeitschriftenartikel
Articular cartilage calcification of the hip and knee is highly prevalent, independent of age but associated with histological osteoarthritis: evidence for a systemic disorder
In: Osteoarthritis and Cartilage, 2016, S. 2092-2099, ISSN 10634584, 10.1016/j.joca.2016.06.020
Articular cartilage calcification of the humeral head is highly prevalent and associated with osteoarthritis in the general population
In: Journal of Orthopaedic Research, 2016, S. 1984-1990, ISSN 07360266, 10.1002/jor.23227
Hyaline cartilage calcification of the first metatarsophalangeal joint is associated with osteoarthritis but independent of age and BMI
In: BMC musculoskeletal disorders - London: BioMed Central, 2000, Bd. 17.2016, Art.-Nr. 474, insges. 8 S.
Buchbeitrag
Arthrose
In: Kapitel 321-488: Intensivmedizin, Urologie/Nephrologie, Gastroenterologie, Immunologie, Endokrinologie, Neurologie, Vergiftungen, Umwelteinflüsse - [New York]: McGraw-Hill Education . - 2016, S. 2737-2745
2015
Anderes Material
Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation.
In: Nature communications, Vol. 6, 2015, S. 7554, ISSN 2041-1723, 10.1038/ncomms8554
2014
Begutachteter Zeitschriftenartikel
Cellular and molecular mechanisms of cartilage damage and repair
In: Drug Discovery Today, Vol. 19, 2014, Issue 8, S. 1172-1177, ISSN 13596446, 10.1016/j.drudis.2014.05.014
Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2
In: Virulence, Vol. 5, 2014, Issue 7, S. 761-771, ISSN 21505594, 10.4161/viru.29062
2013
Begutachteter Zeitschriftenartikel
Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-κB
In: Annals of the Rheumatic Diseases, Vol. 72, 2013, Issue 11, S. 1874-1881, ISSN 00034967, 10.1136/annrheumdis-2012-202080
Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice
In: Arthritis and Rheumatism, Vol. 65, 2013, Issue 3, S. 743-752, ISSN 00043591, 10.1002/art.37817
Syndecans in cartilage breakdown and synovial inflammation
In: Nature Reviews Rheumatology, Vol. 9, 2013, Issue 1, S. 43-55, ISSN 17594790, 10.1038/nrrheum.2012.178
TRPC6 regulates CXCR2-mediated chemotaxis of murine neutrophils
In: Journal of Immunology, Vol. 190, 2013, Issue 11, S. 5496-5505, ISSN 00221767, 10.4049/jimmunol.1201502
2012
Begutachteter Zeitschriftenartikel
Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice
In: Annals of the Rheumatic Diseases, Vol. 71, 2012, Issue 7, S. 1249-1253, ISSN 00034967, 10.1136/annrheumdis-2011-200892
News from the osteoarthritis research [Neues aus der Arthroseforschung]
In: Deutsche Medizinische Wochenschrift, Vol. 137, 2012, Issue 36, S. 1766-1768, ISSN 00120472, 10.1055/s-0032-1305207
Pathogenetic-oriented therapies for osteoarthritis - Are new DMOADS on the way? [Pathogenetisch orientierte therapieansätze bei der osteoarthrose - Sind DMOADs in der pipeline?]
In: Aktuelle Rheumatologie, Vol. 37, 2012, Issue 6, S. 358-365, ISSN 0341051X, 10.1055/s-0032-1314795
Transient receptor potential canonical channel 1 impacts on mechanosignaling during cell migration.
In: Pflügers Archiv : European journal of physiology, Vol. 464, 2012, Issue 6, S. 623-630, ISSN 14322013
Transport Mechanisms and Their Pathology-Induced Regulation Govern Tyrosine Kinase Inhibitor Delivery in Rheumatoid Arthritis
In: PLoS ONE, Vol. 7, 2012, Issue 12, ISSN 19326203, 10.1371/journal.pone.0052247
2011
Begutachteter Zeitschriftenartikel
WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
In: Journal of Cell Biology, Vol. 193, 2011, Issue 3, S. 551-564, ISSN 00219525, 10.1083/jcb.201011051
2010
Begutachteter Zeitschriftenartikel
Cartilage biology, pathology, and repair
In: Cellular and Molecular Life Sciences, Vol. 67, 2010, Issue 24, S. 4197-4211, ISSN 1420682X, 10.1007/s00018-010-0498-0
Molecular mechanisms of cartilage remodelling in osteoarthritis
In: International Journal of Biochemistry and Cell Biology, Vol. 42, 2010, Issue 10, S. 1594-1601, ISSN 13572725, 10.1016/j.biocel.2010.06.022
2009
Begutachteter Zeitschriftenartikel
Calcification of articular cartilage in human osteoarthritis
In: Arthritis and Rheumatism, Vol. 60, 2009, Issue 9, S. 2694-2703, ISSN 00043591, 10.1002/art.24774
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis
In: Nature Medicine, Vol. 15, 2009, Issue 9, S. 1072-1076, ISSN 10788956, 10.1038/nm.1998
2005
Begutachteter Zeitschriftenartikel
Gender differences in cardiac arrhythmias
In: Herz, Vol. 30, 2005, Issue 5, S. 390-400, ISSN 03409937, 10.1007/s00059-005-2724-3
Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome
In: Cardiovascular Research, Vol. 68, 2005, Issue 3, S. 441-453, ISSN 00086363, 10.1016/j.cardiores.2005.06.027
2004
Begutachteter Zeitschriftenartikel
Amino acid substitutions in putative selectivity filter regions III and IV in KdpA alter ion selectivity of the KdpFABC complex from Escherichia coli
In: Journal of Bacteriology, Vol. 186, 2004, Issue 16, S. 5519-5522, ISSN 00219193, 10.1128/JB.186.16.5519-5522.2004
2003
Begutachteter Zeitschriftenartikel
The Methanocaldococcus jannaschii protein Mj0968 is not a P-type ATPase
In: FEBS Letters, Vol. 543, 2003, Issue 1-3, S. 31-36, ISSN 00145793, 10.1016/S0014-5793(03)00372-7
10/2015 | Professor for Experimental Orthopaedics, University Hospital Magdeburg |
05/2013-10/2015 | DFG Emmy-Noether Group Leader at the Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Germany |
10/2011-04/2013 | Postdoc. fellow: Postdoctoral fellowship of the DFG at the Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Germany |
10/2010-09/2011 | Postdoc. fellow: Postdoctoral fellowship of the DFG at the Centre for Experimental Medicine and Rheumatology, Queen Mary, London |
2008 -2010 | Postdoc. fellow: Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Germany |
2004 - 2007 | Ph.D.-thesis: "Pathomechanisms of potassium channel (HERG-) Mutations causing the LQT 2 syndrome am Leibniz-Institute for Arteriosklerosis Reserarch (LIFA) at the University of Muenster, Germany |
2002-2003 | Undergradute research at the Department of Microbiology, University of Osnabrueck, Germany |
1997-2002 | Diploma (Biology): "Amino acid substitutions in putative selectively filter regions III and IV in KdpA of the KdpFABC coplex from Escherichia coli am Department of Microbiology, University of Osnabrueck, Germany |