Prof. Müller
Prof. Dr. rer. nat. Andreas Müller
Institut für Molekulare und Klinische Immunologie (IMKI)
Fax: +49 391 67 15852
Prof. Dr. rer. nat. Andreas Müller
Institut für Molekulare und Klinische Immunologie (IMKI)
Fax: +49 391 67 15852
Aktuelle Projekte
- ERC Starting Grant ImmProDynamics, Dissecting the interplay between the dynamics of immune responses and pathogen proliferation in vivo
Laufzeit: 01.03.2017 - 28.02.2022 - Untersuchung intrazellulärer Überlebensstrategien von Staphylococcus aureus mittels eines neuen Reportersystems zur Proliferationsmessung
Laufzeit: 01.11.2017 - 31.10.2020 - NeutrEat - Rolle von "Eat Me" Signalen auf Neutrophilen Granulozyten als Schutz- und Pathomechanismus bei Schlaganfall und Infektionskrankheiten
Laufzeit: 01.09.2017 - 31.08.2020 - Pathogene als Sensorsysteme zur Messung der Wirksamkeit einer Immunantwort während der Infektion
Laufzeit: 01.12.2014 - 30.05.2018
Abgeschlossene Projekte
- Zentrale Plattform für Bildgebungsverfahren
Laufzeit: 01.01.2014 - 31.12.2017
2018
Begutachteter Zeitschriftenartikel
Beware the intruder - real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 13.2018, 3, Art.-Nr. e0193970, insges. 9 S.; http://dx.doi.org/10.1371/journal.pone.0193970
2017
Abstrakt
Dynein light intermediate chain 1 (LIC1) in T cell signalling and immunological synapse organisation of Tregs
In: European journal of immunology - Weinheim: Wiley VCH, Bd. 47.2017, Suppl. 2, P369, S. 268; http://dx.doi.org/10.1002/eji.201770300
c-MET dependent neutrophil responses limit anti-tumoral T cell expansion and immunotherapy of cancer
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 26.2017, 3, P219 (OP01/03), S. E93-E94; http://onlinelibrary.wiley.com/doi/10.1111/exd.13280/full
Begutachteter Zeitschriftenartikel
D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes
In: Molecular and cellular biology: MCB - Washington, DC: Soc, Bd. 37.2017, 7, Seite e.00509-e.00516; http://dx.doi.org/10.1128/MCB.00509-16
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling
In: Science signaling: the signal transduction knowledge environment - Washington, DC [u.a.]: Assoc, Bd. 10.2017, 462, insges. 14 S.; http://dx.doi.org/10.1126/scisignal.aaf4736
Frontline Science - Leishmania mexicana amastigotes can replicate within neutrophils
In: Journal of leukocyte biology: JLB - Bethesda, Md: Soc. for Leukocyte Biology, Bd. 102.2017, 5, S. 1187-1198; http://dx.doi.org/10.1189/jlb.4HI0417-158R
Reactive neutrophil responses dependent on the receptor tyrosine kinase c-MET limit cancer immunotherapy
In: Immunity - [Cambridge, Mass.]: Cell Press, Bd. 47.2017, 4, S. 789-802; http://dx.doi.org/10.1016/j.immuni.2017.09.012
TCR signalling network organization at the immunological synapses of murine regulatory T cells
In: European journal of immunology - Weinheim: Wiley-VCH, Bd. 47.2017, 12, S. 2043-2058; http://dx.doi.org/10.1002/eji.201747041
2016
Begutachteter Zeitschriftenartikel
Chronic Toxoplasma gondii infection enhances [beta]-amyloid phagocytosis and clearance by recruited monocytes
In: Acta Neuropathologica Communications. - London : Biomed Central; Bd. 4.2016, Art.-Nr. 25, insges. 19 S.
2015
Begutachteter Zeitschriftenartikel
Rapid sequestration of Leishmania mexicana by neutrophils contributes to the development of chronic lesion
In: PLoS pathogens. - Lawrence, Kan : PLoS; Bd. 11.2015, 5, Art.-Nr. e1004929, insges. 23 S.
2014
Abstrakt
Phagocytosis of Abeta by infiltrating myeloid cells in a mouse model of Alzheimer's disease
In: Journal of neuroimmunology : official journal of the International Society for Neuroimmunology. - Amsterdam [u.a.] : Elsevier Science, Bd. 275.2014, 1/2, S. 120
Begutachteter Zeitschriftenartikel
Collective nitric oxide production provides tissue-wide immunity during Leishmania infection
In: Journal of Clinical Investigation, Vol. 124, 2014, Issue 4, S. 1711-1722, ISSN 00219738, 10.1172/JCI72058
2013
Begutachteter Zeitschriftenartikel
NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium
In: PLoS ONE, Vol. 8, 2013, Issue 10, ISSN 19326203, 10.1371/journal.pone.0077204
Photoconvertible pathogen labeling reveals nitric oxide control of leishmania major infection in vivo via dampening of parasite metabolism
In: Cell Host and Microbe, Vol. 14, 2013, Issue 4, S. 460-467, ISSN 19313128, 10.1016/j.chom.2013.09.008
2012
Begutachteter Zeitschriftenartikel
CD4 + T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation
In: Immunity, Vol. 37, 2012, Issue 1, S. 147-157, ISSN 10747613, 10.1016/j.immuni.2012.05.015
How many dendritic cells are required to initiate a T-cell response?
In: Blood, Vol. 120, 2012, Issue 19, S. 3945-3948, ISSN 00064971, 10.1182/blood-2012-01-408260
Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes
In: Cell Host and Microbe, Vol. 11, 2012, Issue 1, S. 19-32, ISSN 19313128, 10.1016/j.chom.2011.11.013
2011
Begutachteter Zeitschriftenartikel
Stromal IFN-γr-signaling modulates goblet cell function during salmonella Typhimurium infection
In: PLoS ONE, Vol. 6, 2011, Issue 7, ISSN 19326203, 10.1371/journal.pone.0022459
2010
Begutachteter Zeitschriftenartikel
Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, 2010, Issue 47, S. 20441-20446, ISSN 00278424, 10.1073/pnas.1013827107
Caspase-1 activation via Rho GTPases: A common theme in mucosal infections?
In: PLoS Pathogens, Vol. 6, 2010, Issue 2, ISSN 15537366, 10.1371/journal.ppat.1000795
Host-specific symbiotic requirement of BdeAB, a RegR-controlled RND-type efflux system in Bradyrhizobium japonicum
In: FEMS Microbiology Letters, Vol. 312, 2010, Issue 2, S. 184-191, ISSN 03781097, 10.1111/j.1574-6968.2010.02115.x
In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of s. Typhimurium can proceed in the absence of flagellin
In: PLoS ONE, Vol. 5, 2010, Issue 8, ISSN 19326203, 10.1371/journal.pone.0012477
2009
Begutachteter Zeitschriftenartikel
Accelerated type III secretion system 2-dependent enteropathogenesis by a Salmonella enterica serovar enteritidis PT4/6 strain
In: Infection and Immunity, Vol. 77, 2009, Issue 9, S. 3569-3577, ISSN 00199567, 10.1128/IAI.00511-09
The S. Typhimurium Effector SopE Induces Caspase-1 Activation in Stromal Cells to Initiate Gut Inflammation
In: Cell Host and Microbe, Vol. 6, 2009, Issue 2, S. 125-136, ISSN 19313128, 10.1016/j.chom.2009.07.007
2008
Begutachteter Zeitschriftenartikel
Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in ΔinvG S. Typhimurium colitis
In: Journal of Experimental Medicine, Vol. 205, 2008, Issue 2, S. 437-450, ISSN 00221007, 10.1084/jem.20070633
2007
Begutachteter Zeitschriftenartikel
Two newly identified SipA domains (F1, F2) steer effector protein localization and contribute to Salmonella host cell manipulation
In: Molecular Microbiology, Vol. 65, 2007, Issue 3, S. 741-760, ISSN 0950382X, 10.1111/j.1365-2958.2007.05823.x
2005
Begutachteter Zeitschriftenartikel
Real-time imaging of type III secretion: Salmonella SipA injection into host cells
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, 2005, Issue 35, S. 12548-12553, ISSN 00278424, 10.1073/pnas.0503407102
The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms
In: Journal of Immunology, Vol. 174, 2005, Issue 3, S. 1675-1685, ISSN 00221767
- Prof. Dr. Eva Medina, Helmholtz Zentrum für Infektionsforschung, Braunschweig
Dies trägt maßgeblich zum Verständnis bei, wie eine Immunantwort aufgebaut, erhalten und - wenn nötig - wieder abgeschaltet wird, um den Organismus vor Krankheitserregern zu verteidigen, aber auch dem Aufbau von schädlichen Autoimmunerkrankungen - Überreaktionen des Immunsystems - vorzubeugen.
Unsere Forschungsgruppe "Intravitalmikroskopie von Infektion und Immunität" (INMI) hat sich auf die Multiphotonenmikroskopie spezialisiert, um das Zusammenspiel von Wirt und Pathogen im lebenden Gewebe zu verfolgen. Unser Fokus gilt hierbei der Frage, wie ein Pathogen auf den Stress reagiert, dem es aufgrund einer Immunantwort ausgesetzt ist. Indem wir Infektionserreger mit fluoreszierenden Reportersystemen (vom Erreger produzierte Farbstoffe, die auf biologische Veränderungen reagieren) ausstatten, können wir Prozesse wir Zellteilung und Proteinproduktion, aber auch die Aktivität von stressinduzierten Enzymen im lebenden Pathogen bestimmen.
Die Vermessung dieser Parameter während der Infektion erlaubt uns Rückschlüsse darauf, wann und unter welchen Bedingungen die Immunantwort am effektivsten ist. Da die biologischen Prozesse im Pathogen Einfluss auf seine Empfindlichkeit gegenüber Antibiotika haben, können wir auch herausfinden, wie die Immunantwort am besten mit therapeutischen Maßnahmen unterstützt werden kann.
1. General Information
Prof. Dr. Andreas J. Müller, Date of birth: September 4th, 1980, male
Professor (W2)
Institute of Molecular and Clinical Immunology
Medical Faculty
Otto-von-Guericke-University Magdeburg
2nd affiliation:
Helmholtz Centre for Infection Research Braunschweig
2. Education
10/00-10/04 Studies in Biology, Swiss Federal Institute of Technology (ETH) Zürich
3. Degrees
12/13 W2-Professor, Otto-von-Guericke-University Magdeburg
11/09 Doctor of Sciences (equivalent to PhD), ETH Zürich
10/04 Diploma in Biology (equivalent to M. sc.), ETH Zürich, passed with distinction
4. Scientific Career
since 12/13 W2-Professor for "Intravital Imaging of Infection and Immunity at the Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg, and at the Helmholtz Centre for Infection Research, Braunschweig.
07/13-11/13 Postdoctoral fellow at the Institute of Biochemistry, University of Lausanne, Switzerland (Research Group of Prof. Fabienne Tacchini-Cottier).
05/10-06/13 Postdoctoral fellow at the Immunology Department, Institut Pasteur, Paris (Research Group of Dr. Philippe Bousso).
12/04-05/09 Graduate student and postdoctoral fellow at the Institute of Microbiology and Immunology, ETH Zürich (Research group of Prof. Wolf-Dietrich Hardt).
5. Honours, awards
05/10 PhD thesis awarded with Medal of the ETH.
11/05 Master thesis awarded with Medal of the ETH.
10/14 Jürgen Wehland Prize of the Helmholtz Centre for Infection Research.
6. Third-party funding of the last 5 years
| Project title | Funding period | Funding agency Project number |
| DFG Project Grant "Pathogens as sensors for measuring immune defense efficiency in the on-going infection. | 10/2014-09/2017 | DFG MU 3742/2-1 |
| Collaborative Research Centre 854, Project Z01 "Multimodal Imaging Platform. to M. Riek-Burchardt, A. Müller, W. Zuschratter | 01/2014-12/2017 | DFG SFB854/2 Z01 |
| Pasteur-Roux Post-Doctoral Fellowship "Intravital analysis of the dynamics of effector T cell interactions with Leishmania-infected cells. | 05/2010-04/2012 | Emile Roux Fund No project number assigned |
| Swiss National Science Foundation Project "Intravital analysis of the dynamics of effector T cell interactions with Leishmania-infected cells. (Renounced in favour of the Pasteur-Roux Grant) | 05/2010-04/2011 | SNSF PBEZP3-131125 |