Publikationen
2025
Begutachteter Zeitschriftenartikel
Influenza A virus production following quality by design principles
Zinnecker, Tilia; Thiele, Kristin; Schmidberger, Timo; Genzel, Yvonne; Reichl, Udo
In: Engineering in life sciences - Weinheim : Wiley-VCH, Bd. 25 (2025), Heft 4, insges. 11 S.
Quantification of intracellular influenza A virus protein dynamics in different host cells after seed virus adaptation
Küchler, Jan; Opitz, Patricia; Jordan, Ingo; Genzel, Yvonne; Benndorf, Dirk; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 109 (2025), Artikel 74, insges. 17 S.
2024
Aufsatz
Improved biological methanation using tubular foam-bed reactor
Khesali Aghtaei, Hoda; Hyer, Robert; Reichl, Udo; Benndorf, Dirk
In: Biotechnology for biofuels and bioproducts - London : BioMed Central, Bd. 17 (2024), Artikel 66, insges. 12 S.
Begutachteter Zeitschriftenartikel
Parallel multifactorial process optimization and intensification for high-yield production of Live YF17D-vectored zika vaccine
Göbel, Sven; Kazemi, Ozeir; Ma, Ji; Jordan, Ingo; Sandig, Volker; Paulissen, Jasmine; Kerstens, Winnie; Thibaut, Hendrik Jan; Reichl, Udo; Dallmeier, Kai; Genzel, Yvonne
In: Vaccines - Basel : MDPI, Bd. 12 (2024), Heft 7, Artikel 755, insges. 23 S.
Innovations in cell culture-based influenza vaccine manufacturing – from static cultures to high cell density cultivations
Zinnecker, Tilia; Reichl, Udo; Genzel, Yvonne
In: Human vaccines & immunotherapeutics - Austin, Tex. : Landes Bioscience, Bd. 20 (2024), Heft 1, insges. 15 S.
Production of antiviral “OP7 chimera” defective interfering particles free of infectious virus
Pelz, Lars; Dogra, Tanya; Marichal-Gallardo, Pavel; Hein, Marc Dominique; Hemissi, Ghada; Kupke, Sascha Young; Genzel, Yvonne; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 108 (2024), Artikel 97, insges. 15 S.
Production of recombinant vesicular stomatitis virus-based vectors by tangential flow depth filtration
Göbel, Sven; Pelz, Lars; Silva, Cristina A. T.; Brühlmann, Béla; Hill, Charles; Altomonte, Jennifer; Kamen, Amine; Reichl, Udo; Genzel, Yvonne
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 108 (2024), Artikel 240, insges. 18 S.
From single-cell cloning to high-yield influenza virus production - implementing advanced technologies in vaccine process development
Zinnecker, Tilia; Badri, Najd; Araujo, Diogo; Thiele, Kristin; Reichl, Udo; Genzel, Yvonne
In: Engineering in life sciences - Weinheim : Wiley-VCH . - 2024, insges. 14 S. [Online first]
Breakdown of hardly degradable carbohydrates (lignocellulose) in a two-stage anaerobic digestion plant is favored in the main fermenter
Heyer, Robert; Hellwig, Patrick; Maus, Irena; Walke, Danile; Schlüter, Andreas; Hassa, Julia; Sczyrba, Alexander; Tubbesing, Tom; Klocke, Michael; Mächtig, Torsten; Schallert, Kay; Seick, Ingolf; Reichl, Udo; Benndorf, Dirk
In: Water research - Amsterdam [u.a.] : Elsevier Science, Bd. 250 (2024), Artikel 121020, insges. 11 S.
Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle "OP7"
Rüdiger, Daniel; Piasecka, Julita; Küchler, Jan; Pontes, Carolina; Laske, Tanja; Kupke, Sascha Y.; Reichl, Udo
In: iScience - Amsterdam : Elsevier, Bd. 27 (2024), Heft 4, Artikel 109421, insges. 22 S.
Macrophage- and CD4+ T cell-derived SIV differ in glycosylation, infectivity and neutralization sensitivity
Karsten, Christina B.; Büttner, Falk; Cajic, Samanta; Nehlmeier, Inga; Roshani, Berit; Klippert, Antonina; Sauermann, Ulrike; Stolte-Leeb, Nicole; Reichl, Udo; Gerardy-Schahn, Rita; Rapp, Erdmann; Stahl-Hennig, Christine
In: PLoS pathogens / Public Library of Science - Lawrence, Kan. : PLoS, Bd. 20 (2024), Heft 5, Artikel e1012190, insges. 20 S.
Model-based optimization of cell-free enzyme cascades exemplified for the production of GDP-fucose
Huber, Nicolas; Alcalá-Orozco, Edgar Alberto; Rexer, Thomas; Reichl, Udo; Klamt, Steffen
In: Metabolic engineering - Orlando, Fla. : Academic Press, Bd. 81 (2024), S. 10-25
Tracing active members in microbial communities by BONCAT and click chemistry-based enrichment of newly synthesised proteins
Hellwig, Patrick; Kautzner, Daniel; Heyer, Robert; Dittrich, Anna; Wibberg, Daniel; Busche, Tobias; Winkler, Anika; Reichl, Udo; Benndorf, Dirk
In: ISME communications - Oxford : Oxford University Press, Bd. 4 (2024), Heft 1, Artikel ycae153, insges. 14 S.
Dissertation
In-depth characterization and cell culture-based production in influenza A virus defective interfering particles
Pelz, Lars; Reichl, Udo
In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2024, 1 Online-Ressource (Verschiedene Seitenzählungen, 13.32 MB) [Literaturangaben][Literaturangaben]
2023
Abstract
Adjuvanted SARS-CoV-2 spike protein vaccination with altered glycosylation elicits improved TH1 humoral and cellular immunity in mice
Rudert, J.; Bälkner, M.; Juarez-Osorio, M.; Rexer, T.; Reichl, Udo; Jacobsen, H.; Metzdorf, K.; Bruder, D.; Volckmar, J.
In: European journal of immunology - Weinheim : Wiley-VCH, Bd. 53 (2023), Heft S2, S. 358, Artikel P376 [Konferenz: Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), Strasbourg, France, 26-29 September 2023]
Aufsatz
Degradation kinetics of lignocellulolytic enzymes in a biogas reactor using quantitative mass spectrometry
Küchler, Jan; Willenbücher, Katharina; Reiß, Elisabeth; Nuß, Lea; Conrady, Marius; Ramm, Patrice; Schimpf, Ulrike; Reichl, Udo; Szewzyk, Ulrich; Benndorf, Dirk
In: Fermentation - Basel : MDPI, Bd. 9 (2023), Heft 1, Artikel 67, 1 Online-Ressource (12 Seiten)
Buchbeitrag
Upstream processing for viral vaccines - process intensification
Göbel, Sven; Pelz, Lars; Reichl, Udo; Genzel, Yvonne
In: Bioprocessing of viral vaccines , First edition - Abgingdon : Taylor & Francis ; Kamen, Amine . - 2023, S. 137-173
Upstream processing for viral vaccines - general aspects
Pelz, Lars; Göbel, Sven; Jaen, Karim; Reichl, Udo; Genzel, Yvonne
In: Bioprocessing of viral vaccines , First edition - Abgingdon : Taylor & Francis ; Kamen, Amine . - 2023, S. 79-135
Begutachteter Zeitschriftenartikel
Production of retroviral vectors in continuous high cell density culture
Hein, Marc D.; Kazenmaier, Daniel; van Heuvel, Yasemin; Dogra, Tanya; Cattaneo, Maurizio; Kupke, Sascha Y.; Stitz, Jörn; Genzel, Yvonne; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 107 (2023), S. 5947-5961
Broad-spectrum antiviral activity of influenza A Defective Interfering Particles against respiratory syncytial, yellow fever, and Zika virus replication in vitro
Pelz, Lars; Piagnani, Elena; Marsall, Patrick; Wynserski, Nancy; Hein, Marc Dominique; Marichal-Gallardo, Pavel; Kupke, Sascha Young; Reichl, Udo
In: Viruses - Basel : MDPI, Bd. 15 (2023), Heft 9, Artikel 1872, insges. 17 S.
Characterization of a quail suspension cell line for production of a fusogenic oncolytic virus
Göbel, Sven; Jaén, Karim E.; Fernandes, Rita P.; Reiter, Manfred; Altomonte, Jennifer; Reichl, Udo; Genzel, Yvonne
In: Biotechnology & bioengineering - New York, NY [u.a.] : Wiley . - 2023, insges. 12 S. [Early view]
A cell-free multi-enzyme cascade reaction for the synthesis of CDP-glycerol
Alcalá-Orozco, E. Alberto; Grote, Valerian; Fiebig, Timm; Klamt, Steffen; Reichl, Udo; Rexer, Thomas
In: ChemBioChem - Weinheim : Wiley-VCH . - 2023, Artikel e202300463 [Early view]
Cell-free N-glycosylation of peptides using synthetic lipid-linked hybrid and complex N-glycans
Wenzel, Lisa; Hoffmann, Marcus; Rapp, Erdmann; Rexer, Thomas F. T.; Reichl, Udo
In: Frontiers in molecular biosciences - Lausanne : Frontiers, Bd. 10 (2023), insges. 11 S.
Removable Ddes - the missing link for in-depth N-glycan analysis via multi-method approaches
Cajic, Samanta; Hennig, René; Grote, Valerian; Reichl, Udo; Rapp, Erdmann
In: Engineering - Beijing : Engineering Sciences Press., Bd. 26 (2023), S. 132-150
Generation of "OP7 chimera" defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice
Dogra, Tanya; Pelz, Lars; Boehme, Julia D.; Kuechler, Jan; Kershaw, Olivia; Marichal-Gallardo, Pável Alejandro; Baelkner, Maike; Hein, Marc Dominique; Gruber, Achim; Benndorf, Dirk; Genzel, Yvonne; Bruder, Dunja; Kupke, Sascha Young; Reichl, Udo
In: Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature, Bd. 13 (2023), Artikel 20936, insges. 13 S.
Cell-free biosynthesis meets dynamic optimization and control - a fed-batch framework
Espinel-Ríos, Sebastián; Huber, Nicolas; Alcalá-Orozco, Edgar Alberto; Morabito, Bruno; Rexer, Thomas F. T.; Reichl, Udo; Klamt, Steffen; Findeisen, Rolf
In: IFAC-PapersOnLine / Internationale Förderung für Automatische Lenkung - Frankfurt : Elsevier, Bd. 55 (2022), Heft 23, S. 92-97
Process intensification strategies toward cell culture-based high-yield production of a fusogenic oncolytic virus
Göbel, Sven; Jaén, Karim E.; Dorn, Marie; Neumeyer, Victoria; Jordan, Ingo; Sandig, Volker; Reichl, Udo; Altomonte, Jennifer; Genzel, Yvonne
In: Biotechnology & bioengineering - New York, NY [u.a.] : Wiley . - 2023, insges. 19 S.
Reliable N-glycan analysis - removal of frequently occurring oligosaccharide impurities by enzymatic degradation
Burock, Robert; Cajic, Samanta; Henning, René; Buettner, Falk, F. R.; Reichl, Udo; Rapp, Erdmann
In: Molecules - Basel : MDPI, Bd. 28 (2023), Heft 4, Artikel 1843, insges. 19 S.
2022
Aufsatz
Adaptation of a microbial community to demand-oriented biological methanation
Khesali Aghtaei, Hoda; Püttker, Sebastian; Maus, Irena; Heyer, Robert; Huang, Liren; Sczyrba, Alexander; Reichl, Udo; Benndorf, Dirk
In: Biotechnology for biofuels and bioproducts - London : BioMed Central, Bd. 15 (2022), Heft 1, Artikel 125, 1 Online-Ressource (19 Seiten)
Absolute quantification of viral proteins during single-round replication of MDCK suspension cells
Küchler, Jan; Püttker, Sebastian; Lahmann, Patrick; Genzel, Yvonne; Kupke, Sascha; Benndorf, Dirk; Reichl, Udo
In: Journal of proteomics - New York, NY [u.a.] : Elsevier, Bd. 259 (2022), Artikel 104544, insges. 10 S.
Buchbeitrag
Discovering biomarkers for non-alcoholic steatohepatitis patients with and without hepatocellular carcinoma using fecal metaproteomics
Sydor, Svenja; Dandyk, Christian; Schwerdt, Johannes; Manka, Paul; Benndorf, Dirk; Lehmann, Theresa; Schallert, Kay; Wolf, Maximilian; Reichl, Udo; Canbay, Ali E.; Bechmann, Lars P.; Heyer, Robert
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 23 (2022), Heft 16, Artikel 8841, insges. 14 S.
Begutachteter Zeitschriftenartikel
Impact of influenza A virus infection on growth and metabolism of suspension MDCK cells using a dynamic model
Ramos, João Rodrigues Correia; Bissinger, Thomas; Genzel, Yvonne; Reichl, Udo
In: Metabolites - Basel : MDPI, Bd. 12 (2022), Heft 3, Artikel 239, insges. 27 S.
High-titer hepatitis C virus production in a scalable single-use high cell density bioreactor
Offersgaard, Anna; Duarte Hernandez, Carlos Rene; Pihl, Anne Finne; Venkatesan, Nadini Prabhakar; Krarup, Henrik; Lin, Xiangliang; Reichl, Udo; Bukh, Jens; Genzel, Yvonnne; Gottwein, Judith Margarete
In: Vaccines - Basel : MDPI, Bd. 10 (2022), Heft 2, Artikel 249, insges. 24 S.
Human 3D airway tissue models for real-time microscopy - visualizing respiratory virus spreading
Möckel, Marion; Baldok, Nino; Walles, Thorsten; Hartig, Roland; Müller, Andreas Johann; Reichl, Udo; Genzel, Yvonne; Walles, Heike; Wiese-Rischke, Cornelia
In: Cells - Basel : MDPI, Bd. 11 (2022), Heft 22, Artikel 3634, insges. 21 S.
Cell-line screening and process development for a fusogenic oncolytic virus in small-scale suspension cultures
Göbel, Sven; Kortum, Fabian; Chavez, Karim Jaén; Jordan, Ingo; Sandig, Volker; Reichl, Udo; Altomonte, Jennifer; Genzel, Yvonne
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 106 (2022), Heft 13/16, S. 4945-4961
Dissertation
Cell culture-based production of influenza A virus-derived defective interfering particles
Hein, Marc Dominique; Reichl, Udo
In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2022, 1 Online-Ressource (XV, 98, XVII-L Seiten, 5,1 MB) [Literaturverzeichnis: Seite XX-XXXVII]
Development of chromatography-based purification processes for cell culture-derived influenza virus particles
Weigel, Thomas; Reichl, Udo
In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2022, 1 Online-Ressource (XXII, 145 Seiten, 2,22 MB) [Literaturverzeichnis: Seite 119-133]
Mathematical models of influenza A virus infection - multiplicity of infection and its impact on co-infection and virus production
Rüdiger, Daniel; Tsotsas, Evangelos; Reichl, Udo
In: Magdeburg: Universitätsbibliothek, 2022, 1 Online-Ressource (XVIII, 179 Seiten, 8,16 MB), Illustrationen
2021
Aufsatz
Fecal metaproteomics reveals reduced gut inflammation and changed microbial metabolism following lifestyle-induced weight loss
Biemann, Ronald; Buß, Enrico; Benndorf, Dirk; Lehmann, Theresa; Schallert, Kay; Püttker, Sebastian; Reichl, Udo; Isermann, Berend; Schneider, Jochen; Saake, Gunter; Heyer, Robert
In: Biomolecules - Basel : MDPI - Vol.11.2021, 5, 726, insgesamt 13 Seiten
Critical Assessment of MetaProteome Investigation (CAMPI) - a multi-laboratory comparison of established workflows
Van Den Bossche, Tim; Kunath, Benoit J.; Schallert, Kay; Schäpe, Stephanie S.; Abraham, Paul C.; Armengaud, Jean; Arntzen, Magnus Ø.; Bassignani, Ariane; Benndorf, Dirk; Fuchs, Steohan; Giannone, Richard J.; Griffin, Timothy J.; Hagen, Live H.; Halder, Rashi; Henry, Céline; Hettich, Robert L.; Heyer, Robert; Jagtap, Pratik; Jehmlich, Nico; Jensen, Marlene; Juste, Ctherine; Kleiner, Manuel; Langella, Olivier; Lehmann, Theresa; Leith, Emma; May, Patrick; Mesuere, Bart; Miotello, Guylaine; Peters, Samantha L.; Pible, Olivier; Queiros, Pedro T.; Reichl, Udo; Renard, Bernhard Y.; Schiebenhoefer, Henning; Sczyrba, Alexander; Tanca, Alessandro; Trappe, Kathrin; Trezzi, jean-Pierre; Uzzau, Sergio; Verschaffelt, Pieter; Bergen, Martin von; Wilmes, Paul; Wolf, Maximilian; Martens, Lennart; Muth, Thilo
In: Nature Communications - [London] : Nature Publishing Group UK, Bd. 12 (2021), S. 1-15, Artikel 7305
Tracking changes in adaptation to suspension growth for MDCK cells: cell growth correlates with levels of metabolites, enzymes and proteins
Pech, Sabine; Rehberg, Markus; Janke, Robert; Benndorf, Dirk; Genzel, Yvonne; Muth, Thilo; Sickmann, Albert; Rapp, Erdmann; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 105 (2021), S. 1861-1874
OP7, a novel influenza A virus defective interfering particle - production, purification, and animal experiments demonstrating antiviral potential
Hein, Marc D.; Kollmus, Heike; Marichal-Gallardo, Pavel; Püttker, Sebastian; Benndorf, Dirk; Genzel, Yvonne; Schughart, Klaus; Kupke, Sascha Y.; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 105 (2021), Heft 1, S. 129-146
MPA_Pathway_Tool - user-friendly, automatic assignment of microbial community data on metabolic pathways
Walke, Daniel; Schallert, Kay; Ramesh, Prasanna; Benndorf, Dirk; Lange, Emanuel; Reichl, Udo; Heyer, Robert
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 22 (2021), Heft 20, Artikel 10992, insges. 12 S.
Buchbeitrag
Preface
Rapp, Erdmann; Reichl, Udo
In: Advances in Glycobiotechnology - Cham: Springer International Publishing; Rapp, Erdmann . - 2021, S. v-vi
Correction to: Animal Cell Expression Systems
Butler, M.; Reichl, Udo
In: Advances in Glycobiotechnology - Cham: Springer International Publishing; Rapp, Erdmann . - 2021, S. 459-461
Begutachteter Zeitschriftenartikel
Semi-continuous propagation of influenza A virus and its defective interfering particles - analyzing the dynamic competition to select candidates for antiviral therapy
Pelz, Lars; Rüdiger, Daniel; Dogra, Tanya; Alnaji, Fadi G.; Genzel, Yvonne; Brooke, Christopher B.; Kupke, Sascha Y.; Reichl, Udo
In: Journal of virology - Baltimore, Md.: Soc., Bd. 95 (2021), 24, insges. 18 S.
Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N-glycans
Chuzel, Léa; Fossa, Samantha L.; Boisvert, Madison L.; Cajic, Samanta; Heenig, René; Ganatra, Mehul B.; Reichl, Udo; Rapp, Erdmann; Taron, Christopher H.
In: Microbial cell factories - London : Biomed Central, Bd. 20 (2021), S. 1-17, Artikel 162
High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cells
Wu, Yixiao; Bissinger, Thomas; Genzel, Yvonne; Liu, Xuping; Reichl, Udo; Tan, Wen-Song
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 105 (2021), 4, S. 1421-1434
Cell culture-based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system
Hein, Marc D.; Chawla, Anshika; Cattaneo, Maurizio; Kupke, Sascha Y.; Genzel, Yvonne; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 105 (2021), S. 7251–7264
Multienzyme cascades for the in vitro synthesis of guanosine diphosphate Lfucose
Mahour, Reza; Marichal-Gallardo, Pavel A.; Rexer, Thomas; Reichl, Udo
In: ChemCatChem - Weinheim: WILEY-VCH Verlag, Bd. 13 (2021), insges. 11 S.
Continuous purification of influenza A virus particles using pseudo-affinity membrane chromatography
Fortuna, Raquel A.; Taft, Florian; Villain, Louis; Wolff, Michael W.; Reichl, Udo
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, Bd. 342 (2021), S. 139-148
Comprehensive N‐glycosylation analysis of the influenza A virus proteins HA and NA from adherent and suspension MDCK cells
Pralow, Alexander; Hoffmann, Marcus; Nguyen-Khuong, Terry; Pioch, Markus; Hennig, René; Genzel, Yvonne; Rapp, Erdmann; Reichl, Udo
In: The FEBS journal / Vereinigung der Europäischen Biochemischen Gesellschaften - Oxford [u.a.] : Wiley-Blackwell, Bd. 288 (2021), Heft 16, S. 4869-4891
Towards integrated production of an influenza A vaccine candidate with MDCK suspension cells
Bissinger, Thomas; Wu, Yixiao; Marichal-Gallardo, Pável Alejandro; Riedel, Dietmar; Liu, Xuping; Genzel, Yvonne; Tan, Wen-Song; Reichl, Udo
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley, Bd. 118 (2021), 10, S. 3996-4013
Cell-free multi-enzyme synthesis and purification of uridine diphosphate galactose
Mahour, Reza; Lee, Ju Weon; Grimpe, Pia; Boecker, Simon; Grote, Valerian; Klamt, Steffen; Seidel-Morgenstern, Andreas; Rexer, Thomas F. T.; Reichl, Udo
In: ChemBioChem - Weinheim: Wiley-VCH, Bd. 22 (2021), S. 1-11
SARS-CoV-2 production in a scalable high cell density bioreactor
Offersgaard, Anna; Duarte Hernandez, Carlos Rene; Pihl, Anne Finne; Costa, Rui; Venkatesan, Nandine Prabhakar; Lin, Xiangliang; Pham, Long Van; Feng, Shan; Fahnøe, Ulrik; Scheel, Troels Kasper Høyer; Ramirez, Santseharay; Reichl, Udo; Bukh, Jens; Genzel, Yvonne; Gottwein, Judith Margarete
In: Vaccines - Basel: MDPI, Bd. 9 (2021), 7
A high cell density perfusion process for Modified Vaccinia virus Ankara production - process integration with inline DNA digestion and cost analysis
Gränicher, Gwendal; Babakhani, Masoud; Göbel, Sven; Jordan, Ingo; Marichal-Gallardo, Pavel; Genzel, Yvonne; Reichl, Udo
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley . - 2021, insges. 15 S.
Cell-free glycoengineering of the recombinant SARS-CoV-2 spike glycoprotein
Ruhnau, Johannes; Grote, Valerian; Juarez-Osorio, Mariana; Bruder, Dunja; Mahour, Reza; Rapp, Erdmann; Rexer, Thomas F. T.; Reichl, Udo
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, 2013, Bd. 9 (2021), insges. 10 S.
Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteins
Pralow, Alexander; Nikolay, Alexander; Leon, Arnaud; Genzel, Yvonne; Rapp, Erdmann; Reichl, Udo
In: Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature, Bd. 11 (2021), Artikel 5147
Integrated cycles for urban biomass as a strategy to promote a CO2-neutral society - a feasibility study
Meinusch, Nicole; Kramer, Susanne; Körner, Oliver; Wiese, Jürgen; Seick, Ingolf; Beblek, Anita; Berges, Regine; Illenberger, Bernhard; Illenberger, Marco; Uebbing, Jennifer; Wolf, Maximilian; Saake, Gunter; Benndorf, Dirk; Reichl, Udo; Heyer, Robert
In: Sustainability - Basel : MDPI, Bd. 13 (2021), Heft 17, Artikel 9505, insges. 22 S.
Forschungsarbeiten am Institut für Verfahrenstechnik der OttovonGuerickeUniversität Magdeburg
Reichl, Udo; Seidel-Morgenstern, Andreas; Sundmacher, Kai; Tsotsas, Evangelos; Wachem, Berend
In: Chemie - Ingenieur - Technik - Weinheim : Wiley-VCH Verl., Bd. 93 (2021), Heft 3, S. 345-352
Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity
Rand, Ulfert; Kupke, Sascha Young; Shkarlet, Hanna; Hein, Marc Dominique; Hirsch, Tatjana; Marichal-Gallardo, Pável Alejandro; Cicin-Sain, Luka; Reichl, Udo; Bruder, Dunja
In: Cells - Basel: MDPI, 2012, Bd. 10 (2021), 7, insges. 14 S.
Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles
Hein, Marc D.; Arora, Prerna; Marichal-Gallardo, Pável Alejandro; Winkler, Michael; Genzel, Yvonne; Pöhlmann, Stefan; Schughart, Klaus; Kupke, Sascha Y.; Reichl, Udo
In: BMC biology - Berlin: Springer, Bd. 19 (2021)
Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture
Rüdiger, Daniel; Pelz, Lars; Hein, Marc D.; Kupke, Sascha Y.; Reichl, Udo
In: PLoS Computational Biology/ Public Library of Science - San Francisco, Calif.: Public Library of Science, Bd. 17 (2021), 9, insges. 28 S.
Associated viral gene transfer vectors by membrane-based steric exclusion chromatography
Marichal-Gallardo, Pavel; Börner, Kathleen; Pieler, Michael M.; Sonntag-Buck, Vera; Obr, Martin; Bejarano, David; Wolff, Michael W.; Kräusslich, Hans-Georg; Reichl, Udo; Grimm, Dirk
In: Human gene therapy - New York, NY: Liebert, 2021, insgesamt 16 Seiten
Dissertation
Process intensification and integration for the production of vaccines and viral vectors
Gränicher, Gwendal; Reichl, Udo
In: Magdeburg: Universitätsbibliothek, 2021, 1 Online-Ressource (XXX, 222 Seiten, 8,49 MB), Illustrationen, Diagramme
Mathematical models of influenza A virus infection - elucidating the impact of host cell factors and defective interfering particles on virus growth
Laske, Tanja; Sundmacher, Kai; Reichl, Udo
In: Magdeburg: Universitätsbibliothek, 2021, 1 Online-Ressource (XVIII, 233 Seiten, 17,07 MB), Illustrationen, Diagramme
Application of functional metagenomics to the field of glycobiology
Chuzel, Léa; Reichl, Udo
In: Düren: Shaker Verlag, 2022, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2021, XI, 229 Seiten - (Forschungsberichte aus dem Max-Planck-Institut für Dynamik komplexer technischer Systeme; Band 55), ISBN: 3-8440-8437-1 [Literaturverzeichnis: Seite 186-210]
Metaproteomanalyse methanogener Mikrobiome aus Anreicherungskulturen im Labormaßstab
Kohrs, Fabian; Reichl, Udo
In: Magdeburg: Universitätsbibliothek, 2021, 1 Online-Ressource (IX, 123, A-J Seiten, 3,84 MB), Illustrationen
Scalable multi-enzyme platforms for the in vitro glycoengineering of therapeutic proteins & synthesis of human milk oligosaccharides
Mahour, Reza; Reichl, Udo
In: Magdeburg: Universitätsbibliothek, 2022, 1 Online-Ressource (XV, 170 Blätter, 5,8 MB), Illustrationen
Process intensification for the production of MVA and influenza A virus in high density suspension cultures of AGE1.CR.pIX cells
Vázquez Ramírez, Daniel; Reichl, Udo
In: Magdeburg: Universitätsbibliothek, 2021, 1 Online-Ressource (XIV, 136 Seiten, 7,58 MB), Illustrationen
Herausgeberschaft
Advances in glycobiotechnology
Rapp, Erdmann; Reichl, Udo
In: Cham: Springer, 2021, viii, 461 Seiten - (Advances in biochemical engineering/biotechnology; 175), ISBN: 978-3-030-69589-7 [Literaturangaben]
2020
Artikel in Zeitschrift
Synthesis of lipid-linked oligosaccharides by a compartmentalized multi-enzyme cascade for the in vitro N-glycosylation of peptides
Rexer, Thomas F. T.; Wenzel, Lisa; Hoffmann, Marcus; Tischlik, Sebastian; Bergmann, Christin; Grote, Valerian; Boecker, Simon Matthias; Bettenbrock, Katja; Schildbach, Anna; Kottler, Robert; Mahour, Reza; Rapp, Erdmann; Pietzsch, Markus; Reichl, Udo
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, 1984, Bd. 322 (2020), S. 54-65
Buchbeitrag
Impact of feeding and stirring regimes on the internal stratification of microbial communities in the fermenter of anaerobic digestion plants
Heyer, Robert; Klang, Johanna; Hellwig, Patrick; Schallert, Kay; Kress, Philipp; Hülsemann, Benedikt; Theuerl, Susanne; Reichl, Udo; Benndorf, Dirk
In: Bioresource technology - Amsterdam [u.a.] : Elsevier Science - 314(2020), Artikel-Nummer 123679, 1 Online-Ressource
Perfusion control for high cell density cultivation and viral vaccine production
Nikolay, Alexander; Bissinger, Thomas; Gränicher, Gwendal; Wu, Yixiao; Genzel, Yvonne; Reichl, Udo
In: Animal Cell Biotechnology: Methods and Protocols - New York, NY: Springer US; Pörtner, Ralf . - 2020, S. 141-168
Begutachteter Zeitschriftenartikel
Production of Modified Vaccinia Ankara virus by intensified cell cultures - a comparison of platform technologies for viral vector production
Gränicher, Gwendal; Tapia, Felipe; Behrendt, Ilona; Jordan, Ingo; Genzel, Yvonne; Reichl, Udo
In: Biotechnology journal - Weinheim: Wiley-VCH, Bd. 16 (2021), 1, insges. 10 S., 2020
Performance of an acoustic settler versus a hollow fiberbased ATF technology for influenza virus production in perfusion
Gränicher, Gwendal; Coronel, Juliana; Trampler, Felix; Jordan, Ingo; Genzel, Yvonne; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 104.2020, S. 4877-4888
Application of an nnclined settler for cell culture-based influenza A virus production in perfusion mode
Coronel, Juliana; Gränicher, Gwendal; Sandig, Volker; Noll, Thomas; Genzel, Yvonne; Reichl, Udo
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, Volume 8 (2020), article 672, insgesmat 13 Seiten
Virus harvesting in perfusion culture - choosing the right type of hollow fiber membrane
Nikolay, Alexander; Grooth, Joris; Genzel, Yvonne; Wood, Jeffery A.; Reichl, Udo
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley, 2020, insgesamt 13 Seiten[Online first]
Single-cell analysis uncovers a vast diversity in intracellular viral defective interfering RNA content affecting the large cell-to-cell heterogeneity in influenza A virus replication
Kupke, Sascha Young; Ly, Lam-Ha; Börno, Stefan Thomas; Ruff, Alexander; Timmermann, Bernd; Vingron, Martin; Haas, Stefan; Reichl, Udo
In: Viruses - Basel: MDPI, 12 (2020,1), Artikelnummer 71, 19 Seiten
A dynamic model linking cell growth to intracellular metabolism and extracellular byproduct accumulation
Ramos, João R.; Rath, Alexander G.; Genzel, Yvonne; Sandig, Volker; Reichl, Udo
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley . - 2020, insges. 21 S.
Dissertation
Intensified yellow fever and Zika virus production in animal cell culture
Nikolay, Alexander; Reichl, Udo
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2020, XV, 175 Seiten [Literaturverzeichnis: Seite 139-157][Literaturverzeichnis: Seite 139-157]
Single-cell analysis of influenza A virus replication - sources of cell-to-cell heterogeneity and discoverey of a novel type of defective interfering particle
Kupke, Sascha Young; Reichl, Udo
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2020, XV, 155 Seiten [Literaturverzeichnis: Seite 122-136][Literaturverzeichnis: Seite 122-136]
Evaluation of MDCK suspension cell lines for influenza A virus production - media, metabolism, and process conditions
Bissinger, Thomas; Reichl, Udo
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2020, XXVI, 137 Seiten [Literaturverzeichnis: Seite 109-125][Literaturverzeichnis: Seite 109-125]
In-depth mass spectrometry-based glycoproteomics - advances in sample preparation, measurement and data-analysis of glycoproteins
Hoffmann, Marcus; Reichl, Udo; Rapp, Erdmann
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2020, XI, 141 Seiten [Literaturverzeichnis: Seite 118-133][Literaturverzeichnis: Seite 118-133]
2019
Abstract
Dialyseinduzierte Veränderungen im menschlichen Serum-Protein N-Glykosylation
Lindquist, Jonathan; Hennig, René; Rapp, Erdmann; Reichl, Udo; Mertens, Peter Rene
In: Kongress für Nephrologie, 11. Jahrestagung der Deutschen Gesellschaft für Nephrologie: Die Nephrologie als ganzheitliche Disziplin in der Patientenversorgung : 10. 13. Oktober 2019 in Düsseldorf : Programm/ Kongress für Nephrologie, 2019, P256, S. 165
Aufsatz
Metaproteome analysis reveals that syntrophy, competition, and phage-host interaction shape microbial communities in biogas plants
Heyer, Robert; Schallert, Kay; Siewert, C.; Kohrs, F.; Greve, J.; Maus, I.; Klang, J.; Klocke, M.; Heiermann, M.; Hoffmann, Michael; Püttker, Sebastian; Calusinska, M.; Zoun, Roman; Saake, Gunter; Benndorf, Dirk; Reichl, Udo
In: Microbiome - London : Biomed Central, Bd. 7 (2019), Artikel 69, insges. 17 S.
Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis
Lehmann, Tony; Schallert, Kay; Vilchez-Vargas, Ramiro; Benndorf, Dirk; Püttker, Sebastian; Sydor, Svenja; Schulz, Christian; Bechmann, Lars Peter; Canbay, Ali E.; Heidrich, Benjamin; Reichl, Udo; Link, Alexander; Heyer, Robert
In: Journal of proteomics - New York, NY [u.a.] : Elsevier, Bd. 201 (2019), S. 93-103
RedCom - a strategy for reduced metabolic modeling of complex microbial communities and its application for analyzing experimental datasets from anaerobic digestion
Koch, Sabine; Kohrs, Fabian; Lahmann, Patrick; Bissinger, Thomas; Wendschuh, Stefan; Benndorf, Dirk; Reichl, Udo
In: PLoS Computational Biology / Public Library of Science - San Francisco, Calif. : Public Library of Science - Vol. 15 (2019), 2, Artikel e1006759, insgesamt 32 Seiten
Begutachteter Zeitschriftenartikel
Influenza A virus production in a single-use orbital shaken bioreactor with ATF or TFF perfusion systems
Coronel, Juliana; Behrendt, Ilona; Bürgin, Tim; Anderlei, Tibor; Sandig, Volker; Reichl, Udo; Genzel, Yvonne
In: Vaccine - Amsterdam: Elsevier, Bd. 37.2019, 47, S. 7011-7018
Use of sulfated cellulose membrane adsorbers for chromatographic purification of cell cultured-derived influenza A and B viruses
Fortuna, A. Raquel; van Teeffelen, Sebastian; Ley, Adrian; Fischer, Laura M.; Taft, Florian; Genzel, Yvonne; Villain, Louis; Wolff, Michael W.; Reichl, Udo
In: Separation and purification technology - Amsterdam [u.a.]: Elsevier Science, 1997, Bd. 226.2019, S. 350-358
A robust and universal metaproteomics workflow for research studies and routine diagnostics within 24 h using phenol extraction, FASP digest, and the MetaProteomeAnalyzer
Heyer, Robert; Schallert, Kay; Büdel, Anja; Zoun, Roman; Dorl, Sebastian; Behne, Alexander; Kohrs, Fabian; Püttker, Sebastian; Siewert, Corina; Muth, Thilo; Saake, Gunter; Reichl, Udo; Benndorf, Dirk
In: Frontiers in microbiology - Lausanne : Frontiers Media - 10 (2019), article 1883, insgesamt 20 Seiten
A novel type of influenza a virus-derived defective interfering particle with nucleotide substitutions in its genome
Kupke, Sascha Young; Riedel, Dietmar; Frensing, Timo; Zmora, Pawel; Reichl, Udo
In: Journal of virology: publ. by the American Society for Microbiology - Baltimore, Md.: Soc., 1967, Bd. 93.2019, 4, Art.-Nr. e01786, insges. 24 Seiten
Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1
Gränicher, Gwendal; Coronel, Juliana; Pralow, Alexander; Marichal-Gallardo, Pável Alejandro; Wolff, Michael; Rapp, Erdmann; Karlas, Alexander; Sandig, Volker; Genzel, Yvonne; Reichl, Udo
In: Vaccine - Amsterdam: Elsevier, 1983, Bd. 37.2019, 47, S. 7019-7028
High-throughput serum N-glycomics - method comparison and application to study rheumatoid arthritis and pregnancy-associated changes
Reiding, Karli R.; Bondt, Albert; Hennig, René; Gardner, Richard A.; O'Flaherty, Roisin; Trbojevič-Akmačič, Irena; Shubhakar, Archana; Hazes, Johanna M. W.; Reichl, Udo; Fernandes, Daryl L.; Pučič-Bakovič, Maja; Rapp, Erdmann; Spencer, Daniel I. R.; Dolhain, Radboud J. E. M.; Rudd, Pauline M.; Lauc, Gordon; Wuhrer, Manfred
In: Molecular & cellular proteomics: MCP - Bethesda, Md: The American Society for Biochemistry and Molecular Biology, Bd. 18.2019, 1, S. 3-15
A system for production of defective interfering particles in the absence of infectious influenza A virus
Bdeir, Najat; Arora, Prerna; Gärtner, Sabine; Hoffmann, Markus; Reichl, Udo; Pöhlmann, Stefan; Winkler, Michael
In: PLOS ONE - San Francisco, California, US: PLOS, Vol. 14.2019, 3, Artikel e0212757, insgesamt 18 Seiten
Hydrophobic-interaction chromatography for purification of influenza A and B virus
Weigel, Thomas; Soliman, Remon; Wolff, Michael W.; Reichl, Udo
In: Journal of chromatography / B - New York, NY [u.a.]: Science Direct, Bd. 1117.2019, S. 103-117
Enzymatic cascade synthesis provides novel linear human milk oligosaccharides as reference standards for xCGELIF based highthroughput analysis
Fischöder, Thomas; Cajic, Samanta; Reichl, Udo; Rapp, Erdmann; Elling, Lothar
In: Biotechnology journal - Weinheim: Wiley-VCH, Vol. 14 (2019), 3, Artikelnr. 1800305, insges. 9 Seiten
Production of Defective Interfering Particles of influenza A virus in parallel continuous cultures at two residence times - insights from qPCR measurements and viral dynamics modeling
Tapia Delgado, Felipe Ignacio; Laske, Tanja; Wasik, Milena A.; Rammhold, Markus; Genzel, Yvonne; Reichl, Udo
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, 2013, Volume 7 (2019), Artikel 275, insgesamt 15 Seiten
Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the von Magnus effect
Tapia Delgado, Felipe Ignacio; Wohlfahrth, Daniel; Sandig, Volker; Jordan, Ingo; Genzel, Yvonne; Reichl, Udo
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, 14 (2019), 11, article e0224317, insgesamt 21 Seiten
Semi-perfusion cultures of suspension MDCK cells enable high cell concentrations and efficient influenza A virus productionPK2.1
Bissinger, Thomas; Fritsch, Johannes; Mihut, Adrian; Wu, Yxiao; Liu, Xuping; Genzel, Yvonne; Tan, Wen-Song; Reichl, Udo
In: Vaccine - Amsterdam: Elsevier, Bd. 37 (2019), 47, S. 7003-7010
Enzymatic cascades for tailored 13 C 6 and 15 N enriched human milk oligosaccharides
Fischöder, Thomas; Cajic, Samanta; Grote, Valerian; Greifenstein, Raphael; Reichl, Udo; Franzreb, Matthias; Rapp, Erdmann; Elling, Lothar
In: Molecules - Basel : MDPI - Volume 24 (2019), 19, Artikel 3482, insgesamt 21 Seiten
High titer MVA and influenza A virus production using a hybrid fed-batch/perfusion strategy with an ATF system
Vázquez Ramírez, Daniel; Jordan, Ingo; Sandig, Volker; Genzel, Yvonne; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 103 (2019), 7, S. 3025-3035
Dissertation
Continuous upstream processing for cell culture-derived virus production
Tapia Delgado, Felipe Ignacio; Reichl, Udo
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2019, xv, 112 Blätter [Literaturverzeichnis: Blatt 92-106][Literaturverzeichnis: Blatt 92-106]
Charakterisierung der Influenzavirus-Vermehrung in genetisch veränderten humanen Zelllinien zur Optimierung der Impfstoffproduktion
Bachmann, Mandy; Reichl, Udo
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2019, XI, 173 Seiten [Literaturverzeichnis: Seite 133-155][Literaturverzeichnis: Seite 133-155]
Herstellungsprozess für onkolytische Masernviren
Grein, Tanja A.; Reichl, Udo
In: Düren: Shaker Verlag, 2019, XII, 195 Seiten, 24 Illustrationen, Diagramme, 21 cm, 314 g - (Schriftenreihe des Institutes für Bioverfahrenstechnik und Pharmazeutische Technologie; Band 15)
Chromatographic purification of biological macromolecules by their capture on hydrophilic surfaces with the aid of non-ionic polymers
Marichal-Gallardo, Pável Alejandro; Reichl, Udo
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2019, xiii, 118 Blätter [Literaturverzeichnis: Blatt 99-113][Literaturverzeichnis: Blatt 99-113]
2018
Buchbeitrag
Mathematical modeling as a tool to improve influenza vaccine production processes
Duvigneau, Stefanie; Dürr, Robert; Laske, Tanja; Bachmann, Mandy; Dostert, Melanie; Reichl, Udo; Kienle, Achim
In: IFAC-PapersOnLine / Internationale Förderung für Automatische Lenkung - Frankfurt : Elsevier, Bd. 51 (2018), Heft 19, S. 1-4
Begutachteter Zeitschriftenartikel
Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths
Fischer, Laura M.; Wolff, Michael; Reichl, Udo
In: Vaccine - Amsterdam: Elsevier, Bd. 36.2018, 22, S. 3153-3160
Purification of influenza viruslike particles using sulfated cellulose membrane adsorbers
Carvalho, Sofia B.; Fortuna, A. Raquel; Wolff, Michael W.; Peixoto, Cristina; Alves, Paula M.; Reichl, Udo
In: Journal of chemical technology & biotechnology - Chichester: Wiley, Bd. 93.2018, 7, S. 1988-1996[Special issue: Bioseparations]
The fine art of destruction - a guide to indepth glycoproteomic analyses-exploiting the diagnostic potential of fragment ions
Hoffmann, Marcus; Pioch, Markus; Pralow, Alexander; Henning, René; Kottler, Robert; Reichl, Udo; Rapp, Erdmann
In: Proteomics - Weinheim: Wiley VCH, 2001, Vol. 18.2018, 24, Art.-Nr. 1800282
glyXtoolMS - an open-source pipeline for semiautomated analysis of glycopeptide mass spectrometry data
Pioch, Markus; Hoffmann, Marcus; Prahlow, Alexander; Reichl, Udo; Rapp, Erdmann
In: Analytical chemistry: the authoritative voice of the analytical community - Columbus, Ohio: American Chemical Society, 1947, Bd. 90.2018, 20, S. 11908-11916
Cell culture-based production of defective interfering particles for influenza antiviral therapy
Wasik, Milena A.; Eichwald, Luca; Genzel, Yvonne; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 102.2018, 3, S. 1167-1177, 2017
MPA portable - a stand-alone software package for analyzing metaproteome samples on the go
Muth, Thilo; Kohrs, Fabian; Heyer, Robert; Benndorf, Dirk; Rapp, Erdmann; Reichl, Udo; Martens, Lennart; Renard, Bernhard Y.
In: Analytical chemistry - Columbus, Ohio : American Chemical Society , 1947, Bd. 90 (2018), Heft 1, S. 685-689
Improvement of electrospray stability in negative ion mode for nano-PGC-LC-MS glycoanalysis via post-column make-up flow
Nguyen-Khuong, Terry; Pralow, Alexander; Reichl, Udo; Rapp, Erdmann
In: Glycoconjugate journal: official journal of the International Glycoconjugate Organization - Dordrecht [u.a.]: Springer Science + Business Media B.V, Bd. 35.2018, 6, S. 499-509
Optimization of cell culture-derived influenza A virus particles purification using sulfated cellulose membrane adsorbers
Fortuna, Ana Raquel; Taft, Florian; Villain, Louis; Wolff, Michael W.; Reichl, Udo
In: Engineering in life sciences - Weinheim: Wiley-VCH, Bd. 18.2018, 1, S. 29-39
SDSPAGE fractionation to increase metaproteomic insight into the taxonomic and functional composition of microbial communities for biogas plant samples
Wenzel, Lisa; Heyer, Robert; Schallert, Kay; Löser, Lucy; Wünschiers, Röbbe; Reichl, Udo; Benndorf, Dirk
In: Engineering in life sciences - Weinheim : Wiley-VCH, Bd. 18 (2018), Heft 7, S. 498-509
Valorisation of deinking sludge as a substrate for lignocellulolytic enzymes production by Pleurotus ostreatus
Vodovnik, Maša; Vrabec, Katja; Hellwig, Patrick; Benndorf, Dirk; Sežun, Mija; Gregori, Andrej; Gottumukkala, Lalitha D.; Anderson, Robin C.; Reichl, Udo
In: Journal of cleaner production - Amsterdam [u.a.] : Elsevier Science - Vol. 197.2018, Part 1, S. 253-263
A multiscale model of influenza A virus replication covering highly different infection conditions in cell cultures
Rüdiger, D.; Kupke, S. Y.; Reichl, Udo
In: IFAC-PapersOnLine/ Internationale Förderung für Automatische Lenkung - Frankfurt: Elsevier, Bd. 51.2018, 19, S. 32-33[Konferenz: 7th Conference on Foundation of Systems Biology in Engineering, FOSBE 2018, Chicago, Illinois, USA, 05-08 August 2018]
Process intensification of EB66® cell cultivations leads to high-yield yellow fever and Zika virus production
Nikolay, Alexander; Léon, Arnaud; Schwamborn, Klaus; Genzel, Yvonne; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 102.2018, 20, S. 8725-8737
Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine
Mahour, Reza; Klapproth, Jan; Rexer, Thomas F. T.; Schildbach, Anna; Klamt, Steffen; Pietzsch, Markus; Rapp, Erdmann; Reichl, Udo
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, Bd. 283.2018, S. 120-129
Propagation of Brazilian Zika virus strains in static and suspension cultures using Vero and BHK cells
Nikolay, Alexander; Castilho, Leda R.; Reichl, Udo; Genzel, Yvonne
In: Vaccine - Amsterdam: Elsevier, 1983, Bd. 36.2018, 22, S. 3140-3145
High-cell-density cultivations to increase MVA virus production
Vázquez Ramírez, Daniel; Genzel, Yvonne; Jordan, Ingo; Sandig, Volker; Reichl, Udo
In: Vaccine - Amsterdam: Elsevier, Bd. 36 (2018), 22, S. 3124-3133
2017
Buchbeitrag
Animal cell expression systems
Butler, M.; Reichl, Udo
In: Advances in biochemical engineering, biotechnology - Berlin: Springer, S. 1-36, 2017[Online first]
Begutachteter Zeitschriftenartikel
Specific ion effects on the particle size distributions of cell culturederived influenza A virus particles within the Hofmeister series
Pieler, Michael Martin; Heyse, Anja; Wolff, Michael Werner; Reichl, Udo
In: Engineering in life sciences - Weinheim : Wiley-VCH, Bd. 17.2017, 5, S. 470-478
Proteotyping of laboratory-scale biogas plants reveals multiple steady-states in community composition
Kohrs, Fabian; Heyer, Robert; Bissinger, Thomas; Kottler, Robert; Schallert, Kay; Püttker, Sebastian; Behne, Alexander; Rapp, Erdmann; Benndorf, Dirk; Reichl, Udo
In: Anaerobe - London : Academic Press , 1995, Bd. 46 (2017), S. 56-68
Improvement of the glycoproteomic toolbox with the discovery of a unique C-terminal cleavage specificity of flavastacin for N-glycosylated asparagine
Pralow, Alexander; Hoffmann, Marcus; Nguyen-Khuong, Terry; Rapp, Erdmann; Reichl, Udo
In: Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature - Bd. 7.2017, Art.-Nr. 11419, insgesamt 9 Seiten
Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systems
Tapia Delgado, Felipe Ignacio; Jordan, Ingo; Genzel, Yvonne; Reichl, Udo
In: PLOS ONE - San Francisco, California, US : PLOS - Bd. 12.2017, 8, Art.-Nr. e0182553, insges. 17 Seiten
Influence of the production system on the surface properties of influenza A virus particles
Hämmerlein, Frank; Pieler, Michael M.; Hennig, René; Serve, Anja; Rapp, Erdmann; Wolff, Michael W.; Reichl, Udo; Hubbuch, Jürgen
In: Engineering in life sciences - Weinheim : Wiley-VCH, Bd. 17.2017, 10, S. 1071-1077
One pot synthesis of GDP-mannose by a multi-enzyme cascade for enzymatic assembly of lipid-linked oligosaccharides
Rexer, Thomas F. T.; Schildbach, Anna; Klapproth, Jan; Schierhorn, Angelika; Mahour, Reza; Pietzsch, Markus; Rapp, Erdmann; Reichl, Udo
In: Biotechnology & bioengineering - New York, NY [u.a.]: Wiley, Bd. 115 (2018), 1, S. 192-205
Steric exclusion chromatography for purification of cell culture-derived influenza A virus using regenerated cellulose membranes and polyethylene glycol
Marichal-Gallardo, Pável Alejandro; Pieler, Michael M.; Wolff, Michael W.; Reichl, Udo
In: Journal of chromatography - New York, NY [u.a.] : Science Direct, Bd. 1483.2017, S. 110-119
Dissertation
Charakterisierung von mikrobiellen Gemeinschaften aus Biogasanlagen mittels Metaproteomanalyse und Korrelationen der Ergebnisse zu den Prozessparametern
Heyer, Robert Steven; Reichl, Udo
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2017, XVII, 164, xxxvii Blätter, Illustrationen
Investigation of influenza virus particle aggregation and purification with magnetic sulfated cellulose particles
Pieler, Michael Martin; Reichl, Udo
In: Magdeburg, 2017, xxv, 97 Seiten, Illustrationen
Characterisation of cell growth, metabolism and recombinant protein production during transient and steady state conditions for the human cell line AGE1.HN.AAT
Rath, Alexander; Sundmacher, Kai; Reichl, Udo
In: Magdeburg, 2017, XV, 178, xvi Seiten, Illustrationen, Diagramme, 30 cm
2016
Aufsatz
Predicting compositions of microbial communities from stoichiometric models with applications for the biogas process
Koch, Sabine; Benndorf, Dirk; Fronk, Karen; Reichl, Udo; Klamt, Steffen
In: Biotechnology for biofuels - London : BioMed Central, Bd. 9 (2016), Heft 17, insges. 16 S.
Proteotyping of biogas plant microbiomes separates biogas plants according to process temperature and reactor type
Heyer, Robert; Benndorf, Dirk; Kohrs, F.; Vrieze, J.; Boon, N.; Hoffmann, M.; Rapp, Erdmann; Schlüter, A.; Sczyrba, A.; Reichl, Udo
In: Biotechnology for biofuels - London : BioMed Central, Bd. 9 (2016), Heft 1
Begutachteter Zeitschriftenartikel
Early changes in the metabolic profile of activated CD8+ T cells
Cammann, Clemens; Rath, Alexander; Reichl, Udo; Lingel, Holger; Brunner-Weinzierl, Monika; Simeoni, Luca; Schraven, Burkhart; Lindquist, Jonathan A.
In: BMC cell biology - London : BioMed Central - Bd. 17.2016, Art.-Nr. 28, insges. 11 S.
Impaired antiviral response of adenovirus-transformed cell lines supports virus replication
Bachmann, Mandy; Breitwieser, Theresa; Lipps, Christoph; Wirth, Dagmar; Jordan, Ingo; Reichl, Udo; Frensing, Timo
In: Journal of general virology: JGV - Reading: Soc., 1967, Bd. 97.2016, 2, S. 293-298
Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
Tapia Delgado, Felipe Ignacio; Vázquez Ramírez, Daniel; Genzel, Yvonne; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 100 (2016), 5, S. 2121-2132
Sialic acid-specific affinity chromatography for the separation of erythropoietin glycoforms using serotonin as a ligand
Meininger, M.; Stepath, M.; Hennig, R.; Cajic, S.; Rapp, E.; Rotering, H.; Wolff, M. W.; Reichl, Udo
In: Journal of chromatography / B - New York, NY [u.a.]: Science Direct, 1977, Bd. 1012/1013.2016, S. 193-203
Towards personalized diagnostics via longitudinal study of the human plasma N-glycome
Hennig, René; Cajic, Samanta; Borowiak, Matthias; Hoffmann, Marcus; Kottler, Robert; Reichl, Udo; Rapp, Erdmann
In: Biochimica et biophysica acta / General subjects: BBA - Amsterdam [u.a.]: Elsevier, 1964, Bd. 1860.2016, 8, S. 1728-1738
Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells
Frensing, Timo; Kupke, Sascha Young; Bachmann, Mandy; Fritzsche, Susanne; Gallo-Ramirez, Lili E.; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 100.2016, 16, S. 7181-7192
Binding kinetics and multi-bond : finding correlations by synthesizing interactions between ligand-coated bionanoparticles and receptor surfaces
Wang, Wenjing; Voigt, Andreas; Wolff, Michael W.; Reichl, Udo; Sundmacher, Kai
In: Analytical biochemistry : methods in the biological sciences. - San Diego, Calif : Elsevier, Bd. 505.2016, S. 8-17
A membrane-based purification process for cell culture-derived influenza A virus
Weigel, Thomas; Solomaier, Thomas; Wehmeyer, Sebastian; Peuker, Alessa; Wolff, Michael W.; Reichl, Udo
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, 1984, Bd. 220.2016, S. 12-20
Metaproteomics applied to activated sludge for industrial wastewater treatment revealed a dominant methylotrophic metabolism of Hyphomicrobium zavarzinii
Salerno, Carlo; Benndorf, Dirk; Pech, Sabine; Palese, Luigi Leonardo; Reichl, Udo; Pollice, Alfieri
In: Microbial ecology - New York, NY: Springer . - 2016
Site-specific O-glycosylation analysis of human blood plasma proteins
Hoffmann, Marcus; Marx, Kristina; Reichl, Udo; Wuhrer, Manfred; Rapp, Erdmann
In: Molecular & cellular proteomics: MCP - Bethesda, Md: The American Society for Biochemistry and Molecular Biology, 2002, Bd. 15.2016, 2, S. 624-641
Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital Disorder of glycosylation (PMM2-CDG)
Thiesler, Christina T.; Cajic, Samanta; Hoffmann, Dirk; Thiel, Christian; Diepen, Laura van; Hennig, René; Sgodda, Malte; Weiβmann, Robert; Reichl, Udo; Steinemann, Doris; Diekmann, Ulf; Huber, Nicolas M. B.; Oberbeck, Astrid; Cantz, Tobias; Kuss, Andreas W.; Körner, Christian; Schambach, Axel; Rapp, Erdmann; Büttner, Falk
In: Molecular & cellular proteomics - Bethesda, Md. : The American Society for Biochemistry and Molecular Biology, Bd. 15 (2016), Heft 4, S. 1435-1452
A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection
Pieler, Michael M.; Frentzel, Sarah; Bruder, Dunja; Wolff, Michael W.; Reichl, Udo
In: Vaccine - Amsterdam: Elsevier, 1983, Bd. 34.2016, 50, S. 6367-6374
Reprint of "Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs
Laske, Tanja; Heldt, Frank Stefan; Hoffmann, Helene; Frensing, Timo; Reichl, Udo
In: Virus research : an international journal of molecular and cellular virology. - Amsterdam [u.a.] : Elsevier Science, Bd. 218.2016, S. 86-95
Ezrin and HNRNP expression correlate with increased virus release rate and early onset of virus-induced apoptosis of MDCK suspension cells
Kluge, Sabine; Genzel, Yvonne; Laus, Kim; Serve, Anja; Pflugmacher, Antje; Peschel, Britta; Rapp, Erdmann; Reichl, Udo
In: Biotechnology journal : BTJ ; systems & synthetic biology, nanobiotech, medicine. - Weinheim : Wiley-VCH, Bd. 11.2016, 10, S. 1332-1342
Diagnostic concept for dynamically operated biogas production plants
Bensmann, Astrid; Hanke-Rauschenbach, Richard; Heyer, Robert; Kohrs, Fabian; Benndorf, Dirk; Kausmann, Robert; Plöchl, Matthias; Heiermann, Monika; Reichl, Udo; Sundmacher, Kai
In: Renewable energy - Amsterdam [u.a.]: Elsevier Science, Vol. 96.2016, Part A, S. 479-489
Dissertation
Etablierung und Anwendung einer durchflusszytometrischen Methode für die Vitalitätsbestimmung von P. aeruginosa, B. cepacia und S. aureus in Mischkulturen
Rüger, Marc; Reichl, Udo
In: Magdeburg, 2016, XIV, 161, viii Blätter, Illustrationen
Purification of cell culture-derived influenza virus using simulated moving bed chromatography
Kröber, Tina; Reichl, Udo; Seidel-Morgenstern, Andreas
In: Magdeburg, 2016, XX, 171 Seiten, Illustrationen, Diagramme, 30 cm
Proteomanalytik der Adaption tierischer Zelllinien an Suspensionswachstum und optimierte Medien im Kontext der Impfstoffproduktion
Pech, Sabine; Reichl, Udo
In: Magdeburg: Otto-von-Guericke-Universität Magdeburg, 2016, XXIV, 192, lxxvii Seiten, Illustrationen, Diagramme, 30 cm
Novel computational methods for the analysis and interpretation of MS/MS data in metaproteomics
Muth, Thilo; Weiß, Helmut; Reichl, Udo
In: Magdeburg, 2016, XVI, 197 Seiten, Illustrationen
Modellbasierte Bestimmung von Interventionsstrategien zur Optimierung der Produktion von Biokraftstoffen in Cyanobakterien
Erdrich, Philipp; Reichl, Udo; Kienle, Achim
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik 2016, xx, 158 Seiten [Literaturverzeichnis: Seite 131-158][Literaturverzeichnis: Seite 131-158]
2015
Aufsatz
Metaproteomics of activated sludge from a wastewater treatment plant - a pilot study
Püttker, Sebastian; Kohrs, Fabian; Benndorf, Dirk; Heyer, Robert; Rapp, Erdmann; Reichl, Udo
In: Proteomics - Weinheim : Wiley VCH, Bd. 15 (2015), Heft 20, S. 3596-3601
Comparison of influenza virus particle purification using magnetic sulfated cellulose particles with an established centrifugation method for analytics
Serve, Anja; Pieler, Michael Martin; Benndorf, Dirk; Rapp, Erdmann; Wolff, Michael Werner; Reichl, Udo
In: Analytical chemistry - Columbus, Ohio : American Chemical Society, Bd. 87 (2015), Heft 21, S. 10708-10711
Metaproteomics of complex microbial communities in biogas plants
Heyer, Robert; Kohrs, Fabian; Reichl, Udo; Benndorf, Dirk
In: Microbial biotechnology - Oxford : Wiley-Blackwell, Bd. 8 (2015), Heft 5, S. 749-763
The MetaProteomeAnalyzer - a powerful open-source software suite for metaproteomics data analysis and interpretation
Muth, Thilo; Behne, Alexander; Heyer, Robert; Kohrs, Fabian; Benndorf, Dirk; Hoffmann, Marcus; Lehtevä, Miro; Reichl, Udo; Martens, Lennart; Rapp, Erdmann
In: Journal of proteome research - Washington, DC : ACS Publications, Bd. 14 (2015), Heft 3, S. 1557-1565
Fractionation of biogas plant sludge material improves metaproteomic characterization to investigate metabolic activity of microbial communities
Kohrs, Fabian; Wolter, Sophie; Benndorf, Dirk; Heyer, Robert; Hoffmann, Marcus; Rapp, Erdmann; Bremges, Andreas; Sczyrba, Alexander; Schlüter, Andreas; Reichl, Udo
In: Proteomics - Weinheim : Wiley VCH, Bd. 15 (2015), Heft 20, S. 3585-3589
Begutachteter Zeitschriftenartikel
Community shifts in a well-operating agricultural biogas plant - how process variations are handled by the microbiome
Theuerl, Susanne; Kohrs, Fabian; Benndorf, Dirk; Maus, Irena; Wibberg, Daniel; Schlüter, Andres; Kausmann, Robert; Heiermann, Monika; Rapp, Erdmann; Reichl, Udo; Pühler, Alfred; Klocke, Michael
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 99 (2015), 18, S. 7791-7803
Exclusive decoration of simian immunodeficiency virus Env with high-mannose type N-glycans is not compatible with mucosal transmission in rhesus macaques
Karsten, Christina B.; Büttner, Falk; Cajic, Samanta; Nehlmeier, Inga; Neumann, Berit; Klippert, Antonina; Sauermann, Ulrike; Reichl, Udo; Gerardy-Schahn, Rita; Rapp, Erdmann; Stahl-Hennig, Christiane; Pöhlmann, Stefan
In: Journal of virology - Baltimore, Md. : Soc., Bd. 89 (2015), Heft 22, S. 11727-11733
Monitoring changes in proteome during stepwise adaptation of a MDCK cell line from adherence to growth in suspension
Pech, Sabine; Benndorf, Dirk; Genzel, Yvonne; Scharfenberg, Klaus; Rapp, Erdmann; Reichl, Udo
In: Vaccine - Amsterdam: Elsevier, Bd. 33 (2015), 35, S. 4269-4280
Editorial: Can modern vaccine technology pursue the success of traditional vaccine manufacturing?
Grabherr, Reingard; Reichl, Udo
In: Biotechnology journal: BTJ : systems & synthetic biology, nanobiotech, medicine - Weinheim: Wiley-VCH, Bd. 10.2015, 5, S. 657-658
Colonic metaproteomic signatures of active bacteria and the host in obesity
Kolmeder, Carolin A.; Ritari, Jarmo; Verdam, Froukje J.; Muth, Thilo; Keskitalo, Salla; Varjosalo, Markku; Fuentes, Susana; Greve, Jan Willem; Buurman, Wim A.; Reichl, Udo; Rapp, Erdmann; Martens, Lennart; Palva, Airi; Salonen, Anne; Rensen, Sander S.; Vos, Willem M.
In: Proteomics - Weinheim : Wiley VCH, Bd. 15 (2015), Heft 20, S. 3544-3552
Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection
Heldt, Frank S.; Kupke, Sascha Young; Dorl, Sebastian; Reichl, Udo; Frensing, Timo
In: Nature Communications - [London]: Nature Publishing Group UK, 2010, Vol. 6.2015, Art. 8938, insgesamt 12 S.
Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs
Laske, Tanja; Heldt, Frank Stefan; Hoffmann, Helene; Frensing, Timo; Reichl, Udo
In: Virus research: an international journal of molecular and cellular virology - Amsterdam [u.a.]: Elsevier Science, 1984, Bd. 213.2015, S. 90-99
Navigating through metaproteomics data - a logbook of database searching
Muth, Thilo; Kolmeder, Carolin A.; Salojärvi, Jarkko; Keskitalo, Salla; Varjosalo, Markku; Verdam, Froukje J.; Rensen, Sander S.; Reichl, Udo; Vos, Willem M.; Rapp, Erdmann; Martens, Lennart
In: Proteomics - Weinheim: Wiley VCH, 2001, Bd. 15.2015, 20, S. 3439-3453
Bioreactor concepts for cell culture-based viral vaccine production
Gallo-Ramírez, Lilí Esmeralda; Nikolay, Alexander; Genzel, Yvonne; Reichl, Udo
In: Expert review of vaccines - Abingdon, Oxon: Taylor & Francis, 2002, Bd. 14.2015, 9, S. 1181-1195
Dissertation
Population balance modeling of influenza A virus replication in MDCK cells during vaccine production
Müller, Thomas; Kienle, Achim; Reichl, Udo
In: Magdeburg, Univ., Fak. für Elektrotechnik und Informationstechnik, Diss., 2015, X, 127 S.
Infection dynamics and virus-induced apoptosis in influenza virus A infected adherent and suspension MDCK cells
Peschel, Britta; Reichl, Udo; Marwan, Wolfgang
In: Aachen: Shaker, Zugl.: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2015, VI, 180 S. - (Forschungsberichte aus dem Max-Planck-Institut für Dynamik komplexer technischer Systeme; 44), ISBN: 978-3-8440-3738-8
Mathematical models of influenza A virus infection - from intracellular replication to virus growth in cell populations
Heldt, Frank Stefan; Frensing, Timo; Reichl, Udo
In: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2015, 2014, XX, 190 S., graph. Darst.
2014
Aufsatz
Impact of cultivation conditions on N-glycosylation of influenza virus A hemagglutinin produced in MDCK cell culture
Rödig, Jana; Rapp, Erdmann; Bohne, Jana; Kampe, Michael; Kaffka, Helene; Bock, Andreas; Genzel, Yvonne; Reichl, Udo
In: Biotechnology & bioengineering - New York, NY [u.a.] : Wiley, Bd. 110 (2014), Heft 6, S. 1691-1703
Sample prefractionation with liquid isoelectric focusing enables in depth microbial metaproteome analysis of mesophilic and thermophilic biogas plants
Kohrs, Fabian; Heyer, Robert; Magnussen, A.; Benndorf, Dirk; Muth, Thilo; Behne, Alexander; Rapp, Erdmann; Kausmann, Robert; Heiermann, Monika; Klocke, Michael; Reichl, Udo
In: Anaerobe - London : Academic Press, Bd. 29 (2014), S. 59-67
Buchbeitrag
Flow cytometric viability assessment of lactic acid bacteria starter cultures produced by fluidized bed drying
Bensch, Gerald; Rüger, Marc; Wassermann, Magdalena; Weinholz, Susann; Reichl, Udo; Cordes, Christiana
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 98 (2014), Heft 11, S. 4897-4909
Species-specific viability analysis of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus in mixed culture by flow cytometry
Rüger, Marc; Ackermann, Mandy; Reichl, Udo
In: BMC microbiology - London : BioMed Central - Bd. 14.2014, Art. 56, insgesamt 15 S.
Begutachteter Zeitschriftenartikel
The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells
Rath, Alexander; Rehberg, Markus; Janke, Robert; Genzel, Yvonne; Scholz, Sebastian; Noll, Thomas; Rose, Thomas; Sandig, Volker; Reichl, Udo
In: Journal of biotechnology - Amsterdam [u.a.]: Elsevier Science, Bd. 178.2014, S. 43-53
Glycolysis is governed by growth regime and simple enzyme regulation in adherent MDCK cells
Rehberg, Markus; Ritter, Joachim B.; Reichl, Udo
In: PLoS Computational Biology: a new community journal - San Francisco, Calif: Public Library of Science, Vol. 10.2014, 10, Art. e1003885, insgesamt 16 S.
Biological methanation of hydrogen within biogas plants - a model-based feasibility study
Bensmann, Astrid; Hanke-Rauschenbach, R.; Heyer, Robert; Kohrs, Fabian; Benndorf, Dirk; Reichl, Udo; Sundmacher, Kai
In: Applied energy - Amsterdam [u.a.]: Elsevier Science, Bd. 134 (2014), S. 413-425
The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis
Lohr, Verena; Hädicke, Oliver; Genzel, Yvonne; Jordan, Ingo; Büntemeyer, Heino; Klamt, Steffen; Reichl, Udo
In: BMC biotechnology - London: BioMed Central, Vol. 14.2014, Art. 72 insgesamt 14 S.
Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological
Huffman, Jennifer E.; Pučić-Baković, Maja; Klarić, Lucija; Hennig, René; Selman, Maurice H. J.; Vučković, Frano; Novokmet, Mislav; Krištić, Jasminka; Borowiak, Matthias; Muth, Thilo; Polašek, Ozren; Razdorov, Genadij; Gornik, Olga; Plomp, Rosina; Theodoratou, Evropi; Wright, Alan F.; Rudan, Igor; Hayward, Caroline; Campbell, Harry; Deelder, André M.; Reichl, Udo; Aulchenko, Yurii S.; Rapp, Erdmann; Wuhrer, Manfred; Lauc, Gordan
In: Molecular & cellular proteomics: MCP - Bethesda, Md: The American Society for Biochemistry and Molecular Biology, Bd. 13.2014, S. 1598-1610
Changes in intracellular metabolite pools during growth of adherent MDCK cells in two different media
Rehberg, M.; Rath, A.; Ritter, J. B.; Genzel, Y.; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin: Springer, Bd. 98.2014, 1, S. 385-397
Impact of defective interfering particles on virus replication and antiviral host response in cell culture-based influenza vaccine production
Frensing, Timo; Pflugmacher, Antje; Bachmann, Mandy; Peschel, Britta; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin: Springer, 1975, Bd. 98.2014, 21, S. 8999-9008
Avidity of influenza virus: Model-based identification of adsorption kinetics from surface plasmon resonance experiments
Wang, Wenjing; Wolff, Michael W.; Reichl, Udo; Sundmacher, Kai
In: Journal of chromatography / A - New York, NY [u.a.]: Science Direct, Bd. 1326.2014, S. 125-129
Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactor
Tapia Delgado, Felipe Ignacio; Vogel, Thomas; Genzel, Yvonne; Behrendt, Ilona; Hirschel, Mark; Gangemi, J. David; Reichl, Udo
In: Vaccine - Amsterdam: Elsevier, 1983, Bd. 32.2014, 8, S. 1003-1011
Vaccine production - upstream processing with adherent or suspension cell lines
Genzel, Yvonne; Rödig, Jana; Rapp, Erdmann; Reichl, Udo
In: Animal Cell Biotechnology , 3rd ed. 2014 - Totowa, NJ : Humana Press , 2014, S. 371-393 - (Methods in Molecular Biology, Methods and Protocols; 1104)
High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells
Genzel, Yvonne; Vogel, Thomas; Buck, Johannes; Behrendt, Ilona; Vázquez Ramírez, Daniel; Schiedner, Gudrun; Jordan, Ingo; Reichl, Udo
In: Vaccine - Amsterdam: Elsevier, Bd. 32 (2014), 24, S. 2770-2781
A flow-through chromatography process for influenza A and B virus purification
Weigel, Thomas; Solomaier, Thomas; Peuker, Alessa; Pathapati, Trinath; Wolff, Michael W.; Reichl, Udo
In: Journal of virological methods - Amsterdam [u.a.]: Elsevier Science, Bd. 207.2014, S. 45-53
Dissertation
Characterization of the avian designer cells AGE1.CR and AGE1.CR.plX considering growth, metabolism and production of influenza virus and Modified Vaccinia Virus Ankara (MVA)
Lohr, Verena; Reichl, Udo
In: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2014, IX, 178 S., Ill., graph. Darst., 30 cm
Impact of cultivation conditions on N-glycosylation of influenza A virus hemagglutinin, on quasispecies composition, and on immunogenicity of virus preparations
Rödig, Jana Verena; Reichl, Udo
In: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2014, XVII, 159, S44 Bl., graph. Darst.
Habilitation
Improving industrial antibody manufacturing processes using animal cell culture technology
Pohlscheidt, Michael; Reichl, Udo
In: Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Habil.-Schr., 2014, Getr. Zählung, Ill., graph. Darst., 30 cm
Herausgeberschaft
Large-Scale Networks in Engineering and Life Sciences
Benner, Peter; Findeisen, Rolf; Flockerzi, Dietrich; Reichl, Udo; Sundmacher, Kai
In: Cham: Birkhäuser, 2014, Online-Ressource (XIV, 388 p. 111 illus., 63 illus. in color, online resource) - (Modeling and Simulation in Science, Engineering and Technology; SpringerLink; Bücher; Springer eBook Collection; Mathematics and Statistics), ISBN: 978-3-319-08437-4
2013
Aufsatz
Metaproteome analysis of the microbial communities in agricultural biogas plants
Heyer, Robert; Kohrs, Fabian; Benndorf, Dirk; Rapp, Erdmann; Kausmann, Robert; Heiermann, Monika; Klocke, Michael; Reichl, Udo
In: New biotechnology - New York, NY [u.a.] : Elsevier, Bd. 30 (2013), Heft 6, S. 614-622
Begutachteter Zeitschriftenartikel
PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia
Tung, Stephanie; Shi, Yonghong; Wong, Karry; Zhu, Fang; Gorczynski, Reg; Laister, Robert C.; Minden, Mark; Blechert, Anne-Kareen; Genzel, Yvonne; Reichl, Udo; Spaner, David E.
In: Blood. - Stanford, Calif : HighWire Press, Bd. 112.2013, 6, S. 969-980
Development of a high-throughput glycoanalysis method for the characterization of oligosaccharides in human milk utilizing multiplexed capillary gel electrophoresis with laser-induced fluorescence detection
Kottler, Robert; Mank, Marko; Hennig, René; Müller-Werner, Beate; Stahl, Bernd; Reichl, Udo; Rapp, Erdmann
In: Electrophoresis. - Weinheim : Wiley-Blackwell, Bd. 34.2013, 16, S. 2323-2336
Elements in the development of a production process for modified vaccinia virus ankara
Jordan, Ingo; Lohr, Verena; Genzel, Yvonne; Reichl, Udo; Sandig, Volker
In: Microorganisms. - Basel : MDPI, Bd. 1.2013, 1, S. 100-121
Metagenome and metaproteome analyses of microbial communities in mesophilic biogas-producing anaerobic batch fermentations indicate concerted plant carbohydrate degradation
Hanreich, Angelika; Schimpf, Ulrike; Zakrzewski, Martha; Schlüter, Andreas; Benndorf, Dirk; Heyer, Robert; Rapp, Erdmann; Pühler, Alfred; Reichl, Udo; Klocke, Michael
In: Systematic and applied microbiology - München: Elsevier, Bd. 36 (2013), 5, S. 330-338
Proteome analysis of virus–host cell interaction - rabies virus replication in Vero cells in two different media
Pech, Sabine; Rourou, Samia; Vester, Diana; Majoul, Samy; Benndorf, Dirk; Genzel, Yvonne; Rapp, Erdmann; Kallel, Héla; Reichl, Udo
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 97 (2013), Heft 12, S. 5493-5506
Multiscale modeling of influenza A virus infection supports the development of direct-acting antivirals
Heldt, Frank S.; Frensing, Timo; Pflugmacher, Antje; Gröpler, Robin; Peschel, Britta; Reichl, Udo
In: PLoS Computational Biology: a new community journal/ Public Library of Science - San Francisco, Calif.: Public Library of Science, 2005, Bd. 9.2013, 11, Art. e1003372, insges. 13 S.
Searching for a needle in a stack of needles: challenges in metaproteomics data analysis
Muth, Thilo; Benndorf, Dirk; Reichl, Udo; Rapp, Erdmann; Martens, Lennart
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, Bd. 9 (2013), 4, S. 578-585
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