Prof. Hoffmann

Prof. Dr. rer. nat. Werner Hoffmann

Medizinische Fakultät/Universitätsklinikum A.ö.R. (FME/UKMD)
Institut für Molekularbiologie und Medizinische Chemie (IMMC)
Haus 29c, Leipziger Str. 44, 39120, Magdeburg, H29c/301
Projekte
Publikationen

2022

Begutachteter Zeitschriftenartikel

Vilchez-Vargas, Ramiro;  Salm, Franz;  Znalesniak, Eva B.;  Haupenthal, Katharina;  Schanze, Denny;  Zenker, Martin;  Link, Alexander;  Hoffmann, Werner 

Profiling of the bacterial microbiota along the murine alimentary tract
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 3, insges. 15 S.

Hoffmann, Werner 

Self-renewal and cancers of the gastric epithelium - an update and the role of the lectin TFF1 as an antral tumor suppressor
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 10, insges. 23 S.

2021

Begutachteter Zeitschriftenartikel

Hoffmann, Werner 

Salivary trefoil factor family (TFF) peptides and their roles in oral and esophageal protection - therapeutic potential
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 22, insges. 12 S.

Hoffmann, Werner 

Trefoil factor family (TFF) peptides
In: Encyclopedia - Basel: MDPI, 2021, Bd. 1 (2021), 3, S. 974-987

Hoffmann, Werner 

Trefoil factor family (TFF) peptides and their different roles in the mucosal innate immune defense and more - an update
In: Current medicinal chemistry - Hilversum [u.a.]: Bentham Science Publ., Bd. 28 (2021), 36, S. 7387-7399

Hoffmann, Werner 

Trefoil factor family (TFF) peptides and their links to inflammation - a re-evaluation and new medical perspectives
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 9, insges. 22 S.

Dissertation

Heuer, Franziska;  Hoffmann, Werner [AkademischeR BetreuerIn] 

TFF2 (Trefoil Factory Family 2) im Magen von Mensch und Schwein - Charakterisierung der Bindung des Peptids TFF2 an den Mukus
In: Magdeburg, 2021, 146 Blätter, Illustrationen, Diagramme, 30 cm

2020

Begutachteter Zeitschriftenartikel

Emidio, Nayara Braga;  Baik, Hayeon;  Lee, David;  Stürmer, René;  Heuer, Jörn;  Elliott, Alysha G.;  Blaskovich, Mark A. T.;  Haupenthal, Katharina;  Tegtmeyer, Nicole;  Hoffmann, Werner;  Schroeder, Christina I.;  Muttenthaler, Markus 

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action
In: Chemical communications - Cambridge: Soc., 1965, Bd. 56 (2020), 47, S. 6420-6423

Znalesniak, Eva B.;  Salm, Franz;  Hoffmann, Werner 

Molecular alterations in the stomach of Tff1-deficient mice - early steps in antral carcinogenesis
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 2, Art.-Nr. 644, insges. 16 Seiten

Schwarz, Heinz;  Hoffmann, Werner 

Subcellular localization of the TFF peptides xP1 and xP4 in the Xenopus laevis gastric/esophageal mucosa - different secretion modes reflecting diverse protective functions
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 3, Art.-Nr. 761, insges. 9 Seiten

Heuer, Jörn;  Heuer, Franziska;  Stürmer, René;  Harder, Sönke;  Schlüter, Hartmut;  Emidio, Nayara Braga;  Muttenthaler, Markus;  Jechorek, Dörthe;  Meyer, Frank;  Hoffmann, Werner 

The tumor suppressor TFF1 occurs in different forms and interacts with multiple partners in the human gastric mucus barrier - indications for diverse protective functions
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 7, Art.-Nr. 2508, insges. 18 Seiten

Stürmer, René;  Reising, Jana;  Hoffmann, Werner 

Trefoil factor family (TFF) modules are characteristic constituents of separate mucin complexes in the Xenopus laevis integumentary mucus - in vitro binding studies with FIM-A.1
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 7, Art.-Nr. 2400, insges. 11 Seiten

Hoffmann, Werner 

Trefoil factor family (TFF) peptides and their diverse molecular functions in mucus barrier protection and more - changing the paradigm
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 12, Art.-Nr. 4535, insgesamt 20 Seiten

2019

Begutachteter Zeitschriftenartikel

Heuer, Franziska;  Stürmer, René;  Heuer, Jörn;  Kalinski, Thomas;  Lemke, Antje;  Meyer, Frank;  Hoffmann, Werner 

Different forms of TFF2, a lectin of the human gastric mucus barrier - in vitro binding studies
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 23, Art.-Nr. 5871, insges. 13 Seiten

Houben, Till;  Harder, Sönke;  Schlüter, Hartmut;  Kalbacher, Hubert;  Hoffmann, Werner 

Different forms of TFF3 in the human saliva - heterodimerization with IgG Fc binding protein (FCGBP)
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd.20.2019, 20, Art.-Nr. 5000, insges. 10 Seiten

Stürmer, René;  Reising, Jana;  Hoffmann, Werner 

The TFF peptides xP1 and xP4 appear in distinctive forms in the Xenopus laevis gastric mucosa - indications for different protective functions
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd.20.2019, 23, Art.-Nr. 6052, insges. 9 Seiten

Emidio, Nayara Braga;  Hoffmann, Werner;  Brierley, Stuart M.;  Muttenthaler, Markus 

Trefoil factor family - unresolved questions and clinical perspectives
In: Trends in biochemical sciences - Amsterdam [u.a.]: Elsevier Science, Bd. 44.2019, 5, S. 387-390

2018

Begutachteter Zeitschriftenartikel

Stürmer, René;  Harder, Sönke;  Schlüter, Hartmut;  Hoffmann, Werner 

Commercial porcine gastric mucin preparations, also used as artificial saliva, are a rich source for the lectin TFF2 - in vitro binding studies
In: ChemBioChem - Weinheim: Wiley-VCH, Bd. 19.2018, 24, S. 2598-2608

2017

Begutachteter Zeitschriftenartikel

Znalesniak, Eva B.;  Fu, Ting;  Salm, Franz;  Händel, Ulrike;  Hoffmann, Werner 

Transcriptional responses in the murine spleen after Toxoplasma gondii infection - inflammasome and mucus-associated genes
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 6, Art.-Nr. 1245, insges. 10 S.

Bolle, Tim;  Meyer, Frank;  Walcher, Felix;  Lohmann, Christoph H.;  Jockenhövel, Stefan;  Gries, Thomas;  Hoffmann, Werner 

Werkstoffe/Biomaterialien in der interventionellen und operativen Medizin - eine kurze Übersicht und aktuelle Trends
In: Zentralblatt für Chirurgie: Zeitschrift für allgemeine, viszeral-, Thorax- und Gefäßchirurgie - Stuttgart [u.a.]: Thieme, 2000, Bd. 142.2017, 2, S. 216-225

2016

Abstract

Hoffmann,Werner 

What stem cells have to do with stomach cancer
In: 2016

Begutachteter Zeitschriftenartikel

Znalesniak, Eva B.;  Fu, Ting;  Guttek, Karina;  Händel, Ulrike;  Reinhold, Dirk;  Hoffmann, Werner 

Increased cerebral Tff1 expression in two murine models of neuroinflammation
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 39.2016, 6, S. 2287-2296

2015

Begutachteter Zeitschriftenartikel

Hoffmann, Werner 

Current status on stem cells and cancers of the gastric epithelium
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, Bd. 16.2015, 8, S. 19153-19169

Bernstein, Hans-Gert;  Dobrowolny, Henrik;  Trübner, Kurt;  Steiner, Johann;  Bogerts, Bernhard;  Hoffmann, Werner 

Differential regional and cellular distribution of TFF3 peptide in the human brain
In: Amino acids - Wien [u.a.]: Springer, Bd. 47 (2015), 5, S. 1053-1063

Fu, Ting;  Znalesniak, Eva B.;  Kalinski, Thomas;  Möhle, Luisa;  Biswas, Aindrila;  Salm, Franz;  Dunay, Ildikò Rita;  Hoffmann, Werner 

TFF peptides play a role in the immune response following oral infection of mice with Toxoplasma gondii
In: European journal of microbiology and immunology - Budapest: Akad. Kiadó, Bd. 5.2015, 3, S. 221-231

Hoffmann, Werner 

TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)
In: International journal of oncology - Athens: Spandidos Publ, Bd. 47.2015, 3, S. 806-816

2014

Begutachteter Zeitschriftenartikel

Hoffmann, Werner 

Kontinuierliche Regeneration des Magenepithels durch Zelldifferenzierung - Bedeutung für die Karzinogenese
In: Der Pathologe: Organ der Deutschen Abteilung der Internationalen Akademie für Pathologie, der Deutschen, der Österreichischen und der Schweizerischen Gesellschaft für Pathologie und des Berufsverbandes Deutscher Pathologen - Berlin: Springer, 1994, Bd. 35.2014, Suppl.2, S. 202-206

Stürmer, René;  Müller, Stefan;  Hanisch, Franz-Georg;  Hoffmann, Werner 

Porcine gastric TFF2 is a mucus constituent and differs from pancreatic TFF2
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 33 (2014), 4, S. 895-904

Fu, Ting;  Stellmacher, Anne;  Znalesniak, Eva B.;  Dieterich, Daniela C.;  Kalbacher, Hubert;  Hoffmann, Werner 

Tff3 is expressed in neurons and microglial cells
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 34 (2014), 6, S. 1912-1919

Dissertation

Fu, Ting;  Hoffmann, Werner [Gutachter] 

In vivo and in vitro studies on the expression and function of TFF peptides in the gastrointestinal tract and the central nervous system
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014, VIII, 101, VI Bl., Ill., graph. Darst., 30 cm

2013

Begutachteter Zeitschriftenartikel

Hanisch, Franz-Georg;  Ragge, Hubert;  Kalinski, Thomas;  Meyer, Frank;  Kalbacher, Hubert;  Hoffmann, Werner 

Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide
In: Glycobiology: official journal of the Society for Glycobiology - Oxford: Oxford University Press, 1990, Bd. 23.2013, 1, S. 2-11

Hoffmann, Werner 

Self-renewal of the gastric epithelium from stem and progenitor cells
In: Frontiers in bioscience: a journal and virtual library - Searington, NY, Bd. 5 (2013), 2, S. 720-731

Fu, Ting;  Kalbacher, Hubert;  Hoffmann, Werner 

TFF1 is differentially expressed in stationary and migratory rat gastric epithelial cells (RGM-1) after in vitro wounding: Influence of TFF1 RNA interference on cell migration
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 32 (2013), 4, S. 997-1010

Buchbeitrag

Hoffmann, Werner 

TFF peptides
In: Handbook of biologically active peptides - Amsterdam [u.a.]: Elsevier, Acad. Press, S. 1338-1345, 2013

2012

Originalartikel in begutachteter internationaler Zeitschrift

Hoffmann, Werner;  Singh, Shree Ram 

Stem cells in regenerative medicine and cancer. Editorial
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 19 (2012), 35, S. 5964

Hoffmann, Werner 

Stem cells, self-renewal and cancer of the gastric epithelium
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 19 (2012), 35, S. 5975-5983

2011

Originalartikel in begutachteter internationaler Zeitschrift

Hoffmann, Werner 

Gastric stem cells: Of flies and men
In: Cell cycle - London: Taylor & Francis, Bd. 10.2011, 8, S. 1186-1187

Kouznetsova, Irina;  Kalinski, Thomas;  Meyer, Frank;  Hoffmann, Werner 

Self-renewal of the human gastric epithelium: new insights from expression profiling using laser microdissection
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, Bd. 7 (2011), 4, S. 1105-1112

2010

Originalartikel in begutachteter internationaler Zeitschrift

Kouznetsova, Irina;  Gerlach, Klaus L.;  Zahl, Christian;  Hoffmann, Werner 

Expression analysis of human salivary glands by laser microdissection: differences between submandibular and labial glands
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 26.2010, 3, S. 375-382

Albert, Timo K.;  Laubinger, Werner;  Müller, Stefan;  Hanisch, Franz-Georg;  Kalinski, Thomas;  Meyer, Frank;  Hoffmann, Werner 

Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfide
In: Journal of proteome research / publ. by the American Chemical Society - Washington, DC: American Chemical Society, 2002, Bd. 9.2010, 6, S. 3108-3117

Znalesniak, Eva B.;  Hoffmann, Werner 

Modulation of cell-cell contacts during intestinal restitution in vitro and effects of epidermal growth factor (EGF)
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 25.2010, 4/5, S. 533-542

Rinnert, Margarita;  Hinz, Margitta;  Buhtz, Peter;  Reiher, Frank;  Lessel, Wolfgang;  Hoffmann, Werner 

Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine
In: Cell & tissue research - Berlin: Springer, Bd. 339.2010, 3, S. 639-647

2009

Originalartikel in begutachteter internationaler Zeitschrift

Ganss, Bernhard;  Hoffmann, Werner 

Calcium-induced conformational transition of trout ependymins monitored by tryptophan fluorescence
In: The open biochemistry journal - Sharjah [u.a.]: Bentham Open, Bd. 3.2009, S. 14-17

Znalesniak, Eva B.;  Dürer, Uwe;  Hoffmann, Werner 

Expression profiling of stationary and migratory intestinal epithelial cells after in vitro wounding: restitution is accompanied by cell differentiation
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 24.2009, 1/2, S. 125-132

Hoffmann, Werner 

Trefoil factor family (TFF) peptides and chemokine receptors: a promising relationship
In: Journal of medicinal chemistry - Easton, Pa: American Chemical Society, Bd. 52.2009, 21, S. 6505-6510

2008

Originalartikel in begutachteter internationaler Zeitschrift

Lubka, Maria;  Müller, Marcus;  Baus Loncar, Mirela;  Hinz, Margitta;  Blaschke, Karolina;  Hoffmann, Werner;  Pfister, Markus;  Löwenheim, Hubert Martin;  Pusch, Carsten;  Knipper, Marlies;  Blin, Nikolaus 

Lack of Tff3 peptide results in hearing impairment and accelerated presbyacusis
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 21.2008, 5/6, S. 437-444

Hoffmann, Werner 

Regeneration of the gastric mucosa and its glands from stem cells
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 15.2008, 29, S. 3133-3144

2007

Originalartikel in begutachteter internationaler Zeitschrift

Kouznetsova, Irina;  Laubinger, Werner;  Kalbacher, Hubert;  Kalinski, Thomas;  Meyer, Frank;  Roessner, Albert;  Hoffmann, Werner 

Biosynthesis of Gastrokine-2 in the human gastric mucosa: restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 20 (2007), 6, S. 899-908

Kouznetsova, Irina;  Chwieralski, Caroline Elisabeth;  Bälder, Ralf;  Hinz, Margitta;  Braun, Armin;  Krug, Norbert;  Hoffmann, Werner 

Induced trefoil factor family 1 expression by trans-differentiating Clara cells in a murine asthma model
In: American journal of respiratory cell and molecular biology: an official journal of the American Thoracic Society Medical Section of the American Lung Association - New York, NY, Bd. 36.2007, 3, S. 286-295

Kouznetsova, Irina;  Kalinski, Thomas;  Peitz, Ulrich;  Mönkemüller, Klaus E.;  Kalbacher, Hubert;  Vieth, Michael;  Meyer, Frank;  Roessner, Albert;  Malfertheiner, Peter;  Lippert, Hans;  Hoffmann, Werner 

Localization of TFF3 peptide in human esophageal submucosal glands and gastric cardia - differentiation of two types of gastric pit cells along the rostro-caudal axis
In: Cell & tissue research - Berlin: Springer, Bd. 328 (2007), 2, S. 365-374

Hoffmann, Werner 

TFF (trefoil factor family) peptides and their potential roles for differentiation processes during airway remodeling
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 14.2007, 25, S. 2716-2719

Dürer, Uwe;  Hartig, Roland;  Bang, Susanne;  Thim, Lars;  Hoffmann, Werner 

TFF3 and EGF induce different migration patterns of intestinal epithelial cells in vitro and trigger increased internalization of E-cadherin
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 20 (2007), 5, S. 329-346

LeSimple, Pierre;  Seuningen, Isabelle;  Buisine, Marie-Pierre;  Copin, Marie-Christine;  Hinz, Margitta;  Hoffmann, Werner;  Hajj, Rodolphe;  Brody, Steven L.;  Coraux, Christelle;  Puchelle, Edith 

Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation
In: American journal of respiratory cell and molecular biology: an official journal of the American Thoracic Society Medical Section of the American Lung Association - New York, NY, Bd. 36.2007, 3, S. 296-303

2006

Buchbeitrag

Hoffmann, Werner 

TFF (trefoil factor family) peptides
In: Handbook of biologically active peptides - Amsterdam [u.a.]: Elsevier / Acad. Press, S. 1147-1154, 2006

2005

Originalartikel in begutachteter internationaler Zeitschrift

Hoffmann, Werner 

TFF (trefoil factor family) peptide-triggered signals promoting mucosal restitution.
In: Cell. Mol. Life Sci. 2005;62:2932-2938.

Schäfer, Gesa;  Hoffmann, Werner;  Berry, Monica;  Paulsen, Friedrich 

Tränendrüsenassoziierte Muzine
In: Ophthalmologe 2005;102:175-183

2004

Originalartikel in begutachteter internationaler Zeitschrift

Kouznetsova, Irina;  Peitz, Ulrich;  Vieth, Michael W.R.;  Meyer, Frank;  Vestergaard, E. (ext.);  Malfertheiner, Peter;  Roessner, Albert;  Lippert, Hans;  Hoffmann, Werner 

A gradient of TFF3 (trefoil factor family 3) peptide synthesis within the normal human gastric mucosa.
In: Cell Tissue Res. 316(2004), Nr. 2, S. 155 - 165

Steven, P. (ext.);  Schaefer, Gesa Friederike;  Noelle, B. (ext.);  Hinz, Margitta;  Hoffmann, Werner;  Paulsen, F. (ext.) 

Distribution of TFF peptides in corneal disease and pterygium.
In: Peptides 25(2004), Nr. 5, S. 819 - 825

Chwieralski, Caroline;  Schnurra, Ingo;  Thim, L. (ext.);  Hoffmann, Werner 

Epidermal growth factor and trefoil factor family 2 synergistically trigger chemotaxis on BEAS-2B cells via different signaling cascades.
In: Am. J. Respir. Cell Mol. Biol. 31(2004), Nr. 5, S. 528 - 537

Paulsen, F. (ext.);  Schaefer, Gesa Friederike;  Hoffmann, Werner;  Berry, M. (ext.) 

Human lacrimal gland mucins.
In: Cell Tissue Res. 316(2004), Nr. 2, S. 167 - 177

Hertel, Silvia;  Chwieralski, Caroline;  Hinz, Margitta;  Rio, M.C. (ext.);  Tomasetto, C. (ext.);  Hoffmann, Werner 

Profiling trefoil factor family (TFF) expression in the mouse : identification of an antisense TFF1-related transcript in the kidney and liver.
In: Peptides 25(2004), Nr. 5, S. 755 - 762

Peitz, Ulrich;  Kouznetsova, Irina;  Wex, Thomas;  Gebert, Ingrid;  Vieth, Michael W.R.;  Roessner, Albert;  Hoffmann, Werner;  Malfertheiner, Peter 

TFF3 expression at the esophagogastric junction is increased in gastro-esophageal reflux disease (GERD).
In: Peptides 25(2004), Nr. 5, S. 771 - 777

Hinz, Margitta;  Schwegler, Herbert;  Chwieralski, Caroline;  Laube, Gregor;  Linke, Ruediger;  Pohle, W. (ext.);  Hoffmann, Werner 

Trefoil factor family (TFF) expression in the mouse brain and pituitary : changes in the developing cerebellum.
In: Peptides 25(2004), Nr. 5, S. 827 - 832

Hoffmann, Werner 

Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more [Editorial].
In: Peptides 25(2004), Nr. 5, S. 727 - 730

Originalartikel in begutachteter nationaler Zeitschrift

Paulsen, F. (ext.);  Corfield, A. (ext.);  Hinz, Margitta;  Hoffmann, Werner;  Schaudig, U. (ext.);  Thale, A. (ext.);  Berry, M. (ext.) 

Tränenabfluss : Bedeutung von Muzinen und TFF-Peptiden.
In: Ophthalmologe 101(2004), Nr. 1, S. 19 - 24

2003

Originalartikel in begutachteter internationaler Zeitschrift

Paulsen, Friedrich;  Corfiled Anthony;  Hinz, Margitta;  Hoffmann, Werner;  Schaudig, Ulrich;  Thale, Andreas;  Berry, Monica 

Characterization of Mucins in Human Lacrimal Sac and Nasolacrimal Duct
In: Invest. Ophthalmol. Vis. Sci. 2003;44:1807-1813

2002

Buchbeitrag

Schaefer, Gesa Friederike;  Jagla, Wolfgang;  Behrens-Baumann, Wolfgang;  Walter, Sven;  Hoffmann, Werner 

Ocular TFF-peptides : new mucus-associated secretory products of conjunctival goblet cells.
In: Sullivan, D. (Ed.) ; Stern, M. (Ed.) ; Tsubota, K. (Ed.) ; ... (Ed.): Lacrimal gland, tear film, and dry eye syndromes 3 : basic science and clinical relevance ; Part A (3rd International Conference on the Lacrimal Gland, Tear Film, and Dry Eye Syndromes, Mauii Hawaii November 2000). New York [u.a.] : Kluwer Acad. Plenum Publ., 2002, S. 313 - 316 (Advances in experimental medicine and biology ; 506)

Originalartikel in begutachteter internationaler Zeitschrift

Hoffmann, Werner;  Jagla, Wolfgang 

Cell type specific expression of secretory TFF peptides : colocalization with mucins and synthesis in the brain.
In: Int. Rev. Cytol. 213(2002), S. 147 - 181

Graness, Angela;  Chwieralski, Caroline;  Reinhold, Dirk;  Thim, L. (ext.);  Hoffmann, Werner 

Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL- 8 secretion.
In: J. Biol. Chem. 277(2002), Nr. 21, S. 18440 - 18446

Paulsen, F. (ext.);  Hinz, Margitta;  Schaudig, U. (ext.);  Thale, A. (ext.);  Hoffmann, Werner 

TFF peptides in the human efferent tear ducts.
In: Invest. Ophthalmol. Vis. Sci. 43(2002), Nr. 11, S. 3359 - 3364

Kooperationen
  • Institut für Pathologie (FME)
  • FAU Erlangen-Nürnberg (Lehrstuhl für Mikrobiologie)
  • Institut für Molekulare und Klinische Immunologie (FME)
  • Max-Planck-Institut für Entwicklungsbiologie Tübingen
  • TU München (Professur für Biomechanik)
  • Universitätsklinik für Allgemein-, Viszeral-, Gefäß- und Transplantationschirurgie (FME)
  • Universitätsklinik für Gastroenterologie, Hepatologie und Infektiologie (FME)
  • Universitätsklinik für Neurochirurgie (FME)
  • Universitätsklinik für Pneumologie (FME)
  • Universitätsklinikum Hamburg-Eppendorf
  • Institut für Mikrobiologie (FME)
Profil
  • TFF-Peptide in mukösen Epithelien
  • TFF-Peptide im Immun- und zentralen Nervensystem bzw. während entzündlicher Prozesse
  • Erneuerung des Magenepithels durch Differenzierung aus Stamm- und Vorläuferzellen
  • Reparatur muköser Epithelien  durch Zellmigration ("Restitution")
Service
Vita
1955geboren in Salzburg, Österreich  
1973-1978Diplomstudium der Chemie an der Universität Innsbruck; Sponsion zum "Magister rer. nat."
1978-1982 Dissertation am Institut für Molekularbiologie der Österreichischen Akademie der Wissenschaften in Salzburg; Promotion an der Universität Innsbruck zum "Doktor rer. nat."  
1983-1984Postdoctoral Fellow bei ZymoGenetics Inc. in Seattle, USA  
1984-1986Projektleiter am Institut für Molekularbiologie der ÖAW in Salzburg  
1987-1993Leiter der Nachwuchsgruppe Molekulare Genetik am Max-Planck-Institut für Psychiatrie in Martinsried  
1991Habilitation für das Fachgebiet Biochemie an der Universität Innsbruck  
seit 1993Professur für Medizinische Chemie und Direktor des IMMC an der Medizinischen Fakultät der Otto-von-Guericke-Universität Magdeburg
Presse

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