Prof. Hoffmann

Prof. Dr. rer. nat. Werner Hoffmann
Institut für Molekularbiologie und Medizinische Chemie (IMMC)
Aktuelle Projekte
- Molekulare Veränderungen in TFF-defizienten Mäusen
Laufzeit: 01.01.2017 - 30.09.2022 - Biosynthese und Funktion von TFF-Peptiden in mukösen Epithelien: Rolle als Radikalfänger und in der angeborenen Immunabwehr
Laufzeit: 01.01.2017 - 30.09.2022 - Biosynthese und Funktion von endokrin sezernierten TFF-Peptiden
Laufzeit: 01.01.2016 - 30.09.2022
Abgeschlossene Projekte
- Untersuchung der Magenmukusschicht mit Hilfe der Fourier-Transform-Infrarotspektroskopie (FT-IR)
Laufzeit: 01.01.2016 - 31.12.2020 - Biosynthese von Mukusbestandteilen im Magen
Laufzeit: 01.01.2012 - 31.12.2016 - Migration von Epithelzellen
Laufzeit: 01.06.2002 - 31.03.2005 - Rolle von TFF3 im Speichel und Magensaft
Laufzeit: 01.09.2001 - 31.08.2004 - Rolle der TFF-Peptide bei entzündlichen Atemwegserkrankungen
Laufzeit: 01.09.2001 - 31.08.2004 - Molekulare Funktion von TFF-Peptiden: Differenzierung und Wanderung von Zellen in vitro
Laufzeit: 01.10.1998 - 31.12.2001 - Expression von TFF-Peptiden im Gehirn
Laufzeit: 01.03.1996 - 27.02.2001
2022
Begutachteter Zeitschriftenartikel
Profiling of the bacterial microbiota along the murine alimentary tract
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 3, insges. 15 S.
Self-renewal and cancers of the gastric epithelium - an update and the role of the lectin TFF1 as an antral tumor suppressor
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 10, insges. 23 S.
2021
Begutachteter Zeitschriftenartikel
Salivary trefoil factor family (TFF) peptides and their roles in oral and esophageal protection - therapeutic potential
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 22, insges. 12 S.
Trefoil factor family (TFF) peptides
In: Encyclopedia - Basel: MDPI, 2021, Bd. 1 (2021), 3, S. 974-987
Trefoil factor family (TFF) peptides and their different roles in the mucosal innate immune defense and more - an update
In: Current medicinal chemistry - Hilversum [u.a.]: Bentham Science Publ., Bd. 28 (2021), 36, S. 7387-7399
Trefoil factor family (TFF) peptides and their links to inflammation - a re-evaluation and new medical perspectives
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 9, insges. 22 S.
Dissertation
TFF2 (Trefoil Factory Family 2) im Magen von Mensch und Schwein - Charakterisierung der Bindung des Peptids TFF2 an den Mukus
In: Magdeburg, 2021, 146 Blätter, Illustrationen, Diagramme, 30 cm
2020
Begutachteter Zeitschriftenartikel
Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action
In: Chemical communications - Cambridge: Soc., 1965, Bd. 56 (2020), 47, S. 6420-6423
Molecular alterations in the stomach of Tff1-deficient mice - early steps in antral carcinogenesis
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 2, Art.-Nr. 644, insges. 16 Seiten
Subcellular localization of the TFF peptides xP1 and xP4 in the Xenopus laevis gastric/esophageal mucosa - different secretion modes reflecting diverse protective functions
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 3, Art.-Nr. 761, insges. 9 Seiten
The tumor suppressor TFF1 occurs in different forms and interacts with multiple partners in the human gastric mucus barrier - indications for diverse protective functions
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 7, Art.-Nr. 2508, insges. 18 Seiten
Trefoil factor family (TFF) modules are characteristic constituents of separate mucin complexes in the Xenopus laevis integumentary mucus - in vitro binding studies with FIM-A.1
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 7, Art.-Nr. 2400, insges. 11 Seiten
Trefoil factor family (TFF) peptides and their diverse molecular functions in mucus barrier protection and more - changing the paradigm
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 12, Art.-Nr. 4535, insgesamt 20 Seiten
2019
Begutachteter Zeitschriftenartikel
Different forms of TFF2, a lectin of the human gastric mucus barrier - in vitro binding studies
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 23, Art.-Nr. 5871, insges. 13 Seiten
Different forms of TFF3 in the human saliva - heterodimerization with IgG Fc binding protein (FCGBP)
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd.20.2019, 20, Art.-Nr. 5000, insges. 10 Seiten
The TFF peptides xP1 and xP4 appear in distinctive forms in the Xenopus laevis gastric mucosa - indications for different protective functions
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd.20.2019, 23, Art.-Nr. 6052, insges. 9 Seiten
Trefoil factor family - unresolved questions and clinical perspectives
In: Trends in biochemical sciences - Amsterdam [u.a.]: Elsevier Science, Bd. 44.2019, 5, S. 387-390
2018
Begutachteter Zeitschriftenartikel
Commercial porcine gastric mucin preparations, also used as artificial saliva, are a rich source for the lectin TFF2 - in vitro binding studies
In: ChemBioChem - Weinheim: Wiley-VCH, Bd. 19.2018, 24, S. 2598-2608
2017
Begutachteter Zeitschriftenartikel
Transcriptional responses in the murine spleen after Toxoplasma gondii infection - inflammasome and mucus-associated genes
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 6, Art.-Nr. 1245, insges. 10 S.
Werkstoffe/Biomaterialien in der interventionellen und operativen Medizin - eine kurze Übersicht und aktuelle Trends
In: Zentralblatt für Chirurgie: Zeitschrift für allgemeine, viszeral-, Thorax- und Gefäßchirurgie - Stuttgart [u.a.]: Thieme, 2000, Bd. 142.2017, 2, S. 216-225
2016
Abstract
What stem cells have to do with stomach cancer
In: 2016
Begutachteter Zeitschriftenartikel
Increased cerebral Tff1 expression in two murine models of neuroinflammation
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 39.2016, 6, S. 2287-2296
2015
Begutachteter Zeitschriftenartikel
Current status on stem cells and cancers of the gastric epithelium
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, Bd. 16.2015, 8, S. 19153-19169
Differential regional and cellular distribution of TFF3 peptide in the human brain
In: Amino acids - Wien [u.a.]: Springer, Bd. 47 (2015), 5, S. 1053-1063
TFF peptides play a role in the immune response following oral infection of mice with Toxoplasma gondii
In: European journal of microbiology and immunology - Budapest: Akad. Kiadó, Bd. 5.2015, 3, S. 221-231
TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)
In: International journal of oncology - Athens: Spandidos Publ, Bd. 47.2015, 3, S. 806-816
2014
Begutachteter Zeitschriftenartikel
Kontinuierliche Regeneration des Magenepithels durch Zelldifferenzierung - Bedeutung für die Karzinogenese
In: Der Pathologe: Organ der Deutschen Abteilung der Internationalen Akademie für Pathologie, der Deutschen, der Österreichischen und der Schweizerischen Gesellschaft für Pathologie und des Berufsverbandes Deutscher Pathologen - Berlin: Springer, 1994, Bd. 35.2014, Suppl.2, S. 202-206
Porcine gastric TFF2 is a mucus constituent and differs from pancreatic TFF2
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 33 (2014), 4, S. 895-904
Tff3 is expressed in neurons and microglial cells
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 34 (2014), 6, S. 1912-1919
Dissertation
In vivo and in vitro studies on the expression and function of TFF peptides in the gastrointestinal tract and the central nervous system
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014, VIII, 101, VI Bl., Ill., graph. Darst., 30 cm
2013
Begutachteter Zeitschriftenartikel
Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide
In: Glycobiology: official journal of the Society for Glycobiology - Oxford: Oxford University Press, 1990, Bd. 23.2013, 1, S. 2-11
Self-renewal of the gastric epithelium from stem and progenitor cells
In: Frontiers in bioscience: a journal and virtual library - Searington, NY, Bd. 5 (2013), 2, S. 720-731
TFF1 is differentially expressed in stationary and migratory rat gastric epithelial cells (RGM-1) after in vitro wounding: Influence of TFF1 RNA interference on cell migration
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 32 (2013), 4, S. 997-1010
Buchbeitrag
TFF peptides
In: Handbook of biologically active peptides - Amsterdam [u.a.]: Elsevier, Acad. Press, S. 1338-1345, 2013
2012
Originalartikel in begutachteter internationaler Zeitschrift
Stem cells in regenerative medicine and cancer. Editorial
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 19 (2012), 35, S. 5964
Stem cells, self-renewal and cancer of the gastric epithelium
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 19 (2012), 35, S. 5975-5983
2011
Originalartikel in begutachteter internationaler Zeitschrift
Gastric stem cells: Of flies and men
In: Cell cycle - London: Taylor & Francis, Bd. 10.2011, 8, S. 1186-1187
Self-renewal of the human gastric epithelium: new insights from expression profiling using laser microdissection
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, Bd. 7 (2011), 4, S. 1105-1112
2010
Originalartikel in begutachteter internationaler Zeitschrift
Expression analysis of human salivary glands by laser microdissection: differences between submandibular and labial glands
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 26.2010, 3, S. 375-382
Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfide
In: Journal of proteome research / publ. by the American Chemical Society - Washington, DC: American Chemical Society, 2002, Bd. 9.2010, 6, S. 3108-3117
Modulation of cell-cell contacts during intestinal restitution in vitro and effects of epidermal growth factor (EGF)
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 25.2010, 4/5, S. 533-542
Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine
In: Cell & tissue research - Berlin: Springer, Bd. 339.2010, 3, S. 639-647
2009
Originalartikel in begutachteter internationaler Zeitschrift
Calcium-induced conformational transition of trout ependymins monitored by tryptophan fluorescence
In: The open biochemistry journal - Sharjah [u.a.]: Bentham Open, Bd. 3.2009, S. 14-17
Expression profiling of stationary and migratory intestinal epithelial cells after in vitro wounding: restitution is accompanied by cell differentiation
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 24.2009, 1/2, S. 125-132
Trefoil factor family (TFF) peptides and chemokine receptors: a promising relationship
In: Journal of medicinal chemistry - Easton, Pa: American Chemical Society, Bd. 52.2009, 21, S. 6505-6510
2008
Originalartikel in begutachteter internationaler Zeitschrift
Lack of Tff3 peptide results in hearing impairment and accelerated presbyacusis
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 21.2008, 5/6, S. 437-444
Regeneration of the gastric mucosa and its glands from stem cells
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 15.2008, 29, S. 3133-3144
2007
Originalartikel in begutachteter internationaler Zeitschrift
Biosynthesis of Gastrokine-2 in the human gastric mucosa: restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 20 (2007), 6, S. 899-908
Induced trefoil factor family 1 expression by trans-differentiating Clara cells in a murine asthma model
In: American journal of respiratory cell and molecular biology: an official journal of the American Thoracic Society Medical Section of the American Lung Association - New York, NY, Bd. 36.2007, 3, S. 286-295
Localization of TFF3 peptide in human esophageal submucosal glands and gastric cardia - differentiation of two types of gastric pit cells along the rostro-caudal axis
In: Cell & tissue research - Berlin: Springer, Bd. 328 (2007), 2, S. 365-374
TFF (trefoil factor family) peptides and their potential roles for differentiation processes during airway remodeling
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 14.2007, 25, S. 2716-2719
TFF3 and EGF induce different migration patterns of intestinal epithelial cells in vitro and trigger increased internalization of E-cadherin
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 20 (2007), 5, S. 329-346
Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation
In: American journal of respiratory cell and molecular biology: an official journal of the American Thoracic Society Medical Section of the American Lung Association - New York, NY, Bd. 36.2007, 3, S. 296-303
2006
Buchbeitrag
TFF (trefoil factor family) peptides
In: Handbook of biologically active peptides - Amsterdam [u.a.]: Elsevier / Acad. Press, S. 1147-1154, 2006
2005
Originalartikel in begutachteter internationaler Zeitschrift
TFF (trefoil factor family) peptide-triggered signals promoting mucosal restitution.
In: Cell. Mol. Life Sci. 2005;62:2932-2938.
Tränendrüsenassoziierte Muzine
In: Ophthalmologe 2005;102:175-183
2004
Originalartikel in begutachteter internationaler Zeitschrift
A gradient of TFF3 (trefoil factor family 3) peptide synthesis within the normal human gastric mucosa.
In: Cell Tissue Res. 316(2004), Nr. 2, S. 155 - 165
Distribution of TFF peptides in corneal disease and pterygium.
In: Peptides 25(2004), Nr. 5, S. 819 - 825
Epidermal growth factor and trefoil factor family 2 synergistically trigger chemotaxis on BEAS-2B cells via different signaling cascades.
In: Am. J. Respir. Cell Mol. Biol. 31(2004), Nr. 5, S. 528 - 537
Human lacrimal gland mucins.
In: Cell Tissue Res. 316(2004), Nr. 2, S. 167 - 177
Profiling trefoil factor family (TFF) expression in the mouse : identification of an antisense TFF1-related transcript in the kidney and liver.
In: Peptides 25(2004), Nr. 5, S. 755 - 762
TFF3 expression at the esophagogastric junction is increased in gastro-esophageal reflux disease (GERD).
In: Peptides 25(2004), Nr. 5, S. 771 - 777
Trefoil factor family (TFF) expression in the mouse brain and pituitary : changes in the developing cerebellum.
In: Peptides 25(2004), Nr. 5, S. 827 - 832
Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more [Editorial].
In: Peptides 25(2004), Nr. 5, S. 727 - 730
Originalartikel in begutachteter nationaler Zeitschrift
Tränenabfluss : Bedeutung von Muzinen und TFF-Peptiden.
In: Ophthalmologe 101(2004), Nr. 1, S. 19 - 24
2003
Originalartikel in begutachteter internationaler Zeitschrift
Characterization of Mucins in Human Lacrimal Sac and Nasolacrimal Duct
In: Invest. Ophthalmol. Vis. Sci. 2003;44:1807-1813
2002
Buchbeitrag
Ocular TFF-peptides : new mucus-associated secretory products of conjunctival goblet cells.
In: Sullivan, D. (Ed.) ; Stern, M. (Ed.) ; Tsubota, K. (Ed.) ; ... (Ed.): Lacrimal gland, tear film, and dry eye syndromes 3 : basic science and clinical relevance ; Part A (3rd International Conference on the Lacrimal Gland, Tear Film, and Dry Eye Syndromes, Mauii Hawaii November 2000). New York [u.a.] : Kluwer Acad. Plenum Publ., 2002, S. 313 - 316 (Advances in experimental medicine and biology ; 506)
Originalartikel in begutachteter internationaler Zeitschrift
Cell type specific expression of secretory TFF peptides : colocalization with mucins and synthesis in the brain.
In: Int. Rev. Cytol. 213(2002), S. 147 - 181
Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL- 8 secretion.
In: J. Biol. Chem. 277(2002), Nr. 21, S. 18440 - 18446
TFF peptides in the human efferent tear ducts.
In: Invest. Ophthalmol. Vis. Sci. 43(2002), Nr. 11, S. 3359 - 3364
- Institut für Pathologie (FME)
- FAU Erlangen-Nürnberg (Lehrstuhl für Mikrobiologie)
- Institut für Molekulare und Klinische Immunologie (FME)
- Max-Planck-Institut für Entwicklungsbiologie Tübingen
- TU München (Professur für Biomechanik)
- Universitätsklinik für Allgemein-, Viszeral-, Gefäß- und Transplantationschirurgie (FME)
- Universitätsklinik für Gastroenterologie, Hepatologie und Infektiologie (FME)
- Universitätsklinik für Neurochirurgie (FME)
- Universitätsklinik für Pneumologie (FME)
- Universitätsklinikum Hamburg-Eppendorf
- Institut für Mikrobiologie (FME)
- TFF-Peptide in mukösen Epithelien
- TFF-Peptide im Immun- und zentralen Nervensystem bzw. während entzündlicher Prozesse
- Erneuerung des Magenepithels durch Differenzierung aus Stamm- und Vorläuferzellen
- Reparatur muköser Epithelien durch Zellmigration ("Restitution")
1955 | geboren in Salzburg, Österreich |
1973-1978 | Diplomstudium der Chemie an der Universität Innsbruck; Sponsion zum "Magister rer. nat." |
1978-1982 | Dissertation am Institut für Molekularbiologie der Österreichischen Akademie der Wissenschaften in Salzburg; Promotion an der Universität Innsbruck zum "Doktor rer. nat." |
1983-1984 | Postdoctoral Fellow bei ZymoGenetics Inc. in Seattle, USA |
1984-1986 | Projektleiter am Institut für Molekularbiologie der ÖAW in Salzburg |
1987-1993 | Leiter der Nachwuchsgruppe Molekulare Genetik am Max-Planck-Institut für Psychiatrie in Martinsried |
1991 | Habilitation für das Fachgebiet Biochemie an der Universität Innsbruck |
seit 1993 | Professur für Medizinische Chemie und Direktor des IMMC an der Medizinischen Fakultät der Otto-von-Guericke-Universität Magdeburg |