Publikationen

2019

Begutachteter Zeitschriftenartikel

Billing, Ulrike;  Jetka, Tomasz;  Nortmann, Lukas;  Wundrack, Nicole;  Komorowski, Michal;  Waldherr, Steffen;  Schaper, Fred;  Dittrich, Anna 

Robustness and information transfer within IL-6-induced JAK/STAT signalling
In: Communications biology - London: Springer Nature, Vol. 2.2019, Art. 27, insgesamt 14 S.

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Bongartz, Hannes;  Gille, Karen;  Hessenkemper, Wiebke;  Mandel, Katharina;  Lewitzky, Marc;  Feller, Stephan M.;  Schaper, Fred 

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner
In: Cell communication and signaling - London: Biomed Central, Volume 17 (2019), Article 135, insgesamt 23 Seiten

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Klepsch, Oliver;  Namer, Lise Sarah;  Köhler, Nadine;  Kaempfer, Raymond;  Dittrich, Anna;  Schaper, Fred 

Intragenic regulation of SOCS3 isoforms
In: Cell communication and signaling - London: Biomed Central, Volume 17 (2019), 1, Artikel 70, insgesamt 15 Seiten

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Reeh, Heike;  Rudolph, Nadine;  Billing, Ulrike;  Christen, Henrike;  Streif, Stefan;  Bullinger, Eric;  Schliemann-Bullinger, Monica;  Findeisen, Rolf;  Schaper, Fred;  Huber, Heinrich;  Dittrich, Anna 

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression - fusing experimental insights and dynamic modelling
In: Cell communication and signaling - London: Biomed Central, Vol. 17.2019, 1, Art. 17:46, insgesamt 21 Seiten

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Thiele, Sven;  Heise, Sandra;  Hessenkemper, Wiebke;  Bongartz, Hannes;  Fensky, Melissa;  Schaper, Fred;  Klamt, Steffen 

Designing optimal experiments to discriminate interaction graph models
In: IEEE ACM transactions on computational biology and bioinformatics - New York, NY: IEEE, Bd. 16.2019, 3, S. 925-935

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2018

Begutachteter Zeitschriftenartikel

Williams, Jamie J. L.;  Alotaiq, Nasser;  Mullen, William;  Burchmore, Richard;  Liu, Libin;  Baillie, George S.;  Schaper, Fred;  Pilch, Paul F.;  Palmer, Timothy M. 

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability
In: Nature Communications - [London]: Nature Publishing Group UK, Vol. 9.2018, 1, Art. 168, insgesamt 17 S.

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2017

Begutachteter Zeitschriftenartikel

Bongartz, Hannes;  Heßenkemper, Wiebke;  Müller, Christian;  Fensky, Melissa;  Fritsch, Johannes;  Mandel, Katharina;  Behrmann, Iris;  Haan, Claude;  Fischer, Thomas;  Feller, Stephan M.;  Schaper, Fred 

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, Bd. 35.2017, S. 37-47

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2016

Begutachteter Zeitschriftenartikel

Pinno, Jessica;  Bongartz, Hannes;  Klepsch, Oliver;  Wundrack, Nicole;  Poli, Valeria;  Schaper, Fred;  Dittrich, Anna 

Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-Inhibitor REDD1 in a STAT3-dependent manner
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, Bd. 28.2016, 8, S. 907-916

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2015

Begutachteter Zeitschriftenartikel

Dittrich, Anna;  Hessenkemper, Wiebke;  Schaper, Fred 

Systems biology of IL-6, IL-12 family cytokines
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 595-602

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Rose-John, Stefan;  Scheller, Jürgen;  Schaper, Fred 

"Family reunion" - a structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 471-474

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Rudolph, Nadine;  Meyer, Tina;  Franzen, Kristina;  Garbers, Christoph;  Schaper, Fred;  Streif, Stefan;  Dittrich, Anna;  Findeisen, Rolf 

A two-level approach for fusing early signaling events and long term cellular responses
In: IFAC-PapersOnLine/ Internationale Förderung für Automatische Lenkung - Frankfurt: Elsevier, Bd. 48.2015, 8, S. 1228-1233

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Schaper, Fred;  Rose-John, Stefan 

Interleukin-6: Biology, signaling and strategies of blockade
In: Cytokine & growth factor reviews - Amsterdam [u.a.]: Elsevier Science, Bd. 26.2015, 5, S. 475-487

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Wolf, Alexandra;  Eulenfeld, René;  Bongartz, Hannes;  Hessenkemper, Wiebke;  Simister, Philip C.;  Lievens, Sam;  Tavernier, Jan;  Feller, Stephan M.;  Schaper, Fred 

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch
In: Cellular signalling - Amsterdam [u.a.]: Elsevier Science, Bd. 27.2014, 2, S. 340-352, 2015

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2014

Buchbeitrag

Heinrich, Peter C.;  Haan, Serge;  Hermanns, Heike M.;  Müller-Newen, Gerhard;  Schaper, Fred 

Mediatoren
In: Löffler/Petrides Biochemie und Pathobiochemie. - Berlin [u.a.] : Springer, S. 407-410, 2014

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Heinrich, Peter C.;  Haan, Serge;  Hermanns, Heike M.;  Müller-Newen, Gerhard;  Schaper, Fred 

Rezeptoren und ihre Signaltransduktion
In: Löffler/Petrides Biochemie und Pathobiochemie. - Berlin [u.a.] : Springer, S. 411-441, 2014

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Müller-Newen, Gerhard;  Heinrich, Peter C.;  Hermanns, Heike M.;  Schaper, Fred 

Prinzipien zellulärer Kommunikation
In: Löffler/Petrides Biochemie und Pathobiochemie. - Berlin [u.a.] : Springer, S. 395-406, 2014

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2013

Begutachteter Zeitschriftenartikel

Blätke, Mary Ann;  Dittrich, Anna;  Rohr, Christian;  Heiner, Monika;  Schaper, Fred;  Marwan, Wolfgang 

JAK/STAT signalling - an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology
In: Molecular BioSystems. - Cambridge : Royal Society of Chemistry, Bd. 9.2013, S. 1290-1307

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Müller, Pia J.;  Rigboldt, Kristoffer G.;  Paterok, Dirk;  Piehler, Jacob;  Vanselow, Jens;  Lasonder, Edwin;  Andersen, Jens S.;  Schaper, Fred;  Sobota, Radoslaw M. 

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domains point mutations associated with Noonan syndrome and leukemia
In: Journal of proteomics. - New York, NY [u.a.] : Elsevier, Bd. 84.2013, S. 132-147

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Thiem, Stefan;  Pierce, Thomas P.;  Palmieri, Michelle;  Putoczki, Tracy L.;  Buchert, Michael;  Preaudet, Adele;  Farid, Ryan O.;  Love, Chris;  Catimel, Bruno;  Lei, Zhengdeng;  Rozen, Steve;  Gopalakrishnan, Veena;  Schaper, Fred;  Hallek, Michael;  Boussioutas, Alex;  Tan, Patrick;  Jarnicki, Andrew;  Ernst, Matthias 

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice
In: The journal of clinical investigation : JCI ; the publication of the American Society for Clinical Investigation. - Ann Arbor, Mich : ASCJ, Bd. 123.2013, 2, S. 767-781

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Wolf, Alexandra;  Eulenfeld, René;  Gäbler, Karoline;  Rolvering, Catherine;  Haan, Serge;  Behrmann, Iris;  Denecke, Bernd;  Haan, Claude;  Schaper, Fred 

JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells
In: JAK-STAT. - Austin, Tex : Landes Bioscience, Bd. 2.2013, 3, insges. 13 S.

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Buchbeitrag

Dittrich, Anna;  Siewert, Elmar;  Schaper, Fred 

Determination of protein turnover rates in the JAK/STAT pathway using a radioactive pulse-chase approach
In: JAK-STAT signalling : methods and protocols. - New York [u.a.] : Humana Pr., S. 69-80, 2013 - (Methods in molecular biology; 967)

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2012

Buchbeitrag

Blätke, Mary Ann;  Dittrich, Anna;  Heiner, Monika;  Schaper, Fred;  Marwan, Wolfgang 

JAK-STAT signalling as example for a database-supported modular modelling concept
In: Gilbert, David: : Computational Methods in Systems Biology. - Berlin : Springer, S. 362-365, 2012 - (Lecture Notes in Bioinformatics; 7605)

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Originalartikel in begutachteter internationaler Zeitschrift

Bode, Johannes G.;  Albrecht, Ute;  Häussinger, Dieter;  Heinrich, Peter C.;  Schaper, Fred 

Hepatic acute phase proteins - regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kB-dependent signaling
In: European journal of cell biology. - Amsterdam : Elsevier, Bd. 91.2012, 6/7, S. 496-505

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Dittrich, Anna;  Khouri, Christina;  Sackett, Sara Dutton;  Ehlting, Christian;  Böhmer, Oliver;  Albrecht, Ute;  Bode, Johannes G.;  Trautwein, Christian;  Schaper, Fred 

Glucocorticoids increase interleukin-6 dependent gene induction by interfering with the expression of the SOCS 3 feedback inhibitor
In: Hepatology. - Hoboken, NJ : Wiley Interscience, Bd. 55.2012, 1, S. 256-266

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Dittrich, Anna;  Quaiser, Tom;  Khouri, Christina;  Görtz, Dieter;  Mönnigmann, Martin;  Schaper, Fred 

Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling
In: Molecular BioSystems. - Cambridge : Royal Society of Chemistry, 8, S. 2119-2134, 2012

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Eulenfeld, René;  Dittrich, Anna;  Khouri, Christina;  Müller, Pia J.;  Mütze, Barbara;  Wolf, Alexandra;  Schaper, Fred 

Interleukin-6 signalling - more than Jaks and STATs
In: European journal of cell biology. - Amsterdam : Elsevier, Bd. 91.2012, 6/7, S. 486-495

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Garbers, Christoph;  Hermanns, Heike M.;  Schaper, Fred;  Müller-Newen, Gerhard;  Grötzinger, Joachim;  Rose-John, Stefan;  Scheller, Jürgen 

Plasticity and cross-talk of Interleukin 6-type cytokines
In: Cytokine & growth factor reviews. - Oxford [u.a.] : Elsevier, Bd. 23.2012, 3, S. 85-97

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2011

Originalartikel in begutachteter internationaler Zeitschrift

Khouri, Christina;  Dittrich, Anna;  Sackett, Sara Dutton;  Denecke, Bernd;  Trautwein, Christian;  Schaper, Fred 

Glucagon counteracts interleukin-6-dependent gene expression by redundant action of EPAC and PKA
In: Biological chemistry - Berlin [u.a.]: de Gruyter, Bd. 392.2011, S. 1123-1134

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Quaiser, Tom;  Dittrich, Anna;  Schaper, Fred;  Mönnigmann, Martin 

A simple work flow for biologically inspired model reduction - application to early JAK-STAT signaling
In: BMC systems biology - London: BioMed Central, Bd. 5.2011, 30, insges. 30 S.

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Ryll, Anke;  Samaga, Regina;  Schaper, Fred;  Alexopoulos, Leonidas G.;  Klamt, Steffen 

Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, Bd. 7.2011, 12, S. 3253-3270

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Simister, Philip C.;  Schaper, Fred;  O'Reilly, Nicola;  McGowan, Simon;  Feller, Stephan M. 

Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini
In: PLoS biology - Lawrence, KS: PLoS, Bd. 9.2011, 2

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2010

Originalartikel in begutachteter internationaler Zeitschrift

Radtke, Simone;  Wüller, Stefan;  Yang, Xiang-ping;  Lippok, Barbara E.;  Mütze, Barbara;  Mais, Christine;  Schmitz-Van de Leur, Hildegard;  Bode, Johannes G.;  Gaestel, Matthias;  Heinrich, Peter C.;  Behrmann, Iris;  Schaper, Fred;  Hermanns, Heike M. 

Cross-regulation of cytokine signalling - pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation
In: Journal of cell science . - Cambridge : Company of Biologists Limited, Bd. 123.2010, 6, S. 947-959

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2009

Begutachteter Zeitschriftenartikel

Eulenfeld, R.;  Schaper, F. 

A new mechanism for the regulation of Gab1 recruitment to the plasma membrane
In: J Cell Sci, Volume 122, Issue Pt 1, Pages: 55-64, 2009

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Originalartikel in begutachteter internationaler Zeitschrift

Entschladen, Frank;  Lindquist, Jonathan;  Serfling, Edgar;  Thiel, Gerald;  Kieser, Arnd;  Giehl, Klaudia;  Ehrhardt, Christina;  Feller, Stephan M.;  Ullrich, Oliver;  Schaper, Fred;  Janssen, Ottmar;  Hass, Ralf;  Friedrich, Karlheinz 

Signal transduction - receptors, mediators, and genes
In: Science signaling . - Washington, DC [u.a.] : Assoc., Bd. 2.2009, 63, insges. 4 S.

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Friedrich, Karlheinz;  Lindquist, Jonathan;  Entschladen, Frank;  Serfling, Edgar;  Thiel, Gerald;  Kieser, Arnd;  Giehl, Klaudia;  Ehrhardt, Christina;  Feller, Stephan M.;  Ullrich, Oliver;  Schaper, Fred;  Janssen, Ottmar;  Hass, Ralf 

Signal transduction in the footsteps of Goethe and Schiller
In: Cell communication and signaling . - London : Biomed Central, Bd. 7.2009, insges. 6 S.

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2008

Begutachteter Zeitschriftenartikel

Clahsen, T.;  Schaper, F. 

Interleukin-6 acts in the fashion of a classical chemokine on monocytic cells by inducing integrin activation, cell adhesion, actin polymerization, chemotaxis, and transmigration
In: J Leukoc Biol, Volume 84, Issue 6, Pages: 1521-9; 2008

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Sobota, R. M.;  Müller, P. J.;  Heinrich, P. C.;  Schaper, F. 

Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation
In: Biochem J, Volume 412, Issue 1, Pages: 65-72, 2008

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Sobota, R. M.;  Müller, P. J.;  Khouri, C.;  Ullrich, A.;  Poli, V.;  Noguchi, T.;  Heinrich, P. C.;  Schaper, F. 

SHPS-1/SIRP1alpha contributes to interleukin-6 signalling
In: Cell Signal, Volume 20, Issue 7, Pages: 1385-91, 2008

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2007

Begutachteter Zeitschriftenartikel

Albrecht, U.;  Yang, X.;  Asselta, R.;  Keitel, V.;  Tenchini, M. L.;  Ludwig, S.;  Heinrich, P. C.;  Häussinger, D.;  Schaper, F.;  Bode, J. G. 

Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene
In: Cell Signal, Volume 19, Issue 9, Pages: 1866-78, 2007

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Ehlting, C.;  Lai, W. S.;  Schaper, F.;  Brenndorfer, E. D.;  Matthes, R. J.;  Heinrich, P. C.;  Ludwig, S.;  Blackshear, P. J.;  Gaestel, M.;  Häussinger, D.;  Bode, J. G. 

Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade
In: J Immunol, Volume 178, Issue 5, Pages: 2813-26, 2007

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2006

Begutachteter Zeitschriftenartikel

Lehmann, U.;  Sommer, U.;  Smyczek, T.;  Hörtner, M.;  Frisch, W.;  Volkmer-Engert, R.;  Heinrich, P. C.;  Schaper, F.;  Haan, S. 

Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130
In: Cell Signal, Volume 18, Issue 1, Pages: 40-9, 2006

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Stross, C.;  Radtke, S.;  Clahsen, T.;  Gerlach, C.;  Volkmer-Engert, R.;  Schaper, F.;  Heinrich, P. C.;  Hermanns, H. M. 

Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism
In: J Biol Chem, Volume 281, Issue 13, Pages: 8458-68, 2006

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Tron, K.;  Samoylenko, A.;  Musikowski, G.;  Kobe, F.;  Immenschuh, S.;  Schaper, F.;  Ramadori, G.;  Kietzmann, T. 

Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes
In: J Hepatol, Volume 45, Issue 1, Pages: 72-80, 2006

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Lehrbuch

Heinrich, P.C.;  Haan, S.;  Hermanns, H.M.;  Löffler, G.;  Müller-Newen, G.;  Schaper 

Kapitel 25: Kommunikation zwischen Zellen: Extrazelluläre Signalmoleküle, Rezeptoren und Signaltransduktion
In: in: Löffler, G., Petrides, P.E., Heinrich, P.C. (eds.): Biochemie und Pathobiochemie 8. Auflage. Springer-Verlag Berlin Heidelberg, 2006, pp 755-807

2005

Begutachteter Zeitschriftenartikel

Clahsen, T.;  Lehmann, U.;  Stross, C.;  Hermanns, H. M.;  Volkmer-Engert, R.;  Schneider-Mergener, J.;  Heinrich, P. C.;  Schaper, F. 

The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling
In: Cell Signal, Volume 17, Issue 5, Pages: 559-69, 2005

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Sommer, U.;  Schmid, C.;  Sobota, R. M.;  Lehmann, U.;  Stevenson, N. J.;  Johnston, J. A.;  Schaper, F.;  Heinrich, P. C.;  Haan, S. 

Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases
In: J Biol Chem, Volume 280, Issue 36, Pages: 31478-88, 2005

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Yang, X. P.;  Schaper, F.;  Teubner, A.;  Lammert, F.;  Heinrich, P. C.;  Matern, S.;  Siewert, E. 

Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo
In: J Hepatol, Volume 43, Issue 4, Pages: 704-10, 2005

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2004

Begutachteter Zeitschriftenartikel

Fischer, P.;  Lehmann, U.;  Sobota, R. M.;  Schmitz, J.;  Niemand, C.;  Linnemann, S.;  Haan, S.;  Behrmann, I.;  Yoshimura, A.;  Johnston, J. A.;  Müller-Newen, G.;  Heinrich, P. C.;  Schaper, F. 

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
In: Biochem J, Volume 378, Issue Pt 2, Pages: 449-60, 2004

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Weissenbach, M.;  Clahsen, T.;  Weber, C.;  Spitzer, D.;  Wirth, D.;  Vestweber, D.;  Heinrich, P. C.;  Schaper, F. 

Interleukin-6 is a direct mediator of T cell migration
In: Eur J Immunol, Volume 34, Issue 10, Pages: 2895-906, 2004

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Yang, X. P.;  Albrecht, U.;  Zakowski, V.;  Sobota, R. M.;  Häussinger, D.;  Heinrich, P. C.;  Ludwig, S.;  Bode, J. G.;  Schaper, F. 

Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression
In: J Biol Chem, Volume 279, Issue 43, Pages: 45279-89, 2004

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Zhao, L.;  Hart, S.;  Cheng, J.;  Melenhorst, J. J.;  Bierie, B.;  Ernst, M.;  Stewart, C.;  Schaper, F.;  Heinrich, P. C.;  Ullrich, A.;  Robinson, G. W.;  Hennighausen, L. 

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK
In: J Biol Chem, Volume 279, Issue 42, Pages: 44093-100, 2004

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2003

Begutachteter Zeitschriftenartikel

Bode, J. G.;  Ludwig, S.;  Ehrhardt, C.;  Albrecht, U.;  Erhardt, A.;  Schaper, F.;  Heinrich, P. C.;  Häussinger, D. 

IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3
In: Faseb J, Volume 17, Issue 3, Pages: 488-90, 2003

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Bode, J. G.;  Schweigart, J.;  Kehrmann, J.;  Ehlting, C.;  Schaper, F.;  Heinrich, P. C.;  Häussinger, D. 

TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex
In: J Immunol, Volume 171, Issue 1, Pages: 257-66, 2003

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Heinrich, P. C.;  Behrmann, I.;  Haan, S.;  Hermanns, H. M.;  Müller-Newen, G.;  Schaper, F. 

Principles of interleukin (IL)-6-type cytokine signalling and its regulation
In: Biochem J, Volume 374, Issue Pt 1, Pages: 1-20, 2003

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Lehmann, U.;  Schmitz, J.;  Weissenbach, M.;  Sobota, R. M.;  Hörtner, M.;  Friederichs, K.;  Behrmann, I.;  Tsiaris, W.;  Sasaki, A.;  Schneider-Mergener, J.;  Yoshimura, A.;  Neel, B. G.;  Heinrich, P. C.;  Schaper, F. 

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
In: J Biol Chem, Volume 278, Issue 1, Pages: 661-71, 2003

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Niemand, C.;  Nimmesgern, A.;  Haan, S.;  Fischer, P.;  Schaper, F.;  Rossaint, R.;  Heinrich, P. C.;  Müller-Newen, G. 

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
In: J Immunol, Volume 170, Issue 6, Pages: 3263-72, 2003

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Lehrbuch

Heinrich, P.C.;  Schaper, F.;  Timmermann, A.;  Martens, A.;  Lehmann, U. 

Kapitel 28: Endokrine Funktionen II: Zytokine
In: in: Löffler, G., Petrides, P.E. (eds.): Biochemie und Pathobiochemie 7. Auflage. Springer-Verlag Berlin Heidelberg, 2003, pp. 813-835

2001

Begutachteter Zeitschriftenartikel

Bode, J. G.;  Fischer, R.;  Häussinger, D.;  Graeve, L.;  Heinrich, P. C.;  Schaper, F. 

The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B
In: J Immunol, Volume 167, Issue 3, Pages: 1469-1481, 2001

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Bode, J. G.;  Ludwig, S.;  Freitas, C. A.;  Schaper, F.;  Ruhl, M.;  Melmed, S.;  Heinrich, P. C.;  Häussinger, D. 

The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription
In: Biol Chem, Volume 382, Issue 10, Pages: 1447-53, 2001

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Campbell, J. S.;  Prichard, L.;  Schaper, F.;  Schmitz, J.;  Stephenson-Famy, A.;  Rosenfeld, M. E.;  Argast, G. M.;  Heinrich, P. C.;  Fausto, N. 

Expression of suppressors of cytokine signaling during liver regeneration
In: J Clin Invest, Volume 107, Issue 10, Pages: 1285-92, 2001

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Friederichs, K.;  Schmitz, J.;  Weissenbach, M.;  Heinrich, P. C.;  Schaper, F. 

Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited
In: Eur J Biochem, Volume 268, Issue 24, Pages: 6401-7, 2001

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Heinrich, P. C.;  Bode, J.;  Decker, M.;  Graeve, L.;  Martens, A.;  Müller-Newen, G.;  Pflanz, S.;  Schaper, F.;  Schmitz, J. 

Termination and modulation of IL-6-type cytokine signaling
In: Adv Exp Med Biol, Volume 495, Pages: 153-60, 2001

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Strobl, B.;  Arulampalam, V.;  Is'harc, H.;  Newman, S. J.;  Schlaak, J. F.;  Watling, D.;  Costa-Pereira, A. P.;  Schaper, F.;  Behrmann, I.;  Sheehan, K. C.;  Schreiber, R. D.;  Horn, F.;  Heinrich, P. C.;  Kerr, I. M. 

A completely foreign receptor can mediate an interferon-gamma-like response
In: Embo J, Volume 20, Issue 19, Pages: 5431-42, 2001

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2000

Begutachteter Zeitschriftenartikel

Anhuf, D.;  Weissenbach, M.;  Schmitz, J.;  Sobota, R.;  Hermanns, H. M.;  Radtke, S.;  Linnemann, S.;  Behrmann, I.;  Heinrich, P. C.;  Schaper, F. 

Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation
In: J Immunol, Volume 165, Issue 5, Pages: 2535-43, 2000

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Böldicke, T.;  Struck, F.;  Schaper, F.;  Tegge, W.;  Sobek, H.;  Villbrandt, B.;  Lankenau, P.;  Böcher, M. 

A new peptide-affinity tag for the detection and affinity purification of recombinant proteins with a monoclonal antibody
In: J Immunol Methods, Volume 240, Issue 1-2, Pages: 165-83, 2000

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Haan, S.;  Kortylewski, M.;  Behrmann, I.;  Müller-Esterl, W.;  Heinrich, P. C.;  Schaper, F. 

Cytoplasmic STAT proteins associate prior to activation
In: Biochem J, Volume 345 Pt 3, Pages: 417-21, 2000

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Hermanns, H. M.;  Radtke, S.;  Schaper, F.;  Heinrich, P. C.;  Behrmann, I. 

Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor
In: J Biol Chem, Volume 275, Issue 52, Pages: 40742-8, 2000

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Müller-Newen, G.;  Küster, A.;  Wijdenes, J.;  Schaper, F.;  Heinrich, P. C. 

Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies
In: J Biol Chem, Volume 275, Issue 7, Pages: 4579-86, 2000

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Rödel, B.;  Tavassoli, K.;  Karsunky, H.;  Schmidt, T.;  Bachmann, M.;  Schaper, F.;  Heinrich, P.;  Shuai, K.;  Elsässer, H. P.;  Möröy, T. 

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3
In: Embo J, Volume 19, Issue 21, Pages: 5845-55, 2000

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Schmitz, J.;  Weissenbach, M.;  Haan, S.;  Heinrich, P. C.;  Schaper, F. 

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
In: J Biol Chem, Volume 275, Issue 17, Pages: 12848-56, 2000

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Schmitz, J.;  Dahmen, H.;  Grimm, C.;  Gendo, C.;  Muller-Newen, G.;  Heinrich, P. C.;  Schaper, F. 

The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction
In: Journal of Immunology 164, Issue 2, Pages: 848-54, 2000

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Terstegen, L.;  Maassen, B. G.;  Radtke, S.;  Behrmann, I.;  Schaper, F.;  Heinrich, P. C.;  Graeve, L.;  Gatsios, P. 

Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA
In: FEBS Lett, Volume 478, Issue 1-2, Pages: 100-4, 2000

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Terstegen, L.;  Gatsios, P.;  Bode, J. G.;  Schaper, F.;  Heinrich, P. C.;  Graeve, L. 

The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130
In: J Biol Chem, 275, Issue 25, Pages: 18810-17, 2000

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1999

Begutachteter Zeitschriftenartikel

Bode, J.G.;  Nimmesgern, A.;  Schmitz, J.;  Schaper, F.;  Schmitt, M.;  Frisch, W.;  Häussinger, D.;  Heinrich, P.C.;  Graeve, L. 

LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
In: FEBS Letters 463 (3) , pp. 365-370, 1999

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Haan, S.;  Hemmann, U.;  Hassiepen, U.;  Schaper, F., Schneider-Mergener, J.;  Wollmer, A.;  Heinrich, P.C.;  Grötzinger, J. 

Characterization and binding specificity of the monomeric STAT3-SH2 domain
In: Journal of Biological Chemistry 274 (3) , pp. 1342-1348, 1999

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Siewert, E.;  Müller-Esterl, W.;  Starr, R.;  Heinrich, P.C.;  Schaper, F. 

Different protein turnover of interleukin-6-type cytokine signalling components
In: European Journal of Biochemistry 265 (1) , pp. 251-257, 1999

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Thiel, S.;  Behrmann, I.;  Timmermann, A.;  Dahmen, H.;  Müller-Newen, G.;  Schaper, F.;  Tavernier, J.;  Pitard, V.;  Heinrich, P.C.;  Graeve, L. 

Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor.
In: Biochemical Journal 339 (1) , pp. 15-19, 1999

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1998

Begutachteter Zeitschriftenartikel

Heinrich, P.C.;  Behrmann, I.;  Müller-Newen, G.;  Schaper, F.;  Graeve, L. 

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
In: Biochemical J. 224 (2) , pp. 297-314, 1998

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Kirchhoff, S.;  Schaper, F.;  Oumard, A.;  Hauser, H. 

In vivo formation of IRF-1 homodimers
In: Biochimie 80 (8-9) , pp. 659-664, 1998

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Schaper, F.;  Gendo, C.;  Eck, M.;  Schmitz, J.;  Grimm, C.;  Anhuf, D.;  Kerr, I.M.;  Heinrich, P.C. 

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
In: Biochemical Journal 335 (3) , pp. 557-565, 1998

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Schaper, F.;  Kirchhoff, S.;  Posern, G.;  Köster, M.;  Oumard, A.;  Sharf, R.;  Levi, B.-Z.;  Hauser, H. 

Functional domains of interferon regulatory factor 1 (IRF-1)
In: Biochemical Journal 335 (1) , pp. 147-157, 1998

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Thiel, S.;  Dahmen, H.;  Martens, A.;  Müller-Newen, G.;  Schaper, F.;  Heinrich, P.C.;  Graeve, L. 

Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130
In: FEBS Letters 441 (2) , pp. 231-234, 1998

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1997

Begutachteter Zeitschriftenartikel

Schaper, F.;  Siewert, E.;  Gómez-Lechón, M.J.;  Gatsios, P.;  Sachs, M.;  Birchmeier, W.;  Heinrich, P.C.;  Castell, J. 

Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes
In: FEBS Letters 405 (1) , pp. 99-103, 1997

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Sharf, R.;  Meraro, D.;  Azriel, A.;  Thornton, A.M.;  Ozato, K.;  Petricoin, E.F.;  Larner, A.C.;  Schaper, F.;  Hauser, H.;  Levi, B.-Z. 

Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA
In: Journal of Biological Chemistry 272 (15) , pp. 9785-9792, 1997

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1996

Begutachteter Zeitschriftenartikel

Kirchhoff, S.;  Kröger, A.;  Cruz, H.;  Tümmler, M.;  Schaper, F.;  Köster, M.;  Hauser, H. 

Regulation of cell growth by IRF-1 in BHK-21 cells
In: Cytotechnology 22 (1-3) , pp. 147-156, 1996

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1995

Begutachteter Zeitschriftenartikel

Kirchhoff, S.;  Köster, M.;  Wirth, M.;  Schaper, F.;  Gossen, M.;  Bujard, H.;  Hauser, H. 

Identification of mammalian cell clones exhibiting highly regulated expression from inducible promoters
In: Trends in Genetics 11 , pp. 219-220, 1995

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Kirchhoff, S.;  Koromilas, A.E.;  Schaper, F.;  Grashoff, M.;  Sonenberg, N.;  Hauser, H. 

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR
In: Oncogene 11 (3) , pp. 439-445, 1995

Köster, M.;  Kirchhoff, S.;  Schaper, F.;  Hauser, H. 

Proliferation control of mammalian cells by the tumor suppressor IRF-1
In: Cytotechnology 18 (1-2) , pp. 67-75, 1995

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1994

Begutachteter Zeitschriftenartikel

Dirks, W.;  Schaper, F.;  Kirchhoff, S.;  Morelle, C.;  Hauser, H. 

A multifunctional vector family for gene expression in mammalian cells
In: Gene 149 , pp. 387-388, 1994

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Dirks, W.;  Schaper, F.;  Hauser, H. 

A new hybrid promoter directs transcription at identical start points in mammalian cells and in vitro
In: Gene 149 , pp. 389-390, 1994

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1993

Begutachteter Zeitschriftenartikel

Kirchhoff, S.;  Schaper, F.;  Hauser, H. 

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes
In: Nucleic Acids Research 21 (12) , pp. 2881-2889, 1993

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