Prof. Relja

Prof. Dr. phil. nat. Borna Relja
Aktuelle Projekte
- Forschungscampus STIMULATE - Querschnittsthema Immunoprofiling
Laufzeit: 01.10.2020 - 30.09.2025 - Einfluss des Alters und der Alkoholintoxikation auf die Frakturheilung und das regenerative Potential nach Trauma-Hämorrhagie im murinen Tiermodell
Laufzeit: 07.05.2018 - 30.09.2023 - Project 10: Maladaptation of the hepatic barrier in alcohol-induced liver injury within the RTG 2408: Maladaptive Prozesse an physiologischen Grenzflächen bei chronischen Erkrankungen
Laufzeit: 01.04.2020 - 31.03.2023
Abgeschlossene Projekte
- ABINEP Zentralprojekt
Laufzeit: 01.04.2017 - 30.05.2022 - Die pathophysiologische Bedeutung des Club Cell Protein 16 bei der Entstehung respiratorischer Komplikationen - Analyse eines klinischen Kombinationsmodells von Thoraxtrauma und ARDS unter besonderer Berücksichtigung der Funktion neutrophiler Granulozyten
Laufzeit: 01.01.2018 - 31.01.2021 - Modulation der akuten Entzündungsantwort und der hepato-pulmonalen Organdysfunktion durch Alkohol und Ethylpyruvat in einem klinisch relevanten Kombinationsmodell von hämorrhagischem Schock und Thoraxtrauma unter besonderer Berücksichtigung NF-KappaB-vermittelter Pathomechanismen.
Laufzeit: 01.12.2014 - 31.12.2020
2022
Begutachteter Zeitschriftenartikel
Acute alcohol consumption increases systemic endotoxin bioactivity for days in healthy volunteers-with reduced intestinal barrier loss in female
In: European journal of trauma and emergency surgery - Heidelberg: Springer Medizin, 2007, Bd. 48 (2022), 3, S. 1569-1577
Acute intoxication with alcohol reduces trauma-induced proinflammatory response and barrier breakdown in the lung via the Wnt/β-catenin signaling pathway
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 13 (2022), insges. 17 S.
Reduced phagocytosis, ROS production and enhanced apoptosis of leukocytes upon alcohol drinking in healthy volunteers
In: European journal of trauma and emergency surgery - Heidelberg: Springer Medizin, 2007, Bd. 48 (2022), insges. 11 S.
2021
Artikel in Zeitschrift
Diffusion-weighted imaging reflects tumor grading and microvascular invasion in hepatocellular carcinoma
In: Liver cancer - Basel: Karger, 2012, Bd. 10 (2021), 1, S. 10-24
Begutachteter Zeitschriftenartikel
Acute alcohol intoxication modulates monocyte subsets and their functions in a time-dependent manner in healthy volunteers
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 12 (2021), insges. 12 S.
Alterations of growth and focal adhesion molecules in human breast cancer cells exposed to the random positioning machine
In: Frontiers in cell and developmental biology - Lausanne: Frontiers Media, 2013, Bd. 9 (2021), insges. 17 S.
Alterations of phagocytic activity and capacity in granulocytes and monocytes depend on the pathogen strain in porcine polytrauma
In: Frontiers in medicine - Lausanne: Frontiers Media, 2014, Bd. 8 (2021), insges. 10 S.
Anti-inflammatory effects of alcohol are associated with JNK-STAT3 downregulation in an in vitro inflammation model in HepG2 cells
In: Disease markers - New York, NY [u.a.]: Hindawi, 1993 . - 2021, insges. 8 S.
Club cell protein 16 attenuates CD16brightCD62dim immunosuppressive neutrophils in damaged tissue upon posttraumatic sepsis-induced lung injury
In: Journal of Immunology Research - New York, NY: Hindawi, 2014 . - 2021, insges. 14 S.
Effects of immune cells on mesenchymal stem cells during fracture healing
In: World journal of stem cells - Beijing: Beijing Baishideng BioMed Scientific Co., 2010, Bd. 13 (2021), 11, S. 1667-1695
Enhanced pro-inflammatory response and higher mortality rates in geriatric trauma patients
In: European journal of trauma and emergency surgery: official publication of the European Trauma Society - Heidelberg: Springer Medizin, Bd. 47 (2021), 4, S. 1065-1072
Enhanced susceptibility of ADAP-deficient mice to Listeria monocytogenes infection is associated with an altered phagocyte phenotype and function
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 12 (2021), insges. 20 S.
Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 11 (2021), insges. 12 S.
Neutrophil phenotypes and functions in trauma and trauma-related sepsis
In: Shock: injury, inflammation, and sepsis, laboratory and clinical approaches - Hagerstown, Md.: Lippincott, Williams & Wilkins, Bd. 56 (2021), 1, S. 16-29
Selective inhibition of IL-6 trans-signaling has no beneficial effect on the posttraumatic cytokine release after multiple trauma in mice
In: Life - Basel: MDPI, 2011, Bd. 11 (2021), 11, insges. 21 S.
Severe traumatic injury induces phenotypic and functional changes of neutrophils and monocytes
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd. 10 (2021), 18, insges. 19 S.
Standardized porcine unilateral femoral nailing is associated with changes in PMN activation status, rather than aberrant systemic PMN prevalence
In: European Journal of Trauma and Emergency Surgery, 2021, S. , ISSN 1863-9933, 10.1007/s00068-021-01703-2
The future of basic science in orthopaedics and traumatology - Cassandra or Prometheus?
In: European journal of medical research: official organ \"Deutsche AIDS-Gesellschaft\" - London: BioMed Central, 2000, Bd. 26 (2021), insges. 16 S.
The influence of alcohol on the base excess parameter in trauma patients
In: Shock - Hagerstown, Md.: Lippincott, Williams & Wilkins, Bd. 56 (2021), 5, S. 727-732
Trauma-hemorrhage stimulates immune defense, mitochondrial dysfunction, autophagy, and apoptosis in pig liver at 72 h
In: Shock: injury, inflammation, and sepsis, laboratory and clinical approaches - Hagerstown, Md.: Lippincott, Williams & Wilkins, Bd. 55 (2021), 5, S. 630-639
2020
Abstract
Acute alcohol intoxication of healthy volunteers modulates monocyte subsets and their functions in dose- and time-dependent manner
In: Shock: injury, inflammation, and sepsis, laboratory and clinical approaches - Hagerstown, Md.: Lippincott, Williams & Wilkins, 1994, Vol. 53.2020, Suppl. 1, P154, S. 89
DAMP-mediated cardiac dysfunction - cardiomyocytes as actors and target of innate immune response
In: The journal of immunology - Bethesda, Md.: Soc., 1916, Vol. 204.2020, Suppl. 1, 144.18
Trauma-hemorrhage - mitochondrial dysfunction, autophagy and apoptosis in pig liver 72 h post polytrauma
In: Zeitschrift für Orthopädie und Unfallchirurgie: Organ der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie - Stuttgart [u.a.]: Thieme, 2007, Bd. 158.2020, Suppl. 1, DKOU20-150, S. S30-S31
Begutachteter Zeitschriftenartikel
Breast cancer cells in microgravity - new aspects for cancer research
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 19, Art.-Nr. 7345, insges. 22 Seiten
Cardiac Glucose and Fatty Acid Transport After Experimental Mono- and Polytrauma.
In: Shock (Augusta, Ga.), 2020, Bd. 53, Heft 5, S. 620-629
Curcumin - a viable agent for better bladder cancer treatment
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 11, Art.-Nr. 3761, insgesamt 20 Seiten
Damage-associated molecular patterns in trauma
In: European journal of trauma and emergency surgery: official publication of the European Trauma Society - Heidelberg: Springer Medizin, 2007, Bd. 46.2020, 4, S. 751-775
Different experimental multiple trauma models induce comparable inflammation and organ injury
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Vol. 10.2020, Art.-Nr. 20185, insgesamt 12 Seiten
Early local neutralization of CC16 in sepsisinduced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival
In: International journal of molecular medicine - Athens: Spandidos Publ., 1998, Bd. 46.2020, 6, S. 2207-2215
Effects of circulating HMGB-1 and histones on cardiomyocytes-hemadsorption of these DAMPs as therapeutic strategy after multiple trauma
In: Journal of Clinical Medicine: open access journal - Basel: MDPI, 2012, Bd. 9.2020, 5, Art.-Nr. 1421, insgesamt 13 Seiten
Ethanol intoxication alleviates the inflammatory response of remote organs to experimental traumatic brain injury
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 21, Art.-Nr. 8181, insgesamt 14 Seiten
Ethyl pyruvate reduces systemic leukocyte activation via caspase-1 and NF-[kappa]B after blunt chest trauma and haemorrhagic shock
In: Frontiers in medicine - Lausanne: Frontiers Media, 2014, Bd. 7.2020, Art.-Nr. 562904, insgesamt 11 Seiten
Indomethacin increases the efficacy of oxygen utilization of colonic mitochondria and uncouples hepatic mitochondria in tissue homogenates from healthy rats
In: Frontiers in medicine - Lausanne: Frontiers Media, 2014, Bd. 7.2020, Art.-Nr. 463, insgesamt 7 Seiten
Intra-hepatic abscopal effect following radioembolization of hepatic metastases
In: CardioVascular and interventional radiology - Berlin: Springer, 1978, Bd. 43 (2020), 11, S. 1641-1649
M1 but not M0 extracellular vesicles induce polarization of RAW264.7 macrophages via the TLR4-NF[kappa]B pathway in vitro
In: Inflammation - New York, NY [u.a.]: Springer Science + Business Media B.V., 1975, Bd. 43.2020, 5, S. 1611-1619
Neutrophil Phenotypes and Functions in Trauma and Trauma-Related Sepsis.
In: Shock (Augusta, Ga.), 2020
Post-traumatic sepsis is associated with increased C5a and decreased TAFI levels
In: Journal of Clinical Medicine: open access journal - Basel: MDPI, 2012, Bd. 9.2020, 4, Art.-Nr. 1230, insgesamt 15 Seiten
Regulatory T cells modulate CD4 proliferation after severe trauma via IL-10
In: Journal of Clinical Medicine: open access journal - Basel: MDPI, 2012, Bd. 9.2020, 4, Art.-Nr. 1052, insgesamt 15 Seiten
SARS-CoV-2/COVID-19 - evolving reality, global response, knowledge gaps, and opportunities
In: Shock: injury, inflammation, and sepsis, laboratory and clinical approaches - Hagerstown, Md.: Lippincott, Williams & Wilkins, Bd. 54.2020, 4, S. 416-437
Short exposure to ethanol diminishes caspase-1 and ASC activation in human HepG2 cells in vitro
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 9, Art.-Nr. 3196, insges. 18 Seiten
The impact of acute or chronic alcohol intake on the NF-[kappa]B signaling pathway in alcohol-related liver disease
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 24, 9407, insgesamt 35 Seiten
Transarterielle Radioembolisation - Immuneffekte und Immunonkologie
In: Der Radiologe: Zeitschrift für diagnostische und interventionelle Radiologie, Radioonkologie, Nuklearmedizin ; Organ der Arbeitsgemeinschaft Berufsverbände Medizinische Radiologie. Dan - Berlin: Springer, Bd. 60.2020, 8, S. 693-703
Trauma severity and its impact on local inflammation in extremity injury - insights from a combined trauma model in pigs
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Vol. 10.2020, Article 3028, insges. 10 Seiten
2019
Begutachteter Zeitschriftenartikel
A nationwide fluidics biobank of polytraumatized patients: implemented by the Network "Trauma Research" (NTF) as an expansion to the TraumaRegister DGU ® of the German Trauma Society (DGU).
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 3, S. 499-504
Alcohol Binge Reduces Systemic Leukocyte Activation and Pulmonary PMN Infiltration After Blunt Chest Trauma and Hemorrhagic Shock.
In: Inflammation, 2019, Bd. 42, Heft 2, S. 690-701
Alcoholinduced attenuation of posttraumatic inflammation is not necessarily liverprotective following trauma/hemorrhage.
In: International journal of molecular medicine, 2019, Bd. 44, Heft 3, S. 1127-1138
Circulating Extracellular Vesicles and Their miR "Barcode" Differentiate Alcohol Drinkers With Liver Injury and Those Without Liver Injury in Severe Trauma Patients.
In: Frontiers in medicine, 2019, Bd. 6, S. 30
Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2
In: Molecular medicine - [London]: BioMed Central, 1994, Bd.25.2019, Art.-Nr. 45, insges. 13 S.
Contributing factors in the development of acute lung injury in a murine double hit model.
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 1, S. 21-30
Curcumin combined with exposure to visible light blocks bladder cancer cell adhesion and migration by an integrin dependent mechanism
In: European review for medical and pharmacological sciences - Roma: Verduci, 1997, Bd. 23 (2019), 23, S. 10564-10574
Cytokines in inflammatory disease
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd.20.2019, 23, Art.-Nr. 6008, insges. 31 S.
Damage-associated molecular patterns in trauma.
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 4, S. 751-775
Early Local Inhibition of Club Cell Protein 16 Following Chest Trauma Reduces Late Sepsis-Induced Acute Lung Injury.
In: Journal of clinical medicine, 2019, Bd. 8, Heft 6
Endogenous uteroglobin as intrinsic anti-inflammatory signal modulates monocyte and macrophage subsets distribution upon sepsis induced lung injury
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd.10.2019, Art.-Nr. 2276, insges. 14 S.
Enhanced pro-inflammatory response and higher mortality rates in geriatric trauma patients.
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019
Innate immunity and alcohol
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd.8.2019, 11, Art.-Nr. 1981, insges. 31 S.
Is I-FABP not only a marker for the detection abdominal injury but also of hemorrhagic shock in severely injured trauma patients?
In: World journal of emergency surgery : WJES, 2019, Bd. 14, S. 49
Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism.
In: Frontiers in immunology, 2019, Bd. 10, S. 1920
Modeling trauma in rats - similarities to humans and potential pitfalls to consider
In: Journal of translational medicine - London: BioMed Central, 2003, Bd. 17.2019, Art.-Nr. 305, insges. 19 S.
Monotrauma is associated with enhanced remote inflammatory response and organ damage, while polytrauma intensifies both in porcine trauma model.
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 1, S. 31-42
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
In: Brain, behavior, and immunity, 2019, Bd. 81, S. 228-246
Smoking Dependent Alterations in Bone Formation and Inflammation Represent Major Risk Factors for Complications Following Total Joint Arthroplasty.
In: Journal of clinical medicine, 2019, Bd. 8, Heft 3
The influence of alcohol on the outcome of trauma patients: a matched-pair analysis of the TraumaRegister DGU ® .
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 3, S. 463-472
Traumatic injury pattern is of equal relevance as injury severity for experimental (poly)trauma modeling.
In: Scientific reports, 2019, Bd. 9, Heft 1, S. 5706
2018
Begutachteter Zeitschriftenartikel
Comparative analysis of the regulatory T cells dynamics in peripheral blood in human and porcine polytrauma
In: In: Frontiers in Immunology, Bd. 9, MAR, 2018
Danger signals in trauma
In: In: European Journal of Trauma and Emergency Surgery, Bd. 44, 3, S. 301-316, 2018
Early local microcirculation is improved after intramedullary nailing in comparison to external fixation in a porcine model with a femur fracture
In: In: European Journal of Trauma and Emergency Surgery, Bd. 44, 5, S. 689-696, 2018
Ethyl pyruvate ameliorates hepatic injury following blunt chest trauma and hemorrhagic shock by reducing local inflammation, NF-kappaB activation and HMGB1 release
In: In: PLoS ONE, Bd. 13, 2, 2018
Reduced NLRP3 gene expression limits the IL-1 cleavage via inflammasome in monocytes from severely injured trauma patients
In: In: Mediators of Inflammation, Bd. 2018, 2018
Simvastatin exerts anticancer effects in osteosarcoma cell lines via geranylgeranylation and c-Jun activation.
In: International journal of oncology, 2018, Bd. 52, Heft 4, S. 1285-1294
Suppression of the interleukin- 1-induced inflammatory response of human Chang liver cells by acute and subacute exposure to alcohol: An in vitro study
In: In: Croatian Medical Journal, Bd. 59, 2, S. 46-55, 2018
The posttraumatic activation of CD4+ T regulatory cells is modulated by TNFR2- and TLR4-dependent pathways, but not by IL-10.
In: Cellular immunology, 2018, Bd. 331, S. 137-145
Traumatic Injury
In: In: Experientia supplementum (2012), Bd. 108, S. 85-110, 2018
2017
Artikel in Zeitschrift
Correction - Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion
In: OncoTarget: open access impact journal - [S.l.]: Impact Journals LLC, 2010, Bd. 8.2017, 1, S. 1953-1954
Begutachteter Zeitschriftenartikel
Acute Alcohol Binge Deteriorates Metabolic and Respiratory Compensation Capability After Blunt Chest Trauma Followed by Hemorrhagic Shock-A New Research Model.
In: Alcoholism, clinical and experimental research, 2017, Bd. 41, Heft 9, S. 1559-1567
Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury.
In: International immunopharmacology, 2017, Bd. 51, S. 66-75
Cardiac depression in pigs after multiple trauma - Characterization of posttraumatic structural and functional alterations
In: In: Scientific Reports, Bd. 7, 1, 2017
Correction: Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion.
In: Oncotarget, 2017, Bd. 8, Heft 1, S. 1953-1954
Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model
In: In: PLoS ONE, Bd. 12, 11, 2017
Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway.
In: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Bd. 43, Heft 1, S. 17-30
Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-B and HMGB1.
In: Immunobiology, 2017, Bd. 223, Heft 3, S. 310-318
I-FABP is a Novel Marker for the Detection of Intestinal Injury in Severely Injured Trauma Patients
In: In: World Journal of Surgery, Bd. 41, 12, S. 3120-3127, 2017
Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients
In: In: Mediators of Inflammation, Bd. 2017, 2017
Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model.
In: Prostaglandins, leukotrienes, and essential fatty acids, 2017, Bd. 127, S. 25-31
Role of biomarkers in acute traumatic lung injury.
In: Injury, 2017, Bd. 48, Heft 11, S. 2400-2406
Serum -1 Antitrypsin (AAT) antagonizes intrinsic apoptosis induction in neutrophils from patients with systemic inflammatory response syndrome
In: In: PLoS ONE, Bd. 12, 5, 2017
Severe Hemorrhagic Shock Leads to a Delayed Fracture Healing and Decreased Bone Callus Strength in a Mouse Model
In: In: Clinical Orthopaedics and Related Research, Bd. 475, 11, S. 2783-2794, 2017
2016
Artikel in Zeitschrift
Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion
In: OncoTarget - [S.l.]: Impact Journals LLC, 2010, Bd. 7.2016, 15, S. 20410-20424
Begutachteter Zeitschriftenartikel
Adrenergic stimulation alters the expression of inflammasome components and interleukins in primary human monocytes
In: In: Experimental and Therapeutic Medicine, Bd. 11, 1, S. 297-302, 2016
Alcohol Intoxication Reduces Systemic Interleukin-6 Levels and Leukocyte Counts After Severe TBI Compared With Not Intoxicated TBI Patients.
In: Shock (Augusta, Ga.), 2016, Bd. 46, Heft 3, S. 261-9
Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma
In: In: Scientific Reports, Bd. 6, 2016
Correction: Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion
In: In: Oncotarget, Bd. 8, 1, S. 1953-1954, 2016
Effects of positive blood alcohol concentration on outcome and systemic interleukin-6 in major trauma patients.
In: Injury, 2016, Bd. 47, Heft 3, S. 640-5
Influence of gender on systemic IL-6 levels, complication rates and outcome after major trauma.
In: Immunobiology, 2016, Bd. 221, Heft 8, S. 904-10
Long-term effects of induced hypothermia on local and systemic inflammation - Results from a porcine long-term trauma model
In: In: PLoS ONE, Bd. 11, 5, 2016
Phagocytizing activity of PMN from severe trauma patients in different post-traumatic phases during the 10-days post-injury course.
In: Immunobiology, 2016, Bd. 222, Heft 2, S. 301-307
Sera from severe trauma patients with pneumonia and without infectious complications have differential effects on neutrophil biology
In: In: BMC Pulmonary Medicine, Bd. 16, 1, 2016
Simvastatin Reduces Cancerogenic Potential of Renal Cancer Cells via Geranylgeranyl Pyrophosphate and Mevalonate Pathway.
In: Nutrition and cancer, 2016, Bd. 68, Heft 3, S. 420-7
2015
Begutachteter Zeitschriftenartikel
Adrenergic stimulation alters the expression of inflammasome components and interleukins in primary human monocytes.
In: Experimental and therapeutic medicine, 2015, Bd. 11, Heft 1, S. 297-302
Cell-based therapy by implanted human bone marrow-derived mononuclear cells improved bone healing of large bone defects in rats.
In: Tissue engineering. Part A, 2015, Bd. 21, Heft 9-10, S. 1565-78
Differential relevance of NF-B and JNK in the pathophysiology of hemorrhage/resususcitation-induced liver injury after chronic ethanol feeding
In: In: PloS one, 2015, Bd. 10, Heft 9, S. e0137875
Ethanol, ethyl and sodium pyruvate decrease the inflammatory responses of human lung epithelial cells via Akt and NF-B in vitro but have a low impact on hepatocellular cells.
In: International journal of molecular medicine, 2015, Bd. 37, Heft 2, S. 517-25
I-FABP and L-FABP are early markers for abdominal injury with limited prognostic value for secondary organ failures in the post-traumatic course.
In: Clinical chemistry and laboratory medicine, 2015, Bd. 53, Heft 5, S. 771-80
Nlrp1 inflammasome is downregulated in trauma patients
In: In: Journal of Molecular Medicine, Bd. 93, 12, S. 1391-1400, 2015
Pre- or post-treatment with ethanol and ethyl pyruvate results in distinct anti-inflammatory responses of human lung epithelial cells triggered by interleukin-6.
In: Molecular medicine reports, 2015, Bd. 12, Heft 2, S. 2991-8
The effect of brain injury on the inflammatory response following severe trauma.
In: Immunobiology, 2015, Bd. 221, Heft 3, S. 427-31
2014
Begutachteter Zeitschriftenartikel
Decreased inflammatory responses of human lung epithelial cells after ethanol exposure are mimicked by ethyl pyruvate
In: In: Mediators of Inflammation, Bd. 2014, 2014
Modulation of Inflammation by Alcohol Exposure
In: Mediators of Inflammation, Hindawi Limited, Bd. 2014, S. 1-2, Article number 283756
Myeloid knockout of HIF-1 does not markedly affect hemorrhage/resuscitation-induced inflammation and hepatic injury
In: In: Mediators of Inflammation, Bd. 2014, 2014
Treatment of endothelial cell with flavonoids modulates transendothelial leukocyte migration.
In: Phlebology, 2014, Bd. 30, Heft 6, S. 405-11
2013
Begutachteter Zeitschriftenartikel
Effects of acute ethanol gavage on intestinal integrity after hemorrhage/resuscitation.
In: Scandinavian journal of gastroenterology, 2013, Bd. 48, Heft 4, S. 448-58
Establishment and characterization of the Masquelet induced membrane technique in a rat femur critical-sized defect model.
In: Journal of tissue engineering and regenerative medicine, 2013, Bd. 10, Heft 10, S. E382-E396
Pathophysiology of multiple trauma: Intensive care medicine and timing of treatment
In: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2013, Bd. 84, Heft 9, S. 753-8
2012
Begutachteter Zeitschriftenartikel
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) levels are decreased in patients with trauma-induced coagulopathy.
In: Thrombosis research, 2012, Bd. 131, Heft 1, S. e26-30
Acute alcohol intoxication reduces mortality, inflammatory responses and hepatic injury after haemorrhage and resuscitation in vivo
In: In: British Journal of Pharmacology, Bd. 165, 4 B, S. 1188-1199, 2012
Acute ethanol gavage attenuates hemorrhage/resuscitation-induced hepatic oxidative stress in rats
In: In: Oxidative Medicine and Cellular Longevity, 2012
Circulating leukotriene B4 identifies respiratory complications after trauma
In: In: Mediators of Inflammation, Bd. 2012, 2012
Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats
In: In: European Journal of Nutrition, Bd. 51, 3, S. 311-321, 2012
Thrombin-activatable fibrinolysis inhibitor (TAFI) is enhanced in major trauma patients without infectious complications.
In: Immunobiology, 2012, Bd. 218, Heft 4, S. 470-6
2011
Begutachteter Zeitschriftenartikel
Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells.
In: Hepatology research : the official journal of the Japan Society of Hepatology, 2011, Bd. 41, Heft 4, S. 364-74
Effects of green tea catechins on the pro-inflammatory response after haemorrhage/resuscitation in rats.
In: The British journal of nutrition, 2011, Bd. 105, Heft 12, S. 1791-7
Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats.
In: European journal of nutrition, 2011, Bd. 51, Heft 3, S. 311-21
2010
Begutachteter Zeitschriftenartikel
Intestinal-FABP and liver-FABP: Novel markers for severe abdominal injury.
In: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2010, Bd. 17, Heft 7, S. 729-35
Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells.
In: International journal of molecular medicine, 2010, Bd. 26, Heft 5, S. 735-41
Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK.
In: International journal of oncology, 2010, Bd. 38, Heft 3, S. 879-85
Simvastatin reduces mortality and hepatic injury after hemorrhage/resuscitation in rats.
In: Shock (Augusta, Ga.), 2010, Bd. 34, Heft 1, S. 46-54
2009
Begutachteter Zeitschriftenartikel
Inhibition of c-Jun N-terminal kinase after hemorrhage but before resuscitation mitigates hepatic damage and inflammatory response in male rats.
In: Shock (Augusta, Ga.), 2009, Bd. 32, Heft 5, S. 509-16
Rapid development of intestinal cell damage following severe trauma: A prospective observational cohort study
In: In: Critical Care, Bd. 13, 3, 2009
2008
Begutachteter Zeitschriftenartikel
A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.
In: Shock (Augusta, Ga.), 2008, Bd. 30, Heft 2, S. 159-65
Differential effects of GdCl3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock.
In: Microcirculation (New York, N.Y. : 1994), 2008, Bd. 15, Heft 5, S. 427-39
Significant decline of peripheral myeloid dendritic cells following multiple trauma.
In: The Journal of surgical research, 2008, Bd. 154, Heft 2, S. 239-45
2007
Begutachteter Zeitschriftenartikel
CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cells.
In: Experimental cell research, 2007, Bd. 313, Heft 19, S. 4051-65
Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes
In: Journal of Cellular and Molecular Medicine, Wiley, 2007, Bd. 11, Heft 4, S. 826-838
Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium
In: In: British Journal of Cancer, Bd. 96, 11, S. 1699-1706, 2007
2006
Begutachteter Zeitschriftenartikel
Altered expression of beta1 integrins in renal carcinoma cell lines exposed to the differentiation inducer valproic acid.
In: International journal of molecular medicine, 2006, Bd. 18, Heft 2, S. 347-54
CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins.
In: Neoplasia (New York, N.Y.), 2006, Bd. 8, Heft 4, S. 290-301
2005
Begutachteter Zeitschriftenartikel
Modulation of the CXC-chemokine expression profile on tumor cells by the immunosuppressive drug mycophenolate mofetil.
In: International journal of molecular medicine, 2005, Bd. 15, Heft 4, S. 641-7
Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor cells: Impact on tumor recurrence and malignancy
In: In: BMC Cancer, Bd. 5, 2005
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Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells
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