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Acute intoxication with alcohol reduces trauma-induced proinflammatory response and barrier breakdown in the lung via the Wnt/β-catenin signaling pathway
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Acute alcohol intoxication modulates monocyte subsets and their functions in a time-dependent manner in healthy volunteers
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Alterations of phagocytic activity and capacity in granulocytes and monocytes depend on the pathogen strain in porcine polytrauma
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Anti-inflammatory effects of alcohol are associated with JNK-STAT3 downregulation in an in vitro inflammation model in HepG2 cells
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Enhanced pro-inflammatory response and higher mortality rates in geriatric trauma patients
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Enhanced susceptibility of ADAP-deficient mice to Listeria monocytogenes infection is associated with an altered phagocyte phenotype and function
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Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection
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Selective inhibition of IL-6 trans-signaling has no beneficial effect on the posttraumatic cytokine release after multiple trauma in mice
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Trauma-hemorrhage stimulates immune defense, mitochondrial dysfunction, autophagy, and apoptosis in pig liver at 72 h
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Alcohol Binge Reduces Systemic Leukocyte Activation and Pulmonary PMN Infiltration After Blunt Chest Trauma and Hemorrhagic Shock.
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Alcoholinduced attenuation of posttraumatic inflammation is not necessarily liverprotective following trauma/hemorrhage.
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Circulating Extracellular Vesicles and Their miR "Barcode" Differentiate Alcohol Drinkers With Liver Injury and Those Without Liver Injury in Severe Trauma Patients.
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Early Local Inhibition of Club Cell Protein 16 Following Chest Trauma Reduces Late Sepsis-Induced Acute Lung Injury.
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Endogenous uteroglobin as intrinsic anti-inflammatory signal modulates monocyte and macrophage subsets distribution upon sepsis induced lung injury
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Enhanced pro-inflammatory response and higher mortality rates in geriatric trauma patients.
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Innate immunity and alcohol
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Is I-FABP not only a marker for the detection abdominal injury but also of hemorrhagic shock in severely injured trauma patients?
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Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism.
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Modeling trauma in rats - similarities to humans and potential pitfalls to consider
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Monotrauma is associated with enhanced remote inflammatory response and organ damage, while polytrauma intensifies both in porcine trauma model.
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STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
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Smoking Dependent Alterations in Bone Formation and Inflammation Represent Major Risk Factors for Complications Following Total Joint Arthroplasty.
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The influence of alcohol on the outcome of trauma patients: a matched-pair analysis of the TraumaRegister DGU ® .
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Traumatic injury pattern is of equal relevance as injury severity for experimental (poly)trauma modeling.
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Comparative analysis of the regulatory T cells dynamics in peripheral blood in human and porcine polytrauma
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Danger signals in trauma
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Early local microcirculation is improved after intramedullary nailing in comparison to external fixation in a porcine model with a femur fracture
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Ethyl pyruvate ameliorates hepatic injury following blunt chest trauma and hemorrhagic shock by reducing local inflammation, NF-kappaB activation and HMGB1 release
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Reduced NLRP3 gene expression limits the IL-1 cleavage via inflammasome in monocytes from severely injured trauma patients
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Simvastatin exerts anticancer effects in osteosarcoma cell lines via geranylgeranylation and c-Jun activation.
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Suppression of the interleukin- 1-induced inflammatory response of human Chang liver cells by acute and subacute exposure to alcohol: An in vitro study
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The posttraumatic activation of CD4+ T regulatory cells is modulated by TNFR2- and TLR4-dependent pathways, but not by IL-10.
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Traumatic Injury
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Correction - Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion
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Acute Alcohol Binge Deteriorates Metabolic and Respiratory Compensation Capability After Blunt Chest Trauma Followed by Hemorrhagic Shock-A New Research Model.
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Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury.
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Cardiac depression in pigs after multiple trauma - Characterization of posttraumatic structural and functional alterations
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Correction: Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion.
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Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model
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Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway.
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Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-B and HMGB1.
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I-FABP is a Novel Marker for the Detection of Intestinal Injury in Severely Injured Trauma Patients
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Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients
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Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model.
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Role of biomarkers in acute traumatic lung injury.
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Serum -1 Antitrypsin (AAT) antagonizes intrinsic apoptosis induction in neutrophils from patients with systemic inflammatory response syndrome
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Severe Hemorrhagic Shock Leads to a Delayed Fracture Healing and Decreased Bone Callus Strength in a Mouse Model
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Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion
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Adrenergic stimulation alters the expression of inflammasome components and interleukins in primary human monocytes
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Alcohol Intoxication Reduces Systemic Interleukin-6 Levels and Leukocyte Counts After Severe TBI Compared With Not Intoxicated TBI Patients.
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Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma
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Effects of positive blood alcohol concentration on outcome and systemic interleukin-6 in major trauma patients.
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Influence of gender on systemic IL-6 levels, complication rates and outcome after major trauma.
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Long-term effects of induced hypothermia on local and systemic inflammation - Results from a porcine long-term trauma model
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Phagocytizing activity of PMN from severe trauma patients in different post-traumatic phases during the 10-days post-injury course.
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Sera from severe trauma patients with pneumonia and without infectious complications have differential effects on neutrophil biology
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Simvastatin Reduces Cancerogenic Potential of Renal Cancer Cells via Geranylgeranyl Pyrophosphate and Mevalonate Pathway.
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Adrenergic stimulation alters the expression of inflammasome components and interleukins in primary human monocytes.
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Cell-based therapy by implanted human bone marrow-derived mononuclear cells improved bone healing of large bone defects in rats.
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Differential relevance of NF-B and JNK in the pathophysiology of hemorrhage/resususcitation-induced liver injury after chronic ethanol feeding
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Ethanol, ethyl and sodium pyruvate decrease the inflammatory responses of human lung epithelial cells via Akt and NF-B in vitro but have a low impact on hepatocellular cells.
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I-FABP and L-FABP are early markers for abdominal injury with limited prognostic value for secondary organ failures in the post-traumatic course.
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Nlrp1 inflammasome is downregulated in trauma patients
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Pre- or post-treatment with ethanol and ethyl pyruvate results in distinct anti-inflammatory responses of human lung epithelial cells triggered by interleukin-6.
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The effect of brain injury on the inflammatory response following severe trauma.
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Decreased inflammatory responses of human lung epithelial cells after ethanol exposure are mimicked by ethyl pyruvate
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Modulation of Inflammation by Alcohol Exposure
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Myeloid knockout of HIF-1 does not markedly affect hemorrhage/resuscitation-induced inflammation and hepatic injury
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Treatment of endothelial cell with flavonoids modulates transendothelial leukocyte migration.
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Effects of acute ethanol gavage on intestinal integrity after hemorrhage/resuscitation.
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Establishment and characterization of the Masquelet induced membrane technique in a rat femur critical-sized defect model.
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Pathophysiology of multiple trauma: Intensive care medicine and timing of treatment
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Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) levels are decreased in patients with trauma-induced coagulopathy.
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Acute alcohol intoxication reduces mortality, inflammatory responses and hepatic injury after haemorrhage and resuscitation in vivo
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Acute ethanol gavage attenuates hemorrhage/resuscitation-induced hepatic oxidative stress in rats
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Circulating leukotriene B4 identifies respiratory complications after trauma
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Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats
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Thrombin-activatable fibrinolysis inhibitor (TAFI) is enhanced in major trauma patients without infectious complications.
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Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells.
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Effects of green tea catechins on the pro-inflammatory response after haemorrhage/resuscitation in rats.
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Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats.
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Intestinal-FABP and liver-FABP: Novel markers for severe abdominal injury.
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Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells.
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Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK.
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Simvastatin reduces mortality and hepatic injury after hemorrhage/resuscitation in rats.
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Inhibition of c-Jun N-terminal kinase after hemorrhage but before resuscitation mitigates hepatic damage and inflammatory response in male rats.
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Rapid development of intestinal cell damage following severe trauma: A prospective observational cohort study
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A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.
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Differential effects of GdCl3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock.
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Significant decline of peripheral myeloid dendritic cells following multiple trauma.
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CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cells.
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Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes
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Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium
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Altered expression of beta1 integrins in renal carcinoma cell lines exposed to the differentiation inducer valproic acid.
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CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins.
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Modulation of the CXC-chemokine expression profile on tumor cells by the immunosuppressive drug mycophenolate mofetil.
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Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor cells: Impact on tumor recurrence and malignancy
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Prostate tumor CXC-chemokine profile correlates with cell adhesion to endothelium and extracellular matrix.
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Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells
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