Prof. Relja

Prof. Dr. phil. nat. Borna Relja
Aktuelle Projekte
- Forschungscampus STIMULATE - Querschnittsthema Immunoprofiling
Laufzeit: 01.10.2020 - 30.09.2025 - Einfluss des Alters und der Alkoholintoxikation auf die Frakturheilung und das regenerative Potential nach Trauma-Hämorrhagie im murinen Tiermodell
Laufzeit: 07.05.2018 - 30.09.2023 - Project 10: Maladaptation of the hepatic barrier in alcohol-induced liver injury within the RTG 2408: Maladaptive Prozesse an physiologischen Grenzflächen bei chronischen Erkrankungen
Laufzeit: 01.04.2020 - 31.03.2023
Abgeschlossene Projekte
- ABINEP Zentralprojekt
Laufzeit: 01.04.2017 - 30.05.2022 - Die pathophysiologische Bedeutung des Club Cell Protein 16 bei der Entstehung respiratorischer Komplikationen - Analyse eines klinischen Kombinationsmodells von Thoraxtrauma und ARDS unter besonderer Berücksichtigung der Funktion neutrophiler Granulozyten
Laufzeit: 01.01.2018 - 31.01.2021 - Modulation der akuten Entzündungsantwort und der hepato-pulmonalen Organdysfunktion durch Alkohol und Ethylpyruvat in einem klinisch relevanten Kombinationsmodell von hämorrhagischem Schock und Thoraxtrauma unter besonderer Berücksichtigung NF-KappaB-vermittelter Pathomechanismen.
Laufzeit: 01.12.2014 - 31.12.2020
2022
Begutachteter Zeitschriftenartikel
A barrier to defend - models of pulmonary barrier to study acute inflammatory diseases
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 13 (2022), insges. 16 S.
Acute alcohol consumption increases systemic endotoxin bioactivity for days in healthy volunteers-with reduced intestinal barrier loss in female
In: European journal of trauma and emergency surgery - Heidelberg: Springer Medizin, 2007, Bd. 48 (2022), 3, S. 1569-1577
Acute intoxication with alcohol reduces trauma-induced proinflammatory response and barrier breakdown in the lung via the Wnt/β-catenin signaling pathway
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 13 (2022), insges. 17 S.
COL10A1 allows stratification of invasiveness of colon cancer and associates to extracellular matrix and immune cell enrichment in the tumor parenchyma
In: Frontiers in oncology - Lausanne: Frontiers Media, 2011, Bd. 12 (2022), insges. 13 S.
Cigarette smoke extract disturbs mitochondria-regulated airway epithelial cell responses to pneumococci
In: Cells - Basel: MDPI, 2012, Bd. 11 (2022), 11, insges. 27 S.
Club cell protein (CC)16 as potential lung injury marker in a porcine 72 h polytrauma model
In: European journal of trauma and emergency surgery - Heidelberg: Springer Medizin, 2007, Bd. 48 (2022), 6, S. 4719-4726
Correlation of chemokines and growth factors with radiation-induced liver injury after interstitial high dose rate (HDR) brachytherapy of liver metastases
In: Journal of cancer research and clinical oncology - Berlin: Springer, 1904, Bd. 148 (2022), 10, S. 2815-2826
I-FABP as a potential marker for intestinal barrier loss in porcine polytrauma
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd. 11 (2022), 15, insges. 12 S.
Inhibition of macrophage migration inhibitory factor activity attenuates haemorrhagic shock-induced multiple organ dysfunction in rats
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 13 (2022), insges. 13 S.
Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells
In: Environment international - Amsterdam [u.a.]: Elsevier Science, 1978, Bd. 163 (2022), insges. 11 S.
Reduced phagocytosis, ROS production and enhanced apoptosis of leukocytes upon alcohol drinking in healthy volunteers
In: European journal of trauma and emergency surgery - Heidelberg: Springer Medizin, 2007, Bd. 48 (2022), 4, S. 2689-2699
Selective internal radiotherapy changes the immune profiles of extracellular vesicles and their immune origin in patients with inoperable cholangiocarcinoma
In: Cells - Basel: MDPI, 2012, Bd. 11 (2022), 15, insges. 21 S.
TNF-α indicates radiation-induced liver injury after interstitial high dose-rate brachytherapy
In: In vivo - Kapandriti, Attiki: IIAR, 2004, Bd. 36 (2022), 5, S. 2265-2274
2021
Artikel in Zeitschrift
Diffusion-weighted imaging reflects tumor grading and microvascular invasion in hepatocellular carcinoma
In: Liver cancer - Basel: Karger, 2012, Bd. 10 (2021), 1, S. 10-24
Begutachteter Zeitschriftenartikel
Acute alcohol intoxication modulates monocyte subsets and their functions in a time-dependent manner in healthy volunteers
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 12 (2021), insges. 12 S.
Alterations of growth and focal adhesion molecules in human breast cancer cells exposed to the random positioning machine
In: Frontiers in cell and developmental biology - Lausanne: Frontiers Media, 2013, Bd. 9 (2021), insges. 17 S.
Alterations of phagocytic activity and capacity in granulocytes and monocytes depend on the pathogen strain in porcine polytrauma
In: Frontiers in medicine - Lausanne: Frontiers Media, 2014, Bd. 8 (2021), insges. 10 S.
Anti-inflammatory effects of alcohol are associated with JNK-STAT3 downregulation in an in vitro inflammation model in HepG2 cells
In: Disease markers - New York, NY [u.a.]: Hindawi, 1993 . - 2021, insges. 8 S.
Club cell protein 16 attenuates CD16brightCD62dim immunosuppressive neutrophils in damaged tissue upon posttraumatic sepsis-induced lung injury
In: Journal of Immunology Research - New York, NY: Hindawi, 2014 . - 2021, insges. 14 S.
Effects of immune cells on mesenchymal stem cells during fracture healing
In: World journal of stem cells - Beijing: Beijing Baishideng BioMed Scientific Co., 2010, Bd. 13 (2021), 11, S. 1667-1695
Enhanced pro-inflammatory response and higher mortality rates in geriatric trauma patients
In: European journal of trauma and emergency surgery: official publication of the European Trauma Society - Heidelberg: Springer Medizin, Bd. 47 (2021), 4, S. 1065-1072
Enhanced susceptibility of ADAP-deficient mice to Listeria monocytogenes infection is associated with an altered phagocyte phenotype and function
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd. 12 (2021), insges. 20 S.
Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during Leishmania major skin infection
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 11 (2021), insges. 12 S.
Neutrophil phenotypes and functions in trauma and trauma-related sepsis
In: Shock: injury, inflammation, and sepsis, laboratory and clinical approaches - Hagerstown, Md.: Lippincott, Williams & Wilkins, Bd. 56 (2021), 1, S. 16-29
Selective inhibition of IL-6 trans-signaling has no beneficial effect on the posttraumatic cytokine release after multiple trauma in mice
In: Life - Basel: MDPI, 2011, Bd. 11 (2021), 11, insges. 21 S.
Severe traumatic injury induces phenotypic and functional changes of neutrophils and monocytes
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd. 10 (2021), 18, insges. 19 S.
Standardized porcine unilateral femoral nailing is associated with changes in PMN activation status, rather than aberrant systemic PMN prevalence
In: European Journal of Trauma and Emergency Surgery, 2021, S. , ISSN 1863-9933, 10.1007/s00068-021-01703-2
The future of basic science in orthopaedics and traumatology - Cassandra or Prometheus?
In: European journal of medical research: official organ \"Deutsche AIDS-Gesellschaft\" - London: BioMed Central, 2000, Bd. 26 (2021), insges. 16 S.
The influence of alcohol on the base excess parameter in trauma patients
In: Shock - Hagerstown, Md.: Lippincott, Williams & Wilkins, Bd. 56 (2021), 5, S. 727-732
Trauma-hemorrhage stimulates immune defense, mitochondrial dysfunction, autophagy, and apoptosis in pig liver at 72 h
In: Shock: injury, inflammation, and sepsis, laboratory and clinical approaches - Hagerstown, Md.: Lippincott, Williams & Wilkins, Bd. 55 (2021), 5, S. 630-639
2020
Abstract
Acute alcohol intoxication of healthy volunteers modulates monocyte subsets and their functions in dose- and time-dependent manner
In: Shock: injury, inflammation, and sepsis, laboratory and clinical approaches - Hagerstown, Md.: Lippincott, Williams & Wilkins, 1994, Vol. 53.2020, Suppl. 1, P154, S. 89
DAMP-mediated cardiac dysfunction - cardiomyocytes as actors and target of innate immune response
In: The journal of immunology - Bethesda, Md.: Soc., 1916, Vol. 204.2020, Suppl. 1, 144.18
Trauma-hemorrhage - mitochondrial dysfunction, autophagy and apoptosis in pig liver 72 h post polytrauma
In: Zeitschrift für Orthopädie und Unfallchirurgie: Organ der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie - Stuttgart [u.a.]: Thieme, 2007, Bd. 158.2020, Suppl. 1, DKOU20-150, S. S30-S31
Begutachteter Zeitschriftenartikel
Breast cancer cells in microgravity - new aspects for cancer research
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 19, Art.-Nr. 7345, insges. 22 Seiten
Cardiac Glucose and Fatty Acid Transport After Experimental Mono- and Polytrauma.
In: Shock (Augusta, Ga.), 2020, Bd. 53, Heft 5, S. 620-629
Curcumin - a viable agent for better bladder cancer treatment
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 11, Art.-Nr. 3761, insgesamt 20 Seiten
Damage-associated molecular patterns in trauma
In: European journal of trauma and emergency surgery: official publication of the European Trauma Society - Heidelberg: Springer Medizin, 2007, Bd. 46.2020, 4, S. 751-775
Different experimental multiple trauma models induce comparable inflammation and organ injury
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Vol. 10.2020, Art.-Nr. 20185, insgesamt 12 Seiten
Early local neutralization of CC16 in sepsisinduced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival
In: International journal of molecular medicine - Athens: Spandidos Publ., 1998, Bd. 46.2020, 6, S. 2207-2215
Effects of circulating HMGB-1 and histones on cardiomyocytes-hemadsorption of these DAMPs as therapeutic strategy after multiple trauma
In: Journal of Clinical Medicine: open access journal - Basel: MDPI, 2012, Bd. 9.2020, 5, Art.-Nr. 1421, insgesamt 13 Seiten
Ethanol intoxication alleviates the inflammatory response of remote organs to experimental traumatic brain injury
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 21, Art.-Nr. 8181, insgesamt 14 Seiten
Ethyl pyruvate reduces systemic leukocyte activation via caspase-1 and NF-[kappa]B after blunt chest trauma and haemorrhagic shock
In: Frontiers in medicine - Lausanne: Frontiers Media, 2014, Bd. 7.2020, Art.-Nr. 562904, insgesamt 11 Seiten
Indomethacin increases the efficacy of oxygen utilization of colonic mitochondria and uncouples hepatic mitochondria in tissue homogenates from healthy rats
In: Frontiers in medicine - Lausanne: Frontiers Media, 2014, Bd. 7.2020, Art.-Nr. 463, insgesamt 7 Seiten
Intra-hepatic abscopal effect following radioembolization of hepatic metastases
In: CardioVascular and interventional radiology - Berlin: Springer, 1978, Bd. 43 (2020), 11, S. 1641-1649
M1 but not M0 extracellular vesicles induce polarization of RAW264.7 macrophages via the TLR4-NF[kappa]B pathway in vitro
In: Inflammation - New York, NY [u.a.]: Springer Science + Business Media B.V., 1975, Bd. 43.2020, 5, S. 1611-1619
Neutrophil Phenotypes and Functions in Trauma and Trauma-Related Sepsis.
In: Shock (Augusta, Ga.), 2020
Post-traumatic sepsis is associated with increased C5a and decreased TAFI levels
In: Journal of Clinical Medicine: open access journal - Basel: MDPI, 2012, Bd. 9.2020, 4, Art.-Nr. 1230, insgesamt 15 Seiten
Regulatory T cells modulate CD4 proliferation after severe trauma via IL-10
In: Journal of Clinical Medicine: open access journal - Basel: MDPI, 2012, Bd. 9.2020, 4, Art.-Nr. 1052, insgesamt 15 Seiten
SARS-CoV-2/COVID-19 - evolving reality, global response, knowledge gaps, and opportunities
In: Shock: injury, inflammation, and sepsis, laboratory and clinical approaches - Hagerstown, Md.: Lippincott, Williams & Wilkins, Bd. 54.2020, 4, S. 416-437
Short exposure to ethanol diminishes caspase-1 and ASC activation in human HepG2 cells in vitro
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 9, Art.-Nr. 3196, insges. 18 Seiten
The impact of acute or chronic alcohol intake on the NF-[kappa]B signaling pathway in alcohol-related liver disease
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 24, 9407, insgesamt 35 Seiten
Transarterielle Radioembolisation - Immuneffekte und Immunonkologie
In: Der Radiologe: Zeitschrift für diagnostische und interventionelle Radiologie, Radioonkologie, Nuklearmedizin ; Organ der Arbeitsgemeinschaft Berufsverbände Medizinische Radiologie. Dan - Berlin: Springer, Bd. 60.2020, 8, S. 693-703
Trauma severity and its impact on local inflammation in extremity injury - insights from a combined trauma model in pigs
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Vol. 10.2020, Article 3028, insges. 10 Seiten
2019
Begutachteter Zeitschriftenartikel
A nationwide fluidics biobank of polytraumatized patients: implemented by the Network "Trauma Research" (NTF) as an expansion to the TraumaRegister DGU ® of the German Trauma Society (DGU).
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 3, S. 499-504
Alcohol Binge Reduces Systemic Leukocyte Activation and Pulmonary PMN Infiltration After Blunt Chest Trauma and Hemorrhagic Shock.
In: Inflammation, 2019, Bd. 42, Heft 2, S. 690-701
Alcoholinduced attenuation of posttraumatic inflammation is not necessarily liverprotective following trauma/hemorrhage.
In: International journal of molecular medicine, 2019, Bd. 44, Heft 3, S. 1127-1138
Circulating Extracellular Vesicles and Their miR "Barcode" Differentiate Alcohol Drinkers With Liver Injury and Those Without Liver Injury in Severe Trauma Patients.
In: Frontiers in medicine, 2019, Bd. 6, S. 30
Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2
In: Molecular medicine - [London]: BioMed Central, 1994, Bd.25.2019, Art.-Nr. 45, insges. 13 S.
Contributing factors in the development of acute lung injury in a murine double hit model.
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 1, S. 21-30
Curcumin combined with exposure to visible light blocks bladder cancer cell adhesion and migration by an integrin dependent mechanism
In: European review for medical and pharmacological sciences - Roma: Verduci, 1997, Bd. 23 (2019), 23, S. 10564-10574
Cytokines in inflammatory disease
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd.20.2019, 23, Art.-Nr. 6008, insges. 31 S.
Damage-associated molecular patterns in trauma.
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 4, S. 751-775
Early Local Inhibition of Club Cell Protein 16 Following Chest Trauma Reduces Late Sepsis-Induced Acute Lung Injury.
In: Journal of clinical medicine, 2019, Bd. 8, Heft 6
Endogenous uteroglobin as intrinsic anti-inflammatory signal modulates monocyte and macrophage subsets distribution upon sepsis induced lung injury
In: Frontiers in immunology - Lausanne: Frontiers Media, 2010, Bd.10.2019, Art.-Nr. 2276, insges. 14 S.
Enhanced pro-inflammatory response and higher mortality rates in geriatric trauma patients.
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019
Innate immunity and alcohol
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd.8.2019, 11, Art.-Nr. 1981, insges. 31 S.
Is I-FABP not only a marker for the detection abdominal injury but also of hemorrhagic shock in severely injured trauma patients?
In: World journal of emergency surgery : WJES, 2019, Bd. 14, S. 49
Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism.
In: Frontiers in immunology, 2019, Bd. 10, S. 1920
Modeling trauma in rats - similarities to humans and potential pitfalls to consider
In: Journal of translational medicine - London: BioMed Central, 2003, Bd. 17.2019, Art.-Nr. 305, insges. 19 S.
Monotrauma is associated with enhanced remote inflammatory response and organ damage, while polytrauma intensifies both in porcine trauma model.
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 1, S. 31-42
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
In: Brain, behavior, and immunity, 2019, Bd. 81, S. 228-246
Smoking Dependent Alterations in Bone Formation and Inflammation Represent Major Risk Factors for Complications Following Total Joint Arthroplasty.
In: Journal of clinical medicine, 2019, Bd. 8, Heft 3
The influence of alcohol on the outcome of trauma patients: a matched-pair analysis of the TraumaRegister DGU ® .
In: European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019, Bd. 46, Heft 3, S. 463-472
Traumatic injury pattern is of equal relevance as injury severity for experimental (poly)trauma modeling.
In: Scientific reports, 2019, Bd. 9, Heft 1, S. 5706
2018
Begutachteter Zeitschriftenartikel
Comparative analysis of the regulatory T cells dynamics in peripheral blood in human and porcine polytrauma
In: In: Frontiers in Immunology, Bd. 9, MAR, 2018
Danger signals in trauma
In: In: European Journal of Trauma and Emergency Surgery, Bd. 44, 3, S. 301-316, 2018
Early local microcirculation is improved after intramedullary nailing in comparison to external fixation in a porcine model with a femur fracture
In: In: European Journal of Trauma and Emergency Surgery, Bd. 44, 5, S. 689-696, 2018
Ethyl pyruvate ameliorates hepatic injury following blunt chest trauma and hemorrhagic shock by reducing local inflammation, NF-kappaB activation and HMGB1 release
In: In: PLoS ONE, Bd. 13, 2, 2018
Reduced NLRP3 gene expression limits the IL-1 cleavage via inflammasome in monocytes from severely injured trauma patients
In: In: Mediators of Inflammation, Bd. 2018, 2018
Simvastatin exerts anticancer effects in osteosarcoma cell lines via geranylgeranylation and c-Jun activation.
In: International journal of oncology, 2018, Bd. 52, Heft 4, S. 1285-1294
Suppression of the interleukin- 1-induced inflammatory response of human Chang liver cells by acute and subacute exposure to alcohol: An in vitro study
In: In: Croatian Medical Journal, Bd. 59, 2, S. 46-55, 2018
The posttraumatic activation of CD4+ T regulatory cells is modulated by TNFR2- and TLR4-dependent pathways, but not by IL-10.
In: Cellular immunology, 2018, Bd. 331, S. 137-145
Traumatic Injury
In: In: Experientia supplementum (2012), Bd. 108, S. 85-110, 2018
2017
Artikel in Zeitschrift
Correction - Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion
In: OncoTarget: open access impact journal - [S.l.]: Impact Journals LLC, 2010, Bd. 8.2017, 1, S. 1953-1954
Begutachteter Zeitschriftenartikel
Acute Alcohol Binge Deteriorates Metabolic and Respiratory Compensation Capability After Blunt Chest Trauma Followed by Hemorrhagic Shock-A New Research Model.
In: Alcoholism, clinical and experimental research, 2017, Bd. 41, Heft 9, S. 1559-1567
Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury.
In: International immunopharmacology, 2017, Bd. 51, S. 66-75
Cardiac depression in pigs after multiple trauma - Characterization of posttraumatic structural and functional alterations
In: In: Scientific Reports, Bd. 7, 1, 2017
Correction: Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion.
In: Oncotarget, 2017, Bd. 8, Heft 1, S. 1953-1954
Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model
In: In: PLoS ONE, Bd. 12, 11, 2017
Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway.
In: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Bd. 43, Heft 1, S. 17-30
Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-B and HMGB1.
In: Immunobiology, 2017, Bd. 223, Heft 3, S. 310-318
I-FABP is a Novel Marker for the Detection of Intestinal Injury in Severely Injured Trauma Patients
In: In: World Journal of Surgery, Bd. 41, 12, S. 3120-3127, 2017
Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients
In: In: Mediators of Inflammation, Bd. 2017, 2017
Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model.
In: Prostaglandins, leukotrienes, and essential fatty acids, 2017, Bd. 127, S. 25-31
Role of biomarkers in acute traumatic lung injury.
In: Injury, 2017, Bd. 48, Heft 11, S. 2400-2406
Serum -1 Antitrypsin (AAT) antagonizes intrinsic apoptosis induction in neutrophils from patients with systemic inflammatory response syndrome
In: In: PLoS ONE, Bd. 12, 5, 2017
Severe Hemorrhagic Shock Leads to a Delayed Fracture Healing and Decreased Bone Callus Strength in a Mouse Model
In: In: Clinical Orthopaedics and Related Research, Bd. 475, 11, S. 2783-2794, 2017
2016
Artikel in Zeitschrift
Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion
In: OncoTarget - [S.l.]: Impact Journals LLC, 2010, Bd. 7.2016, 15, S. 20410-20424
Begutachteter Zeitschriftenartikel
Adrenergic stimulation alters the expression of inflammasome components and interleukins in primary human monocytes
In: In: Experimental and Therapeutic Medicine, Bd. 11, 1, S. 297-302, 2016
Alcohol Intoxication Reduces Systemic Interleukin-6 Levels and Leukocyte Counts After Severe TBI Compared With Not Intoxicated TBI Patients.
In: Shock (Augusta, Ga.), 2016, Bd. 46, Heft 3, S. 261-9
Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma
In: In: Scientific Reports, Bd. 6, 2016
Correction: Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion
In: In: Oncotarget, Bd. 8, 1, S. 1953-1954, 2016
Effects of positive blood alcohol concentration on outcome and systemic interleukin-6 in major trauma patients.
In: Injury, 2016, Bd. 47, Heft 3, S. 640-5
Influence of gender on systemic IL-6 levels, complication rates and outcome after major trauma.
In: Immunobiology, 2016, Bd. 221, Heft 8, S. 904-10
Long-term effects of induced hypothermia on local and systemic inflammation - Results from a porcine long-term trauma model
In: In: PLoS ONE, Bd. 11, 5, 2016
Phagocytizing activity of PMN from severe trauma patients in different post-traumatic phases during the 10-days post-injury course.
In: Immunobiology, 2016, Bd. 222, Heft 2, S. 301-307
Sera from severe trauma patients with pneumonia and without infectious complications have differential effects on neutrophil biology
In: In: BMC Pulmonary Medicine, Bd. 16, 1, 2016
Simvastatin Reduces Cancerogenic Potential of Renal Cancer Cells via Geranylgeranyl Pyrophosphate and Mevalonate Pathway.
In: Nutrition and cancer, 2016, Bd. 68, Heft 3, S. 420-7
2015
Begutachteter Zeitschriftenartikel
Adrenergic stimulation alters the expression of inflammasome components and interleukins in primary human monocytes.
In: Experimental and therapeutic medicine, 2015, Bd. 11, Heft 1, S. 297-302
Cell-based therapy by implanted human bone marrow-derived mononuclear cells improved bone healing of large bone defects in rats.
In: Tissue engineering. Part A, 2015, Bd. 21, Heft 9-10, S. 1565-78
Differential relevance of NF-B and JNK in the pathophysiology of hemorrhage/resususcitation-induced liver injury after chronic ethanol feeding
In: In: PloS one, 2015, Bd. 10, Heft 9, S. e0137875
Ethanol, ethyl and sodium pyruvate decrease the inflammatory responses of human lung epithelial cells via Akt and NF-B in vitro but have a low impact on hepatocellular cells.
In: International journal of molecular medicine, 2015, Bd. 37, Heft 2, S. 517-25
I-FABP and L-FABP are early markers for abdominal injury with limited prognostic value for secondary organ failures in the post-traumatic course.
In: Clinical chemistry and laboratory medicine, 2015, Bd. 53, Heft 5, S. 771-80
Nlrp1 inflammasome is downregulated in trauma patients
In: In: Journal of Molecular Medicine, Bd. 93, 12, S. 1391-1400, 2015
Pre- or post-treatment with ethanol and ethyl pyruvate results in distinct anti-inflammatory responses of human lung epithelial cells triggered by interleukin-6.
In: Molecular medicine reports, 2015, Bd. 12, Heft 2, S. 2991-8
The effect of brain injury on the inflammatory response following severe trauma.
In: Immunobiology, 2015, Bd. 221, Heft 3, S. 427-31
2014
Begutachteter Zeitschriftenartikel
Decreased inflammatory responses of human lung epithelial cells after ethanol exposure are mimicked by ethyl pyruvate
In: In: Mediators of Inflammation, Bd. 2014, 2014
Modulation of Inflammation by Alcohol Exposure
In: Mediators of Inflammation, Hindawi Limited, Bd. 2014, S. 1-2, Article number 283756
Myeloid knockout of HIF-1 does not markedly affect hemorrhage/resuscitation-induced inflammation and hepatic injury
In: In: Mediators of Inflammation, Bd. 2014, 2014
Treatment of endothelial cell with flavonoids modulates transendothelial leukocyte migration.
In: Phlebology, 2014, Bd. 30, Heft 6, S. 405-11
2013
Begutachteter Zeitschriftenartikel
Effects of acute ethanol gavage on intestinal integrity after hemorrhage/resuscitation.
In: Scandinavian journal of gastroenterology, 2013, Bd. 48, Heft 4, S. 448-58
Establishment and characterization of the Masquelet induced membrane technique in a rat femur critical-sized defect model.
In: Journal of tissue engineering and regenerative medicine, 2013, Bd. 10, Heft 10, S. E382-E396
Pathophysiology of multiple trauma: Intensive care medicine and timing of treatment
In: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2013, Bd. 84, Heft 9, S. 753-8
2012
Begutachteter Zeitschriftenartikel
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) levels are decreased in patients with trauma-induced coagulopathy.
In: Thrombosis research, 2012, Bd. 131, Heft 1, S. e26-30
Acute alcohol intoxication reduces mortality, inflammatory responses and hepatic injury after haemorrhage and resuscitation in vivo
In: In: British Journal of Pharmacology, Bd. 165, 4 B, S. 1188-1199, 2012
Acute ethanol gavage attenuates hemorrhage/resuscitation-induced hepatic oxidative stress in rats
In: In: Oxidative Medicine and Cellular Longevity, 2012
Circulating leukotriene B4 identifies respiratory complications after trauma
In: In: Mediators of Inflammation, Bd. 2012, 2012
Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats
In: In: European Journal of Nutrition, Bd. 51, 3, S. 311-321, 2012
Thrombin-activatable fibrinolysis inhibitor (TAFI) is enhanced in major trauma patients without infectious complications.
In: Immunobiology, 2012, Bd. 218, Heft 4, S. 470-6
2011
Begutachteter Zeitschriftenartikel
Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells.
In: Hepatology research : the official journal of the Japan Society of Hepatology, 2011, Bd. 41, Heft 4, S. 364-74
Effects of green tea catechins on the pro-inflammatory response after haemorrhage/resuscitation in rats.
In: The British journal of nutrition, 2011, Bd. 105, Heft 12, S. 1791-7
Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats.
In: European journal of nutrition, 2011, Bd. 51, Heft 3, S. 311-21
2010
Begutachteter Zeitschriftenartikel
Intestinal-FABP and liver-FABP: Novel markers for severe abdominal injury.
In: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2010, Bd. 17, Heft 7, S. 729-35
Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells.
In: International journal of molecular medicine, 2010, Bd. 26, Heft 5, S. 735-41
Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK.
In: International journal of oncology, 2010, Bd. 38, Heft 3, S. 879-85
Simvastatin reduces mortality and hepatic injury after hemorrhage/resuscitation in rats.
In: Shock (Augusta, Ga.), 2010, Bd. 34, Heft 1, S. 46-54
2009
Begutachteter Zeitschriftenartikel
Inhibition of c-Jun N-terminal kinase after hemorrhage but before resuscitation mitigates hepatic damage and inflammatory response in male rats.
In: Shock (Augusta, Ga.), 2009, Bd. 32, Heft 5, S. 509-16
Rapid development of intestinal cell damage following severe trauma: A prospective observational cohort study
In: In: Critical Care, Bd. 13, 3, 2009
2008
Begutachteter Zeitschriftenartikel
A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.
In: Shock (Augusta, Ga.), 2008, Bd. 30, Heft 2, S. 159-65
Differential effects of GdCl3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock.
In: Microcirculation (New York, N.Y. : 1994), 2008, Bd. 15, Heft 5, S. 427-39
Significant decline of peripheral myeloid dendritic cells following multiple trauma.
In: The Journal of surgical research, 2008, Bd. 154, Heft 2, S. 239-45
2007
Begutachteter Zeitschriftenartikel
CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cells.
In: Experimental cell research, 2007, Bd. 313, Heft 19, S. 4051-65
Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes
In: Journal of Cellular and Molecular Medicine, Wiley, 2007, Bd. 11, Heft 4, S. 826-838
Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium
In: In: British Journal of Cancer, Bd. 96, 11, S. 1699-1706, 2007
2006
Begutachteter Zeitschriftenartikel
Altered expression of beta1 integrins in renal carcinoma cell lines exposed to the differentiation inducer valproic acid.
In: International journal of molecular medicine, 2006, Bd. 18, Heft 2, S. 347-54
CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins.
In: Neoplasia (New York, N.Y.), 2006, Bd. 8, Heft 4, S. 290-301
2005
Begutachteter Zeitschriftenartikel
Modulation of the CXC-chemokine expression profile on tumor cells by the immunosuppressive drug mycophenolate mofetil.
In: International journal of molecular medicine, 2005, Bd. 15, Heft 4, S. 641-7
Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor cells: Impact on tumor recurrence and malignancy
In: In: BMC Cancer, Bd. 5, 2005
Prostate tumor CXC-chemokine profile correlates with cell adhesion to endothelium and extracellular matrix.
In: Life sciences, 2005, Bd. 78, Heft 16, S. 1784-93
Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells
In: In: International Immunopharmacology, Bd. 5, 4, S. 757-769, 2005