Prof. Reichl

Prof. Dr.-Ing. Udo Reichl

Fakultät für Verfahrens- und Systemtechnik (FVST)
International Max Planck Research School
Universitätsplatz 2, 39106, Magdeburg, Gebäude 25, Raum 112
Tel.: +49 391 67 58402
Fax: +49 391 67 11209

Prof. Dr.-Ing. Udo Reichl

Fakultät für Verfahrens- und Systemtechnik (FVST)
International Max Planck Research School
Universitätsplatz 2, 39106, Magdeburg, Gebäude 25, Raum 112
Tel.: +49 391 67 58402
Fax: +49 391 67 11209
Projekte

Aktuelle Projekte

Abgeschlossene Projekte

Publikationen

2017

Begutachteter Zeitschriftenartikel
Hämmerlein, Frank;  Pieler, Michael M.;  Hennig, René;  Serve, Anja;  Rapp, Erdmann;  Wolff, Michael W.;  Reichl, Udo;  Hubbuch, Jürgen 

Influence of the production system on the surface properties of influenza A virus particles
In: Engineering in life sciences - Weinheim: Wiley-VCH, Bd. 17.2017, 10, S. 1071-1077; http://dx.doi.org/10.1002/elsc.201700058

Kohrs, Fabian;  Heyer, Robert;  Bissinger, Thomas;  Kottler, Robert;  Schallert, Kay;  Püttker, Sebastian;  Behne, A.;  Rapp, Erdmann;  Benndorf, Dirk;  Reichl, Udo 

Proteotyping of laboratory-scale biogas plants reveals multiple steady-states in community composition
In: Anaerobe: the official journal of the Anaerobe Society of the Americas - London: Academic Press, Bd. 46.2017, S. 56-68; http://dx.doi.org/10.1016/j.anaerobe.2017.02.005

Marichal-Gallardo, Pavel;  Pieler, Michael M.;  Wolff, Michael W.;  Reichl, Udo 

Steric exclusion chromatography for purification of cell culture-derived influenza A virus using regenerated cellulose membranes and polyethylene glycol
In: Journal of chromatography / A: including electrophoresis, mass spectrometry and other separation and detection methods - New York, NY [u.a.]: Science Direct, Bd. 1483.2017, S. 110-119; http://dx.doi.org/10.1016/j.chroma.2016.12.076

Pieler, Michael Martin;  Heyse, Anja;  Wolff, Michael Werner;  Reichl, Udo 

Specific ion effects on the particle size distributions of cell culturederived influenza A virus particles within the Hofmeister series
In: Engineering in life sciences - Weinheim: Wiley-VCH, Bd. 17.2017, 5, S. 470-478; https://doi.org/10.1002/elsc.201600153

Pralow, Alexander;  Hoffmann, Marcus;  Nguyen-Khuong, Terry;  Rapp, Erdmann;  Reichl, Udo 

Improvement of the glycoproteomic toolbox with the discovery of a unique C-terminal cleavage specificity of flavastacin for N-glycosylated asparagine
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 7.2017, Art.-Nr. 11419, insgesamt 9 Seiten; http://dx.doi.org/10.1038/s41598-017-11668-1

Tapia, Felipe;  Jordan, Ingo;  Genzel, Yvonne;  Reichl, Udo 

Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systems
In: PLoS one - Lawrence, Kan: PLoS, Bd. 12.2017, 8, Art.-Nr. e0182553, insges. 17 Seiten; http://dx.doi.org/10.1371/journal.pone.0182553

Dissertation
Heyer, Robert Steven;  Reichl, Udo [AkademischeR BetreuerIn] 

Charakterisierung von mikrobiellen Gemeinschaften aus Biogasanlagen mittels Metaproteomanalyse und Korrelationen der Ergebnisse zu den Prozessparametern
In: Magdeburg, 2017, XVII, 164, xxxvii Blätter, Illustrationen

2016

Begutachteter Zeitschriftenartikel
Bachmann, Mandy;  Breitwieser, Theresa;  Lipps, Christoph;  Wirth, Dagmar;  Jordan, Ingo;  Reichl, Udo;  Frensing, Timo 

Impaired antiviral response of adenovirus-transformed cell lines supports virus replication
In: Journal of general virology : JGV. - Reading : Soc, Bd. 97.2016, 2, S. 293-298

Bensmann, Astrid;  Hanke-Rauschenbach, Richard;  Heyer, Robert;  Kohrs, Fabian;  Benndorf, Dirk;  Kausmann, Robert;  Plöchl, Matthias;  Heiermann, Monika;  Reichl, Udo;  Sundmacher, Kai 

Diagnostic concept for dynamically operated biogas production plants
In: Renewable energy : an international journal ; the official journal of WREN, The World Renewable Energy Network. - Amsterdam [u.a.] : Elsevier Science; Vol. 96.2016, Part A, S. 479-489

Cammann, Clemens;  Rath, Alexander;  Reichl, Udo;  Lingel, Holger;  Brunner-Weinzierl, Monika;  Simeoni, Luca;  Schraven, Burkhart;  Lindquist, Jonathan A. 

Early changes in the metabolic profile of activated CD8+ T cells
In: BMC cell biology. - London : BioMed Central; Bd. 17 (2016), Art.-Nr. 28, insges. 11 S.

Frensing, Timo;  Kupke, Sascha Y.;  Bachmann, Mandy;  Fritzsche, Susanne;  Gallo-Ramirez, Lili E.;  Reichl, Udo 

Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 100.2016, 16, S. 7181-7192

Hennig, René;  Cajic, Samanta;  Borowiak, Matthias;  Hoffmann, Marcus;  Kottler, Robert;  Reichl, Udo;  Rapp, Erdmann 

Towards personalized diagnostics via longitudinal study of the human plasma N-glycome
In: Biochimica et biophysica acta / General subjects. - Amsterdam [u.a.] : Elsevier, Bd. 1860.2016, 8, S. 1728-1738

Heyer, Robert;  Benndorf, Dirk;  Kohrs, F.;  Vrieze, J.;  Boon, N.;  Hoffmann, M.;  Rapp, Erdmann;  Schlüter, A.;  Sczyrba, A.;  Reichl, Udo 

Proteotyping of biogas plant microbiomes separates biogas plants according to process temperature and reactor type
In: Biotechnology for biofuels - London: BioMed Central, Bd. 9.2016, 1; http://dx.doi.org/10.1186/s13068-016-0572-4

Hoffmann, Marcus;  Marx, Kristina;  Reichl, Udo;  Wuhrer, Manfred;  Rapp, Erdmann 

Site-specific O-glycosylation analysis of human blood plasma proteins
In: Molecular & cellular proteomics : MCP. - Bethesda, Md : The American Society for Biochemistry and Molecular Biology, Bd. 15.2016, 2, S. 624-641

Kluge, Sabine;  Genzel, Yvonne;  Laus, Kim;  Serve, Anja;  Pflugmacher, Antje;  Peschel, Britta;  Rapp, Erdmann;  Reichl, Udo 

Ezrin and HNRNP expression correlate with increased virus release rate and early onset of virus-induced apoptosis of MDCK suspension cells
In: Biotechnology journal : BTJ ; systems & synthetic biology, nanobiotech, medicine. - Weinheim : Wiley-VCH, Bd. 11.2016, 10, S. 1332-1342

Koch, Sabine;  Benndorf, Dirk;  Fronk, Karen;  Reichl, Udo;  Klamt, Steffen 

Predicting compositions of microbial communities from stoichiometric models with applications for the biogas process
In: Biotechnology for biofuels. - London : BioMed Central, Bd. 9.2016, 17, insges. 16 S.

Laske, Tanja;  Heldt, Frank Stefan;  Hoffmann, Helene;  Frensing, Timo;  Reichl, Udo 

Reprint of "Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs
In: Virus research : an international journal of molecular and cellular virology. - Amsterdam [u.a.] : Elsevier Science, Bd. 218.2016, S. 86-95

Meininger, M.;  Stepath, M.;  Hennig, R.;  Cajic, S.;  Rapp, E.;  Rotering, H.;  Wolff, M. W.;  Reichl, Udo 

Sialic acid-specific affinity chromatography for the separation of erythropoietin glycoforms using serotonin as a ligand
In: Journal of chromatography / B. - New York, NY [u.a.] : Science Direct, Bd. 1012/1013.2016, S. 193-203

Pieler, Michael M.;  Frentzel, Sarah;  Bruder, Dunja;  Wolff, Michael W.;  Reichl, Udo 

A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection
In: Vaccine. - Amsterdam : Elsevier, Bd. 34.2016, 50, S. 6367-6374

Salerno, Carlo;  Benndorf, Dirk;  Kluge, Sabine;  Palese, Luigi Leonardo;  Reichl, Udo;  Pollice, Alfieri 

Metaproteomics applied to activated sludge for industrial wastewater treatment revealed a dominant methylotrophic metabolism of Hyphomicrobium zavarzinii
In: Microbial ecology : official journal of the International Society for Microbial Ecology. - New York, NY : Springer, 2016

Tapia, Felipe;  Vázquez-Ramírez, Daniel;  Genzel, Yvonne;  Reichl, Udo 

Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 100.2016, 5, S. 2121-2132

Thiesler, Christina T.;  Cajic, Samanta;  Hoffmann, Dirk;  Thiel, Christian;  Diepen, Laura van;  Hennig, René;  Sgodda, Malte;  Weiβ  mann, Robert;  Reichl, Udo;  Steinemann, Doris;  Diekmann, Ulf;  Huber, Nicolas M. B.;  Oberbeck, Astrid;  Cantz, Tobias;  Kuss, Andreas W.;  Körner, Christian;  Schambach, Axel;  Rapp, Erdmann;  Buettner, Falk F. R. 

Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital Disorder of glycosylation (PMM2-CDG)
In: Molecular & cellular proteomics : MCP. - Bethesda, Md : The American Society for Biochemistry and Molecular Biology, Bd. 15.2016, 4, S. 1435-1452

Wang, Wenjing;  Voigt, Andreas;  Wolff, Michael W.;  Reichl, Udo;  Sundmacher, Kai 

Binding kinetics and multi-bond : finding correlations by synthesizing interactions between ligand-coated bionanoparticles and receptor surfaces
In: Analytical biochemistry : methods in the biological sciences. - San Diego, Calif : Elsevier, Bd. 505.2016, S. 8-17

2015

Begutachteter Zeitschriftenartikel
Gallo-Ramírez, Lilí Esmeralda;  Nikolay, Alexander;  Genzel, Yvonne;  Reichl, Udo 

Bioreactor concepts for cell culture-based viral vaccine production
In: Expert review of vaccines. - London : Informa Healthcare, Bd. 14.2015, 9, S. 1181-1195

Grabherr, Reingard;  Reichl, Udo 

Editorial: Can modern vaccine technology pursue the success of traditional vaccine manufacturing?
In: Biotechnology journal : BTJ. - Weinheim : Wiley-VCH, Bd. 10.2015, 5, S. 657-658

Heldt, Frank S.;  Kupke, Sascha Y.;  Dorl, Sebastian;  Reichl, Udo;  Frensing, Timo 

Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection
In: Nature Communications. - London : Nature Publishing Group; Vol. 6.2015, Art. 8938, insgesamt 12 S.

Heyer, Robert;  Kohrs, Fabian;  Reichl, Udo;  Benndorf, Dirk 

Metaproteomics of complex microbial communities in biogas plants
In: Microbial biotechnology. - Oxford : Wiley-Blackwell, Bd. 8.2015, 5, S. 749-763

Karsten, Christina B.;  Buettner, Falk F. R.;  Cajic, Samanta;  Nehlmeier, Inga;  Neumann, Berit;  Klippert, Antonina;  Sauermann, Ulrike;  Reichl, Udo;  Gerardy-Schahn, Rita;  Rapp, Erdmann;  Stahl-Hennig, Christiane;  Pöhlmann, Stefan 

Exclusive decoration of simian immunodeficiency virus Env with high-mannose type N-glycans is not compatible with mucosal transmission in rhesus macaques
In: Journal of virology : publ. by the American Society for Microbiology. - Baltimore, Md : Soc, Bd. 89.2015, 22, S. 11727-11733

Kluge, Sabine;  Benndorf, Dirk;  Genzel, Yvonne;  Scharfenberg, Klaus;  Rapp, Erdmann;  Reichl, Udo 

Monitoring changes in proteome during stepwise adaptation of a MDCK cell line from adherence to growth in suspension
In: Vaccine. - Amsterdam : Elsevier, Bd. 33.2015, 35, S. 4269-4280

Kohrs, Fabian;  Wolter, Sophie;  Benndorf, Dirk;  Heyer, Robert;  Hoffmann, Marcus;  Rapp, Erdmann;  Bremges, Andreas;  Sczyrba, Alexander;  Schlüter, Andreas;  Reichl, Udo 

Fractionation of biogas plant sludge material improves metaproteomic characterization to investigate metabolic activity of microbial communities
In: Proteomics. - Weinheim : Wiley VCH, Bd. 15.2015, 20, S. 3585-3589

Kolmeder, Carolin A.;  Ritari, Jarmo;  Verdam, Froukje J.;  Muth, Thilo;  Keskitalo, Salla;  Varjosalo, Markku;  Fuentes, Susana;  Greve, Jan Willem;  Buurman, Wim A.;  Reichl, Udo;  Rapp, Erdmann;  Martens, Lennart;  Palva, Airi;  Salonen, Anne;  Rensen, Sander S.;  Vos, Willem M. de 

Colonic metaproteomic signatures of active bacteria and the host in obesity
In: Proteomics. - Weinheim : Wiley VCH, Bd. 15.2015, 20, S. 3544-3552

Laske, Tanja;  Heldt, Frank Stefan;  Hoffmann, Helene;  Frensing, Timo;  Reichl, Udo 

Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs
In: Virus research : an international journal of molecular and cellular virology. - Amsterdam [u.a.] : Elsevier Science, Bd. 213.2015, S. 90-99

Muth, Thilo;  Kolmeder, Carolin A.;  Salojärvi, Jarkko;  Keskitalo, Salla;  Varjosalo, Markku;  Verdam, Froukje J.;  Rensen, Sander S.;  Reichl, Udo;  Vos, Willem M. de;  Rapp, Erdmann;  Martens, Lennart 

Navigating through metaproteomics data - a logbook of database searching
In: Proteomics. - Weinheim : Wiley VCH, Bd. 15.2015, 20, S. 3439-3453

Muth, Thilo;  Behne, Alexander;  Heyer, Robert;  Kohrs, Fabian;  Benndorf, Dirk;  Hoffmann, Marcus;  Lehtevä, Miro;  Reichl, Udo;  Martens, Lennart;  Rapp, Erdmann 

The MetaProteomeAnalyzer - a powerful open-source software suite for metaproteomics data analysis and interpretation
In: Journal of proteome research. - Washington, DC : ACS Publications, Bd. 14.2015, 3, S. 1557-1565

Püttker, Sebastian;  Kohrs, Fabian;  Benndorf, Dirk;  Heyer, Robert;  Rapp, Erdmann;  Reichl, Udo 

Metaproteomics of activated sludge from a wastewater treatment plant - a pilot study
In: Proteomics. - Weinheim : Wiley VCH, Bd. 15.2015, 20, S. 3596-3601

Serve, Anja;  Pieler, Michael Martin;  Benndorf, Dirk;  Rapp, Erdmann;  Wolff, Michael Werner;  Reichl, Udo 

Comparison of influenza virus particle purification using magnetic sulfated cellulose particles with an established centrifugation method for analytics
In: Analytical chemistry : the authoritative voice of the analytical community. - Columbus, Ohio : American Chemical Society, Bd. 87.2015, 21, S. 10708-10711

Theuerl, Susanne;  Kohrs, Fabian;  Benndorf, Dirk;  Maus, Irena;  Wibberg, Daniel;  Schlüter, Andres;  Kausmann, Robert;  Heiermann, Monika;  Rapp, Erdmann;  Reichl, Udo;  Pühler, Alfred;  Klocke, Michael 

Community shifts in a well-operating agricultural biogas plant - how process variations are handled by the microbiome
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 99.2015, 18, S. 7791-7803

2014

Begutachteter Zeitschriftenartikel
Bensch, Gerald;  Rüger, Marc;  Wassermann, Magdalena;  Weinholz, Susann;  Reichl, Udo;  Cordes, Christiana 

Flow cytometric viability assessment of lactic acid bacteria starter cultures produced by fluidized bed drying
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 98.2014, 11, S. 4897-4909

Bensmann, Astrid;  Hanke-Rauschenbach, R.;  Heyer, Robert;  Kohrs, Fabian;  Benndorf, Dirk;  Reichl, Udo;  Sundmacher, Kai 

Biological methanation of hydrogen within biogas plants: A model-based feasibility study
In: Applied energy. - Amsterdam [u.a.] : Elsevier Science, Bd. 134.2014, S. 413-425

Frensing, Timo;  Pflugmacher, Antje;  Bachmann, Mandy;  Peschel, Britta;  Reichl, Udo 

Impact of defective interfering particles on virus replication and antiviral host response in cell culture-based influenza vaccine production
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 98.2014, 21, S. 8999-9008

Genzel, Yvonne;  Vogel, Thomas;  Buck, Johannes;  Behrendt, Ilona;  Vazquez Ramirez, Daniel;  Schiedner, Gudrun;  Jordan, Ingo;  Reichl, Udo 

High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells
In: Vaccine. - Amsterdam : Elsevier, Bd. 32.2014, 24, S. 2770-2781

Huffman, Jennifer E.;  Puč  ić  -Baković  , Maja;  Klarić  , Lucija;  Hennig, René;  Selman, Maurice H. J.;  Vuč  ković  , Frano;  Novokmet, Mislav;  Kriš  tić  , Jasminka;  Borowiak, Matthias;  Muth, Thilo;  Polaš  ek, Ozren;  Razdorov, Genadij;  Gornik, Olga;  Plomp, Rosina;  Theodoratou, Evropi;  Wright, Alan F.;  Rudan, Igor;  Hayward, Caroline;  Campbell, Harry;  Deelder, André M.;  Reichl, Udo;  Aulchenko, Yurii S.;  Rapp, Erdmann;  Wuhrer, Manfred;  Lauc, Gordan 

Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological
In: Molecular & cellular proteomics. - Bethesda, Md : The American Society for Biochemistry and Molecular Biology, Bd. 13.2014, S. 1598-1610

Kohrs, Fabian;  Heyer, Robert;  Magnussen, A.;  Benndorf, Dirk;  Muth, T.;  Behne, A.;  Rapp, E.;  Kausmann, R.;  Heiermann, M.;  Klocke, M.;  Reichl, Udo 

Sample prefractionation with liquid isoelectric focusing enables in depth microbial metaproteome analysis of mesophilic and thermophilic biogas plants
In: Anaerobe. - London : Academic Press, Bd. 29.2014, S. 59-67

Lohr, Verena;  Hädicke, Oliver;  Genzel, Yvonne;  Jordan, Ingo;  Büntemeyer, Heino;  Klamt, Steffen;  Reichl, Udo 

The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis
In: BMC biotechnology. - London : BioMed Central; Vol. 14.2014, Art. 72 insgesamt 14 S.

Rath, Alexander G.;  Rehberg, Markus;  Janke, Robert;  Genzel, Yvonne;  Scholz, Sebastian;  Noll, Thomas;  Rose, Thomas;  Sandig, Volker;  Reichl, Udo 

The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells
In: Journal of biotechnology. - Amsterdam [u.a.] : Elsevier Science, Bd. 178.2014, S. 43-53

Rehberg, M.;  Rath, A.;  Ritter, J. B.;  Genzel, Y.;  Reichl, Udo 

Changes in intracellular metabolite pools during growth of adherent MDCK cells in two different media
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 98.2014, 1, S. 385-397

Rehberg, Markus;  Ritter, Joachim B.;  Reichl, Udo 

Glycolysis is governed by growth regime and simple enzyme regulation in adherent MDCK cells
In: PLoS Computational Biology. - San Francisco, Calif : Public Library of Science; Vol. 10.2014, 10, Art. e1003885, insgesamt 16 S.

Rödig, Jana Verena;  Rapp, Erdmann;  Bohne, Jana;  Kampe, Michael;  Kaffka, Helene;  Bock, Andreas;  Genzel, Yvonne;  Reichl, Udo 

Impact of cultivation conditions on N-glycosylation of influenza virus a hemagglutinin produced in MDCK cell culture
In: Biotechnology & bioengineering. - New York, NY [u.a.] : Wiley, Bd. 110.2014, 6, S. 1691-1703

Rüger, Marc;  Ackermann, Mandy;  Reichl, Udo 

Species-specific viability analysis of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus in mixed culture by flow cytometry
In: BMC microbiology. - London : BioMed Central; Bd. 14.2014, Art. 56, insgesamt 15 S.

Tapia, Felipe;  Vogel, Thomas;  Genzel, Yvonne;  Behrendt, Ilona;  Hirschel, Mark;  Gangemi, J. David;  Reichl, Udo 

Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactor
In: Vaccine. - Amsterdam : Elsevier, Bd. 32.2014, 8, S. 1003-1011

Weigel, Thomas;  Solomaier, Thomas;  Peuker, Alessa;  Pathapati, Trinath;  Wolff, Michael W.;  Reichl, Udo 

A flow-through chromatography process for influenza A and B virus purification
In: Journal of virological methods. - Amsterdam [u.a.] : Elsevier Science, Bd. 207.2014, S. 45-53

Buchbeitrag
Genzel, Yvonne;  Rödig, Jana;  Rapp, Erdmann;  Reichl, Udo 

Vaccine production - upstream processing with adherent or suspension cell lines
In: Pörtner, Ralf: : Animal Cell Biotechnology. - Totowa, NJ : Humana Press, S. 371-393, 2014 - (Methods in Molecular Biology, Methods and Protocols; 1104)

Herausgeberschaft
Benner, Peter;  Findeisen, Rolf;  Flockerzi, Dietrich;  Reichl, Udo;  Sundmacher, Kai 

Large-Scale Networks in Engineering and Life Sciences
In: Heidelberg [u.a.]: Springer, Imprint: Birkhäuser, 2014; Online-Ressource (XIV, 388 p. 111 illus., 63 illus. in color): online resource - (Modeling and Simulation in Science, Engineering and Technology), ISBN 978-3-319-08437-4

2013

Begutachteter Zeitschriftenartikel
Behne, Alexander;  Muth, Thilo;  Borowiak, Matthias;  Reichl, Udo;  Rapp, Erdmann 

glyXalign - high-throughput migration time alignment preprocessing of electrophoretic data retrieved via multiplexed capillary gel electrophoresis with laser-induced fluorescence detection-based glycoprofiling
In: Electrophoresis. - Weinheim : Wiley-Blackwell, Bd. 34.2013, 16, S. 2311-2315

Benndorf, Dirk;  Reichl, Udo 

Proteomics in environmental and technical microbiology
In: Engineering in life sciences. - Weinheim : Wiley-VCH, Bd. 14.2013, 1, S. 27-46

Borchers, Steffen;  Freund, Susann;  Rath, Alexander;  Streif, Stefan;  Reichl, Udo;  Findeisen, Rolf 

Identification of growth phases and influencing factors in cultivation of AGE1.HN cells using set-based methods
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 8.2013, 8, insges. 11 S.

Freund, Susann;  Rath, Alexander;  Barradas, Oscar Platas;  Skerhutt, Eva;  Scholz, Sebastian;  Jens Niklas,;  Sandig, Volker;  Rose, Thomas;  Heinzle, Elmar;  Noll, Thomas;  Pörtner, Ralf;  Zeng, An Ping;  Reichl, Udo 

Batch-to-batch variability of two human designer cell lines - AGE1.HN and AGE1.HN.AAT ; carried out by different laboratories under defined culture conditions using a mathematical model
In: Engineering in life sciences. - Weinheim : Wiley-VCH, Bd. 13.2013, 6, S. 580-592

Genzel, Yvonne;  Behrendt, Ilona;  Rödig, Jana;  Rapp, Erdmann;  Kueppers, Claudia;  Kochanek, Stefan;  Schiedner, Gudrun;  Reichl, Udo 

CAP, a new human suspension cell line for influenza virus production
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 97.2013, 1, S. 111-122, 2012

Genzel, Yvonne;  Frensing, Timo;  Reichl, Udo 

Herstellung moderner Grippeimpfstoffe
In: Chemie in unserer Zeit. - Weinheim : Wiley-VCH, Bd. 47.2013, 1, S. 12-22

Hanreich, Angelika;  Schimpf, Ulrike;  Zakrzewski, Martha;  Schlüter, Andreas;  Benndorf, Dirk;  Heyer, Robert;  Rapp, Erdmann;  Pühler, Alfred;  Reichl, Udo;  Klocke, Michael 

Metagenome and metaproteome analyses of microbial communities in mesophilic biogas-producing anaerobic batch fermentations indicate concerted plant carbohydrate degradation
In: Systematic and applied microbiology - München: Elsevier, Bd. 36.2013, 5, S. 330-338; http://dx.doi.org/10.1016/j.syapm.2013.03.006

Heldt, Frank S.;  Frensing, Timo;  Pflugmacher, Antje;  Gröpler, Robin;  Peschel, Britta;  Reichl, Udo 

Multiscale modeling of influenza A virus infection supports the development of direct-acting antivirals
In: PLoS Computational Biology. - San Francisco, Calif : Public Library of Science; Bd. 9.2013, 11, Art. e1003372, insges. 13 S.

Heuer, Robert;  Kohrs, Fabian;  Benndorf, Dirk;  Rapp, E.;  Kausmann, R.;  Heiermann, M.;  Klocke, M.;  Reichl, Udo 

Metaproteome analysis of the microbial communities in agricultural biogas plants
In: New biotechnology. - New York, NY [u.a.] : Elsevier, Bd. 30.2013, 6, S. 614-622

Hädicke, O.;  Lohr, V.;  Genzel, Y.;  Reichl, Udo;  Klamt, S. 

Evaluating differences of metabolic performances - statistical methods and their application to animal cell cultivations
In: Biotechnology & bioengineering. - New York, NY [u.a.] : Wiley, Bd. 110.2013, 10, S. 2633-2642

Hütter, Julia;  Rödig, Jana V.;  Höper, Dirk;  Seeberger, Peter H.;  Reichl, Udo;  Rapp, Erdmann;  Lepenies, Bernd 

Toward animal cell culturebased influenza vaccine design - viral hemagglutinin N-glycosylation markedly impacts immunogenicity
In: The journal of immunology. - Bethesda, Md : Soc, Bd. 19.2013, 1, S. 220-230

Jordan, Ingo;  Lohr, Verena;  Genzel, Yvonne;  Reichl, Udo;  Sandig, Volker 

Elements in the development of a production process for modified vaccinia virus ankara
In: Microorganisms. - Basel : MDPI, Bd. 1.2013, 1, S. 100-121

Kluge, Sabine;  Rourou, Samia;  Vester, Diana;  Majoul, Samy;  Genzel, Yvonne;  Rapp, Erdmann;  Kallel, Héla;  Reichl, Udo 

Proteome analysis of virushost cell interaction - rabies virus replication in Vero cells in two different media
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 97.2013, 12, S. 5493-5506

Kottler, Robert;  Mank, Marko;  Hennig, René;  Müller-Werner, Beate;  Stahl, Bernd;  Reichl, Udo;  Rapp, Erdmann 

Development of a high-throughput glycoanalysis method for the characterization of oligosaccharides in human milk utilizing multiplexed capillary gel electrophoresis with laser-induced fluorescence detection
In: Electrophoresis. - Weinheim : Wiley-Blackwell, Bd. 34.2013, 16, S. 2323-2336

Kröber, T.;  Wolff, M. W.;  Hundt, B.;  Seidel-Morgenstern, Andreas;  Reichl, Udo 

Continuous purification of influenza virus using simulated moving bed chromatography
In: Journal of chromatography. - New York, NY [u.a.] : Science DirectJournal of chromatography / A, Bd. 1307.2013, S. 99-110

Muth, Thilo;  Brenndorf, Dirk;  Reichl, Udo;  Rapp, Erdmann;  Martens, Lennart 

Searching for a needle in a stack of needles: challenges in metaproteomics data analysis
In: Molecular BioSystems. - Cambridge : Royal Society of Chemistry, Bd. 9.2013, 4, S. 578-585

Müller, Thomas;  Dürr, Robert;  Isken, Britta;  Schulze-Horsel, Josef;  Reichl, Udo;  Kienle, Achim 

Distributed modeling of human influenza a virushost cell interactions during vaccine production
In: Biotechnology & bioengineering. - New York, NY [u.a.] : Wiley, Bd. 110.2013, 8, S. 2252-2266

Neumann, A.;  Hoyer, W.;  Wolff, M. W.;  Reichl, Udo;  Pfitzner, A.;  Roth, B. 

New method for density determination of nanoparticles using a CPS disc centrifuge
In: Colloids and surfaces. - Amsterdam [u.a.] : Elsevier ScienceColloids and surfaces / B, Bd. 104.2013, S. 27-31

Peschel, B.;  Frentzel, S.;  Laske, T.;  Genzel, Y.;  Reichl, Udo 

Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line
In: Vaccine. - Amsterdam : Elsevier, Bd. 31.2013, 48, S. 5693-5699

Tung, Stephanie;  Shi, Yonghong;  Wong, Karry;  Zhu, Fang;  Gorczynski, Reg;  Laister, Robert C.;  Minden, Mark;  Blechert, Anne-Kareen;  Genzel, Yvonne;  Reichl, Udo;  Spaner, David E. 

PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia
In: Blood. - Stanford, Calif : HighWire Press, Bd. 112.2013, 6, S. 969-980

Originalartikel in begutachteter internationaler Zeitschrift
Rehberg, M.;  Ritter, J. B.;  Genzel, Y.;  Flockerzi, D.;  Reichl, Udo 

The relation between growth phases, cell volume changes and metabolism of adherent cells during cultivation
In: Journal of biotechnology. - Amsterdam [u.a.] : Elsevier Science, Bd. 164.2013, 4, S. 489-499

2012

Abstrakt
Hütter, J.;  Rödig, J.;  Höper, D.;  Reichl, Udo;  Seeberger, P. H.;  Rapp, E.;  Lepenies, B. 

Glycosylation matters - role of viral hemagglutinin N-glycosylation in immunogenicity
In: Immunology. - Oxford [u.a.] : Wiley-Blackwell, Bd. 137.2012, 1, S. 760

Artikel in Kongressband
Dürr, Robert;  Müller, Thomas;  Isken, Britta;  Schulze-Horstel, Josef;  Reichl, Udo;  Kienle, Achim 

Distributed modeling and parameter estimation of influenza virus replication during vaccine production authors
In: MATHMOD 2012. - Vienna : ARGESIM, ARGE Simulation News, Vienna Univ. of Technology, insges. 6 S. - (ARGESIM report; 38)

Begutachteter Zeitschriftenartikel
Barradas, Oscar Platas;  Jandt, Uwe;  Phan, Linh Da Minh;  Villanueva, Mario E.;  Schaletzky, Martin;  Rath, Alexander;  Freund, Susann;  Reichl, Udo;  Skerhutt, Eva;  Scholz, Sebastian;  Noll, Thomas;  Sandig, Volker;  Pörtner, Ralf;  Zeng, An-Ping 

Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture
In: Engineering in life sciences. - Weinheim : Wiley-VCH, Bd. 12.2012, 5, S. 518-528

Carrondo, Manuel J. T.;  Alves, Paula M.;  Carinhas, Nuno;  Glassey, Jarka;  Hesse, Friedemann;  Merten, Otto-Wilhelm;  Micheletti, Martina;  Noll, Thomas;  Oliveira, Rui;  Reichl, Udo;  Staby, Arne;  Teixeira, Ana P.;  Weichert, Henry;  Mandenius, Carl-Fredrik 

How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?
In: Biotechnology journal. - Weinheim : Wiley-VCH, Bd. 7.2012, 12, S. 1522-1529

Hanreich, Angelika;  Heyer, Robert;  Benndorf, Dirk;  Rapp, Erdmann;  Pioch, Markus;  Reichl, Udo;  Klocke, Michael 

Metaproteome analysis to determine the metabolically active part of a thermophilic microbial community producing biogas from agricultural biomass
In: Canadian journal of microbiology. - Plattsburgh, NY : NRC Research Press, Bd. 58.2012, 7, S. 917-922

Heldt, Frank S.;  Frensing, Timo;  Reichl, Udo 

Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis
In: Journal of virology. - Baltimore, Md : Soc, Bd. 86.2012, 15, S. 7806-7817

Isken, B.;  Genzel, Y.;  Reichl, Udo 

Productivity, apoptosis, and infection dynamics of influenza A/PR/8 strains and A/PR/8-based reassortants
In: Vaccine. - Amsterdam : Elsevier, Bd. 30.2012, 35, S. 5253-5261

Lohr, Verena;  Genzel, Yvonne;  Jordan, Ingo;  Katinger, Dietmar;  Mahr, Stefan;  Sanding, Volker;  Reichl, Udo 

Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells
In: BMC biotechnology. - London : BioMed Central, Bd. 12.2012, 79, insges. 9 S.

Rüger, Marc;  Bensch, Gerald;  Tüngler, Ralf;  Reichl, Udo 

A flow cytometric method for viability assessment of Staphylococcus aureus and Burkholderia cepacia in mixed culture
In: Cytometry. - Hoboken, NJ : Wiley-LissCytometry / A, Bd. 81.2012, 12, S. 1055-1066

Originalartikel in begutachteter internationaler Zeitschrift
Kluge, Sabine;  Hoffmann, Marcus;  Benndorf, Dirk;  Rapp, Erdmann;  Reichl, Udo 

Proteomic tracking and analysis of a bacterial mixed culture
In: Proteomics. - Weinheim : Wiley-Blackwell, Bd. 12.2012, 12, S. 1893-1901

Popov, Mladen;  Nacheva, Genoveva;  Reichl, Udo;  Ivanov, Ivan 

Effect of the 3'-terminal truncation of the human interferon-gamma gene on plasmid segregation in escherichia coli
In: Biotechnology & biotechnological equipment. - Sofia : Diagnosis Press, Bd. 26.2012, 2, S. 2930-2936

Riedele, Christian;  Reichl, Udo 

Time-kill studies with a ceftazidime-treated mixed culture consisting of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus
In: Engineering in life sciences. - Weinheim : Wiley-Blackwell, Bd. 12.2012, 2, S. 188-197

Roedig, Jana Verena;  Rapp, Erdmann;  Höper, Dirk;  Genzel, Yvonne;  Reichl, Udo 

Impact of host cell line adaptation on quasispecies composition and glycosylation of influenza A virus hemagglutinin
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 6.2012, 12, insges. 10 S.

Seitz, Claudia;  Isken, Britta;  Heynisch, Björn;  Rettkowski, Maria;  Frensing, Timo;  Reichl, Udo 

Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host response
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 93.2012, 2, S. 601-611

2011

Dissertation
Vester, Diana;  Reichl, Udo 

Molecular biological analysis of dynamic interactions between influenza viruses and host cells - host cell proteomes and viral replication dynamics
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2011; XVIII, 176 S.: graph. Darst.

Originalartikel in begutachteter internationaler Zeitschrift
Barradas, Oscar Platas;  Zeng, An-Ping;  Pörtner, Ralf;  Jandt, Uwe;  Phan, Linh Da Minh;  Villanueva, Mario;  Rath, Alexander;  Reichl, Udo;  Schräder, Eva;  Scholz, Sebastian;  Noll, Thomas;  Sandig, Volker 

Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture
In: BMC proceedings. - London : BioMed Central, Bd. 5.2011, S. 3

Bock, A.;  Schulze-Horsel, J.;  Schwarzer, J.;  Rapp, E.;  Genzel, Y.;  Reichl, Udo 

High-density microcarrier cell cultures for influenza virus production
In: Biotechnology progress. - Hoboken, NJ : Wiley, Bd. 27.2011, 1, S. 241-250

Frensing, Timo;  Seitz, Claudius;  Heynisch, Bjoern;  Patzina, Corinna;  Kochs, Georg;  Reichl, Udo 

Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells
In: Vaccine. - Amsterdam : Elsevier, Bd. 29.2011, 41, S. 7125-7129

Janke, R.;  Genzel, Y.;  Händel, N.;  Wahl, A.;  Reichl, Udo 

Metabolic adaptation of MDCK cells to different growth conditions - effects on catalytic activities of central metabolic enzymes
In: Biotechnology and bioengineering. - New York, NY [u.a.] : Wiley, Bd. 108.2011, 11, S. 2691-2704

Kuhn, Ramona;  Benndorf, Dirk;  Rapp, Erdmann;  Reichl, Udo;  Palese, Luigi Leonardo;  Pollice, Alfieri 

Metaproteome analysis of sewage from membrane bioreactors
In: Proteomics. - Weinheim : Wiley-Blackwell, Bd. 11.2011, 13, S. 2738-2744

Popov, Mladen;  Petrov, Stefan;  Nacheva, Genoveva;  Ivanov, Ivan;  Reichl, Udo 

Effects of a recombinant gene expression on ColE1-like plasmid segregation in Escherichia coli
In: BMC biotechnology. - London : BioMed Central, Bd. 11.2011, 18, insges. 12 S.

Riedele, Christian;  Reichl, Udo 

Interspecies effects in a ceftazidime-treated mixed culture of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus: analysis at the single-species level
In: The journal of antimicrobial chemotherapy. - Oxford : Oxford Univ. Press, Bd. 66.2011, 1, S. 138-145

Roedig, Jana V.;  Rapp, Erdmann;  Genzel, Yvonne;  Reichl, Udo 

Impact of different influenza cultivation conditions on HA N-Glycosylation
In: BMC proceedings. - London : BioMed Central, Bd. 5.2011, S. 4

Rödig, Jana;  Rapp, Erdmann;  Djeljadini, Suzana;  Lohr, Verena;  Genzel, Yvonne;  Jordan, Ingo;  Sandig, Volker;  Reichl, Udo 

Impact of influenza virus adaptation status on HA N-glycosylation patterns in cell culture-based vaccine production
In: Journal of carbohydrate chemistry. - London [u.a.] : Taylor & Francis, Bd. 30.2011, 4/6, S. 281-290

Schmidt, Julia K.;  Riedele, Christian;  Regestein, Lars;  Rausenberger, Julia;  Reichl, Udo 

A novel concept combining experimental and mathematical analysis for the identification of unknown interspecies effects in a mixed culture
In: Biotechnology and bioengineering. - New York, NY [u.a.] : Wiley, Bd. 108.2011, 8, S. 1900-1911

Scholz, Sebastian;  Luebbecke, Miriam;  Rath, Alexander;  Schräder, Eva;  Rose, Thomas;  Büntemeyer, Heino;  Scheper, Thomas;  Reichl, Udo;  Noll, Thomas 

Characterization of the human AGE1.HN cell line: a systems biology approach
In: BMC proceedings. - London : BioMed Central, Bd. 5.2011, S. 3

Schräder, Eva;  Zeng, An-Ping;  Heinzle, Elmar;  Noll, Thomas;  Scholz, Sebastian;  Niklas, Jens;  Rath, Alexander;  Barradas, Oscar;  Jandt, Uwe;  Sandig, Volker;  Rose, Thomas;  Pörtner, Ralf;  Reichl, Udo 

Characterisation of cultivation of the human cell line AGE1.HN.AAT
In: BMC proceedings. - London : BioMed Central, Bd. 5.2011, S. 2

W Wolf, Michael;  Reichl, Udo 

Downstream processing of cell culture-derived virus particles
In: Expert review of vaccines. - London : Expert Reviews, Bd. 10.2011, 10, S. 1451-1475

Originalartikel in begutachteter zeitschriftenartiger Reihe
Janke, Robert;  Genzel, Yvonne;  Wetzel, Maria;  Reichl, Udo 

Effect of influenza virus infection on key metabolic enzyme activities in MDCK cells
In: BMC proceedings. - London : BioMed Central, Bd. 5.2011, S. 4

Müller, Thomas;  Dürr, Robert;  Isken, Britta;  Schulze-Horsel, Josef;  Reichl, Udo;  Kienle, Achim 

Population balance modelling of influenza virus replication during vaccine production - influence of apoptosis
In: 21st European Symposium on Computer Aided Process Engineering ; Pt. B. - Amsterdam [u.a.] : Elsevier, S. 1336-1340, 2011 - (Computer-aided chemical engineering; 29) ; Kongress: ESCAPE; 21 (Chalkidiki, Greece) : 2011.05.29-06.01

2010

Originalartikel in begutachteter internationaler Zeitschrift
Genzel, Yvonne;  Dietzsch, Christian;  Rapp, Erdmann;  Schwarzer, Jana;  Reichl, Udo 

MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation
In: Applied microbiology and biotechnology. - Berlin : Springer, Bd. 88.2010, 2, S. 461-475

Heynisch, Björn;  Frensing, T.;  Heinze, K.;  Seitz, C.;  Genzel, Y.;  Reichl, Udo 

Differential activation of host cell signalling pathways through infection with two variants of influenza A/Puerto Rico/8/34 (H1N1) in MDCK cells
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 28.2010, 51, S. 8210-8218

Janke, R.;  Genzel, Y.;  Freund, S.;  Wolff, Michael;  Grammel, H.;  Rühmkorf, C.;  Seidemann, J.;  Wahl, A.;  Reichl, Udo 

Expression, purification, and characterization of a His 6-tagged glycerokinase from Pichia farinosa for enzymatic cycling assays in mammalian cells
In: Journal of biotechnology . - Amsterdam : Elsevier, Bd. 150.2010, 3, S. 396-403

Janke, R.;  Genzel, Y.;  Wahl, A.;  Reichl, Udo 

Measurement of key metabolic enzyme activities in mammalian cells using rapid and sensitive microplate-based assays
In: Biotechnology and bioengineering. - New York, NY [u.a.] : Wiley, Bd. 107.2010, 3, S. 566-581

Kalmbach, Andreas;  Bordás, Róbert;  Öncül, Alper A.;  Thévenin, Dominique;  Genzel, Yvonne;  Reichl, Udo 

Experimental characterization of flow conditions in 2 L and 20 L bioreactors with wave-induced motion
In: Biotechnology progress. - Hoboken, NJ : Wiley, Bd. 27.2011, 2, S. 402-409

Kröber, Tina;  Knöchlein, Anne;  Eisold, Katrin;  Kalbfuß-Zimmermann, Bernd;  Reichl, Udo 

DNA depletion by precipitation in the purification of cell culture-derived influenza vaccines
In: Chemical engineering & technology. - Weinheim : Wiley-VCH, Bd. 33.2010, 6, S. 941-959

Kuhn, R.;  Benndorf, Dirk;  Rapp, E.;  Reichl, Udo;  Pollice, A.;  Palese, L. L. 

Metaproteomanalyse von Klärschlamm aus Membranbioreaktoren
In: Chemie - Ingenieur - Technik . - Weinheim : Wiley-VCH Verl., Bd. 82.2010, 9, S. 1539

Lohr, V.;  Genzel, Y.;  Behrendt, I.;  Scharfenberg, K.;  Reichl, Udo 

A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor
In: Vaccine. - Amsterdam : Elsevier, Bd. 28.2010, 38, S. 6256-6264

Ritter, Joachim B.;  Wahl, Aljoscha S.;  Freund, Susann;  Genzel, Yvonne;  Reichl, Udo 

Metabolic effects of influenza virus infection in cultured animal cells - intra- and extracellular metabolite profiling
In: BMC systems biology. - London : BioMed Central, Bd. 4.2010, 61, insges. 22 S.

Rollié, Sascha;  Lendeckel, Uwe;  Naumann, Michael;  Reichl, Udo;  Sundmacher, Kai 

Dynamics of bionanoparticle targeting in mixtures of human tumour cells by validated population balance modelling
In: Soft matter. - Cambridge : RSC Publ, Bd. 6.2010, 6, S. 1203-1216

Seitz, Claudius;  Frensing, Timo;  Höper, Dirk;  Kochs, Georg;  Reichl, Udo 

High yields of influenza A virus in MadinDarby canine kidney cells are promoted by an insufficient interferon-induced antiviral state
In: The journal of general virology. - Reading : Society for General Microbiology, Bd. 91.2010, 7, S. 1754-1763

Vester, Diana;  Lagoda, Antje;  Hoffmann, Diana;  Seitz, Claudius;  Heldt, Stefan;  Bettenbrock, Katja;  Genzel, Yvonne;  Reichl, Udo 

Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamics
In: Journal of virological methods. - Amsterdam : Elsevier, North-Holland Biomed. Press, Bd. 168.2010, 1/2, S. 63-71

Vester, Diana;  Rapp, Erdmann;  Kluge, Sabine;  Genzel, Yvonne;  Reichl, Udo 

Virushost cell interactions in vaccine production cell lines infected with different human influenza A virus variants: A proteomic approach
In: Journal of proteomics. - Amsterdam [u.a.] : Elsevier, Bd. 73.2010, 9, S. 1656-1669

Wolff, Michael;  Siewert, Corina;  Lehmann, Sylvia;  Post Hansen, Sara;  Djurup, Rene;  Faber, Rene;  Reichl, Udo 

Capturing of cell culture-derived modified Vaccinia Ankara virus by ion exchange and pseudo-affinity membrane adsorbers
In: Biotechnology and bioengineering . - New York, NY [u.a.] : Wiley, Bd. 105.2010, 4, S. 761-769

Wolff, Michael W.;  Siewert, Corina;  Post Hansen, Sara;  Faber, Rene;  Reichl, Udo 

Purification of cell culture-derived modified vaccinia ankara virus by pseudo-affinity membrane adsorbers and hydrophobic interaction chromatography
In: Biotechnology and bioengineering. - New York, NY [u.a.] : Wiley, Bd. 107.2010, 2, S. 312-320

Öncül, Alper A.;  Bordás, Robert;  Thévenin, Dominique;  Genzel, Yvonne;  Reichl, Udo 

CFD-Modellierung der Zellkultivierung in Wave-Bioreaktoren
In: Chemie - Ingenieur - Technik . - Weinheim : Wiley-VCH Verl., Bd. 82.2010, 9, S. 1512

Öncül, Alper A.;  Kalmbach, Andreas;  Genzel, Yvonne;  Reichl, Udo;  Thévenin, Dominique 

Characterization of flow conditions in 2 L and 20 L wave bioreactors using computational fluid dynamics
In: Biotechnology progress . - Hoboken, NJ : Wiley, Bd. 26.2010, 1, S. 101-110

2009

Artikel in Kongressband
Öncül, Alper A.;  Genzel, Yvonne;  Reichl, Udo;  Thévenin, Dominique 

Flow characterization in wave bioreactors using computational fluid dynamics
In: 21th Meeting of the European Society for Animal Cell Technology \"Cellular Solutions for Clinical Challenges\", ESACT 2009 . - Dublin, insges. 17 S. ; Kongress: ESACT; 21 (Dublin) : 2009.06.07-10

Originalartikel in begutachteter internationaler Zeitschrift
Lohr, V.;  Rath, A.;  Genzel, Y.;  Jordan, I.;  Sandig, V.;  Reichl, Udo 

New avian suspension cell lines provide production of influenza virus and MVA in serum-free media - studies on growth, metabolism and virus propagation
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 27.2009, 36, S. 4975-4982

Opitz, Lars;  Hohlweg, Jonas;  Reichl, Udo;  Wolff, Michael W. 

Purification of cell culture-derived influenza virus A/Puerto Rico/8/34 by membrane-based immobilized metal affinity chromatography
In: Journal of virological methods . - Amsterdam : Elsevier, North-Holland Biomed. Press, Bd. 161.2009, 2, S. 312-316

Opitz, Lars;  Lehmann, Sylvia;  Reichl, Udo;  Wolff, Michael W. 

Sulfated membrane adsorbers for economic pseudo-affinity capture of influenza virus particles
In: Biotechnology and bioengineering . - New York, NY [u.a.] : Wiley, Bd. 103.2009, 6, S. 1144-1154

Rapp, Erdmann;  Charvát, Ales;  Beinsen, Alexander;  Plessmann, Uwe;  Reichl, Udo;  Seidel-Morgenstern, Andreas;  Urlaub, Henning;  Abel, Bernd 

Atmospheric pressure free liquid infrared MALDI mass spectrometry - toward a combined ESI/MALDI-liquid chromatography interface
In: Analytical chemistry . - Washington, DC : Soc., Bd. 81.2009, 1, S. 443-452

Schulze-Horsel, J.;  Schulze, M.;  Agalaridis, G.;  Genzel, Y.;  Reichl, Udo 

Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine productionFlow cytometry and mathematical modeling
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 27.2009, 20, S. 2712-2722

Schwarzer, Jana;  Rapp, Erdmann;  Hennig, René;  Genzel, Yvonne;  Jordan, Ingo;  Sandig, Volker;  Reichl, Udo 

Glycan analysis in cell culture-based influenza vaccine production - influence of host cell line strain on the glycosylation pattern of viral hemagglutinin
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 27.2009, 32, S. 4325-4336

Schwarzer, Jana;  Rapp, Erdmann;  Hennig, René;  Genzel, Yvonne;  Jordan, Ingo;  Sandig, Volker;  Reichl, Udo 

Glycan analysis in cell culture-based influenza vaccine production: Influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 27.2009, 32, S. 4325-4336

Vester, Diana;  Rapp, Erdmann;  Gade, Dörte;  Genzel, Yvonne;  Reichl, Udo 

Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines
In: Proteomics . - Weinheim : Wiley VCH, Bd. 9.2009, 12, S. 3316-3327

Öncül, Alper A.;  Kalmbach, A.;  Genzel, Y.;  Reichl, Udo;  Thévenin, Dominique 

Numerische und experimentelle Untersuchung der Fließbedingungen in Wave-Bioreaktoren
In: Chemie - Ingenieur - Technik . - Weinheim : Wiley-VCH Verl., Bd. 81.2009, 8, S. 1241

2008

Originalartikel in begutachteter internationaler Zeitschrift
Antoniukas, Linas;  Grammel, Hartmut;  Sasnauskas, Kestutis;  Reichl, Udo 

Profiling of external metabolites during production of hantavirus nucleocapsid protein with recombinant saccharomyces cerevisiae
In: Biotechnology letters. - Dordrecht [u.a.] : Kluwer Academic Publ., Bd. 30.2008, 3, S. 415-420

Kalbfuss, Bernd;  Knöchlein, Anne;  Kröber, Tina;  Reichl, Udo 

Monitoring influenza virus content in vaccine production - precise assays for the quantitation of hemagglutination and neuraminidase activity
In: Biologicals . - Amsterdam [u.a.] : Elsevier, Bd. 36.2008, 3, S. 145-161

Kalbfuss, Bernd;  Flockerzi, Dietrich;  Seidel-Morgenstern, Andreas;  Reichl, Udo 

Size-exclusion chromatography as a linear transfer system - purification of human influenza virus as an example
In: Journal of chromatography . - Amsterdam [u.a.] : Elsevier, Bd. 873.2008, 1, S. 102-112

Möhler, Lars;  Bock, Andreas;  Reichl, Udo 

Segregated mathematical model for growth of anchorage-dependent MDCK cells in microcarrier culture
In: Biotechnology progress . - Hoboken, NJ : Wiley, Bd. 24.2008, 1, S. 110-119

Pohlscheidt, M.;  Langer, U.;  Minuth, T.;  Bödecker, B.;  Apeler, H.;  Hörlein, H.-D.;  Paulsen, D.;  Rübsamen-Waigmann, H.;  Henzler, H.-J.;  Reichl, Udo 

Development and optimisation of a procedure for the production of parapoxvirus ovis by large-scale microcarrier cell culture in a non-animal, non-human and non-plant-derived medium
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 26.2008, 12, S. 1552-1565

Pohlscheidt, Michael;  Bödeker, Berthold;  Langer, Uwe;  Apeler, Heiner;  Hörlein, Hans-Dietrich;  Rübsamen-Waigmann, Helga;  Reichl, Udo;  Henzler, Hans-Jürgen 

Auslegungsunterlagen für Bioreaktoren zur Maßstabsvergrößerung eines microcarrierbasierenden Virusproduktionsprozesses
In: Chemie - Ingenieur - Technik . - Weinheim : Wiley-VCH Verl., Bd. 80.2008, 6, S. 821-830

Ritter, Joachim B.;  Genzel, Yvonne;  Reichl, Udo 

Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells - optimization using experimental design
In: Analytical biochemistry . - San Diego, Calif. : Elsevier, Bd. 373.2008, 2, S. 349-369

Schulze-Horsel, Josef;  Genzel, Yvonne;  Reichl, Udo 

Flow cytometric monitoring of influenza A virus infection in MDCK cells during vaccine production
In: BMC biotechnology . - London : BioMed Central, Bd. 8.2008, 45, insges. 23 S.; Abstract unter URL: http://dx.doi.org/10.1186/1472-6750-8-45

Schwarzer, Jana;  Rapp, Erdmann;  Reichl, Udo 

N-glycan analysis by CGE-LIF - profiling influenza A virus hemagglutinin N-glycosylation during vaccine production
In: Electrophoresis . - Weinheim : Wiley-Blackwell, Bd. 29.2008, 20, S. 4203-4214

Sidorenko, Y.;  Antoniukas, L.;  Schulze-Horsel, J.;  Kremling, A.;  Reichl, Udo 

Mathematical model of growth and heterologous hantavirus protein production of the recombinant yeast saccharomyces cerevisiae
In: Engineering in life sciences . - Weinheim : Wiley-Blackwell, Bd. 8.2008, 4, S. 399-414

Sidorenko, Y.;  Schulze-Horsel, J.;  Voigt, Andreas;  Reichl, Udo;  Kienle, Achim 

Stochastic population balance modeling of influenza virus replication in vaccine production processes
In: Chemical engineering science. - Amsterdam : Elsevier, Bd. 63.2008, 1, S. 157-169

Sidorenko, Y.;  Voigt, Andreas;  Schulze-Horsel, J.;  Reichl, Udo;  Kienle, Achim 

Stochastic population balance modeling of influenza virus replication in vaccine production processes. II. detailed description of the replication mechanism
In: Chemical engineering science. - Amsterdam : Elsevier, Bd. 63.2008, 8, S. 2299-2304

Sidorenko, Yury;  Wahl, Aljoscha;  Dauner, Michael;  Genzel, Yvonne;  Reichl, Udo 

Comparison of metabolic flux distributions for MDCK cell growth in glutamine- and pyruvate-containing media
In: Biotechnology progress . - Hoboken, NJ : Wiley, Bd. 24.2008, 2, S. 311-320

Wahl, Aljoscha;  Sidorenko, Yury;  Dauner, Michael;  Genzel, Yvonne;  Reichl, Udo 

Metabolic flux model for an anchorage-dependent MDCK cell line - characteristic growth phases and minimum substrate consumption flux distribution
In: Biotechnology and bioengineering . - New York, NY [u.a.] : Wiley, Bd. 101.2008, 1, S. 135-152

Originalartikel in begutachteter zeitschriftenartiger Reihe
Müller, Thomas;  Schulze-Horsel, Josef;  Sidorenko, Yury;  Reichl, Udo;  Kienle, Achim 

Population balance modeling of influenza virus replication in MDCK cells during vaccine production
In: 18th European Symposium on Computer Aided Process Engineering. - Amsterdam [u.a.] : Elsevier, S. 133-138, 2008 - (Computer-aided chemical engineering; 25) ; Kongress: ESCAPE; 18 (Lyon) : 2008.06.01-04

2007

Buchbeitrag
Bock, A.;  Reichl, Udo 

Closed loop control of perfusion systems in high-density cell culture
In: Cell technology for cell products . - Dordrecht : Springer Netherland, ISBN 978-1-402-05475-4, S. 549-551, 2007 ; Kongress: European Society for Animal Cell Technology meeting; 19 (Harrogate) : 2005.06.05-08

Genzel, Yvonne;  Schulze-Horsel, Josef;  Möhler, Lars;  Sidorenko, Yury;  Reichl, Udo 

Influenza vaccine - challanges in mammalian cell culture technology
In: Cell technology for cell products . - Dordrecht : Springer Netherland, ISBN 978-1-402-05475-4, S. 503-508, 2007 ; Kongress: European Society for Animal Cell Technology meeting; 19 (Harrogate) : 2005.06.05-08

Genzel, Yvonne;  Fischer, Marlies;  Olmer, Ruth Maria;  Schäfer, Bastian;  Best, Claudia;  König, Susanne;  Hundt, Boris;  Reichl, Udo 

Serum-free influenza vaccine production with MDCK cells in wave-bioreactor and 5L-stirred tank bioreactor
In: Cell technology for cell products . - Dordrecht : Springer Netherland, ISBN 978-1-402-05475-4, S. 563-565, 2007 ; Kongress: European Society for Animal Cell Technology meeting; 19 (Harrogate) : 2005.06.05-08

Genzel, Yvonne;  Reichl, Udo 

Vaccine production - state of the art and future needs in upstream processing
In: Animal cell biotechnology . - Totowa, NJ : Humana Press, ISBN 1-588-29660-1, S. 457-473; Methods in biotechnology; 24, 2007

Pohlscheidt, M.;  Langer, U.;  Bödeker, B.;  Paulsen, D.;  Rübsamen-Waigmann, H.;  Reichl, Udo;  Henzler, H. J.;  Apeler, H. 

Strategies for large scale production of Parapoxvirus Ovis NZ-2
In: Cell technology for cell products . - Dordrecht : Springer Netherland, ISBN 978-1-402-05475-4, S. 707-710, 2007 ; Kongress: European Society for Animal Cell Technology meeting; 19 (Harrogate) : 2005.06.05-08

Reichl, Udo;  Sidorenko, Yury 

Dynamics of virus-host cell interaction
In: Bioinformatics - from genomes to therapies; Vol. 2: Getting at the inner workings: molecular interactions . - Weinheim : WILEY-VCH, S. 861-898, 2007

Ritter, Joachim B.;  Genzel, Yvonne;  Reichl, Udo 

Monitoring of extracellular TCA cycle intermediates in mammalian cell culture
In: Cell technology for cell products . - Dordrecht : Springer Netherland, ISBN 978-1-402-05475-4, S. 603-605, 2007 ; Kongress: European Society for Animal Cell Technology meeting; 19 (Harrogate) : 2005.06.05-08

Schulze-Horsel, Josef;  Genzel, Yvonne;  Reichl, Udo 

Monitoring cell physiology in influenza vaccine production by flow cytometry
In: Cell technology for cell products . - Dordrecht : Springer Netherland, ISBN 978-1-402-05475-4, S. 531-533, 2007 ; Kongress: European Society for Animal Cell Technology meeting; 19 (Harrogate) : 2005.06.05-08

Originalartikel in begutachteter internationaler Zeitschrift
Antoniukas, Linas;  Grammel, Hartmut;  Sasnauskas, Kestutis;  Reichl, Udo 

Profiling of external metabolites during production of hantavirus nucleocapsid protein with recombinant saccharomyces cerevisiae
In: Biotechnology letters . - Dordrecht [u.a.] : Springer Science + Business Media B.V, insges. 6 S.; Abstract unter URL: http://dx.doi.org/10.1007/s10529-007-9577-1, 2007

Bandaru, Krishna S. V. S. R.;  Kessler, Lars Christian;  Wolf, Michael W.;  Reichl, Udo;  Seidel-Morgenstern, Andreas;  Pushpavanam, Subramaniam 

Hydrodynamic characteristics and expansion behavior of beds containing single and binary mixtures of particles
In: Industrial & engineering chemistry research . - Washington, DC : American Chemical Society, Bd. 46.2007, 13, S. 4686-4694

Hundt, B.;  Best, Claudia;  Schlawin, N.;  Kaßner, H.;  Genzel, Y.;  Reichl, Udo 

Establishment of a mink enteritis vaccine production process in stirred-tank reactor and wave bioreactor microcarrier culture in 1-10 L scale
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 25.2007, 20, S. 3987-3995

Kalbfuss, Bernd;  Wolff, Michael;  Geisler, Liane;  Tappe, Alexander;  Wickramasinghe, Ranil;  Thom, Volkmar;  Reichl, Udo 

Direct capture of influenza A virus from cell culture supernatant with Sartobind anion-exchange membrane adsorbers
In: Journal of membrane science . - Amsterdam : Elsevier, Bd. 299.2007, 1/2, S. 251-260

Nischang, Ivo;  Reichl, Udo;  Seidel-Morgenstern, Andreas;  Tallarek, Ulrich 

Concentration polarization and nonequilibrium electroosmotic slip in dense multiparticle systems
In: Langmuir . - Washington, DC : ACS, Bd. 23.2007, 18, S. 9271-9281

Opitz, Lars;  Lehmann, Sylvia;  Zimmermann, Anke;  Reichl, Udo;  Wolf, Michael W. 

Impact of adsorbents selection on capture efficiency of cell culture derived human influenza viruses
In: Journal of biotechnology . - Amsterdam : Elsevier, Bd. 131.2007, 3, S. 309-317

Opitz, Lars;  Salaklang, Jatuporn;  Büttner, Hermann;  Reichl, Udo;  Wolff, Michael W. 

Lectin-affinity chromatography for downstream processing of MDCK cell culture derived human influenza A viruses
In: Vaccine . - Amsterdam : Elsevier, ISSN 0264-410x, Bd. 25.2007, 5, S. 939-947

Schmidt, Julia;  König, Brigitte;  Reichl, Udo 

Characterization of a three bacteria mixed culture in a chemostat - evaluation and application of a quantitative terminal-restriction fragment length polymorphism (T-RFLP) analysis for absolute and species specific cell enumeration
In: Biotechnology and bioengineering . - New York, NY [u.a.] : Wiley, Bd. 96.2007, 4, S. 738-756

2006

Originalartikel in begutachteter internationaler Zeitschrift
Heßeler, Julia;  Schmidt, Julia K.;  Reichl, Udo;  Flockerzi, Dietrich 

Coexistence in the chemostat as a result of metabolic by-products
In: Journal of mathematical biology - Berlin: Springer, Bd. 53.2006, 4, S. 556-584; http://han.med.uni-magdeburg.de/han/905/www.springerlink.com/content/n371g0x5481w2664/?p=4b51d079e61a4d68a6f7726f7dd1145e&pi=5

Kalbfuss, Bernd;  Genzel, Yvonne;  Wolff, Michael;  Zimmermann, Anke;  Morenweiser, Robert;  Reichl, Udo 

Harvesting and concentration of human influenza - a virus produced in serum-free mammalian cell culture for the production of vaccines
In: Biotechnology and bioengineering - New York, NY [u.a.]: Wiley, Bd. 97.2007, 1, S. 73-85, 2006; http://dx.doi.org/10.1002/bit.21139

Kalbfuss, Bernd;  Wolff, Michael;  Morenweiser, Robert;  Reichl, Udo 

Purification of cell culture-derived human influenza a virius by size-exclusion and anion-exchange chromatography
In: Biotechnology and bioengineering - New York, NY [u.a.]: Wiley, Bd. 96.2007, 5, S. 932-944, 2006; http://dx.doi.org/10.1002/bit.21109

Ritter, Joachim B.;  Genzel, Yvonne;  Reichl, Udo 

High-performance anion-exchange chromatography using on-line electrolytic eluent generation for the determination of more than 25 intermediates from energy metabolism of mammalian cells in culture
In: Journal of chromatography / B - New York, NY [u.a.]: Science Direct, Bd. 843.2006, 2, S. 216-226; http://dx.doi.org/10.1016/j.jchromb.2006.06.004

2005

Buchbeitrag
Genzel, Y. (ext.);  Alt, R. (ext.);  Reichl, Udo 

Glutamine-free media for vaccine production processes.
In: Godia, Francesc (Hrsg.) ; Fussenegger, Martin (Hrsg.): Animal cell technology meets genomics ( 18th ESACT meeting Granada, Spain, May 11 - 14 2003). - proceedings. Dordrecht : Springer, 2005, S. 767 - 770 (ESACT 18)

Hundt, Boris;  Schaenzler, A. (ext.);  Reichl, Udo 

Serum free cultivation of primary chicken embryo fibroblasts in microcarrier systems for vaccine production.
In: Godia, Francesc (Hrsg.) ; Fussenegger, Martin (Hrsg.): Animal cell technology meets genomics ( 18th ESACT meeting Granada, Spain, May 11 - 14 2003). - proceedings. Dordrecht : Springer, 2005, S. 771 - 774 (ESACT 18)

Originalartikel in begutachteter internationaler Zeitschrift
Genzel, Yvonne (ext.);  Ritter, Joachim B. (ext.);  Koenig, Susanne (ext.);  Alt, Ruediger (ext.);  Reichl, Udo 

Substitution of glutamine by pyruvate to reduce ammonia formation and groth inhibition of mammalian cells.
In: Biotechnology progress [New York, NY] 21(2005), S. 58 - 69

Moehler, Lars;  Flockerzi, Dietrich (ext.);  Sann, Heiner (ext.);  Reichl, Udo 

Mathematical model of influenza a virus production in large-scale microcarrier culture.
In: Biotechnology and bioengineering [New York, NY] 90(2005), Nr. 4, S. 46 - 58

Nayak, Deba Prasad (ext.);  Lehmann, Sylvia (ext.);  Reichl, Udo 

Downstream processing of MDCK cell-derived equine influenza virus.
In: Journal of Chromatography B [Amsterdam] 823(2005), S. 75 - 81

Wickramasinghe, S.R. (ext.);  Kalbfuss, B. (ext.);  Zimmermann, A. (ext.);  Thom, V. (ext.);  Reichl, Udo 

Tangential flow microfiltration and ultrafiltration for human influenza a virus concentration and purification.
In: Biotechnology and bioengineering [New York, NY] 92(2005), Nr. 2, S. 199 - 208

2004

Artikel in Kongressband
Sidorenko, Y. (ext.);  Reichl, Udo 

A mathematical model for the replication of influenza a virus in MDCK cells.
In: BioPerspectives 2004 : mit 22. DECHEMA-Jahrestagung der Biotechnologen (Wiesbaden, 4. - 6. Mai 2004). - Tagungshandbuch. Frankfurt am Main, 2004, S. 82

Originalartikel in begutachteter internationaler Zeitschrift
Genzel, Y. (ext.);  Behrendt, I. (ext.);  Koenig, S. (ext.);  Sann, H. (ext.);  Reichl, Udo 

Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture.
In: Vaccine [Amsterdam] 22(2004), S. 2202 - 2208

Genzel, Yvonne (ext.);  Koenig, Susanne (ext.);  Reichl, Udo 

Amino acid analysis in mammalian cell culture media containing serum and high glucose concentrations by anion exchange chromatography and integrated pulsed amperometric detecion.
In: Analytical biochemistry [New York, NY] 335(2004), S. 119 - 125

Nayak, Deba Prasad (ext.);  Reichl, Udo 

Neuraminidase activity assays for monitoring MDCK cell culture derived influenza virus.
In: Journal of virological methods [Amsterdam] 122(2004), S. 9 - 15

Sidorenko, Y. (ext.);  Reichl, Udo 

Structured model of influenza virus replication in MDCK cells.
In: Biotechnology and bioengineering [New York, NY] 88(2004), Nr. 1, S. 1 - 14

2003

Artikel in Kongressband
Reichl, Udo;  Genzel, Yvonne (ext.);  Moehler, Lars;  Sydorenko, I. (ext.);  Sann, H. (ext.) 

Animal cell cultures for the production of viral vaccines.
In: VDI-Gesellschaft (Veranst.) ; DECHEMA e. V. (Veranst.): GVC/DECHEMA : Vortrags- und Diskussionstagung (\"Zellkulturen : vom biologischen System zum Produktionsprozess\" Bad Dürkheim, 26. bis 28. Mai 2003). - Tagungsband. Bad Dürkheim, 2003, S. 32 - 35

Originalartikel in begutachteter internationaler Zeitschrift
Tallarek, Ulrich;  Rapp, Erdmann (ext.);  Sann, Heiner (ext.);  Reichl, Udo;  Seidel Morgenstern, Andreas 

Quantitative study of electrokinetic transport in porous media by confocal laser scanning microscopy.
In: Langmuir [Washington, DC] 19(2003), Nr. 11, S. 4527 - 4531

2002

Originalartikel in begutachteter internationaler Zeitschrift
Trotha, Rene;  Reichl, Udo;  Thies, Frank;  Sperling, Danuta;  Koenig, Wolfgang;  Koenig, Brigitte 

Adaption of a fragment analysis technique to an automated high-throughput multicapillary electrophoresis device for the precise qualitative and quantitative characterization of microbial communities.
In: Electrophoresis [Weinheim] 23(2002), S. 1070 - 1079

2001

Buchbeitrag
Genzel, Yvonne (ext.);  Voges, Lars;  Reichl, Udo 

Development of bioprocess concepts on vaccine production : influenza virus as an example.
In: Lindner-Olsson, E. (Hrsg.) ; Chatzissavidou, N. (Hrsg.) ; Lüllau, E. (Hrsg.): Animal cell technology : from target to market (17th ESACT meeting, Tylösand, Sweden, June 10-14, 2001). - proceedings. Dordrecht : Kluwer, 2001, S. 344 - 346

Originalartikel in begutachteter nationaler Zeitschrift
Kremling, Andreas (ext.);  Bettenbrock, Katja (ext.);  Stelling, Joerg (ext.);  Reichl, Udo;  Gilles, Ernst-Dieter (ext.) 

Systemorientierte Bioprozesstechnik : interdisziplinäre Forschung in Biologie, System- und Computerwissenschaften.
In: Magdeburger Wissenschaftsjournal [Magdeburg] 6(2001), Nr. 1/2, S. 29 - 36

2000

Buchbeitrag
Reichl, Udo 

ISCOM vaccines : antigen production and downstream processing.
In: Brunner, Herwig (Hrsg.): Biochemical engineering (4th International congress Stuttgart 17 and 18 February, 2000). - proceedings. Stuttgart : Fraunhofer-IRB-Verl., 2000, S. 314 - 318

Kooperationen
Profil
  • Fermentationstechnik
  • Säugerzellen, Hefen, Bakterien
  • Aufarbeitungstechnik
  • Modellierung, Simulation und Optimierung von Bioprozessen
  • Prozessüberwachung und -regelung
Service
Kooperation und Serviceleistungen nach individueller Absprache zu folgenden Themengebieten:
  • Fermentationstechnik
  • Säugerzellen, Hefen, Bakterien
  • Aufarbeitungstechnik
  • Modellierung, Simulation und Optimierung von Bioprozessen
  • Prozessüberwachung und -regelung
Bitte wenden Sie sich an das Sekretariat: thomas.mund@ovgu.de
Vita
1980 - 1987Studium Biologie, Diplom, Universität Saarbrücken
1991Promotion
1992 - 1993Postdoc am Biotechnology Laboratory, University of British Colum-bia, Vancouver, Kanada
1993Wissenschaftlicher Mitarbeiter der Arbeitsgruppe Biotechnologie, Institut für Systemdynamik und Regelungstechnik, Universität Stuttgart
1993Projektleiter Mikrocarrier, Pitman-Moore GmbH, Burgwedel
1993 - 1996Abteilungsleiter Virusproduktion, Pitman-Moore GmbH, Burgwedel
1996 - 1999Stellvertretender Herstellungsleiter, Mallinckrodt Vet GmbH / Essex Animal Health, Burgwedel
seit 1999o. Professor für Bioprozesstechnik, Otto-von-Guericke-Universität, Magdeburg
seit 2000Direktor am Max-Planck-Institut für Dynamik komplexer technischer Systeme, Abteilung System- und signalorientierte Bioprozesstechnik, Magdeburg
2003 - 2004Geschäftsführender Leiter des Instituts für Verfahrenstechnik, Otto-von-Guericke-Universität, Magdeburg
2005 - 2006Geschäftsführender Direktor am Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg
seit 2005Mitglied der Perspektivenkommission der CPTS der Max-Planck-Gesellschaft
seit 2007Sprecher der IMPRS ("International Max Planck Research School for Analysis, Design and Optimization in Chemical and Biochemical Process Engineering")
2009 - 2010Geschäftsführender Leiter des Instituts für Verfahrenstechnik, Otto-von-Guericke-Universität, Magdeburg
2011 - 2012Geschäftsführender Direktor am Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg
Presse
Seit Jahrzehnten werden Hühnereier erfolgreich zur Herstellung von Grippeimpfstoff genutzt. Momentan werden gut95 % der hergestellten Vakzindosen damit abgedeckt. Im Falle einer Pandemie reichen die Produktionskapazitäten mit Hühnereiern allerdings nicht aus, daher sind die Bestrebungen groß, Zellkulturen als Alternative zu nutzen. Im Veterinärbereich hat der Wechsel zu zellkulturbasierten Impfstoffen bereits begonnen.