Prof. Nora Kulak

Aktuelle Projekte
- Entwicklung von Assays für Enzyminhibierung und reaktive Sauerstoffspezies
Laufzeit: 01.05.2020 - 30.04.2023 - Synthese von Curcumin-Metallkomplexen für biomedizinische Anwendungen
Laufzeit: 28.09.2020 - 27.06.2021
Abgeschlossene Projekte
- Antimikrobielle Eigenschaften von Cu(II)-Komplexen
Laufzeit: 17.03.2020 - 09.09.2020 - Synthese von Fe(III)-Komplexen als MRT-Kontrastmittel
Laufzeit: 12.03.2020 - 04.09.2020
2020
Begutachteter Zeitschriftenartikel
Exploring the relationship between structure and activity in BODIPYs designed for antimicrobial phototherapy
In: Organic & biomolecular chemistry: OBC - Cambridge: Royal Society of Chemistry, Bd. 18.2020, 13, S. 2416-2431
2019
Begutachteter Zeitschriftenartikel
Biological activity of amphiphilic metal complexes
In: In: Coordination Chemistry Reviews, Bd. 385, S. 191-207, 2019
Click chemistry on silicon nitride for biosensor fabrication
In: In: Applied Surface Science, Bd. 481, S. 10-15, 2019
Flexible vs. rigid bis(2-benzimidazolyl) ligands in Cu(II) complexes: Impact on redox chemistry and oxidative DNA cleavage activity
In: In: Journal of Inorganic Biochemistry, Bd. 194, S. 223-232, 2019
Synthesis of Porphyrinoids, BODIPYs, and (Dipyrrinato)ruthenium(II) Complexes from Prefunctionalized Dipyrromethanes
In: In: European Journal of Organic Chemistry, Bd. 2019, 25, S. 4020-4033, 2019
Nicht begutachteter Zeitschriftenartikel
Fluoreszenzsensoren für die DNA-Spaltung
In: GIT Labor-Fachzeitschrift, 2019, 29-31
2018
Begutachteter Zeitschriftenartikel
A fluorescence assay for the detection of hydrogen peroxide and hydroxyl radicals generated by metallonucleases
In: In: Chemical Communications, Bd. 54, 95, S. 13411-13414, 2018
Cu(II) complexes with hydrazone-functionalized phenanthrolines as self-activating metallonucleases
In: In: Inorganica Chimica Acta, Bd. 481, S. 79-86, 2018
Efficient Artificial Nucleases for Mediating DNA Cleavage Based on Tuning the Steric Effect in the Pyridyl Derivatives of Tripod Tetraamine-Cobalt(II) Complexes
In: In: European Journal of Inorganic Chemistry, Bd. 2018, 20, S. 2322-2338, 2018
Monoalkylated Cyclen Complexes for Efficient Proteolysis: Influence of Donor Atom Exchange
In: In: ChemistrySelect, Bd. 3, 44, S. 12552-12559, 2018
Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors
In: In: Inorganic Chemistry, Bd. 57, 9, S. 5004-5012, 2018
Pre-/post-functionalization in dipyrrin metal complexes-antitumor and antibacterial activity of their glycosylated derivatives
In: In: Dalton Transactions, Bd. 47, 35, S. 12373-12384, 2018
Synthesis and Evaluation of Artificial DNA Scissors: An Interdisciplinary Undergraduate Experiment
In: In: Journal of Chemical Education, Bd. 95, 10, S. 1848-1855, 2018
2017
Abstract
Development of Efficient Artificial Nucleases for DNA Cleavage Based Pyridyl Tripod Cobalt(II) Complexes
In: J. Biol. Inorg. Chem. 2017, 22, S247 (Tagungsband ICBIC 18 Florianópolis)
Begutachteter Zeitschriftenartikel
Sequential Nucleophilic Substitution of the -Pyrrole and p-Aryl Positions of meso-Pentafluorophenyl-Substituted BODIPYs
In: In: European Journal of Organic Chemistry, Bd. 2017, 22, S. 3187-3196, 2017
Synthesis of fluorine-containing 1,10-phenanthrolines using mild versions of Skraup and Doebner-von Miller reactions
In: In: Journal of Fluorine Chemistry, Bd. 193, S. 98-105, 2017
2016
Begutachteter Zeitschriftenartikel
New azidation methods for the functionalization of silicon nitride and application in copper-catalyzed azide-alkyne cycloaddition (CuAAC)
In: In: Surface and Interface Analysis, Bd. 48, 7, S. 621-625, 2016
Nucleophilic Aromatic Substitution on Pentafluorophenyl-Substituted Dipyrranes and Tetrapyrroles as a Route to Multifunctionalized Chromophores for Potential Application in Photodynamic Therapy
In: In: Chemistry - A European Journal, Bd. 22, 39, S. 13953-13964, 2016
Significantly enhanced proteolytic activity of cyclen complexes by monoalkylation
In: In: Dalton Transactions, Bd. 45, 26, S. 10500-10504, 2016
Synchrotron-radiation XPS analysis of ultra-thin silane films: Specifying the organic silicon
In: In: Applied Surface Science, Bd. 363, S. 406-411, 2016
Tuning the DNA binding and cleavage of bpa Cu(II) complexes by ether tethers with hydroxyl and methoxy groups
In: In: Inorganica Chimica Acta, Bd. 452, S. 159-169, 2016
2015
Begutachteter Zeitschriftenartikel
Fluorophore ATCUN complexes: Combining agent and probe for oxidative DNA cleavage
In: In: Chemical Communications, Bd. 51, 62, S. 12395-12398, 2015
From Cyclen to 12-Crown-4 Copper(II) Complexes: Exchange of Donor Atoms Improves DNA Cleavage Activity
In: In: European Journal of Inorganic Chemistry, Bd. 2015, 28, S. 4722-4730, 2015
Mononuclear Cu(ii) and Zn(ii) complexes with a simple diamine ligand: Synthesis, structure, phosphodiester binding and DNA cleavage studies
In: In: RSC Advances, Bd. 5, 29, S. 22405-22418, 2015
Quantification of Silane Molecules on Oxidized Silicon: Are there Options for a Traceable and Absolute Determination?
In: In: Analytical Chemistry, Bd. 87, 19, S. 10117-10124, 2015
Nicht begutachteter Zeitschriftenartikel
Activatable Metallonucleases
In: Elsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (Hrsg.: J. Reedijk), Elsevier, Waltham/MA, 2015
2014
Abstract
Amphiphilic metal complexes of cyclen derivatives for improved protein cleavage via particle formation
In: J. Biol. Inorg. Chem. 2014, 19, S803S804 (Tagungsband EuroBIC 12 Zürich)
Copper complexes of novel anthraquinone-substituted cyclen derivatives for DNA cleavage
In: J. Biol. Inorg. Chem. 2014, 19, S804 (Tagungsband EuroBIC 12 Zürich)
Fluorophore ATCUN complexes: dual probes for DNA cleavage
In: J. Biol. Inorg. Chem. 2014, 19, S803 (Tagungsband EuroBIC 12 Zürich)
Tuning the nuclease activity of macrocyclic copper complexes
In: J. Biol. Inorg. Chem. 2014, 19, S752S753 (Tagungsband EuroBIC 12 Zürich)
Begutachteter Zeitschriftenartikel
Copper complexes of N-donor ligands as artificial nucleases
In: In: European Journal of Inorganic Chemistry, Bd. 2014, 16, S. 2597-2612, 2015
2013
Begutachteter Zeitschriftenartikel
Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties
In: In: ACS Nano, Bd. 7, 7, S. 5675-5683, 2013
Reaction of a bis(benzoylhydrazone) with copper(II): Complex formation, hydroxylation, and DNA cleavage activity
In: In: European Journal of Inorganic Chemistry, 34, S. 5843-5853, 2013
Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(ii) complexes of heterosubstituted cyclens
In: In: Dalton Transactions, Bd. 42, 13, S. 4357-4360, 2013
Nicht begutachteter Zeitschriftenartikel
DNA und Proteine mit Metallen spalten
In: GIT Labor-Fachzeitschrift 2013, 448450
DNA und Proteine schneiden so geht es mit Metallkomplexen
In: Nachrichten aus der Chemie 2013, 61, 10031007
2012
Begutachteter Zeitschriftenartikel
Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells
In: In: Journal of Inorganic Biochemistry, Bd. 110, S. 58-63, 2012
Redox activation of metal-based prodrugs as a strategy for drug delivery
In: In: Advanced Drug Delivery Reviews, Bd. 64, 11, S. 993-1004, 2012
alphaVbeta3 integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug
In: In: ACS Nano, Bd. 6, 5, S. 4530-4539, 2012
2011
Begutachteter Zeitschriftenartikel
Role of Endonucleases XPF and XPG in Nucleotide Excision Repair of Platinated DNA and Cisplatin/Oxaliplatin Cytotoxicity
In: In: ChemBioChem, Bd. 12, 7, S. 1115-1123, 2011
2010
Begutachteter Zeitschriftenartikel
Amine species on self-assembled monolayers of -aminothiolates on gold as identified by XPS and NEXAFS spectroscopy
In: In: Surface and Interface Analysis, Bd. 42, 6-7, S. 1184-1187, 2010
Self-assembled monolayers of aromatic -aminothiols on gold: Surface chemistry and reactivity
In: In: Langmuir, Bd. 26, 6, S. 3949-3954, 2010
2009
Begutachteter Zeitschriftenartikel
Application of XPS and ToF-SIMS for surface chemical analysis of DNA microarrays and their substrates
In: In: Analytical and Bioanalytical Chemistry, Bd. 393, 8, S. 1907-1912, 2009
XPS and NEXAFS studies of aliphatic and aromatic amine species on functionalized surfaces
In: In: Surface Science, Bd. 603, 18, S. 2849-2860, 2009
2008
Begutachteter Zeitschriftenartikel
Optimization of cleaning and aminosilanization protocols for Si wafers to be used as platforms for biochip microarrays by surface analysis (XPS, ToF-SIMS and NEXAFS spectroscopy)
In: In: Surface and Interface Analysis, Bd. 40, 3-4, S. 180-183, 2008
Using enzymatic amplification by aldolase for the optical detection of DNA by an artificial signal cascade
In: In: Bioorganic and Medicinal Chemistry Letters, Bd. 18, 17, S. 4786-4788, 2008
Nicht begutachteter Zeitschriftenartikel
Surface chemical analysis of DNA microarrays
In: BIOforum Europe 2008, 12, 1416
2006
Begutachteter Zeitschriftenartikel
A metal-ion-releasing probe for DNA detection by catalytic signal amplification
In: In: Angewandte Chemie - International Edition, Bd. 45, 24, S. 4013-4015, 2006
Enzymatic amplification in a bioinspired, autonomous signal cascade
In: In: Chemical Communications, 42, S. 4375-4376, 2006
- Koordinationschemie und biologische Anwendungen von Metallkomplexen:
- Metallbasierte künstliche Nucleasen, Proteasen und Enzyminhibitoren
- Fluorierte Ligandensysteme für bioaktive Metallkomplexe
- Supramolekulare Aggregation und Immobilisierung bioaktiver Metallkomplexe
- Oligonucleotid- und Peptid-Metallkomplex-Konjugate
- Koordinationschemie der f-Elemente
seit 03/2020 | Professur (Lehrstuhl für Anorganische Chemie) Otto-von-Guericke-Universität Magdeburg Institut für Chemie |
2011¿2020 | Juniorprofessur (Bioanorganische Chemie) Freie Universität Berlin Institut für Chemie und Biochemie |
2008¿2010 | Postdoktorat Massachusetts Institute of Technology (MIT), Cambridge/MA, USA Department of Chemistry, Betreuer Prof. Dr. Stephen Lippard |
2006¿2008 | Postdoktorat Bundesanstalt für Materialforschung und -prüfung (BAM), Berlin Schicht- und Oberflächenanalytik, Betreuer Dr. Wolfgang Unger |
2003¿2006 | Promotion Ruprecht-Karls-Universität Heidelberg Anorganisch-Chemisches Institut, Betreuer Prof. Dr. Roland Krämer |
1998¿2003 | Studium der Chemie Ruprecht-Karls-Universität Heidelberg |
EHRUNGEN UND AUSZEICHNUNGEN
2016 Dr. Otto Röhm Gedächtnisstiftung
2008 Postdoc-Stipendium des DAAD (2 Jahre)
2004 Promotionsstipendium des Landes Baden-Württemberg (2 Jahre)
2003 Dr. Sophie-Bernthsen-Preis für das Diplom
MITGLIEDSCHAFTEN
Gesellschaft Deutscher Chemiker (GDCh)
American Chemical Society (ACS)
Deutscher Hochschulverband (DHV)
Society of Biological Inorganic Chemistry (SBIC)