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Targeting RIPK1 in AML cells carrying FLT3-ITD
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Mathematical models for cytarabine-derived myelosuppression in acute myeloid leukaemia
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Clinical predictors and prognostic impact of recovery of wall motion abnormalities in takotsubo syndrome - results from the International Takotsubo Registry
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Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling
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SDF1 α-induced chemotaxis of JAK2-V617F-positive cells is dependent on Bruton tyrosine kinase and its downstream targets PI3K/ AKT, PLCγ1 and RhoA. Letters to the editor
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Milzzyste nach Bauchtrauma?
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Primary ecthyma gangraenosum due to central venous catheter-related bloodstream infection with Pseudomonas aeruginosa
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Dose reduction and high-risk disease as risk factors for early death in primary CNS lymphoma. Letter to the editor
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Is bendamustine-rituximab a reasonable treatment in selected older patients with diffuse large B cell lymphoma? - Results from a multicentre, retrospective study
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Therapeutic potential of Axl blockade in BCR-ABL negative myeloproliferative neoplasms (MPN)
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Infectious complications in patients with multiple myeloma, malignant lymphoma and germ cell tumor receiving autologous blood stem cell transplantation - a retrospective single center analysis
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A randomized clinical trial of coping support intervention for parents of adolescent and young adults (AYA) with hematological malignancies
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Randomisierte klinische Studie zu einer Coping Support Intervention für Eltern von Adoleszenten und jungen Erwachsenen (AYA) mit hämatologischen Malignomen
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Risk of central venous catheter (CVC)-related bloodstream infections (CRBSI) in cancer patients (pts) with or without neutropenia at time of CVC insertion
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JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation
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Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors
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Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation
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Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia
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Mathematical modeling of RBC count dynamics after blood loss
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Das internistische Jahr 2017 - die wichtigsten Fortschritte und Entwicklungen
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Variant allele frequency kinetics of tyrosine kinase gene mutations in core-binding factor acute myeoloid leukemia (CBF-AML) under treatment with and without dasatinib
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CTLA-4 mediated effects on STATs regulate differentiation and plasticity of Tc17 cells
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Preclinical evaluation of immuno-/proteasome inhibitors in soft-tissue sarcoma
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Three cases of herpes virus reactivation after allogeneic stem cell transplantation
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Epidemiological, genetic and clinical characterization of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO) (NCT01252485)
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NFKB pathway promotes tumor progression through Brutons tyrosine kinase in MLL+ acute myeloid leukemia
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A simple prognostic index for prediction of central venous catheter-related bloodstream infections in patients with haematological malignancies (CIPS-H)
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Impact of treatment delay on prognosis in patients with primary CNS lymphoma
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Early death in patients with primary CNS lymphoma
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The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs
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The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells
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Phase II study of bortezomib, cyclophosphamide and dexamethasone as induction therapy in multiple myeloma - DSMM XI trial
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Response-adapted consolidation with bortezomib after ASCT improves progression-free survival in newly diagnosed multiple myeloma
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RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts
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JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1
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Gain of function in Jak2V617F positive T-cells. Letter to the editor
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Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
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Determination of a cutoff time point for prophylactic exchange of central venous catheters for prevention of central venous catheterrelated bloodstream infections in patients with hematological malignancies
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Impact of lymphopenia on prognosis of patients with primary central nervous system lymphoma - Letter to the editor
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Impact of pretreatment characteristics and salvage strategy on outcome in patients with relapsed acute myeloid leukemia - letter to the editor
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Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN
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Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation - a case report
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Tumor-Lyse-Syndrom
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Research and science
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Effectiveness of tigecycline (TGC) in hematological patients (pts) with persisting or recurring fever - a retrospective, monocentric review of 78 cases
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Characteristics and treatment of sarcoma patients in a single-center analysis
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Expression level of JAK2-V617F determines sensitivity to tyrosine kinase inhibitor Ruxolitinib in HEK293 Flp-In cells and can be augmented by treatment with inhibitors of PI3K/Akt pathway in JAK2-V617F - positive murine progenitor cells
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LPS stimulation induces ROS formation, apoptosis, DNA damage and oxidation of cysteine residues in FLT3-ITD positive cell lines resulting in FLT3-tyrosine kinase inhibitor resistance
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Reactive oxygen species (ROS) modulates sensitivity to FLT3-tyrosine kinase inhibitors in murine and human FLT3-ITD positive AML cell lines
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Regulatory role of intracellular ROS levels and effects of antioxidants (NAC, Tempol) on proliferation, cell cycle and sensitivity to treatment with tyrosine kinase inhibitor Ruxolitinib in JAK2-V617F - positive myeloproliferative neoplasms
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Hematopoietic Stem Cell Transplantation (HSCT) as compared to Consolidation Chemotherapy (CT) increases leukemia free survival in patients between 60 and 75 years with Acute Myelogenous Leukemia (AML) irrespective of the genetic risk - report from the AML 2004 of the East German Study Group (OSHO)
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Prophylactic exchange of central venous catheters (CVC) for prevention of CVC-related bloodstream infections (CRBSI) in patients with haematological malignancies - indirect evidence from pooled data of the SECRECY registry and the COAT study
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Cell intrinsic induction of IP-10 in MPN
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Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo
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Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger) - a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network
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Parameter estimation for leukocyte dynamics after chemotherapy
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Hemophagocytic lymphohistiocytosis as an unusual cause of prolonged bicytopenia after chemotherapy
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Psycho-oncologic interventions for parents of cancer patients - systematic review
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Weichteiltumoren - allgemein-klinische Aspekte ; chirurgische und medikamentöse Therapie
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Epo-induced erythroid maturation is dependent on Plc[gamma]1 signaling
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G-PCNSL-SG-1 randomised phase III trial of high-dose methotrexate with or without whole-brain radiotherapy for primary central nervous system lymphoma (PCNSL) - long-term follow-up
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Impact of cold shock protein Ybx1 on hematopoietic stem cell development and function
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Rapid induction of cytological remission by bendamustine in a rare case of T-PLL with leukostasis symptoms
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Overexpression of the Cell Division Cycle 25C phosphatase in a two-hit-model of acute myeloid leukemia (AML) suppresses apoptosis upon cytotoxic treatment
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Mathematical modelling of neutropenia of AML patients treated with chemotherapy
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A case of acute myeloid leucaemia after EHEC infection
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Drug treatment is superior to allografting as first line therapy in chronic myeloid leukemia.
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Novel Bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinases.
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