JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation
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Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia
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Mathematical modeling of RBC count dynamics after blood loss
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Das internistische Jahr 2017 - die wichtigsten Fortschritte und Entwicklungen
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Variant allele frequency kinetics of tyrosine kinase gene mutations in core-binding factor acute myeoloid leukemia (CBF-AML) under treatment with and without dasatinib
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CTLA-4 mediated effects on STATs regulate differentiation and plasticity of Tc17 cells
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Preclinical evaluation of immuno-/proteasome inhibitors in soft-tissue sarcoma
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Three cases of herpes virus reactivation after allogeneic stem cell transplantation
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Epidemiological, genetic and clinical characterization of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO) (NCT01252485)
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NFKB pathway promotes tumor progression through Brutons tyrosine kinase in MLL+ acute myeloid leukemia
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A simple prognostic index for prediction of central venous catheter-related bloodstream infections in patients with haematological malignancies (CIPS-H)
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Impact of treatment delay on prognosis in patients with primary CNS lymphoma
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Early death in patients with primary CNS lymphoma
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The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells
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The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs
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Phase II study of bortezomib, cyclophosphamide and dexamethasone as induction therapy in multiple myeloma - DSMM XI trial
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Response-adapted consolidation with bortezomib after ASCT improves progression-free survival in newly diagnosed multiple myeloma
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RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts
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JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1
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Gain of function in Jak2V617F positive T-cells. Letter to the editor
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Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
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Determination of a cutoff time point for prophylactic exchange of central venous catheters for prevention of central venous catheterrelated bloodstream infections in patients with hematological malignancies
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Impact of lymphopenia on prognosis of patients with primary central nervous system lymphoma - Letter to the editor
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Impact of pretreatment characteristics and salvage strategy on outcome in patients with relapsed acute myeloid leukemia - letter to the editor
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Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN
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Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation - a case report
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Tumor-Lyse-Syndrom
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Research and science
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Effectiveness of tigecycline (TGC) in hematological patients (pts) with persisting or recurring fever - a retrospective, monocentric review of 78 cases
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Characteristics and treatment of sarcoma patients in a single-center analysis
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Expression level of JAK2-V617F determines sensitivity to tyrosine kinase inhibitor Ruxolitinib in HEK293 Flp-In cells and can be augmented by treatment with inhibitors of PI3K/Akt pathway in JAK2-V617F - positive murine progenitor cells
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LPS stimulation induces ROS formation, apoptosis, DNA damage and oxidation of cysteine residues in FLT3-ITD positive cell lines resulting in FLT3-tyrosine kinase inhibitor resistance
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Reactive oxygen species (ROS) modulates sensitivity to FLT3-tyrosine kinase inhibitors in murine and human FLT3-ITD positive AML cell lines
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Regulatory role of intracellular ROS levels and effects of antioxidants (NAC, Tempol) on proliferation, cell cycle and sensitivity to treatment with tyrosine kinase inhibitor Ruxolitinib in JAK2-V617F - positive myeloproliferative neoplasms
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Prophylactic exchange of central venous catheters (CVC) for prevention of CVC-related bloodstream infections (CRBSI) in patients with haematological malignancies: indirect evidence from pooled data of the SECRECY registry and the COAT study
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Cell intrinsic induction of IP-10 in MPN
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Randomized comparison of pegylated IFN-a2b versus IFN-a2b maintenance following tandem autologous transplant in multiple myeloma
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Long-term follow-up of the AML97 study for patients aged 60 years and above with acute myeloid leukaemia - a study of the East German Haematology and Oncology Study Group (OSHO)
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Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo
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Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo
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Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger) - a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network
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Leukemogenic potency of the novel FLT3-N676K mutant
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NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD positive AML cells
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Optimum experimental design for patient specific mathematical leukopenia models
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Prolonged cellular midostaurin retention suggests potential alternative dosing strategies for FLT3-ITD-positive leukemias - letter to the editor
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Kinomics screening identifies aberrant phosphorylation of CDC25C in FLT3-ITD-positive AML
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Parameter estimation for leukocyte dynamics after chemotherapy
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Hemophagocytic lymphohistiocytosis as an unusual cause of prolonged bicytopenia after chemotherapy
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Characteristics and outcome of patients with primary CNS lymphoma in a real-life setting compared to a clinical trial
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Verminderung der magnetischen Nahfeldeinkopplung auf Leiterplattenebene durch reziproke Systemanalysen
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Requirement for phospholipase C gamma 1 (PLCG1) in development and maintenance of hematopoietic stem- and progenitor cells
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Results from two phase 3 studies of post-transplant bortezomib (BTZ) consolidation vs observation (OBS) in patients with newly diagnosed multiple myeloma (NDMM)
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Psycho-oncologic interventions for parents of cancer patients - systematic review
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The somatic burden score - a quantitative tool to evaluate the somatic burden due to chemotherapy-induced adverse events
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Distinct and non-overlapping functions of LLGL1 and scribble in hematopoietic stem cells
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Delayed entry of blood cultures into blood culture incubators has no negative effect of on overall culture positivity
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Results from two phase III studies of bortezomib (BTZ) consolidation vs observation (OBS) post-transplant in patients (pts) with newly diagnosed multiple myeloma (NDMM)
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A pro-active follow-up with higher completeness can significantly influence survival data
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Clinical outcome of primary CNS lymphoma comparing the setting of real-life with a clinical trial - a single centre experience of 95 patients
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Evolutionarily conserved signaling pathways - Acting in the shadows of acute myelogenous leukemia's genetic diversity
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Sustained remission of blastic plasmacytoid dendritic cell neoplasm after unrelated allogeneic stem cell transplantation - a single center experience
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How health-related quality-of-life outcomes in patients with acute promyelocytic leukemia can help physicians in decision making. Correspondence
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Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma
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Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
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Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function
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Central venous catheter-related bloodstream infections in obese hematologic patients. Letter to the editor
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Prediction of central venous catheterrelated bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS)
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Weichteiltumoren - allgemein-klinische Aspekte ; chirurgische und medikamentöse Therapie
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Epo-induced erythroid maturation is dependent on Plc[gamma]1 signaling
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Efficient analysis and reduction of magnetic near-field-coupling in mixed-signal PCBs via the reciprocity principle
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Eine Ärztin mit großem Einsatz und bei Patienten und MItarbeitern gleichermaßen beliebt - Im Gedenken an Prof. Dr. med. Astrid Franke
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Distinct biological and transcriptional features of FLT3-ITD variants in vitro and in vivo
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Epidemiological analysis of multidrug-resistant Gramnegative bacteria (MRGN) among haemato-oncological patients
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G-PCNSL-SG-1 randomised phase III trial of high-dose methotrexate with or without whole-brain radiotherapy for primary central nervous system lymphoma (PCNSL) - long-term follow-up
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Impact of cold shock protein Ybx1 on hematopoietic stem cell development and function
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Rapid induction of cytological remission by bendamustine in a rare case of T-PLL with leukostasis symptoms
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Overexpression of the Cell Division Cycle 25C phosphatase in a two-hit-model of acute myeloid leukemia (AML) suppresses apoptosis upon cytotoxic treatment
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Mathematical modelling of neutropenia of AML patients treated with chemotherapy
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Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function
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A case of acute myeloid leucaemia after EHEC infection
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Allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm
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A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling
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Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies
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The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML
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Identification of DAPK as a scaffold protein for the LIMK/cofilin complex in TNF-induced apoptosis
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Maligne Lymphome - Diagnostik und Therapie
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Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression
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Strukturierte psychoonkologische Kurzintervention für Eltern Adoleszenter und junger Erwachsener (AYA) mit malignen hämatologischen Erkrankungen: eine randomisierte klinische Studie
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Aktuelle und neue Therapieoptionen bei myeloproliferativen Erkrankungen
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3,4-Diarylmaleimides - a novel class of kinase inhibitors - effectively induce apoptosis in FLT3-ITD-dependent cells
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Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies
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Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells
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Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia
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Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation
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Rethinking bioactivity of FLT3 inhibitors
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Beyond diagnosis: subjective theories of illness in adult patients with acute myeloid leukemia
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Phase IIB trial of oral midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3
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Nilotinib is active in chronic and accelerated phase chronic myeloid leukemia following failure of imatinib and dasatinib therapy
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Dose intensity of chemotherapy in patients with relapsed Hodgkin's lymphoma
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FLT3 as a therapeutic target in AML: still challenging after all these years
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Severe paraneoplastic pemphigus in a patient with follicular lymphoma
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Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-[gamma]1-driven activation of mTOR/p70S6-kinase pathway
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Molekularpathologie von Sarkomen: Erste Ergebnisse des Sarkomforschungsverbundes KoSar
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A Novel Molecular Mechanism of Primary Resistance to FLT3-Kinase Inhibitors in Acute Myeloid Leukaemia.
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Identification of a Novel Type of ITD Mutations Located in Non-Juxtamembrane Domains of the FLT3 Tyrosine Kinase Receptor.
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Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin lymphoma
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Bis(1H-indol-2-yl)methanones are effective inhibitors of FLT3-ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro
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Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
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Favorable long-term follow-up results over six years for response, survival and safety with imatinib mesylate therapy in chronic phase chronic myeloid leukemia post failure of interferon-alpha treatment.
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The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukaemia.
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Entwicklung von Tyrosinkinase-Inhibitoren bei hämatologischen Neoplasien. FLT3 und JAK2 als therapeutische Targets.
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LS104, a non ATP-competitive small molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2-V617F positive cells.
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Co-expression of tyrosine kinase receptors in gastric adenocarcinoma ¿ a rationale for a new molecular targeting strategy?
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Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukaemia in myeloid blast crisis.
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A neoepitope generated by a FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T-cells.
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Drug treatment is superior to allografting as first line therapy in chronic myeloid leukemia.
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Results of a multicenter phase II trial for older patients with c-kit positive acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) using low-dose Ara-C (LDAC) and Imatinib (IM).
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Cross-inhibition of IFN-induced signal transduction by GM-CSF through a block in STAT1- activation.
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Five-Year Follow-up of Imatinib Therapy for Newly Diagnosed Chronic Myeloid Leukemia in Chronic-Phase Shows Sustained Responses and High Overall Survival.
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A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
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Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia (AML) by mutation of Asn-676 in the FLT3 tyrosine kinase domain.
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Novel Bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinases.
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Histone deacetylase inhibition by valproic acid downregulates c-FLIP and sensitizes hepatoma cells towards CD95- and TRAIL-receptor mediated apoptosis and chemotherapy.
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