Targeting RIPK1 in AML cells carrying FLT3-ITD
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Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling
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Primary ecthyma gangraenosum due to central venous catheter-related bloodstream infection with Pseudomonas aeruginosa
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Therapeutic potential of Axl blockade in BCR-ABL negative myeloproliferative neoplasms (MPN)
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Infectious complications in patients with multiple myeloma, malignant lymphoma and germ cell tumor receiving autologous blood stem cell transplantation - a retrospective single center analysis
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A randomized clinical trial of coping support intervention for parents of adolescent and young adults (AYA) with hematological malignancies
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Randomisierte klinische Studie zu einer Coping Support Intervention für Eltern von Adoleszenten und jungen Erwachsenen (AYA) mit hämatologischen Malignomen
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Risk of central venous catheter (CVC)-related bloodstream infections (CRBSI) in cancer patients (pts) with or without neutropenia at time of CVC insertion
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JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation
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Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors
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Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation
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Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia
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Mathematical modeling of RBC count dynamics after blood loss
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Das internistische Jahr 2017 - die wichtigsten Fortschritte und Entwicklungen
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Variant allele frequency kinetics of tyrosine kinase gene mutations in core-binding factor acute myeoloid leukemia (CBF-AML) under treatment with and without dasatinib
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CTLA-4 mediated effects on STATs regulate differentiation and plasticity of Tc17 cells
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Preclinical evaluation of immuno-/proteasome inhibitors in soft-tissue sarcoma
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Three cases of herpes virus reactivation after allogeneic stem cell transplantation
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Epidemiological, genetic and clinical characterization of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO) (NCT01252485)
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NFKB pathway promotes tumor progression through Brutons tyrosine kinase in MLL+ acute myeloid leukemia
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A simple prognostic index for prediction of central venous catheter-related bloodstream infections in patients with haematological malignancies (CIPS-H)
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Impact of treatment delay on prognosis in patients with primary CNS lymphoma
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Early death in patients with primary CNS lymphoma
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The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs
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The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells
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Phase II study of bortezomib, cyclophosphamide and dexamethasone as induction therapy in multiple myeloma - DSMM XI trial
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Response-adapted consolidation with bortezomib after ASCT improves progression-free survival in newly diagnosed multiple myeloma
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RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts
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JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1
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Gain of function in Jak2V617F positive T-cells. Letter to the editor
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Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
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Determination of a cutoff time point for prophylactic exchange of central venous catheters for prevention of central venous catheterrelated bloodstream infections in patients with hematological malignancies
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Impact of lymphopenia on prognosis of patients with primary central nervous system lymphoma - Letter to the editor
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Impact of pretreatment characteristics and salvage strategy on outcome in patients with relapsed acute myeloid leukemia - letter to the editor
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Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN
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Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation - a case report
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Tumor-Lyse-Syndrom
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Research and science
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Effectiveness of tigecycline (TGC) in hematological patients (pts) with persisting or recurring fever - a retrospective, monocentric review of 78 cases
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Characteristics and treatment of sarcoma patients in a single-center analysis
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Expression level of JAK2-V617F determines sensitivity to tyrosine kinase inhibitor Ruxolitinib in HEK293 Flp-In cells and can be augmented by treatment with inhibitors of PI3K/Akt pathway in JAK2-V617F - positive murine progenitor cells
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LPS stimulation induces ROS formation, apoptosis, DNA damage and oxidation of cysteine residues in FLT3-ITD positive cell lines resulting in FLT3-tyrosine kinase inhibitor resistance
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Reactive oxygen species (ROS) modulates sensitivity to FLT3-tyrosine kinase inhibitors in murine and human FLT3-ITD positive AML cell lines
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Regulatory role of intracellular ROS levels and effects of antioxidants (NAC, Tempol) on proliferation, cell cycle and sensitivity to treatment with tyrosine kinase inhibitor Ruxolitinib in JAK2-V617F - positive myeloproliferative neoplasms
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Hematopoietic Stem Cell Transplantation (HSCT) as compared to Consolidation Chemotherapy (CT) increases leukemia free survival in patients between 60 and 75 years with Acute Myelogenous Leukemia (AML) irrespective of the genetic risk - report from the AML 2004 of the East German Study Group (OSHO)
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Prophylactic exchange of central venous catheters (CVC) for prevention of CVC-related bloodstream infections (CRBSI) in patients with haematological malignancies - indirect evidence from pooled data of the SECRECY registry and the COAT study
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Cell intrinsic induction of IP-10 in MPN
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Randomized comparison of pegylated IFN-a2b versus IFN-a2b maintenance following tandem autologous transplant in multiple myeloma
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Long-term follow-up of the AML97 study for patients aged 60 years and above with acute myeloid leukaemia - a study of the East German Haematology and Oncology Study Group (OSHO)
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Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo
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Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo
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Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger) - a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network
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Leukemogenic potency of the novel FLT3-N676K mutant
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NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD positive AML cells
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Optimum experimental design for patient specific mathematical leukopenia models
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Prolonged cellular midostaurin retention suggests potential alternative dosing strategies for FLT3-ITD-positive leukemias - letter to the editor
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Kinomics screening identifies aberrant phosphorylation of CDC25C in FLT3-ITD-positive AML
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Parameter estimation for leukocyte dynamics after chemotherapy
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Prognostic relevance of DHAP dose-density in relapsed Hodgkin lymphoma - an analysis of the German Hodgkin-Study Group
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Biased low incidence of central venous catheter-related bloodstream infections in controlled clinical trials? - letter to the editor
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Hemophagocytic lymphohistiocytosis as an unusual cause of prolonged bicytopenia after chemotherapy
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Characteristics and outcome of patients with primary CNS lymphoma in a real-life setting compared to a clinical trial
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Verminderung der magnetischen Nahfeldeinkopplung auf Leiterplattenebene durch reziproke Systemanalysen
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Requirement for phospholipase C gamma 1 (PLCG1) in development and maintenance of hematopoietic stem- and progenitor cells
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Results from two phase 3 studies of post-transplant bortezomib (BTZ) consolidation vs observation (OBS) in patients with newly diagnosed multiple myeloma (NDMM)
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The novel FLT3-N676K mutant induces acute leukemia independently of the Inv(16) chimeric gene CBFB-MYH11
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Psycho-oncologic interventions for parents of cancer patients - systematic review
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The somatic burden score - a quantitative tool to evaluate the somatic burden due to chemotherapy-induced adverse events
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Distinct and non-overlapping functions of LLGL1 and scribble in hematopoietic stem cells
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Delayed entry of blood cultures into blood culture incubators has no negative effect of on overall culture positivity
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Results from two phase III studies of bortezomib (BTZ) consolidation vs observation (OBS) post-transplant in patients (pts) with newly diagnosed multiple myeloma (NDMM)
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Clinical outcome of primary CNS lymphoma comparing the setting of real-life with a clinical trial - a single centre experience of 95 patients
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How health-related quality-of-life outcomes in patients with acute promyelocytic leukemia can help physicians in decision making. Correspondence
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Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma
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Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
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Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function
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Central venous catheter-related bloodstream infections in obese hematologic patients. Letter to the editor
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Prediction of central venous catheterrelated bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS)
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Weichteiltumoren - allgemein-klinische Aspekte ; chirurgische und medikamentöse Therapie
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Epo-induced erythroid maturation is dependent on Plc[gamma]1 signaling
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Efficient analysis and reduction of magnetic near-field-coupling in mixed-signal PCBs via the reciprocity principle
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Eine Ärztin mit großem Einsatz und bei Patienten und MItarbeitern gleichermaßen beliebt - Im Gedenken an Prof. Dr. med. Astrid Franke
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Distinct biological and transcriptional features of FLT3-ITD variants in vitro and in vivo
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Epidemiological analysis of multidrug-resistant Gramnegative bacteria (MRGN) among haemato-oncological patients
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G-PCNSL-SG-1 randomised phase III trial of high-dose methotrexate with or without whole-brain radiotherapy for primary central nervous system lymphoma (PCNSL) - long-term follow-up
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Impact of cold shock protein Ybx1 on hematopoietic stem cell development and function
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Rapid induction of cytological remission by bendamustine in a rare case of T-PLL with leukostasis symptoms
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Overexpression of the Cell Division Cycle 25C phosphatase in a two-hit-model of acute myeloid leukemia (AML) suppresses apoptosis upon cytotoxic treatment
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Mathematical modelling of neutropenia of AML patients treated with chemotherapy
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Prediction of central venous catheter- (CVC-) related bloodstream infections (CRBSIs) in cancer patients (pts) using the Infection Probability Score (IPS): first results from the SECRECY registry
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JAK2V617F mutation is sufficient for autocrine induction of IP-10 in hematopoietic cells
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DAPK-HSF1 interaction as a positive-feedback mechanism stimulating TNF-induced apoptosis in colorectal cancer cells
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The incidence of norovirus infections in cancer patients shows less seasonal variability compared to patients with other diseases. Letter to the editor
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Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function
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A case of acute myeloid leucaemia after EHEC infection
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Allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm
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A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling
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Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies
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The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML
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Identification of DAPK as a scaffold protein for the LIMK/cofilin complex in TNF-induced apoptosis
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Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cells. Letter to the editor
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Maligne Lymphome - Diagnostik und Therapie
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Strukturierte psychoonkologische Kurzintervention für Eltern Adoleszenter und junger Erwachsener (AYA) mit malignen hämatologischen Erkrankungen: eine randomisierte klinische Studie
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