deutsch
Aims and Focus
Main focus:
Cultivation of mammalian cell lines in suspension and on microcarriers for the production of vaccines and pharmaceuticals. High cell density cultivations, fed-batch and perfusion systems. Downstream processing of virus particles, viral antigens and of recombinant proteins.
Tools:
- on-line biosensors
- off-line analytics (metabolites, products)
- chromatography (SEC, AC, IEX, HIC)
- flow cytometry
- real time PCR
- ELISAs & microassays
- 2D - DIGE
- mass spectrometry (MS)
- laser scanning microscopy
- proteomics & glycomics platform
- dynamical models (cell growth and virus replication)
- flux analyses