Prof. Hoffmann

Prof. Dr. rer. nat. Werner Hoffmann

Medizinische Fakultät/Universitätsklinikum A.ö.R. (FME/UKMD)
Institut für Molekularbiologie und Medizinische Chemie (IMMC)
Haus 29c, Leipziger Str. 44, 39120, Magdeburg, H29c/301
Projekte

Aktuelle Projekte

Abgeschlossene Projekte

Publikationen

2019

Begutachteter Zeitschriftenartikel

Houben, Till;  Harder, Sönke;  Schlüter, Hartmut;  Kalbacher, Hubert;  Hoffmann, Werner 

Different forms of TFF3 in the human saliva - heterodimerization with IgG Fc binding protein (FCGBP)
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, Bd.20.2019, 20, Art.-Nr. 5000, insges. 10 Seiten

Emidio, Nayara Braga;  Hoffmann, Werner;  Brierley, Stuart M.;  Muttenthaler, Markus 

Trefoil factor family - unresolved questions and clinical perspectives
In: Trends in biochemical sciences - Amsterdam [u.a.]: Elsevier Science, Bd. 44.2019, 5, S. 387-390

2018

Begutachteter Zeitschriftenartikel

Stürmer, René;  Harder, Sönke;  Schlüter, Hartmut;  Hoffmann, Werner 

Commercial porcine gastric mucin preparations, also used as artificial saliva, are a rich source for the lectin TFF2 - in vitro binding studies
In: ChemBioChem - Weinheim: Wiley-VCH, Bd. 19.2018, 24, S. 2598-2608

2017

Begutachteter Zeitschriftenartikel

Znalesniak, Eva B.;  Fu, Ting;  Salm, Franz;  Händel, Ulrike;  Hoffmann, Werner 

Transcriptional responses in the murine spleen after Toxoplasma gondii infection - inflammasome and mucus-associated genes
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, Bd. 18.2017, 6, Art.-Nr. 1245, insges. 10 S.

Bolle, Tim;  Meyer, Frank;  Walcher, Felix;  Lohmann, Christoph H.;  Jockenhövel, Stefan;  Gries, Thomas;  Hoffmann, Werner 

Werkstoffe/Biomaterialien in der interventionellen und operativen Medizin - eine kurze Übersicht und aktuelle Trends
In: Zentralblatt für Chirurgie: Zeitschrift für allgemeine, viszeral-, Thorax- und Gefäßchirurgie - Stuttgart [u.a.]: Thieme, Bd. 142.2017, 2, S. 216-225

2016

Abstrakt

Hoffmann,Werner 

What stem cells have to do with stomach cancer
In: 2016

Begutachteter Zeitschriftenartikel

Znalesniak, Eva B.;  Fu, Ting;  Guttek, Karina;  Händel, Ulrike;  Reinhold, Dirk;  Hoffmann, Werner 

Increased cerebral Tff1 expression in two murine models of neuroinflammation
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 39.2016, 6, S. 2287-2296

2015

Begutachteter Zeitschriftenartikel

Hoffmann, Werner 

Current status on stem cells and cancers of the gastric epithelium
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, Bd. 16.2015, 8, S. 19153-19169

Bernstein, Hans-Gert;  Dobrowolny, Henrik;  Trübner, Kurt;  Steiner, Johann;  Bogerts, Bernhard;  Hoffmann, Werner 

Differential regional and cellular distribution of TFF3 peptide in the human brain
In: Amino acids - Wien [u.a.]: Springer, Bd. 47.2015, 5, S. 1053-1063

Fu, Ting;  Znalesniak, Eva B.;  Kalinski, Thomas;  Möhle, Luisa;  Biswas, Aindrila;  Salm, Franz;  Dunay, Ildikò Rita;  Hoffmann, Werner 

TFF peptides play a role in the immune response following oral infection of mice with Toxoplasma gondii
In: European journal of microbiology and immunology - Budapest: Akad. Kiadó, Bd. 5.2015, 3, S. 221-231

Hoffmann, Werner 

TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)
In: International journal of oncology - Athens: Spandidos Publ, Bd. 47.2015, 3, S. 806-816

2014

Begutachteter Zeitschriftenartikel

Hoffmann, Werner 

Kontinuierliche Regeneration des Magenepithels durch Zelldifferenzierung - Bedeutung für die Karzinogenese
In: Der Pathologe: Organ der Deutschen Abteilung der Internationalen Akademie für Pathologie, der Deutschen, der Österreichischen und der Schweizerischen Gesellschaft für Pathologie und des Berufsverbandes Deutscher Pathologen - Berlin: Springer, Bd. 35.2014, Suppl.2, S. 202-206

Stürmer, René;  Müller, Stefan;  Hanisch, Franz-Georg;  Hoffmann, Werner 

Porcine gastric TFF2 is a mucus constituent and differs from pancreatic TFF2
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 33.2014, 4, S. 895-904

Fu, Ting;  Stellmacher, Anne;  Znalesniak, Eva B.;  Dieterich, Daniela C.;  Kalbacher, Hubert;  Hoffmann, Werner 

Tff3 is expressed in neurons and microglial cells
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 34.2014, 6, S. 1912-1919

Dissertation

Fu, Ting;  Hoffmann, Werner [Gutachter] 

In vivo and in vitro studies on the expression and function of TFF peptides in the gastrointestinal tract and the central nervous system
In: Magdeburg Univ., Fak. für Naturwiss., Diss., 2014, VIII, 101, VI Bl., Ill., graph. Darst., 30 cm

2013

Begutachteter Zeitschriftenartikel

Hanisch, Franz-Georg;  Ragge, Hubert;  Kalinski, Thomas;  Meyer, Frank;  Kalbacher, Hubert;  Hoffmann, Werner 

Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide
In: Glycobiology: official journal of the Society for Glycobiology - Oxford: Oxford University Press, Bd. 23.2013, 1, S. 2-11

Hoffmann, Werner 

Self-renewal of the gastric epithelium from stem and progenitor cells
In: Frontiers in bioscience / Scholar edition - Searington, NY, Bd. 5.2013, 2, S. 720-731

Fu, Ting;  Kalbacher, Hubert;  Hoffmann, Werner 

TFF1 is differentially expressed in stationary and migratory rat gastric epithelial cells (RGM-1) after in vitro wounding: Influence of TFF1 RNA interference on cell migration
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 32.2013, 4, S. 997-1010

Buchbeitrag

Hoffmann, Werner 

TFF peptides
In: Handbook of biologically active peptides - Amsterdam [u.a.]: Elsevier, Acad. Press, S. 1338-1345, 2013

2012

Originalartikel in begutachteter internationaler Zeitschrift

Hoffmann, Werner;  Singh, Shree Ram 

Stem cells in regenerative medicine and cancer. Editorial
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 19.2012, 35, S. 5964

Hoffmann, Werner 

Stem cells, self-renewal and cancer of the gastric epithelium
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 19.2012, 35, S. 5975-5983

2011

Originalartikel in begutachteter internationaler Zeitschrift

Hoffmann, Werner 

Gastric stem cells: Of flies and men
In: Cell cycle - London: Taylor & Francis, Bd. 10.2011, 8, S. 1186-1187

Kouznetsova, Irina;  Kalinski, Thomas;  Meyer, Frank;  Hoffmann, Werner 

Self-renewal of the human gastric epithelium: new insights from expression profiling using laser microdissection
In: Molecular BioSystems - Cambridge: Royal Society of Chemistry, Bd. 7.2011, 4, S. 1105-1112

2010

Originalartikel in begutachteter internationaler Zeitschrift

Kouznetsova, Irina;  Gerlach, Klaus L.;  Zahl, Christian;  Hoffmann, Werner 

Expression analysis of human salivary glands by laser microdissection: differences between submandibular and labial glands
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 26.2010, 3, S. 375-382

Albert, Timo K.;  Laubinger, Werner;  Müller, Stefan;  Hanisch, Franz-Georg;  Kalinski, Thomas;  Meyer, Frank;  Hoffmann, Werner 

Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfide
In: Journal of proteome research - Washington, DC: American Chemical Society, Bd. 9.2010, 6, S. 3108-3117

Znalesniak, Eva B.;  Hoffmann, Werner 

Modulation of cell-cell contacts during intestinal restitution in vitro and effects of epidermal growth factor (EGF)
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 25.2010, 4/5, S. 533-542

Rinnert, Margarita;  Hinz, Margitta;  Buhtz, Peter;  Reiher, Frank;  Lessel, Wolfgang;  Hoffmann, Werner 

Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine
In: Cell & tissue research - Berlin: Springer, Bd. 339.2010, 3, S. 639-647

2009

Originalartikel in begutachteter internationaler Zeitschrift

Ganss, Bernhard;  Hoffmann, Werner 

Calcium-induced conformational transition of trout ependymins monitored by tryptophan fluorescence
In: The open biochemistry journal - Sharjah [u.a.]: Bentham Open, Bd. 3.2009, S. 14-17

Znalesniak, Eva B.;  Dürer, Uwe;  Hoffmann, Werner 

Expression profiling of stationary and migratory intestinal epithelial cells after in vitro wounding: restitution is accompanied by cell differentiation
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 24.2009, 1/2, S. 125-132

Hoffmann, Werner 

Trefoil factor family (TFF) peptides and chemokine receptors: a promising relationship
In: Journal of medicinal chemistry - Easton, Pa: American Chemical Society, Bd. 52.2009, 21, S. 6505-6510

2008

Originalartikel in begutachteter internationaler Zeitschrift

Lubka, Maria;  Müller, Marcus;  Baus Loncar, Mirela;  Hinz, Margitta;  Blaschke, Karolina;  Hoffmann, Werner;  Pfister, Markus;  Löwenheim, Hubert Martin;  Pusch, Carsten;  Knipper, Marlies;  Blin, Nikolaus 

Lack of Tff3 peptide results in hearing impairment and accelerated presbyacusis
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 21.2008, 5/6, S. 437-444

Hoffmann, Werner 

Regeneration of the gastric mucosa and its glands from stem cells
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 15.2008, 29, S. 3133-3144

2007

Originalartikel in begutachteter internationaler Zeitschrift

Kouznetsova, Irina;  Laubinger, Werner;  Kalbacher, Hubert;  Kalinski, Thomas;  Meyer, Frank;  Roessner, Albert;  Hoffmann, Werner 

Biosynthesis of Gastrokine-2 in the human gastric mucosa: restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 20.2007, 6, S. 899-908

Kouznetsova, Irina;  Chwieralski, Caroline Elisabeth;  Bälder, Ralf;  Hinz, Margitta;  Braun, Armin;  Krug, Norbert;  Hoffmann, Werner 

Induced trefoil factor family 1 expression by trans-differentiating Clara cells in a murine asthma model
In: American journal of respiratory cell and molecular biology: an official journal of the American Thoracic Society Medical Section of the American Lung Association - New York, NY, Bd. 36.2007, 3, S. 286-295

Kouznetsova, Irina;  Kalinski, Thomas;  Peitz, Ulrich;  Mönkemüller, Klaus E.;  Kalbacher, Hubert;  Vieth, Michael;  Meyer, Frank;  Roessner, Albert;  Malfertheiner, Peter;  Lippert, Hans;  Hoffmann, Werner 

Localization of TFF3 peptide in human esophageal submucosal glands and gastric cardia - differentiation of two types of gastric pit cells along the rostro-caudal axis
In: Cell & tissue research - Berlin: Springer, Bd. 328.2007, 2, S. 365-374

Hoffmann, Werner 

TFF (trefoil factor family) peptides and their potential roles for differentiation processes during airway remodeling
In: Current medicinal chemistry: the new international journal for timely in-depth reviews in medicinal chemistry - Schiphol: Bentham, Bd. 14.2007, 25, S. 2716-2719

Dürer, Uwe;  Hartig, Roland;  Bang, Susanne;  Thim, Lars;  Hoffmann, Werner 

TFF3 and EGF induce different migration patterns of intestinal epithelial cells in vitro and trigger increased internalization of E-cadherin
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Basel: Karger, Bd. 20.2007, 5, S. 329-346

LeSimple, Pierre;  Seuningen, Isabelle;  Buisine, Marie-Pierre;  Copin, Marie-Christine;  Hinz, Margitta;  Hoffmann, Werner;  Hajj, Rodolphe;  Brody, Steven L.;  Coraux, Christelle;  Puchelle, Edith 

Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation
In: American journal of respiratory cell and molecular biology: an official journal of the American Thoracic Society Medical Section of the American Lung Association - New York, NY, Bd. 36.2007, 3, S. 296-303

2006

Buchbeitrag

Hoffmann, Werner 

TFF (trefoil factor family) peptides
In: Handbook of biologically active peptides - Amsterdam [u.a.]: Elsevier / Acad. Press, S. 1147-1154, 2006

2005

Originalartikel in begutachteter internationaler Zeitschrift

Hoffmann, Werner 

TFF (trefoil factor family) peptide-triggered signals promoting mucosal restitution.
In: Cell. Mol. Life Sci. 2005;62:2932-2938.

Schäfer, Gesa;  Hoffmann, Werner;  Berry, Monica;  Paulsen, Friedrich 

Tränendrüsenassoziierte Muzine
In: Ophthalmologe 2005;102:175-183

2004

Originalartikel in begutachteter internationaler Zeitschrift

Kouznetsova, Irina;  Peitz, Ulrich;  Vieth, Michael W.R.;  Meyer, Frank;  Vestergaard, E. (ext.);  Malfertheiner, Peter;  Roessner, Albert;  Lippert, Hans;  Hoffmann, Werner 

A gradient of TFF3 (trefoil factor family 3) peptide synthesis within the normal human gastric mucosa.
In: Cell Tissue Res. 316(2004), Nr. 2, S. 155 - 165

Steven, P. (ext.);  Schaefer, Gesa Friederike;  Noelle, B. (ext.);  Hinz, Margitta;  Hoffmann, Werner;  Paulsen, F. (ext.) 

Distribution of TFF peptides in corneal disease and pterygium.
In: Peptides 25(2004), Nr. 5, S. 819 - 825

Chwieralski, Caroline;  Schnurra, Ingo;  Thim, L. (ext.);  Hoffmann, Werner 

Epidermal growth factor and trefoil factor family 2 synergistically trigger chemotaxis on BEAS-2B cells via different signaling cascades.
In: Am. J. Respir. Cell Mol. Biol. 31(2004), Nr. 5, S. 528 - 537

Paulsen, F. (ext.);  Schaefer, Gesa Friederike;  Hoffmann, Werner;  Berry, M. (ext.) 

Human lacrimal gland mucins.
In: Cell Tissue Res. 316(2004), Nr. 2, S. 167 - 177

Hertel, Silvia;  Chwieralski, Caroline;  Hinz, Margitta;  Rio, M.C. (ext.);  Tomasetto, C. (ext.);  Hoffmann, Werner 

Profiling trefoil factor family (TFF) expression in the mouse : identification of an antisense TFF1-related transcript in the kidney and liver.
In: Peptides 25(2004), Nr. 5, S. 755 - 762

Peitz, Ulrich;  Kouznetsova, Irina;  Wex, Thomas;  Gebert, Ingrid;  Vieth, Michael W.R.;  Roessner, Albert;  Hoffmann, Werner;  Malfertheiner, Peter 

TFF3 expression at the esophagogastric junction is increased in gastro-esophageal reflux disease (GERD).
In: Peptides 25(2004), Nr. 5, S. 771 - 777

Hinz, Margitta;  Schwegler, Herbert;  Chwieralski, Caroline;  Laube, Gregor;  Linke, Ruediger;  Pohle, W. (ext.);  Hoffmann, Werner 

Trefoil factor family (TFF) expression in the mouse brain and pituitary : changes in the developing cerebellum.
In: Peptides 25(2004), Nr. 5, S. 827 - 832

Hoffmann, Werner 

Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more [Editorial].
In: Peptides 25(2004), Nr. 5, S. 727 - 730

Originalartikel in begutachteter nationaler Zeitschrift

Paulsen, F. (ext.);  Corfield, A. (ext.);  Hinz, Margitta;  Hoffmann, Werner;  Schaudig, U. (ext.);  Thale, A. (ext.);  Berry, M. (ext.) 

Tränenabfluss : Bedeutung von Muzinen und TFF-Peptiden.
In: Ophthalmologe 101(2004), Nr. 1, S. 19 - 24

2003

Originalartikel in begutachteter internationaler Zeitschrift

Paulsen, Friedrich;  Corfiled Anthony;  Hinz, Margitta;  Hoffmann, Werner;  Schaudig, Ulrich;  Thale, Andreas;  Berry, Monica 

Characterization of Mucins in Human Lacrimal Sac and Nasolacrimal Duct
In: Invest. Ophthalmol. Vis. Sci. 2003;44:1807-1813

2002

Buchbeitrag

Schaefer, Gesa Friederike;  Jagla, Wolfgang;  Behrens-Baumann, Wolfgang;  Walter, Sven;  Hoffmann, Werner 

Ocular TFF-peptides : new mucus-associated secretory products of conjunctival goblet cells.
In: Sullivan, D. (Ed.) ; Stern, M. (Ed.) ; Tsubota, K. (Ed.) ; ... (Ed.): Lacrimal gland, tear film, and dry eye syndromes 3 : basic science and clinical relevance ; Part A (3rd International Conference on the Lacrimal Gland, Tear Film, and Dry Eye Syndromes, Mauii Hawaii November 2000). New York [u.a.] : Kluwer Acad. Plenum Publ., 2002, S. 313 - 316 (Advances in experimental medicine and biology ; 506)

Originalartikel in begutachteter internationaler Zeitschrift

Hoffmann, Werner;  Jagla, Wolfgang 

Cell type specific expression of secretory TFF peptides : colocalization with mucins and synthesis in the brain.
In: Int. Rev. Cytol. 213(2002), S. 147 - 181

Graness, Angela;  Chwieralski, Caroline;  Reinhold, Dirk;  Thim, L. (ext.);  Hoffmann, Werner 

Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL- 8 secretion.
In: J. Biol. Chem. 277(2002), Nr. 21, S. 18440 - 18446

Paulsen, F. (ext.);  Hinz, Margitta;  Schaudig, U. (ext.);  Thale, A. (ext.);  Hoffmann, Werner 

TFF peptides in the human efferent tear ducts.
In: Invest. Ophthalmol. Vis. Sci. 43(2002), Nr. 11, S. 3359 - 3364

Kooperationen
  • Institut für Pathologie
  • Klinik für Chirurgie
Profil
Molekulare Zellbiologie
Service
Vita
1955geboren in Salzburg, Österreich  
1973-1978Diplomstudium der Chemie an der Universität Innsbruck; Sponsion zum "Magister rer. nat."
1978-1982 Dissertation am Institut für Molekularbiologie der Österreichischen Akademie der Wissenschaften in Salzburg; Promotion an der Universität Innsbruck zum "Doktor rer. nat."  
1983-1984Postdoctoral Fellow bei ZymoGenetics Inc. in Seattle, USA  
1984-1986Projektleiter am Institut für Molekularbiologie der ÖAW in Salzburg  
1987-1993Leiter der Nachwuchsgruppe Molekulare Genetik am Max-Planck-Institut für Psychiatrie in Martinsried  
1991Habilitation für das Fachgebiet Biochemie an der Universität Innsbruck  
seit 1993Professur für Medizinische Chemie und Direktor des IMMC an der Medizinischen Fakultät der Otto-von-Guericke-Universität Magdeburg
Presse

Letzte Änderung: 22.08.2018 - Ansprechpartner: Webmaster