Prof. Fischer

Prof. Dr. med. Thomas Fischer

Medizinische Fakultät
Zentrum für Innere Medizin (ZIM): Universitätsklinik für Hämatologie und Onkologie (KHAE)
Haus 39, 40, Leipziger Str. 44, 39120 Magdeburg,
Tel.: +49 391 67 13266
Fax: +49 391 67 13267

Prof. Dr. med. Thomas Fischer

Medizinische Fakultät
Zentrum für Innere Medizin (ZIM): Universitätsklinik für Hämatologie und Onkologie (KHAE)
Haus 39, 40, Leipziger Str. 44, 39120 Magdeburg,
Tel.: +49 391 67 13266
Fax: +49 391 67 13267
Projekte

Aktuelle Projekte

Abgeschlossene Projekte

Publikationen

2017

Begutachteter Zeitschriftenartikel
Arra, Aditya;  Lingel, Holger;  Kuropka, Benno;  Pick, Jonas;  Schnöder, Tina;  Fischer, Thomas;  Freund, Christian;  Pierau, Mandy;  Brunner-Weinzierl, Monika 

The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs
In: OncoImmunology - Austin, Tex: Landes Bioscience, Bd. 6.2017, 2, Art.-Nr. e1273300, insges. 5 S.; http://dx.doi.org/10.1080/2162402X.2016.1273300

Gieseler-Halbach, Steffi;  Meltendorf, Stefan;  Pierau, Mandy;  Weinert, Sönke;  Heidel, Florian;  Fischer, Thomas;  Handschuh, Juliane;  Braun-Dullaeus, Ruediger C.;  Schrappe, Martin;  Lindquist, Jonathan A.;  Mertens, Peter Rene;  Thomas, Ulrich;  Brunner-Weinzierl, Monika 

RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts
In: Cell death and differentiation - Houndmills, Basingstoke: Nature Publishing Group, Bd. 24.2017, 2, S. 371-383; http://dx.doi.org/10.1038/cdd.2016.141

Gupta, Nibedita;  Edelmann, Bärbel;  Schnöder, Tina;  Saalfeld, Felix C.;  Wolleschak, Denise;  Kliche, Stefanie;  Schraven, Burkhart;  Heidel, Florian;  Fischer, Thomas 

JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1 (VCAM1)
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - Basingstoke: Nature Publ. Group, Bd. 31.2017; http://dx.doi.org/10.1038/leu.2017.26

Nishanth, Gopala;  Wolleschak, Denise;  Fahldieck, Corinna;  Fischer, Thomas;  Mullally, Ann;  Perner, Florian;  Schnöder, Tina M.;  Just, Sissy;  Heidel, Florian;  Schlüter, Dirk 

Gain of function in Jak2V617F positive T-cells. Letter to the editor
In: Leukemia: normal and malignant hemopoiesis : a peer-reviewed journal - Basingstoke: Nature Publ. Group, Bd. 31.2017, insges. 13 S.; http://dx.doi.org/10.1038/leu.2017.6

Zeremski, Vanja;  Mawrin, Christian;  Fischer, Thomas;  Schalk, Enrico 

Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation - a case report
In: Molecular and clinical oncology: an international journal devoted to oncology - Athens: Spandidos Publ, Bd. 6.2017, 1, S. 79-82; http://dx.doi.org/10.3892/mco.2016.1080

2016

Abstrakt
Fischer, Thomas 

Research and science
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Seite 326

Geßner, Daniel;  Deubrecht, Stefanie;  Fischer, Thomas;  Schalk, Enrico 

Effectiveness of tigecycline (TGC) in hematological patients (pts) with persisting or recurring fever - a retrospective, monocentric review of 78 cases
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. P957, Seite 296

Glade, Julia;  Krogel, Christian;  Roessner, Albert;  Fischer, Thomas;  Heidel, Florian;  Wolleschak, Denise 

Characteristics and treatment of sarcoma patients in a single-center analysis
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. P917, Seite 279-280

Müller, Christian;  Schnöder, Tina M.;  Edelmann-Stephan, Bärbel;  Hessenkemper, Wiebke;  Bongartz, Hannes;  Schaper, Fred;  Fischer, Thomas 

Expression level of JAK2-V617F determines sensitivity to tyrosine kinase inhibitor Ruxolitinib in HEK293 Flp-In cells and can be augmented by treatment with inhibitors of PI3K/Akt pathway in JAK2-V617F - positive murine progenitor cells
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. P510, Seite 148-149

Müller, Christian;  Schnöder, Tina;  Simeoni, Luca;  Heidel, Florian;  Thurm, Christoph;  Schraven, Burkhart;  Fischer, Thomas 

LPS stimulation induces ROS formation, apoptosis, DNA damage and oxidation of cysteine residues in FLT3-ITD positive cell lines resulting in FLT3-tyrosine kinase inhibitor resistance
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 101.2016, s1, Abs. E877, S. 360

Müller, Christian;  Simeoni, Luca;  Heidel, Florian;  Schraven, Burkhart;  Fischer, Thomas 

Reactive oxygen species (ROS) modulates sensitivity to FLT3-tyrosine kinase inhibitors in murine and human FLT3-ITD positive AML cell lines
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 101.2016, s1, Abs. E885, S. 362-363

Müller, Christian;  Schnöder, Tina M.;  Edelmann-Stephan, Bärbel;  Wolleschak, Denise;  Simeoni, Luca;  Fischer, Thomas 

Regulatory role of intracellular ROS levels and effects of antioxidants (NAC, Tempol) on proliferation, cell cycle and sensitivity to treatment with tyrosine kinase inhibitor Ruxolitinib in JAK2-V617F - positive myeloproliferative neoplasms
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. P509, Seite 148

Schalk, Enrico;  Biehl, Lena M.;  Färber, Jacqueline;  Huth, Alexandra;  Panse, Jens;  Krämer, Carolin;  Hentrich, Marcus;  Engelhardt, Monika;  Schäfer-Eckart, Kerstin;  Kofla, Grzegorz;  Kiehl, Michael;  Wendtner, Clemens-M.;  Karthaus, Meinolf;  Cornely, Oliver A.;  Fischer, Thomas;  Vehreschild, Maria J. G. T. 

Prophylactic exchange of central venous catheters (CVC) for prevention of CVC-related bloodstream infections (CRBSI) in patients with haematological malignancies: indirect evidence from pooled data of the SECRECY registry and the COAT study
In: Oncology research and treatment. - Basel : Karger; Bd. 39 (2016), Suppl.3, Abs. V44, Seite 8

Schnöder, Tina M.;  Eberhardt, Judith;  Nimmagadda, Subbaiah Chery;  Weinert, Sönke;  Wolleschak, Denise;  Sammt, Anja;  Fahldieck, Corinna;  Schönborn, Uta;  Fischer, Thomas;  Heidel, Florian H. 

Cell intrinsic induction of IP-10 in MPN
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. V107, Seite 26

Schreder, Martin;  Liebisch, Peter;  Hebart, Holger;  Holler, Ernst;  Engelhardt, Monika;  Metzner, Bernd;  Peest, Dietrich;  Aulitzky, Walter;  Straka, Christian;  Fischer, Thomas;  Sezer, Orhan;  Hentrich, Marcus;  Ostermann, Helmut;  Peschel, Christian;  Heß, Georg;  Hertenstein, Bernd;  Wolf, Hans-Heinrich;  Jung, Wolfram;  Frickhofen, Norbert;  Maschmeyer, Georg;  Langer, Christian;  Meisner, Christoph;  Kanz, Lothar;  Einsele, Hermann;  Knop, Stefan 

Randomized comparison of pegylated IFN-a2b versus IFN-a2b maintenance following tandem autologous transplant in multiple myeloma
In: Oncology research and treatment. - Basel : Karger; Bd. 39.2016, Suppl. 3, Abs. P546, Seite 163

Artikel in Zeitschrift
Kahl, Christoph;  Krahl, Rainer;  Becker, Cornelia;  Al-Ali, Haifa Kathrin;  Sayer, Herbert, G.;  Schulze, Antje;  Herold, Michael;  Hänel, Mathias;  Scholl, Sebastian;  Hochhaus, Andreas;  Uharek, Lutz;  Maschmeyer, Georg;  Haehling, Detlev;  Junghanß, Christian;  Peter, Norma;  Kämpfe, Dietrich;  Kettner, Erika;  Heinicke, Thomas;  Fischer, Thomas;  Kreibich, Ute;  Wolf, Hans-Heinrich;  Niederwieser, Dietger 

Long-term follow-up of the AML97 study for patients aged 60 years and above with acute myeloid leukaemia - a study of the East German Haematology and Oncology Study Group (OSHO)
In: Journal of cancer research and clinical oncology - Berlin: Springer, Bd. 142.2016, 1, S. 305-315; http://dx.doi.org/10.1007/s00432-015-2045-8

Begutachteter Zeitschriftenartikel
Arreba-Tutusaus, Patricia;  Mack, Thomas S.;  Bullinger, Lars;  Schnöder, Tina M.;  Polanetzki, Anja;  Weinert, Sönke;  Ballaschk, Anne;  Wang, Z.;  Deshpande, Aniruddha J.;  Armstrong, Scott A.;  Döhner, Konstanze;  Fischer, Thomas;  Heidel, Florian H. 

Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo
In: Leukemia : normal and malignant hemopoiesis ; a peer-reviewed journal. - Basingstoke : Nature Publ. Group, Bd. 30.2016, 5, S. 1220-1225

Ebert, Caroline;  Perner, Florian;  Wolleschak, Denise;  Schnöder, Tina M.;  Fischer, Thomas;  Heidel, Florian H. 

Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata Storti Foundation; Bd. 101.2016, 3, S. e81-e85

Hermine, Olivier;  Hoster, Eva;  Walewski, Jan;  Bosly, André;  Stilgenbauer, Stephan;  Thieblemont, Catherine;  Szymczyk, Michal;  Bouabdallah, Reda;  Kneba, Michael;  Hallek, Michael;  Salles, Gilles;  Feugier, Pierre;  Ribrag, Vincent;  Birkmann, Josef;  Forstpointner, Roswitha;  Haioun, Corinne;  Hänel, Mathias;  Casasnovas, René Olivier;  Finke, Jürgen;  Peter, Norma;  Bouabdallah, Kamal;  Sebban, Catherine;  Fischer, Thomas;  Dührsen, Ulrich;  Metzner, Bernd;  Maschmeyer, Georg;  Kanz, Lothar;  Schmidt, Christian;  Delarue, Richard;  Brousse, Nicole;  Klapper, Wolfram;  Macintyre, Elizabeth;  Delfau-Larue, Marie-Hélène;  Pott, Christiane;  Hiddemann, Wolfgang;  Unterhalt, Michael;  Dreyling, Martin 

Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger) - a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network
In: The lancet <London>. - London [u.a.] : Elsevier, Bd. 388.2016, 10044, S. 565-575

Huang, Kezhi;  Yang, Min;  Pan, Zengkai;  Heidel, Florian H.;  Scherr, Michaela;  Eder, Matthias;  Fischer, Thomas;  Büsche, Guntram;  Welte, Karl;  Neuhoff, Nils von;  Ganser, Arnold;  Li, Zhixiong 

Leukemogenic potency of the novel FLT3-N676K mutant
In: Annals of hematology : organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie. - Berlin : Springer, Bd. 95.2016, 5, S. 783-791

Jayavelu, Ashok Kumar;  Müller, Jörg P.;  Bauer, Reinhard;  Böhmer, Sylvia-Annette;  Lässig, Julia;  Cerny-Reiterer, Sabine;  Sperr, Wolfgang R.;  Valent, Peter;  Maurer, Barbara;  Moriggl, Richard;  Schröder, Katrin;  Shah, Ajay M.;  Fischer, Mike;  Scholl, Sebastian;  Barth, Jessica;  Oellerich, Thomas;  Berg, Tobias;  Serve, Hubert;  Frey, Stephanie;  Fischer, Thomas;  Heidel, Florian H.;  Böhmer, Frank-D. 

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD positive AML cells
In: Leukemia : normal and malignant hemopoiesis ; a peer-reviewed journal. - Basingstoke : Nature Publ. Group, Bd. 30.2016, 2, S. 473-483

Jost, Felix;  Rinke, Kristine;  Fischer, Thomas;  Schalk, Enrico;  Sager, Sebastian 

Optimum experimental design for patient specific mathematical leukopenia models
In: IFAC-PapersOnLine - Frankfurt: Elsevier, Bd. 49.2016, 26, S. 344-349, 49 2016 26 344-349; http://dx.doi.org/10.1016/j.ifacol.2016.12.150 ; [Kongress: Foundations of Systems Biology in Engineering, FOSBE 2016, Magdeburg, Germany, 9-12 October, 2016]

Lipka, Daniel B.;  Wagner, Marie-Christine;  Dziadosz, Marek;  Fischer, Thomas 

Prolonged cellular midostaurin retention suggests potential alternative dosing strategies for FLT3-ITD-positive leukemias - letter to the editor
In: Leukemia : normal and malignant hemopoiesis ; a peer-reviewed journal. - Basingstoke : Nature Publ. Group, Bd. 30.2016, 10, S. 2090-2093

Perner, Florian;  Schnöder, Tina M.;  Fischer, Thomas;  Heidel, Florian H. 

Kinomics screening identifies aberrant phosphorylation of CDC25C in FLT3-ITD-positive AML
In: Anticancer research : international journal of cancer research and treatment. - Attiki, Bd. 36.2016, 12, S. 6249-6258

Rinke, Kristine;  Jost, Felix;  Findeisen, Rolf;  Fischer, Thomas;  Bartsch, Rainer;  Schalk, Enrico;  Sager, Sebastian 

Parameter estimation for leukocyte dynamics after chemotherapy
In: IFAC-PapersOnLine - Frankfurt: Elsevier, Bd. 49.2016, 26, S. 44-49, 49 2016 26 44-49; http://dx.doi.org/10.1016/j.ifacol.2016.12.101 ; [Kongress: Foundations of Systems Biology in Engineering, FOSBE 2016, Magdeburg, Germany, 9-12 October, 2016]

Sasse, Stephanie;  Alram, Magdalena;  Müller, Horst;  Smardová, Lenka;  Metzner, Bernd;  Döhner, Hartmut;  Fischer, Thomas;  Niederwieser, Dietger W.;  Schmitz, Norbert;  Schäfer-Eckart, Kerstin;  Raemaekers, John M. M.;  Schmalz, Oliver;  Tresckow, Bastian von;  Engert, Andreas;  Borchmann, Peter 

Prognostic relevance of DHAP dose-density in relapsed Hodgkin lymphoma - an analysis of the German Hodgkin-Study Group
In: Leukemia and lymphoma. - London [u.a.] : Taylor & Francis Group, Bd. 57.2016, 5, S. 1067-1073

Schalk, Enrico;  Fischer, Thomas 

Biased low incidence of central venous catheter-related bloodstream infections in controlled clinical trials? - letter to the editor
In: Infection control and hospital epidemiology : the official journal of the Society for Healthcare Epidemiology of America. - Cambridge : Cambridge Univ. Press, Bd. 37.2016, 5, S. 617-619

Schalk, Enrico;  Fischer, Thomas 

Hemophagocytic lymphohistiocytosis as an unusual cause of prolonged bicytopenia after chemotherapy
In: Clinical Case Reports. - Chichester : Wiley, Bd. 4.2016, 10, S. 1017-1018

Zeremski, Vanja;  Koehler, Michael;  Fischer, Thomas;  Schalk, Enrico 

Characteristics and outcome of patients with primary CNS lymphoma in a real-life setting compared to a clinical trial
In: Annals of hematology : organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie. - Berlin : Springer, Bd. 95.2016, 5, S. 793-799

Buchbeitrag
Mantzke, Andreas;  Fischer, Thomas;  Leone, Marco 

Verminderung der magnetischen Nahfeldeinkopplung auf Leiterplattenebene durch reziproke Systemanalysen
In: EMV 2016 : Internationale Fachmesse und Kongress für Elektromagnetische Verträglichkeit : Düsseldorf, 23. - 25.02.2016. - Aachen : Apprimus Verlag, S. 669-676 ; [Kongress: EMV 2016, Internationale Fachmesse und Kongress für Elektromagnetische Verträglichkeit, Düsseldorf, 23. - 25.02.2016]

Nicht begutachteter Zeitschriftenartikel
Braun-Dullaeus, Rüdiger C. 

Das internistische Jahr 2015 - die wichtigsten Fortschritte und Entwicklungen
In: Ärzteblatt Sachsen-Anhalt : offizielles Mitteilungsblatt der Ärztekammer Sachsen-Anhalt. - Magdeburg : Ärztekammer Sachsen-Anhalt, Bd. 27.2016, 5, S. 19-22

2015

Abstrakt
Arreba-Tutusaus, Patricia;  Schnoeder, Tina;  Fischer, Thomas;  Heidel, Florian H. 

Requirement for phospholipase C gamma 1 (PLCG1) in development and maintenance of hematopoietic stem- and progenitor cells
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 100.2015, Suppl. 1, Abs. E1133, S. 452

Einsele, Hermann;  Vogel, Martin;  Müller, Jürgen;  Knop, Stefan;  Kropff, Martin;  Langer, Christian;  Sayer, Herbert;  Jung, Wolfram;  Wandt, Hannes;  Bassermann, Florian;  Gramatzki, Martin;  Rösler, Wolf;  Brugger, Wolfram;  Engelhardt, Monika Martha;  Fischer, Thomas;  Giagounidis, Aristoteles;  Heidemann, Else;  Kröger, Nicolaus;  Sezer, Orhan;  Bentz, Martin;  Pfreundschuh, Michael;  Salwender, Hans;  Ludwig, Wolf-Dieter;  Röllig, Christoph;  Staib, Peter;  Runde, Volker;  Scheid, Christof;  Ostermann, Helmut;  Heß, Georg;  Hebart, Holger;  Repp, Roland;  Hart, Christina;  Frickhofen, Norbert;  Straka, Christian;  Pflüger, Karl-Heinz 

Results from two phase 3 studies of post-transplant bortezomib (BTZ) consolidation vs observation (OBS) in patients with newly diagnosed multiple myeloma (NDMM)
In: Haematologica : journal of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 100.2015, Suppl. 1, Abs. S426, S. 151

Huang, Kezhi;  Yang, Min;  Pan, Zengkai;  Heidel, Florian H.;  Scherr, Michaela;  Eder, Matthias;  Fischer, Thomas;  Büsche, Guntram;  Neuhoff, Nils von;  Ganser, Arnold;  Li, Zhixiong 

The novel FLT3-N676K mutant induces acute leukemia independently of the Inv(16) chimeric gene CBFB-MYH11
In: Blood : journal of the American Society of Hematology. - Stanford, Calif : HighWire Press, Bd. 126.2015, 23, S. 1383

Koehler, Michael;  Hoppe, Susanne;  Peplinski, D.;  Richter, Diana;  Frommer, Jörg;  Flechtner, Hans-Henning;  Fischer, Thomas 

Psycho-oncologic interventions for parents of cancer patients - systematic review
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, V565, S. 172

Koehler, Michael;  Fischer, Thomas;  Kropf, Siegfried;  Frommer, Jörg 

The somatic burden score - a quantitative tool to evaluate the somatic burden due to chemotherapy-induced adverse events
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, V630, S. 192

Mohr, Juliane;  Frey, Stephanie;  Bullinger, Lars;  Schnoeder, Tina M.;  Weinert, Soenke;  Huber, Tobias B.;  Kaehne, Thilo;  Armstrong, Scott A.;  Fischer, Thomas;  Heidel, Florian H. 

Distinct and non-overlapping functions of LLGL1 and scribble in hematopoietic stem cells
In: Experimental hematology : official publication of the International Society for Experimental Hematology. - Kidlington [u.a] : Elsevier; Bd. 43.2015, 9 Suppl., Abs. 3065, S. S67

Schalk, Enrico;  Färber, Jacqueline;  Fischer, Thomas 

Delayed entry of blood cultures into blood culture incubators has no negative effect of on overall culture positivity
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, V628, S. 191-192

Straka, Christian;  Vogel, Martin;  Müller, Jürgen;  Kropff, Martin;  Metzner, Bernd;  Langer, Christian;  Sayer, Herbert;  Jung, Wolfram;  Dürk, Heinz Albert;  Wandt, Hannes;  Bassermann, Florian;  Gramatzki, Martin;  Rösler, Wolf;  Knop, Stefan;  Wolf, Hans-Heinrich;  Brugger, Wolfram;  Engelhardt, Monika Martha;  Fischer, Thomas;  Einsele, Hermann 

Results from two phase III studies of bortezomib (BTZ) consolidation vs observation (OBS) post-transplant in patients (pts) with newly diagnosed multiple myeloma (NDMM)
In: Journal of clinical oncology / Englische Ausgabe. - Alexandria, Va : American Society of Clinical Oncology; Bd. 33.2015, 15 Suppl., Abs. 8511, insges. 1 S.

Zeremski, Vanja;  Koehler, Michael;  Fischer, Thomas;  Schalk, Enrico 

A pro-active follow-up with higher completeness can significantly influence survival data
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, P508, S. 155

Zeremski, Vanja;  Fischer, Thomas;  Schalk, Enrico 

Clinical outcome of primary CNS lymphoma comparing the setting of real-life with a clinical trial - a single centre experience of 95 patients
In: Oncology research and treatment. - Basel : Karger; Bd. 38.2015, Suppl. 5, V707, S. 211-212

Begutachteter Zeitschriftenartikel
Heidel, Florian;  Arreba-Tutusaus, Patricia;  Armstrong, Scott A.;  Fischer, Thomas 

Evolutionarily conserved signaling pathways - Acting in the shadows of acute myelogenous leukemia's genetic diversity
In: Clinical cancer research. - Philadelphia, Pa. [u.a.] : AACR, Bd. 21.2014, 2, S. 240-248, 2015

Heinicke, Thomas;  Hütten, Heiko;  Kalinski, Thomas;  Franke, Ingolf;  Bonnekoh, Bernd;  Fischer, Thomas 

Sustained remission of blastic plasmacytoid dendritic cell neoplasm after unrelated allogeneic stem cell transplantation - a single center experience
In: Annals of hematology : organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie. - Berlin : Springer, Bd. 94.2015, 2, S. 283-287

Koehler, Michael;  Fischer, Thomas 

How health-related quality-of-life outcomes in patients with acute promyelocytic leukemia can help physicians in decision making. Correspondence
In: Journal of clinical oncology : JCO ; official journal of the American Society of Clinical Oncology. - Alexandria, Va : American Society of Clinical Oncology, Bd. 33.2015, 9, S. 1090-1091

Korfel, Agnieszka;  Thiel, Eckhard;  Martus, Peter;  Möhle, Robert;  Griesinger, Frank;  Rauch, Michael;  Röth, Alexander;  Hertenstein, Bernd;  Fischer, Thomas;  Hundsberger, Thomas;  Mergenthaler, Hans G.;  Junghanß, Christian;  Birnbaum, Tobias;  Fischer, Lars;  Jahnke, Kristoph;  Herrlinger, Ulrich;  Roth, Patrick;  Bamberg, Michael;  Pietsch, Torsten;  Weller, Michael 

Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma
In: Neurology : official journal of the American Academy of Neurology. - Hagerstown, Md : Lippincott Williams & Wilkins, Bd. 84.2015, 12, S. 1242-1248

Neumann, Jens;  Riek-Burchardt, Monika;  Herz, Josephine;  Doeppner, Thorsten R.;  König, Rebecca;  Hütten, Heiko;  Etemire, Eloho;  Männ, Linda;  Klingberg, Anika;  Fischer, Thomas;  Görtler, Michael W.;  Heinze, Hans-Jochen;  Reichardt, Peter;  Schraven, Burkhart;  Hermann, Dirk M.;  Reymann, Klaus G.;  Gunzer, Matthias 

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
In: Acta neuropathologica. - Berlin : Springer, Bd. 129.2015, 2, S. 259-277

Perner, Florian;  Schnöder, Tina M.;  Ranjan, Satish;  Wolleschak, Denise;  Ebert, Carolin;  Pils, Marina C.;  Frey, Stephanie;  Polanetzki, Anja;  Fahldieck, Corinna;  Schönborn, Uta;  Schraven, Burkhart;  Isermann, Berend;  Fischer, Thomas;  Heidel, Florian H. 

Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function
In: Leukemia : normal and malignant hemopoiesis ; a peer-reviewed journal. - Basingstoke : Nature Publ. Group, Bd. 30.2016, 4, S. 991-995

Schalk, Enrico;  Färber, Jacqueline;  Fischer, Thomas;  Heidel, Florian H. 

Central venous catheter-related bloodstream infections in obese hematologic patients. Letter to the editor
In: Infection control and hospital epidemiology : the official journal of the Society for Healthcare Epidemiology of America. - Cambridge : Cambridge Univ. Press, Bd. 36.2015, 8, S. 995-996

Schalk, Enrico;  Hanus, Lynn;  Färber, Jacqueline;  Fischer, Thomas;  Heidel, Florian H. 

Prediction of central venous catheterrelated bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS)
In: Annals of hematology : organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie. - Berlin : Springer, Bd. 94.2015, 9, S. 1451-1456

Schalk, Enrico;  Garlipp, Benjamin;  Bruns, Christiane J.;  Fischer, Thomas 

Weichteiltumoren - allgemein-klinische Aspekte ; chirurgische und medikamentöse Therapie
In: Der Onkologe : Organ der Deutschen Krebsgesellschaft e.V. - Berlin : Springer, Bd. 21.2015, 12, S. 1147-1161

Schnöder, Tina M.;  Arreba-Tutusaus, Patricia;  Griehl, Inga;  Bullinger, Lars;  Buschbeck, Marcus;  Lane, Steven W.;  Döhner, Konstanze;  Plass, Christoph;  Lipka, Daniel B.;  Heidel, Florian H.;  Fischer, Thomas 

Epo-induced erythroid maturation is dependent on Plc[gamma]1 signaling
In: Cell death and differentiation. - Houndmills, Basingstoke : Nature Publishing Group, Bd. 22.2015, 6, S. 974-985

Buchbeitrag
Mantzke, Andreas;  Leone, Marco;  Fischer, Thomas 

Efficient analysis and reduction of magnetic near-field-coupling in mixed-signal PCBs via the reciprocity principle
In: Proceedings of IEEE International Symposium on Electromagnetic Compatibility and EMC Europe. - Piscataway, NJ : IEEE, S. 91-95, 2015

Nicht begutachteter Zeitschriftenartikel
Fischer, Thomas;  Schalk, Enrico 

Eine Ärztin mit großem Einsatz und bei Patienten und MItarbeitern gleichermaßen beliebt - Im Gedenken an Prof. Dr. med. Astrid Franke
In: UMMD aktuell : Informationen für Patienten, Mitarbeiter und Studierende des Universitätsklinikums Magdeburg A.ö.R. und der Medizinischen Fakultät der Otto-von-Guericke-Universität Magdeburg. - Magdeburg : Klinikumsvorstand, 1, S. 15, 2015

2014

Abstrakt
Arreba-Tutusaus, Patricia;  Mack, Thomas;  Bullinger, Lars;  Polanetzki, Anja;  Schnöder, Tina M.;  Doehner, Konstanze;  Fischer, Thomas;  Heidel, Florian H. 

Distinct biological and transcriptional features of FLT3-ITD variants in vitro and in vivo
In: Oncology research and treatment. - Basel : Karger; Bd. 37.2014, Suppl. 5, V641, S. 206

Gehring, Sonja;  Färber, Jacqueline;  Fischer, Thomas;  Schalk, Enrico 

Epidemiological analysis of multidrug-resistant Gramnegative bacteria (MRGN) among haemato-oncological patients
In: Oncology research and treatment. - Basel : Karger; Bd. 37.2014, Suppl. 5, P874, S. 292

Korfel, Agnieszka;  Thiel, Eckhard;  Martus, Peter;  Möhle, Robert;  Griesinger, Frank;  Rauch, Michael;  Röth, Alexander;  Hertenstein, Bernd;  Fischer, Thomas;  Hundsberger, Thomas;  Mergenthaler, Hans-Günther;  Junghanß, Christian;  Birnbaum, Tobias;  Fischer, Lars;  Jahnke, Kristoph;  Herrlinger, Ulrich;  Roth, Patrick;  Bamberg, Michael;  Pietsch, Torsten;  Weller, Michael 

G-PCNSL-SG-1 randomised phase III trial of high-dose methotrexate with or without whole-brain radiotherapy for primary central nervous system lymphoma (PCNSL) - long-term follow-up
In: Oncology research and treatment. - Basel : Karger; Bd. 37.2014, Suppl. 5, V122, S. 33

Mashamba, Nomusa;  Wolleschak, Denise;  Thangapandi, Veera R.;  Frey, Stephanie;  Schnöder, Tina M.;  Fischer, Thomas;  Heidel, Florian 

Impact of cold shock protein Ybx1 on hematopoietic stem cell development and function
In: Haematologica, the hematology journal : official organ of the European Hematology Association. - Pavia : Ferrata-Storti Foundation; Bd. 99.2014, Suppl.1, S. 175-176

Müller, Christian;  Schröder, Nicolas;  Becker, Elke;  Tanev, Ivan;  Smid, Jan;  Heidel, Florian;  Schalk, Enrico;  Wolleschak, Denise;  Hanus, Lynn;  Fischer, Thomas 

Rapid induction of cytological remission by bendamustine in a rare case of T-PLL with leukostasis symptoms
In: Oncology research and treatment. - Basel : Karger; Bd. 37.2014, Suppl. 5, P787, S. 258

Perner, Florian;  Mack, Thomas S.;  Schnöder, Tina;  Heidel, Florian H.;  Fischer, Thomas 

Overexpression of the Cell Division Cycle 25C phosphatase in a two-hit-model of acute myeloid leukemia (AML) suppresses apoptosis upon cytotoxic treatment
In: Oncology research and treatment. - Basel : Karger; Bd. 37.2014, Suppl. 5, P417, S. 125

Rinke, Kristine;  Bartsch, Rainer;  Fischer, Thomas;  Schalk, Enrico;  Sager, Sebastian 

Mathematical modelling of neutropenia of AML patients treated with chemotherapy
In: Oncology research and treatment. - Basel : Karger; Bd. 37.2014, Suppl. 5, P501, S. 159

Schalk, Enrico;  Hanus, Lynn;  Färber, Jacqueline;  Fischer, Thomas;  Heidel, Florian H. 

Prediction of central venous catheter- (CVC-) related bloodstream infections (CRBSIs) in cancer patients (pts) using the Infection Probability Score (IPS): first results from the SECRECY registry
In: Oncology research and treatment. - Basel : Karger; Bd. 37.2014, Suppl. 5, V301, S. 94

Schnöder, Tina M.;  Pandey, Akhilesh Datt;  Nimmagadda, Subbaiah Chery;  Wang, Xu;  Maubach, Gunter;  Wolleschak, Denise;  Naumann, Michael;  Schlüter, Dirk;  Lane, Steven W.;  Mullally, Ann;  Heidel, Florian H.;  Fischer, Thomas 

JAK2V617F mutation is sufficient for autocrine induction of IP-10 in hematopoietic cells
In: Oncology research and treatment. - Basel : Karger; Bd. 37.2014, Suppl. 5, V618, S. 199

Begutachteter Zeitschriftenartikel
Benderska, Natalya;  Ivanovska, Jelena;  Rau, Tilman T.;  Schulze-Luehrmann, Jan;  Mohan, Suma;  Chakilam, Saritha;  Gandesiri, Muktheshwar;  Ziesché, Elisabeth;  Fischer, Thomas;  Söder, Stephan;  Agaimy, Abbas;  Distel, Luitpold;  Sticht, Heinrich;  Mahadevan, Vijayalakshmi;  Schneider-Stock, Regine 

DAPK-HSF1 interaction as a positive-feedback mechanism stimulating TNF-induced apoptosis in colorectal cancer cells
In: Journal of cell science : Company of Biologists. - Cambridge : Company of Biologists Limited, Bd. 127.2014, 24, S. 5273-5287

Koehler, Michael;  Fischer, Thomas;  Kropf, Siegfried;  Frommer, Jörg 

Quantitative tool to evaluate the somatic burden due to chemotherapy-induced adverse events - the somatic burden score
In: Supportive care in cancer. - Berlin : Springer, Bd. 22.2014, 11, S. 3089-3099

Krüger, William H.;  Hirt, Carsten;  Basara, Nadezda;  Sayer, Herbert G.;  Behre, Gerhard;  Fischer, Thomas;  Grobe, Norbert;  Maschmeyer, Georg;  Niederwieser, Dietger;  Dölken, Gottfried 

Allogeneic stem cell transplantation for mantle cell lymphoma - final report from the prospective trials of the East German Study Group Haematology/Oncology (OSHO)
In: Annals of hematology. - Berlin : Springer, Bd. 93.2014, 9, S. 1587-1597

Schalk, Enrico;  Färber, Jacqueline;  Fischer, Thomas 

Multidrug-resistant gram-negative bacteria in hematology and oncology
In: Infection control and hospital epidemiology. - New York, NY : JSTOR, Bd. 35.2014, 9, S. 1203-1204

Schalk, Enrico;  Geginat, Gernot;  Schulz, Christian;  Schlüter, Dirk;  Fischer, Thomas 

The incidence of norovirus infections in cancer patients shows less seasonal variability compared to patients with other diseases. Letter to the editor
In: Annals of hematology. - Berlin : Springer, Bd. 93.2014, 5, S. 889-890

Wolleschak, Denise;  Mack, Thomas S.;  Perner, Florian;  Frey, Stephanie;  Schnoeder, Tina M.;  Wagner, Marie-Christine;  Höding, Christine;  Pils, Marina C.;  Parkner, Andreas;  Kliche, Stefanie;  Schraven, Burkhart;  Hebel, Katrin;  Brunner-Weinzierl, Monika;  Ranjan, Satish;  Isermann, Berend;  Lipka, Daniel B.;  Fischer, Thomas;  Heidel, Florian H. 

Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function
In: Haematologica, the hematology journal : official organ of the European Hematology Association. - Pavia : Ferrata Storti Foundation; Bd. 99.2014, 6, S. e90-e93

2013

Abstrakt
Hanus, Lynn;  Schalk, Enrico;  Schulz, Christian;  Bartsch, Peter;  Tanev, Ivan;  Malfertheiner, Peter;  Mertens, Peter;  Braun-Dullaeus, Rüdiger;  Fischer, Thomas 

A case of acute myeloid leucaemia after EHEC infection
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, P565, S. 166

Heinicke, Thomas;  Hütten, Heiko;  Fischer, Thomas 

Allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm
In: Bone marrow transplantation. - London : Nature Publishing Group; Bd. 48.2013, Suppl.2s, R1531, S. S541

Koehler, Michael;  Fischer, Thomas 

Health-related quality of life and distress in patients with systemic malignancies stratified by age: AYA patients have the worst mental health
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, V399, S. 108-109

Koehler, Michael;  Hoppe, Susanne;  Bartsch, Rainer;  Frommer, Jörg;  Flechtner, Hans-Henning;  Jentsch-Ullrich, Kathleen;  Heidel, Florian;  Fischer, Thomas 

The Magdeburg model of care for adolescents and young adults with cancer (MC AYA): A pilot approach
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, P552, S. 162

Krogel, Christian;  Schalk, Enrico;  Wolleschak, Denise;  Fischer, Thomas;  Heidel, Florian 

Successful treatment of recurrent Desmoid fibromatosis in an adult using low dose chemotherapy with methotrexate and vinblastine
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, P819, S. 249

Schalk, Enrico;  Geginat, Gernot;  Schulz, Christian;  Schlüter, Dirk;  Fischer, Thomas 

Epidemiological data on norovirus infections in cancer patients, 2009-2012
In: Onkologie. - Basel : Karger; Bd. 36.2013, Suppl. 7, P271, S. 82

Begutachteter Zeitschriftenartikel
Caldarelli, Antonio;  Müller, Jörg P.;  Paskowski-Rogacz, Maciej;  Herrmann, Katja;  Bauer, Reinhard;  Koch, S.;  Heninger, Anne-Kristin;  Krastev, Dragomir;  Ding, Li;  Kasper, Stefan;  Fischer, Thomas;  Brodhun, Michael;  Böhmer, Frank-D.;  Buchholz, Frank 

A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 27.2013, insges. 10 S.

DeAngelo, Daniel J.;  Spencer, Andrew;  Bhalla, Kapil N.;  Prince, H. Miles;  Fischer, Thomas;  Kindler, Thomas;  Giles, Francis J.;  Scott, Jeffrey W.;  Parker, Katie;  Liu, Angela;  Woo, Margaret;  Atadja, Peter;  Mishra, K. K.;  Ottmann, Oliver G. 

Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 27.2013, 8, S. 1628-1636

Heidel, Florian H.;  Bullinger, Lars;  Arreba-Tutusaus, Patricia;  Wang, Zhu;  Gaebel, Julia;  Hirt, Carsten;  Niederwieser, Dietger;  Lane, Steven W.;  Döhner, Konstanze;  Vasioukhin, Valera;  Fischer, Thomas;  Armstrong, Scott A. 

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML
In: The journal of experimental medicine. - New York, NY : Rockefeller Univ. PressThe journal of experimental medicine <New York, NY>, Bd. 210.2013, 1, S. 15-22

Ivanovska, Jelena;  Tregubova, Alexandra;  Mahadevan, Vijayalakshmi;  Chakilam, Saritha;  Gandesiri, Muktheshwar;  Benderska, Natalya;  Ettle, Benjamin;  Hartmann, Arndt;  Söder, Stephan;  Ziesché, Elisabeth;  Fischer, Thomas;  Lautscham, Lena;  Fabry, Ben;  Segerer, Gabriela;  Gohla, Antje;  Schneider-Stock, Regine 

Identification of DAPK as a scaffold protein for the LIMK/cofilin complex in TNF-induced apoptosis
In: International journal of biochemistry & cell biology. - Amsterdam : Elsevier, Bd. 45.2013, 8, S. 1720-1729

Koehler, Michael;  Fischer, Thomas;  Frommer, Jörg 

Caught by an acute leukaemia: Facing patients' own experiences
In: Leukemia research. - Amsterdam : Elsevier, Bd. 37.2013, 5, S. 481-482

Roeyen, Claudia R. C. van;  Scurt, Florian G.;  Brandt, Sabine;  Kuhl, Vanessa A.;  Martinkus, Sandra;  Djudjaj, Sonja;  Raffetseder, Ute;  Royer, Hans-Dieter;  Stefanidis, Ioannis;  Dunn, Sandra E.;  Dooley, Steven;  Weng, Honglei;  Fischer, Thomas;  Lindquist, Jonathan A.;  Mertens, Peter R. 

Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities
In: Cell communication and signaling. - London : Biomed Central; Bd. 11.2013, 1, Art.-Nr. 63, insges. 16 S.

Wagner, Marie-Christine;  Dziadosz, Marek;  Melo, Junia V.;  Heidel, Florian;  Fischer, Thomas;  Lipka, Daniel B. 

Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cells. Letter to the editor
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 27.2013, 7, S. 1567-1570

Wolleschak, Denise;  Schalk, Enrico;  Krogel, Christian;  Schnoeder, Tina M.;  Luehr, Helga;  Jentsch-Ullrich, Kathleen;  Fischer, Thomas;  Heidel, Florian H. 

Rapid induction of complete molecular remission by sequential therapy with LDAC and sorafenib in FLT3-ITD-positive patients unfit for intensive treatment: two cases and review of the literature
In: Journal of hematology & oncology. - London : Biomed Central, Bd. 6.2013, insges. 6 S.

Nicht begutachteter Zeitschriftenartikel
Schalk, Enrico;  Wolleschak, Denise;  Fischer, Thomas 

Maligne Lymphome - Diagnostik und Therapie
In: Tumorzentrum aktuell // Tumorzentrum Magdeburg/Sachsen-Anhalt. - Magdeburg : Tumorzentrum, Bd. 10.2013, 1, S. 24-28

2012

Artikel in Zeitschrift
Arora, Deepika;  Köthe, Susanne;  Eijnden, Monique van den;  Huijsduijnen, Rob Hooft van;  Heidel, Florian;  Fischer, Thomas;  Scholl, Sebastian;  Tölle, Benjamin;  Böhmer, Sylvia-Annette;  Lennartsson, Johan;  Isken, Fabienne;  Müller-Tidow, Carsten;  Böhmer, Frank-D. 

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression
In: Cell communication and signaling. - London : Biomed Central; Bd. 10.2012, Artikel-Nr. 19, insges. 15 S.

Begutachteter Zeitschriftenartikel
Köhler, Michael;  Frommer, Jörg;  Flechtner, Hans-Henning;  Kropf, Siegfried;  Fischer, Thomas 

Strukturierte psychoonkologische Kurzintervention für Eltern Adoleszenter und junger Erwachsener (AYA) mit malignen hämatologischen Erkrankungen: eine randomisierte klinische Studie
In: Tumorzentrum aktuell // Tumorzentrum Magdeburg/Sachsen-Anhalt. - Magdeburg : Tumorzentrum, Bd. 9.2012, 1, S. 30-35

Wolleschak, Denise;  Fischer, Thomas;  Heidel, Florian 

Aktuelle und neue Therapieoptionen bei myeloproliferativen Erkrankungen
In: Tumorzentrum aktuell // Tumorzentrum Magdeburg/Sachsen-Anhalt. - Magdeburg : Tumorzentrum, Bd. 9.2012, 1, S. 21-29

Originalartikel in begutachteter internationaler Zeitschrift
Dziadosz, Marek;  Wagner, Marie-Christine;  Lipka, Daniel B.;  Fischer, Thomas;  Bartels, Heidemarie 

High-performance liquid chromatography with ultraviolet detection and protein precipitation as a way of quantitative determination of nilotinib with and without internal standard
In: Journal of liquid chromatography & related technologies. - Philadelphia, Pa. : Taylor & Francis, Bd. 35.2012, 17, S. 2503-2510

Heidel, Florian H.;  Mack, Thomas S.;  Razumovskaya, Elena;  Blum, Marie-Christine;  Lipka, Daniel B.;  Ballaschk, Anne;  Kramb, Jan-Peter;  Plutizki, Stanislav;  Rönnstrand, Lars;  Dannhardt, Gerd;  Fischer, Thomas 

3,4-Diarylmaleimides - a novel class of kinase inhibitors - effectively induce apoptosis in FLT3-ITD-dependent cells
In: Annals of hematology. - Berlin : Springer, Bd. 91.2012, 3, S. 331-344

Kasper, Stefan;  Breitenbuecher, Frank;  Heidel, Florian;  Hoffarth, Sandra;  Markova, Boyka;  Schuler, Martin;  Fischer, Thomas 

Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies
In: Blood cancer journal. - London [u.a.] : Nature Publishing Group, Bd. 2.2012, 3, insges. 10 S.

Lipka, Daniel B.;  Wagner, Marie-Christine;  Dziadosz, Marek;  Schnöder, Tina;  Heidel, Florian;  Schemionek, Mirle;  Melo, Junia V.;  Kindler, Thomas;  Müller-Tidow, Carsten;  Koschmieder, Steffen;  Fischer, Thomas 

Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells
In: PLoS one. - Lawrence, Kan : PLoS, Bd. 7.2012, 7, insges. 16 S.

Stone, Richard M.;  Fischer, Thomas;  Paquette, Ronald;  Schiller, Gary;  Schiffer, Charles A.;  Ehninger, Gerhard;  Cortes, Jorge;  Kantarjian, Hagop M.;  DeAngelo, Daniel J.;  Huntsman-Labed, Alice;  Dutreix, Catherine;  DelCorral, A.;  Giles, Francis 

Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia
In: Leukemia. - Basingstoke : Nature Publ. Group, Bd. 26.2012, 9, S. 2061-2068

Zirm, Elisabeth;  Spies-Weisshart, Bärbel;  Heidel, Florian;  Schnetzke, Ulf;  Böhmer, Frank-Dietmar;  Hochhaus, Andreas;  Fischer, Thomas;  Scholl, Sebastian 

Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation
In: British journal of haematology. - Oxford [u.a.] : Wiley-Blackwell, Bd. 157.2012, 4, S. 483-492

2011

Originalartikel in begutachteter internationaler Zeitschrift
Fischer, Thomas 

Rethinking bioactivity of FLT3 inhibitors
In: Blood. - Washington, DC : American Society of Hematology, Bd. 117.2011, 12, S. 3247-3248

Köhler, Michael;  Köhler, Katharina;  Koenigsmann, Michael;  Kreutzmann, Nicole;  Fischer, Thomas;  Frommer, Jörg 

Beyond diagnosis: subjective theories of illness in adult patients with acute myeloid leukemia
In: Hematology. - London [u.a.] : Maney, Bd. 16.2011, 1, S. 5-13

2010

Originalartikel in begutachteter internationaler Zeitschrift
Fischer, Thomas;  Stone, Richard M.;  DeAngelo, Daniel J.;  Galinsky, Ilene;  Estey, Elihu;  Lanza, Carlo;  Fox, Edward;  Ehninger, Gerhard;  Feldman, Eric J.;  Schiller, Gary J.;  Klimek, Virginia M.;  Nimer, Stephen D.;  Gilliland, D. Gary;  Dutreix, Catherine;  Huntsman-Labed, Alice;  Virkus, Jodi;  Giles, Francis J. 

Phase IIB trial of oral midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3
In: Journal of clinical oncology . - Alexandria, Va. : American Society of Clinical Oncology, Bd. 28.2010, 28, S. 4339-4345

Giles, Francis J.;  Abruzzese, Elisabetta;  Rosti, Gianantonio;  Kim, Dong-Wook;  Bhatia, Ravi;  Bosly, André;  Goldberg, Stuart;  Kam, Grace L. S.;  Jagasia, Madan;  Mendrek, Wlodzimierz;  Fischer, Thomas;  Facon, Thierry;  Dünzinger, Ulrich;  Marin, David;  Müller, Martin C.;  Shou, Yaping;  Gallagher, Neil J.;  Larson, Richard A.;  Mahon, François-Xavier;  Baccarani, Michele;  Cortes, Jorge;  Kantarjian, Hagop M. 

Nilotinib is active in chronic and accelerated phase chronic myeloid leukemia following failure of imatinib and dasatinib therapy
In: Leukemia . - Basingstoke : Nature Publ. Group, Bd. 24.2010, 7, S. 1299-1301

Josting, Andreas;  Müller, Horst;  Borchmann, Peter;  Baars, Joke W.;  Metzner, Bernd;  Döhner, Hartmut;  Aurer, Igor;  Smardova, Lenka;  Fischer, Thomas;  Niederwieser, Dietger;  Schäfer-Eckart, Kerstin;  Schmitz, Norbert;  Sureda, Anna;  Glossmann, Jan;  Diehl, Volker;  DeJong, Daphne;  Hansmann, Martin-Leo;  Raemaekers, John;  Engert, Andreas 

Dose intensity of chemotherapy in patients with relapsed Hodgkin's lymphoma
In: Journal of clinical oncology . - Alexandria, Va. : American Society of Clinical Oncology, Bd. 28.2010, 34, S. 5074-5080

Kindler, Thomas;  Lipka, Daniel;  Fischer, Thomas 

FLT3 as a therapeutic target in AML: still challenging after all these years
In: Blood . - Washington, DC : American Society of Hematology, Bd. 116.2010, 24, S. 5089-5102

Krogel, Christian;  Fischer, Thomas;  Heidel, Florian 

Severe paraneoplastic pemphigus in a patient with follicular lymphoma
In: European journal of haematology . - Oxford : Wiley-Blackwell, Bd. 84.2010, 4, S. 365, insges. 1 S.

Markova, Boyka;  Albers, Corinna;  Breitenbücher, Frank;  Melo, Junia V.;  Brümmendorf, Tim H.;  Heidel, Florian;  Lipka, Daniel;  Duyster, Justus;  Huber, Christoph;  Fischer, Thomas 

Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-[gamma]1-driven activation of mTOR/p70S6-kinase pathway
In: Oncogene . - Basingstoke : Nature Publ. Group, Bd. 29.2010, 5, S. 739-751

Originalartikel in begutachteter nationaler Zeitschrift
Rüsseler, Anna Vanessa;  Brors, Benedikt;  Fischer, Thomas;  Hartmann, Jörg T.;  Hartmann, Wolfgang;  Hohenberger, Peter;  Lichter, Peter;  Marx, Alexander;  Mechtersheimer, Gunhild;  Penzel, Roland;  Renner, Marcus;  Schildhaus, Hans-Ulrich;  Schirmacher, Peter;  Sievers, Elisabeth;  Ströbel, Philipp;  Wardelmann, Eva;  Ziesché, Elisabeth;  Büttner, Reinhard 

Molekularpathologie von Sarkomen: Erste Ergebnisse des Sarkomforschungsverbundes KoSar
In: Der Pathologe : Organ der Deutschen Abteilung der Internationalen Akademie für Pathologie, der Deutschen, der Österreichischen und der Schweizerischen Gesellschaft für Pathologie und des Berufsverbandes Deutscher Pathologen. - Heidelberg : Springer-Medizin-Verl; Bd. 31.2010, Suppl.2, S. 211-214

2009

Nicht begutachteter Zeitschriftenartikel
Köhler, Michael;  Bölter, Annette;  Lange, Julia;  Dogan, Elif;  Heine, Viktoria;  Fischer, Thomas;  Frommer, Jörg 

Krebspatienten brauchen ein individuelles psychologisches Angebot - 2. Magdeburger Psychoonkologisches Kolloquium
In: Ärzteblatt Sachsen-Anhalt . - Magdeburg : Ärztekammer Sachsen-Anhalt, Bd. 20.2009, 4, S. 50-54

Originalartikel in begutachteter internationaler Zeitschrift
Breitenbuecher, F;  Markova, B;  Kasper, S;  Carius, B;  Stauder, T;  Kindler, T;  Böhmer, F;  Huber, C;  Fischer, Thomas 

A Novel Molecular Mechanism of Primary Resistance to FLT3-Kinase Inhibitors in Acute Myeloid Leukaemia.
In: Blood 2009 Apr 23;113(17):4063-73. Epub 2009 Jan 14.

Breitenbuecher, F;  Schnittger, S;  Grundler, R;  Markova, B;  Carius, B;  Brecht, A;  Duyster, J;  Haferlach, T;  Huber, C;  Fischer, Thomas 

Identification of a Novel Type of ITD Mutations Located in Non-Juxtamembrane Domains of the FLT3 Tyrosine Kinase Receptor.
In: Blood 2009 Apr 23;113(17):4074-7. Epub 2008 May 15.

Dickinson, Michael;  Ritchie, David;  DeAngelo, Daniel J.;  Spencer, Andrew;  Ottmann, Oliver G.;  Fischer, Thomas;  Bhalla, Kapil N.;  Liu, Angela;  Parker, Katie;  Scott, Jeffrey W.;  Bishton, Mark;  Prince, H. Miles 

Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin lymphoma
In: British journal of haematology . - Oxford [u.a.] : Wiley-Blackwell, Bd. 147.2009, 1, S. 97-101

Heidel, Florian;  Lipka, Daniel;  Mirea, Fian K.;  Mahboobi, Siavosh;  Grundler, Rebekka;  Kancha, Rama K.;  Duyster, Justus;  Naumann, Michael;  Huber, Christoph;  Böhmer, Frank D.;  Fischer, Thomas 

Bis(1H-indol-2-yl)methanones are effective inhibitors of FLT3-ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro
In: British journal of haematology . - Oxford [u.a.] : Wiley-Blackwell, Bd. 144.2009, 6, S. 865-874

Kayser, Sabine;  Schlenk, Richard F.;  Londono, Martina Correa;  Breitenbücher, Frank;  Wittke, Kerstin;  Du, Juan;  Groner, Silja;  Späth, Daniela;  Krauter, Jürgen;  Ganser, Arnold;  Döhner, Hartmut;  Fischer, Thomas;  Döhner, Konstanze 

Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
In: Blood . - Washington, DC : American Society of Hematology, Bd. 114.2009, 12, S. 2386-2392

2008

Originalartikel in begutachteter internationaler Zeitschrift
Hochhaus A;  Druker B;  Sawyers C;  Guilhot F;  Schiffer C A;  Cortes J;  Niederwieser D W;  Gambacorti C;  Stone R M;  Goldman J;  Fischer, T;  O'Brien S G;  Reiffers, J J;  Mone M;  Krahnke T;  Talpaz M;  Kantarjian H M 

Favorable long-term follow-up results over six years for response, survival and safety with imatinib mesylate therapy in chronic phase chronic myeloid leukemia post failure of interferon-alpha treatment.
In: Blood 111(3):1039-43, 2008

Kasper, S;  Breitenbuecher, F;  Kindler, T;  Heidel, Florian;  Lipka, Daniel;  Elliot, J;  Huber, C;  Fischer, Thomas 

The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukaemia.
In: Leuk Res. 2008 Nov;32(11):1698-708. Epub 2008 Jun 16.

Lipka, Daniel;  Heidel, Florian;  Huber, C;  Fischer, Thomas 

Entwicklung von Tyrosinkinase-Inhibitoren bei hämatologischen Neoplasien. FLT3 und JAK2 als therapeutische Targets.
In: Pharm Unserer Zeit. 2008;37(5):394-403.

Lipka, Daniel;  Hoffmann, L S;  Heidel, Florian;  Markova, B;  Blum, M -C;  Breitenbuecher, F;  Kasper, S;  Kindler, T;  Levine, R L;  Huber, C;  Fischer, Thomas 

LS104, a non ATP-competitive small molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2-V617F positive cells.
In: Mol Cancer Ther 7(5): 1176-1184, 2008.

2007

Originalartikel in begutachteter internationaler Zeitschrift
Deininger, M;  Cortes, J;  Paquette, R;  Park ,B;  Niederwieser, D;  Stone, R;  Hochhaus, A;  Reiffers, J;  Fischer, Thomas;  Kantarjian, H;  Baccarani, M;  Gambacorti-Passerini, C;  So, C;  Krahnke, T;  Gathmann, I;  Druker, D;  Smith Brian;  Guilhot, F 

The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells.
In: Cancer 110:1509-19, 2007.

Drescher, D;  Moehler, M;  Gockel, I;  Frerichs, K;  Müller, A;  Biesterfeld ,S;  Holtmann, M;  Mudter, J;  Wehler, T;  Fischer, T;  Junginger, T;  Galle, P R;  Schimanski, C C 

Co-expression of tyrosine kinase receptors in gastric adenocarcinoma ¿ a rationale for a new molecular targeting strategy?
In: World J Gastroenterol 13(26):3605-9, 2007.

Frühauf, S;  Topaly, J;  Buss, E;  Fischer, T;  Ottmann, O;  Emmerich, B;  Müller, M;  Schuld, P;  Balleisen, L;  Hehlmann, R;  Ho, A;  Hochaus ,A 

Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukaemia in myeloid blast crisis.
In: Cancer 109:1543-9, 2007.

Graf, C;  Heidel, F;  Tenzer, S;  Radsak, M;  Solem, F;  Britten, C;  Huber, C;  Fischer, Thomas;  Wölfel, T 

A neoepitope generated by a FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T-cells.
In: Blood 109(7):2985-2988, 2007.

Hehlmann, R;  Berger, U;  Pfirrmann, M;  Heimpel, H;  Hochhaus, A;  Hasford, J;  Kolb, HJ;  Lahaye, T;  Maywald, O;  Reiter, A;  Hossfeld, DK;  Huber, C;  Löffler, H;  Pralle, H;  Queisser, W;  Tobler, A;  Nerl, C;  Solenthaler, M;  Goebeler, ME;  Griesshammer, M;  Fischer, Thomas;  Kremers, S;  Eimermacher, H;  Pfreundschuh, M;  Hirschmann, WD;  Lechner, K;  Wassmann, B;  Falge, C;  Kirchner, HH;  Gratwohl ,A. 

Drug treatment is superior to allografting as first line therapy in chronic myeloid leukemia.
In: Blood 109:4686-92, 2007

Heidel, F;  Cortes, J;  Rücker, F G;  Aulitzky, W;  Letvak, L;  Kindler, T;  Huber, C;  Döhner, H;  Kantarjian, H;  Fischer, T 

Results of a multicenter phase II trial for older patients with c-kit positive acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) using low-dose Ara-C (LDAC) and Imatinib (IM).
In: Cancer 109(5):907-14, 2007.

Kasper, S;  Kindler, T;  Breitenbücher, F;  Sonnenschein, S;  Böhmer, Frank D;  Huber,C;  Fischer, Thomas 

Cross-inhibition of IFN-induced signal transduction by GM-CSF through a block in STAT1- activation.
In: J Interferon Cytokine Res 27(11):947-59, 2007.

2006

Originalartikel in begutachteter internationaler Zeitschrift
Druker, B J;  Guilhot, F;  O'Brien, S G;  Gathmann, I;  Kantarjian, H;  Gattermann, N;  Deininger, M W N;  Silver, R T;  Goldman, J M;  Stone ,R M;  Cervantes, F;  Hochhaus, A;  Powell, B L;  Gabrilove, J L;  Rousselot, P;  Reiffers ,J;  Cornelissen, J J;  Hughes, T;  Agis, H;  Fischer, Thomas;  Verhoef, G;  Shepherd, J;  Saglio, G;  Gratwohl, A;  Nielsen, JL;  Radich, JP;  Simonsson, B;  Taylor, K;  Baccarani, M;  So C;  Letvak, L;  Larson, RA;  IRIS Investigators 

Five-Year Follow-up of Imatinib Therapy for Newly Diagnosed Chronic Myeloid Leukemia in Chronic-Phase Shows Sustained Responses and High Overall Survival.
In: New England Journal of Medicine 355:2408-17, 2006

Giles, F;  Fischer, T;  Cortes, J;  Garcia-Manero, G;  Beck, J;  Ravandi, F;  Masson, E;  Rae, P;  Laird, G;  Sharma, S;  Kantarjian, H;  Dugan, M;  Albitar, M;  Bhalla, K 

A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
In: Clinical Cancer Research 1;12(15):4628-35, 2006.

Heidel, F;  Solem, F K;  Breitenbuecher, F;  Lipka, D B;  Kasper, S;  Thiede, H M;  Serve, C Brandts, H;  Roesel, J;  Giles, F;  Feldman, E;  Ehninger, G;  Schille, G J;  Nimer, S;  Stone ,R M;  Kindler, T;  Cohen, P S;  Huber, C;  Fischer, Thomas 

Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia (AML) by mutation of Asn-676 in the FLT3 tyrosine kinase domain.
In: Blood 107(1):293-300, 2006.

Mahboobi, S;  Uecker, A;  Sellmer, A;  Cénac, C;  Höcher, H;  Pongratz, H;  Eichhorn, E;  Hufsky, H;  Trümpler, A;  Sicker, M;  Heidel Florian;  Fischer, Thomas;  Stocking, C;  Elz, S;  Böhmer, FD;  Dove, S 

Novel Bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinases.
In: Journal of Medicinal Chemistry 49: 3101-3115, 2006.

Schuchmann, M;  Schulze-Bergkamen, H;  Fleischer, B;  Schattenberg, J;  Siebler, J;  Weinmann, A;  Teufel, A;  Wörns, M;  Fischer, T;  Strand, S;  Lohse, A W;  Galle, P R 

Histone deacetylase inhibition by valproic acid downregulates c-FLIP and sensitizes hepatoma cells towards CD95- and TRAIL-receptor mediated apoptosis and chemotherapy.
In: Oncology Reports 15: 227-230, 2006.

Kooperationen
Profil
  • Hämatologie/Onkologie
  • Innere Medizin
  • Onkogene Signaltransduktion
Service
Beratung, Diagnostik und Therapie:
  • bei gutartigen und bösartigen hämatologischen Erkrankungen;
  • bei Leukämien, myelodysplastischem Syndrom, myeloproliferativen Neoplasien, Lymphomen, Multiplem Myelom (Plasmozytom);
  • bei Tumorerkrankungen;
  • bei Weichteilsarkomen;
  • bei sogenanntem ¿CUP¿-Syndrom.
  Beratung zur hämatopoetischen Stammzelltransplantation
Vita
STUDIUM
1980 - 1981 Rumänisch Studium an der Universität Craiova, Rumänien
1981 - 1982 Medizinstudium an der Universität Cluj, Rumänien
1982 - 1983 Medizinstudium an der Georg-August-Universität Göttingen
1983 - 1984 Medizinstudium an der Medizinischen Hochschule Hannover
1985 Stipendiat der Soltenborn-Stiftung
1984 - 1987 Medizinstudium an der Georg-August-Universität Göttingen
1987 - 1988 Praktisches Jahr: Tufts University, Boston, USA (Stipendiat des "Biomedical Sciences Exchange Program between The United States and West Germany"); Krh. Seesen; Krh. Bad Harzburg
AKADEMISCHE GRADE
1988 Promotion zum Dr. med. an der Georg-August-Universität Göttingen,   Bewertung: Magna cum laude
2000 Habilitation und venia legendi für das Fach "Innere Medizin" am Fachbereich Medizin der Johannes Gutenberg-Universität Mainz (Molekulare Untersuchungen zur Signaltransduktion IFN-induzierter Gene in leukämischen und normalen hämatopoetischen Zellen)
BERUFLICHER WERDEGANG
10/1988 - 3/1990 DFG-Postdoktorandenstipendium in der klinischen Arbeitsgruppe der Max-Planck-Gesellschaft an der Medizinischen Universitätsklinik Göttingen (Leiter: Prof. Dr. K. Pfizenmaier)
4/1990 - 9/1990 "Postdoctoral Research Fellowship¿ am "Hospital for Sick Children¿, Toronto, Kanada (Prof. Dr. B. Williams)
10/1990 - 11/1996 Assistent an der III. Medizinischen Klinik der Johannes-Gutenberg-Universität Mainz (Direktor: Prof. Dr. C. Huber)
1/1995 - 12/1995 "Clinical Fellowship¿ in Hämatologie/Onkologie am "Department for Hematology and Medical Oncology¿, Cleveland Clinic Foundation, Cleveland, USA
5/1996 Facharzt-Anerkennung ¿Arzt für Innere Medizin¿
12/1996 - 6/2008 Oberarzt und Arbeitsgruppenleiter an der Medizinischen Klinik der Johannes Gutenberg-Universität Mainz. Aufbau und Leitung des wissenschaftlichen Labors für Onkogene Signaltransduktion.
1/1998 Anerkennung ¿Hämatologie und Internistische Onkologie¿
3/2001- 4/2004 Medical Director und Vertreter von Prof. Dr. med. Christoph Huber an der III. Medizinischen Klinik und Poliklinik der Johannes Gutenberg-Universität Mainz. Strategisches, operatives, wirtschaftliches, personalführendes und administratives "Management" der III. Medizinischen Klinik und Poliklinik.
3/2005 Berufung auf eine Professur (W2) für "Leukämie- und Tumorforschung" im Fachbereich Medizin der Johannes Gutenberg-Universität Mainz an der III. Medizinischen Klinik und Poliklinik (Stiftungsprofessur).
Seit 5/2009  Univ.-Professor (W3) und Direktor der Klinik für Hämatologie und Onkologie an der Otto-von-Guericke-Universität Magdeburg
presse

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