Prof. Bommhardt

apl. Prof. Dr. rer. nat. habil. Ursula Bommhardt

Medizinische Fakultät/Universitätsklinikum A.ö.R. (FME/UKMD)
Institut für Molekulare und Klinische Immunologie (IMKI)
Haus 26, Leipziger Str. 44, 39120, Magdeburg,
Projekte
Publikationen

2018

Begutachteter Zeitschriftenartikel

Rheinländer, Andreas;  Schraven, Burkhart;  Bommhardt, Ursula 

CD45 in human physiology and clinical medicine
In: Immunology letters - Amsterdam [u.a.]: Elsevier Science, Bd. 196.2018, S. 22-32; http://dx.doi.org/10.1016/j.imlet.2018.01.009

2017

Abstrakt

Mirdamadi, Yasaman Sadat;  Thielitz, Anja;  Goihl, Alexander;  Guttek, Karina;  Zouboulis, Christos C.;  Reinhold, Dirk;  Bommhardt, Ursula;  Quist, Sven Roy;  Gollnick, Harald 

Insights into the mechanism of action of insulin-like growth factor-1 and insulin in human T cells in vitro
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 26.2017, 3, P081 (OP06/06), S. E35; http://onlinelibrary.wiley.com/doi/10.1111/exd.13280/full

Mirdamadi, Yasaman Sadat;  Thielitz, Anja;  Wiede, Antje;  Goihl, Alexander;  Zouboulis, Christos C.;  Reinhold, Dirk;  Bommhardt, Ursula;  Quist, Sven Roy;  Gollnick, Harald 

Insights into the mechanism of action of isotretinoin in human sebocytes in vitro
In: Experimental dermatology: the official journal of the European Immunodermatology Society - Oxford: Wiley-Blackwell, Bd. 26.2017, 3, P082, S. E35-E36; http://onlinelibrary.wiley.com/doi/10.1111/exd.13280/full

Begutachteter Zeitschriftenartikel

Mirdamadi, Yasaman Sadat;  Thielitz, Anja;  Wiede, Antje;  Goihl, Alexander;  Zouboulis, Christos C.;  Bommhardt, Ursula;  Quist, Sven Roy;  Gollnick, Harald 

Effects of isotretinoin on the phosphoinositide-3-kinase/Akt/FoxO1 pathway and molecular functions of SZ95 sebocytes in vitro
In: Journal of clinical & experimental dermatology research - Los Angeles, CA: Omics international, Bd. 8.2017, 3, Art.-Nr. 1000399, insges. 12 S.; http://dx.doi.org/10.4172/2155-9554.1000399

Mirdamadi, Yasaman Sadat;  Bommhardt, Ursula;  Goihl, Alexander;  Guttek, Karina;  Zouboulis, Christos C.;  Quist, Sven Roy;  Gollnick, Harald 

Insulin and insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro
In: Dermato-endocrinology - Austin, Tex: Landes Bioscience, Bd. 9.2017, Art.-Nr. e1356518, insges. 13 S.; http://dx.doi.org/10.1080/19381980.2017.1356518

2016

Begutachteter Zeitschriftenartikel

Lowinus, Theresa;  Bose, Tanima;  Busse, Stefan;  Busse, Mandy;  Reinhold, Dirk;  Schraven, Burkhart;  Bommhardt, Ursula H. H. 

Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness
In: OncoTarget : open access impact journal. - [S.l.] : Impact Journals LLC, Bd. 7.2016, 33, S. 53797-53807

2015

Abstrakt

Mirdamadi, Yasaman;  Thielitz, Anja;  Wiede, Antje;  Goihl, Alexander;  Zouboulis, Christos C.;  Reinhold, Dirk;  Bommhardt, Ursula;  Quist, Sven;  Gollnick, Harald 

Effects of isotretinoin on FoxO1 transcriptional regulation and molecular functions of SZ95 sebocytes
In: Experimental dermatology : the official journal of the European Immunodermatology Society. - Oxford : Wiley-Blackwell; Bd. 24.2015, 3, P068, S. E12

Begutachteter Zeitschriftenartikel

Mirdamadi, Yasaman;  Thielitz, Anja;  Wiede, Antje;  Goihl, Alexander;  Papakonstantinou, Eleni;  Hartig, Roland;  Zouboulis, Christos C.;  Reinhold, Dirk;  Simeoni, Luca;  Bommhardt, Ursula;  Quist, Sven;  Gollnick, Harald 

Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro
In: Molecular and cellular endocrinology. - Amsterdam [u.a.] : Elsevier Science, Bd. 415.2015, S. 32-44

Linker, Ralf A.;  Lee, De-Hyung;  Flach, Anne-Christine;  Litke, Tanja;  Brandt, Jens van den;  Reichardt, Holger M.;  Lingner, Thomas;  Bommhardt, Ursula;  Sendtner, Michael;  Gold, Ralf;  Flügel, Alexander;  Lühder, Fred 

Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage
In: European journal of immunology. - Weinheim : Wiley-VCH, Bd. 45.2015, 5, S. 1326-1338

Busse, Stefan;  Steiner, Johann;  Glorius, Sarah;  Dobrowolny, Henrik;  Greiner-Bohl, Sabrina;  Mawrin, Christian;  Bommhardt, Ursula;  Hartig, Roland;  Bogerts, Bernhard;  Busse, Mandy 

VGF expression by T lymphocytes in patients with Alzheimer's disease
In: OncoTarget : open access impact journal. - [S.l.] : Impact Journals LLC, Bd. 6.2015, 17, S. 14843-14851

2014

Abstrakt

Lühder, Fred;  Linker, Ralf;  Lee, De-hyung;  Reichardt, Holger;  Bommhardt, Ursula;  Gold, Ralf;  Flügel, Alexander 

Critical role of thymocyte-derived brain-derived neurotrophic factor in T cell maturation
In: Journal of neuroimmunology : official journal of the International Society for Neuroimmunology. - Amsterdam [u.a.] : Elsevier Science, Bd. 275.2014, 1/2, S. 202-203

Begutachteter Zeitschriftenartikel

Busse, Stefan;  Steiner, Johann;  Micheel, Justus;  Dobrowolny, Henrik;  Mawrin, Christian;  Krause, Tim J.;  Adamaszek, Michael;  Bogerts, Bernhard;  Bommhardt, Ursula;  Hartig, Roland;  Busse, Mandy 

Age-related increase of VGF-expression in T lymphocytes
In: Aging. - [S.l.] : Impact Journals, LLC, Bd. 6.2014, 6, S. 440-453

Kahlfuß, Sascha;  Simma, Narasimhulu;  Mankiewicz, Judith;  Bose, Tanima;  Lowinus, Theresa;  Klein-Hessling, Stefan;  Sprengel, Rolf;  Schraven, Burkhart;  Heine, Martin;  Bommhardt, Ursula 

Immunosuppression by N-Methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells
In: Molecular and cellular biology. - Washington, DC : Soc, Bd. 34.2014, 5, S. 820-831

Simma, Narasimhulu;  Bose, Tanima;  Kahlfuß, Sascha;  Mankiewicz, Judith;  Lowinus, Theresa;  Lühder, Fred;  Schüler, Thomas;  Schraven, Burkhart;  Heine, Martin;  Bommhardt, Ursula 

NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells
In: Cell communication and signaling. - London : Biomed Central; Bd. 12.2014, Art.-Nr. 75, insges. 13 S.

Dissertation

Bose, Tanima;  Bommhardt, Ursula [Gutachter] 

Crosstalk between NMDAR antagonists and potassium channels in murine and human lymphocytes
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014; 92 Bl.: graph. Darst.; 30 cm

2013

Abstrakt

Patra, Amiya K.;  Avots, Andris;  Zahedi, René P.;  Schüler, Thomas;  Sickmann, Albert;  Bommhardt, Ursula;  Serfling, Edgar 

Interleukin-7-mediated NFAT activation sets the threshold for T cell development
In: Cytokine. - London : Academic Press; Bd. 63.2013, 3, Abs. 196, S. 289

Begutachteter Zeitschriftenartikel

Patra, Amiya Kumar;  Avots, Andris;  Zahedi, René Peiman;  Schüler, Thomas;  Sickmann, Albert;  Bommhardt, Ursula;  Serfling, Edgar 

An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development
In: Nature immunology - New York, NY: SpringerNature, Bd. 14.2013, 2, S. 127-135; http://dx.doi.org/10.1038/ni.2507

2012

Dissertation

Pierau, Mandy;  Bommhardt, Ursula [Gutachter] 

Proteinkinase B- und TGFβ1-Signalwege - Untersuchungen zu ihrer Interaktion bei der Th-Zelldifferenzierung
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2012; 143 Bl.: graph. Darst.

Originalartikel in begutachteter internationaler Zeitschrift

Pierau, Mandy;  Na, Shin-Young;  Simma, Narasimhulu;  Lowinus, Theresa;  Marx, Alexander;  Schraven, Burkhart;  Bommhardt, Ursula H. 

Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function
In: European journal of immunology. - Weinheim : Wiley VCH, Bd. 42.2012, 12, S. 3381-3393

2011

Dissertation

Engelmann, Swen;  Bommhardt, Ursula [Gutachter] 

Einfluss von Proteinkinase B (PKB/Akt) auf Differenzierungsprozesse von T-Helferzellen und den Verlauf der Experimentellen Autoimmunen Enzephalomyelitis (EAE)
In: Magdeburg Univ., Fak. für Naturwiss., Diss., 2011, III, 104 Bl., graph. Darst., 30 cm

Originalartikel in begutachteter internationaler Zeitschrift

Bhattacharyya, Sankar;  Deb, Jolly;  Patra, Amiya K.;  Pham, Duong Anh Thuy;  Chen, Wen;  Väth, Martin;  Berberich-Siebelt, Friederike;  Klein-Hessling, Stefan;  Lamperti, Edward D.;  Reifenberg, Kurt;  Jellusova, Julia;  Schweizer, Astrid;  Nitschke, Lars;  Leich, Ellen;  Rosenwald, Andreas;  Brunner, Cornelia;  Engelmann, Swen;  Bommhardt, Ursula;  Avots, Andris;  Müller, Martin R.;  Kondo, Eisaku;  Serfling, Edgar 

NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network
In: The journal of experimental medicine. - New York, NY : Rockefeller Univ. PressThe journal of experimental medicine <New York, NY>, Bd. 208.2011, 4, S. 823-839

2010

Dissertation

Drewes, Thomas;  Bommhardt, Ursula [Gutachter] 

Cross-talk of protein kinase B (PKB/Akt) with the transcription factor NFAT and the Src kinase Fyn in T lymphocytes
In: Magdeburg, Univ., Fak. für Naturwiss., Diss., 2010; III, 116 Bl.: graph. Darst.; 30 cm

Originalartikel in begutachteter internationaler Zeitschrift

Bommhardt, Ursula 

Hedgehog signalling in T-cell development: A non-redundant role for Gli1
In: Cell cycle . - Georgetown, Tex. : Landes Bioscience, Bd. 9.2010, 22, S. 4428

Bommhardt, Ursula 

Hedgehog signalling in T-cell development: A non-redundant role for Gli1.
In: Cell Cycle. 2010 Nov 15;9(22):4433-4432.

2009

Originalartikel in begutachteter internationaler Zeitschrift

Bajbouj, Khuloud;  Pöhlmann, Angela;  Küster, Dörthe;  Drewes, Thomas;  Haase, Kathrin;  Hartig, Roland;  Teller, Anne;  Kliche, Stefanie;  Walluscheck, Diana;  Ivanovska, Jelena;  Chakilam, Saritha;  Ulitzsch, Annika;  Bommhardt, Ursula;  Leverkus, Martin;  Roessner, Albert;  Schneider-Stock, Regine 

Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNF[alpha]-induced apoptosis in colorectal tumor cells
In: The American journal of pathology . - Bethesda, Md. : American Society for Investigative Pathology, Bd. 175.2009, 2, S. 557-570

Pierau, Mandy;  Engelmann, Swen;  Reinhold, Dirk;  Lapp, Thabo;  Schraven, Burkhart;  Bommhardt, Ursula 

Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 183.2009, 10, S. 6124-6134

2008

Originalartikel in begutachteter internationaler Zeitschrift

Bekeredjian-Ding, Isabelle;  Doster, Anne;  Schiller, Martin;  Heyder, Petra;  Lorenz, Hanns-Martin;  Schraven, Burkhart;  Bommhardt, Ursula;  Heeg, Klaus 

TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells
In: The journal of immunology . - Bethesda, Md. : American Assoc. of Immunologists, Bd. 181.2008, 12, S. 8267-8277

2007

Originalartikel in begutachteter internationaler Zeitschrift

Saez-Rodriguez, Julio;  Simeoni, Luca;  Lindquist, Jonathan;  Hemenway, Rebecca;  Bommhardt, Ursula;  Arndt, Börge;  Haus, Utz-Uwe;  Weismantel, Robert;  Gilles, Ernst D.;  Klamt, Steffen;  Schraven, Burkhart 

A logical model provides insights into T cell receptor signaling
In: Public Library of Science : PLoS Computational Biology . - San Francisco, Calif. : Public Library of Science, Bd. 3.2007, 8, insges. 11 S.; Abstract unter URL: http://dx.doi.org/10.1371/journal.pcbi.0030163

Bommhardt, Ursula 

Glis: novel modulators of TCR signaling?
In: Blood: the journal of hematology - Washington, DC: American Society of Hematology, Bd. 109.2007, 9, S. 3618-3619; http://bloodjournal.hematologylibrary.org/content/vol109/issue9/

Masse, Guillemette X.;  Corcuff, Erwan;  Decaluwe, Hélène;  Bommhardt, Ursula;  Lantz, Olivier;  Buer, Jan;  DiSanto, James P. 

[Gamma]c cytokines provide multiple homeostatic signals to naive CD4+ T cells
In: European journal of immunology - Weinheim: Wiley VCH, Bd. 37.2007, 9, S. 2606-2616; http://www3.interscience.wiley.com/cgi-bin/abstract/114801695/ABSTRACT

2006

Originalartikel in begutachteter internationaler Zeitschrift

Patra, Amiya Kumar;  Drewes, Thomas;  Engelmann, Swen;  Chuvpilo, Sergei;  Kishi, Hiroyuki;  Hünig, Thomas;  Serfling, Edgar;  Bommhardt, Ursula H. 

PKB rescues Calcineurin/NFAT-induced arrest of Rag expression and Pre-T cell differentiation
In: The journal of immunology: official journal of the American Association of Immunologists - Rockville, Md: American Association of Immunologists, Bd. 177.2006, 7, S. 4567-4576; http://www.jimmunol.org/cgi/content/abstract/177/7/4567

Kooperationen
  • Dr. Michael Kreutz, IfN
  • Prof. E. Serfling, Würzburg
  • Dr. Martin Heine, IfN
Profil
Zelluläre und molekulare Immunologie
  • T-Zellreifung
  • T-Zellaktivierung- und differenzierung: Th17, Treg...
  • Signaltransduktion in T-Zellen, ins. PKB/Akt-Signalgebung
  • Autoimmunität und Tumorgenese
Service
Phänotypische und funktionelle Analyse von Immunzellen
Vita
presse

Letzte Änderung: 22.08.2018 - Ansprechpartner: Webmaster